International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112510 - 112510
Published: June 18, 2024
Language: Английский
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Language: Английский
Citations
9
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 4, 2025
Acute lung injury (ALI) is a severe respiratory disease accompanied by diffuse inflammatory responses induced various clinical causes. Many fresh medicinal plants have shown better efficacy than their dried forms in preventing and treating diseases like inflammation. As classical Chinese herb, platycodon grandiflorum (PG) has been demonstrated effective pneumonia, but most of previous studies focused on the processed or PG formats, while specific benefits its form are still underexplored. Exosome-like nanoparticles derived from expected to point out an important direction for exploring material basis mechanism this herbal medicine. The could effectively improve ALI lipopolysaccharide (LPS), relieve histopathological weight loss, reduce levels factors mice, exhibiting treatment ALI. Further extraction purification exosome-like (PGLNs) that PGLNs had good biocompatibility, with characteristics consistent general nanoparticles. Besides, proteomic analysis indicated were rich variety proteins. Animal experiments showed improved pathological changes LPS-induced tissues, inhibited expression promoted anti-inflammatory factors, exerted regulatory effect polarization macrophages. Cell further confirmed be taken up RAW264.7 cells repolarize M1 macrophages into M2 type, therefore reducing secretion harmful cytokines. Moreover, non-targeted metabolomics reveals inflammation control macrophage manner closely linked pathways including glycolysis lipid metabolism, highlighting potential which protect lungs damage Fresh repair effects form. one active substances PG, may regulate regulating metabolic metabolism glycolysis, so as injury.
Language: Английский
Citations
1
Life Sciences, Journal Year: 2024, Volume and Issue: 346, P. 122648 - 122648
Published: April 15, 2024
Acute lung injury (ALI) is a life-threatening disease characterized by inflammatory cell infiltration and epithelial injury. Icariside II (ICS II), one of the main active ingredients Herba Epimedii, exhibits anti-inflammatory immunomodulatory effects. However, effect mechanism ICS in ALI remain unclear. The purpose current study was to investigate pharmacological underlying ALI. Models neutrophil-like cells, human peripheral blood neutrophils, lipopolysaccharide (LPS)-induced mouse model were utilized. RT-qPCR Western blotting determined gene protein expression levels. Protein distribution quantification analyzed immunofluorescence. significantly reduced histopathological damage, edema, infiltration, it pro-inflammatory cytokines There an excessive activation neutrophils leading significant production NETs mice, process mitigated administration II. In vivo vitro studies found that could decrease NET formation targeting neutrophil C-X-C chemokine receptor type 4 (CXCR4). Further data showed reduces overproduction dsDNA, NETs-related component, thereby suppressing cGAS/STING/NF-κB signalling pathway mediators release cells. This suggested may alleviate LPS-induced modulating response, indicating its potential as therapeutic agent for treatment.
Language: Английский
Citations
6
Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)
Published: July 30, 2024
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. The inflammatory cytokine storm causes systemic damage, especially acute lung injury in sepsis. In this study, we found that the expression of S-phase kinase-associated protein 2 (Skp2) was significantly decreased sepsis-induced (ALI). activated MEK/ERK pathway and inhibited Skp2 pulmonary epithelium, resulting reduction K48 ubiquitination solute carrier family 3 member (SLC3A2), thereby impairing its membrane localization cystine/glutamate exchange function. Consequently, intracellular redox reactions induced ferroptosis epithelial cells, leading injury. Finally, demonstrated intravenous administration mRNA-encapsulating lipid nanoparticles (LNPs) epithelium alleviated septic mice. Taken together, these data provide an innovative understanding underlying mechanisms ALI promising therapeutic strategy for
Language: Английский
Citations
4
European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 282, P. 117068 - 117068
Published: Nov. 15, 2024
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1875 - 1875
Published: Feb. 3, 2024
Acute lung injury (ALI) is a serious inflammatory disease with high morbidity and mortality. Rosavin an anti-inflammatory antioxidant phenylpropanoid glucoside, which isolated from Rhodiola rosea L. However, its potential molecular mechanisms whether it has protective effects against lipopolysaccharide (LPS)-induced ALI remain to be elucidated. To assess the in vitro anti-lung activity of rosavin, RAW264.7 A549 cells were stimulated using 1 μg/mL LPS. attenuated LPS-induced activation TLR-4/NF-κB signaling pathway inhibited release factors cells. A mouse model acute was constructed by intraperitoneal injection 5 mg/kg LPS observe therapeutic effect rosavin. Transcriptomics analysis Western blot assays utilized verify mechanism, rosavin (20, 40, 80 mg/kg) dose-dependently ameliorated histopathological alterations, reduced levels factors, TLR-4/NF-κB/MAPK apoptosis activation. promising candidate for inhibiting pathway.
Language: Английский
Citations
4
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 22, 2025
Objective This study aims to conduct a bibliometric analysis assess the present state, thematic focus, and emerging developments in research literature on involvement of pyroptosis pathogenesis treatment acute lung injury (PFALI), as well other pertinent areas. Methods examined PFALI published from 1 January 2004 24 May 2024, utilizing Web Science database. The was conducted using CiteSpace, VOSviewer, R, GraphPad Prism 8.0, encompassed metadata countries, institutions, authors, journals, keywords represented literature. Results analyzed 1,495 publications, comprising 1,194 articles 301 reviews, publication output PFALI. China exhibited highest with 964 (64.48%) articles. Central South University most prolific institution, contributing 54 (3.61%) publications. Zhou, Yong had greatest individual record, 15 (3.59%) journal International Immunopharmacology PFALI-related at 76 (5.09%). identified frontiers for upcoming years include “iron,” “sirt1,” “repair,” “alveolar macrophage pyroptosis.” Conclusion comprehensively trends advancements related PFALI, including contributions key countries.
Language: Английский
Citations
0
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: Jan. 29, 2025
Language: Английский
Citations
0
ChemMedChem, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 23, 2025
Acute lung injury (ALI) is a severe condition often seen in intensive care unit patients. Due to limited treatment options, ALI linked high rates of mortality and morbidity. Bacterial viral infections are significant contributors ALI. For instance, acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can lead strong inflammatory response that may progress ALI, leading cause death COVID-19 cases. Prior research has demonstrated sulfonamides sydnones exhibit anti-inflammatory antiviral properties, which led us develop compounds containing both scaffolds. Most the new sulfonamide-sydnone hybrids expected be orally bioavailable based on silico ADME predictions. They effectively suppressed development lipopolysaccharide (LPS)-challenged mice inhibited replication Calu-3 cells, with minimal cytotoxicity non-infected Vero E6 cells. Molecular docking investigations indicated some possible targets for action sydnones, highlighting interaction non-structural proteins SARS-CoV-2. Additionally, combined experimental theoretical studies strongly interact human serum albumin, suggesting extended residence time bloodstream.
Language: Английский
Citations
0
Frontiers in Digital Health, Journal Year: 2025, Volume and Issue: 7
Published: March 4, 2025
Background Acute lung injury is a common respiratory emergency that seriously affects the life, health and quality of life patients, especially after global COVID-19 pneumonia. The application nanotechnology in acute promising. In response to knowledge explosion resulting from rapid publication growth, we applied bibliometric analysis explore research profile thematic trends field. Methods Articles reviews related 2004 2023 were searched. Java-based Citespace, VOSviewer, R software-based Bibiometrix used systematically evaluate publications by spatiotemporal distribution, author subject categories, topic references, keywords. Results A total 1,347 included. number papers has grown exponentially over past 20 years. China was most productive country out all 53 countries, followed United States. Chinese Academy Sciences institution with 76 papers. PARTICLE AND FIBRE TOXICOLOGY journal. top five high-frequency keywords inflammation, oxidative stress, toxicity, vitro , respiratory-distress-syndrome. And emerging delivery, covid-19, extracellular vesicles, therapy, sars-cov-2. Drug delivery are focus current research. Two areas represented development trends: novel nanocarriers higher efficiency lower biotoxicity, other impact nanomaterials progression injury. Conclusion field been period last three Delivery,targeted exosm have this trends:novel biotoxicity such as exosomes solid lipid nanoparticles,
Language: Английский
Citations
0