Acute lung injury and post-cardiac arrest syndrome: a narrative review DOI Creative Commons
Yusuke Endo, Tomoaki Aoki, Daniel Jafari

et al.

Journal of Intensive Care, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 3, 2024

Abstract Background Post-cardiac arrest syndrome (PCAS) presents a multifaceted challenge in clinical practice, characterized by severe neurological injury and high mortality rates despite advancements management strategies. One of the important critical aspects PCAS is post-arrest lung (PALI), which significantly contributes to poor outcomes. PALI arises from complex interplay pathophysiological mechanisms, including trauma chest compressions, pulmonary ischemia–reperfusion (IR) injury, aspiration, systemic inflammation. Despite its significance, pathophysiology remains incompletely understood, necessitating further investigation optimize therapeutic approaches. Methods This review comprehensively examines existing literature elucidate epidemiology, pathophysiology, strategies for PALI. A comprehensive search was conducted identify preclinical studies investigating Data these were synthesized provide overview management. Results Epidemiological have highlighted substantial prevalence post-cardiac patients, with up 50% survivors experiencing acute injury. Diagnostic imaging modalities, X-rays, computed tomography, ultrasound, play crucial role identifying assessing severity. Pathophysiologically, encompasses spectrum factors, compression-related trauma, IR inflammation, collectively contribute dysfunction Therapeutically, lung-protective ventilation strategies, such as low tidal volume optimization positive end-expiratory pressure, emerged cornerstone approaches Additionally, hypothermia emerging therapies targeting mitochondrial hold promise mitigating PALI-related morbidity mortality. Conclusion represents significant care, prompt diagnosis targeted interventions improve Mitochondrial-related are among novel Further research warranted enhance care paradigms. Graphical

Language: Английский

Restoring Mitochondrial Function and Muscle Satellite Cell Signaling: Remedies against Age-Related Sarcopenia DOI Creative Commons
Emanuele Marzetti, Biliana Lozanoska‐Ochser, Riccardo Calvani

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 415 - 415

Published: March 28, 2024

Sarcopenia has a complex pathophysiology that encompasses metabolic dysregulation and muscle ultrastructural changes. Among the drivers of intracellular changes fibers in sarcopenia, mitochondria their quality control pathways play relevant roles. Mononucleated stem cells/satellite cells (MSCs) have been attributed critical role repair after an injury. The involvement supporting MSC-directed is unclear. There evidence reduction mitochondrial biogenesis blunts repair, thus indicating delivery functional to injured muscles can be harnessed limit fibrosis enhance restoration function. Injection autologous respiration-competent from uninjured sites damaged tissue shown reduce infarct size cell survival preclinical models ischemia-reperfusion. Furthermore, incorporation donor into MSCs enhances lung cardiac repair. This strategy also tested for regeneration purposes traumatic injuries. Indeed, systemic promotes restores mass function while reducing during recovery In this review, we discuss contribution altered MSC sarcopenia illustrate prospect harnessing as therapeutic against age-related sarcopenia.

Language: Английский

Citations

9
The role of homogenization cycles and Poloxamer 188 on the quality of mitochondria isolated for use in mitochondrial transplantation therapy DOI Creative Commons
Ryosuke Takegawa, Kei Hayashida,

Atsushi Murao

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 27, 2025

Language: Английский

Citations

0
Mitochondrial transplantation improves outcomes after cardiac arrest and resuscitation in mice DOI
Tomoaki Aoki, Yusuke Endo,

Tai Yin

et al.

Resuscitation, Journal Year: 2025, Volume and Issue: unknown, P. 110535 - 110535

Published: Feb. 1, 2025

Language: Английский

Citations

0
Stroke Studies in Large Animals: Prospects of Mitochondrial Transplantation and Enhancing Efficiency using Hydrogels and Nanoparticle-assisted Delivery DOI
Öner Ülger, Ismail Eş, Christopher M. Proctor

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102469 - 102469

Published: Aug. 25, 2024

Language: Английский

Citations

3
Acute lung injury and post-cardiac arrest syndrome: a narrative review DOI Creative Commons
Yusuke Endo, Tomoaki Aoki, Daniel Jafari

et al.

Journal of Intensive Care, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 3, 2024

Abstract Background Post-cardiac arrest syndrome (PCAS) presents a multifaceted challenge in clinical practice, characterized by severe neurological injury and high mortality rates despite advancements management strategies. One of the important critical aspects PCAS is post-arrest lung (PALI), which significantly contributes to poor outcomes. PALI arises from complex interplay pathophysiological mechanisms, including trauma chest compressions, pulmonary ischemia–reperfusion (IR) injury, aspiration, systemic inflammation. Despite its significance, pathophysiology remains incompletely understood, necessitating further investigation optimize therapeutic approaches. Methods This review comprehensively examines existing literature elucidate epidemiology, pathophysiology, strategies for PALI. A comprehensive search was conducted identify preclinical studies investigating Data these were synthesized provide overview management. Results Epidemiological have highlighted substantial prevalence post-cardiac patients, with up 50% survivors experiencing acute injury. Diagnostic imaging modalities, X-rays, computed tomography, ultrasound, play crucial role identifying assessing severity. Pathophysiologically, encompasses spectrum factors, compression-related trauma, IR inflammation, collectively contribute dysfunction Therapeutically, lung-protective ventilation strategies, such as low tidal volume optimization positive end-expiratory pressure, emerged cornerstone approaches Additionally, hypothermia emerging therapies targeting mitochondrial hold promise mitigating PALI-related morbidity mortality. Conclusion represents significant care, prompt diagnosis targeted interventions improve Mitochondrial-related are among novel Further research warranted enhance care paradigms. Graphical

Language: Английский

Citations

3