Clinical and Demographic Profile of Syrian Patients with Malignant Glioma: A Six-Month Retrospective Analysis DOI
R.O. Ibrahim,

Zein Al-Abideen Douba,

Reema Khaddam

et al.

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2024, Volume and Issue: 4(6), P. 49 - 57

Published: Oct. 28, 2024

This study presents a retrospective analysis of glioblastoma cases admitted to Tishreen University Hospital in Lattakia, Syria, between February and August 2024. The examines the several potential risk factors including age, sex, genetic predispositions, lifestyle such as smoking alcohol consumption. It also explores most commonly encountered tumor grade presence various neurological symptoms, well treatment outcomes. A total 30 were enrolled this study, 63% which males, highest age incidence was 40 50 years. Only 6% had family history glioblastoma, 66% patients smokers. Memory disorders, visual impairments, headaches common with 100% reporting nausea vomiting. Glioblastoma diagnosis primarily established through MRI contrast (76%), predominant modality surgery combined radiotherapy chemotherapy (80%). Post-treatment relapse occurred 26% patients, median remission period four months. These findings provide important insights into clinical characteristics outcomes region.

Language: Английский

Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma DOI Open Access
Md. Ataur Rahman,

Meser M. Ali

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2975 - 2975

Published: Aug. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Language: Английский

Citations

10
Emerging nanoplatforms towards microenvironment-responsive glioma therapy DOI

Nigam Sekhar Tripathy,

Liza Sahoo,

Safal Kumar Paikray

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(2)

Published: Jan. 15, 2025

Language: Английский

Citations

1
Stimuli-Responsive Polymeric Nanocarriers Accelerate On-Demand Drug Release to Combat Glioblastoma DOI
Muhammad Ismail,

Yibin Wang,

Yundong Li

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Glioblastoma multiforme (GBM) is a highly malignant brain tumor with poor prognosis and limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great promise for improving the modalities of GBM. At beginning review, we highlighted stimuli-active polymeric carrying therapies that potentially boost anti-GBM responses employing endogenous (pH, redox, hypoxia, enzyme) or exogenous stimuli (light, ultrasonic, magnetic, temperature, radiation) as triggers controlled drug release mainly via hydrophobic/hydrophilic transition, degradability, ionizability, etc. Modifying these target ligands further enhanced their capacity to traverse blood-brain barrier (BBB) preferentially accumulate in glioma cells. These unique features lead more effective cancer minimal adverse reactions superior therapeutic outcomes. Finally, review summarizes existing difficulties future prospects treating Overall, this offers theoretical guidelines developing intelligent versatile facilitate precise GBM clinical settings.

Language: Английский

Citations

8
Glioblastoma Tumor Microenvironment: An Important Modulator for Tumoral Progression and Therapy Resistance DOI Creative Commons
Ligia Gabriela Tătăranu,

Șerban Turliuc,

A. El Kamel

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 9881 - 9894

Published: Sept. 5, 2024

The race to find an effective treatment for glioblastoma (GBM) remains a critical topic, because of its high aggressivity and impact on survival the quality life. Currently, due GBM's heterogeneity, conventional success rate response therapy are relatively low, with median less than 20 months. A new point view can be provided by comprehension tumor microenvironment (TME) in pursuance development therapeutic strategies aim longer improved life disease-free interval (DFI). main components GBM TME represented extracellular matrix (ECM), glioma cells stem (GSCs), immune (microglia, macrophages, neutrophils, lymphocytes), neuronal cells, all them having dynamic interactions being able influence tumoral growth, progression, drug resistance thus potential target. This paper will review latest research targets form up-to-date strategy.

Language: Английский

Citations

4
Diffusion tensor imaging changes along the perivascular spaces may serve as a prognostic factor for high-grade glioma DOI
Lang Wang, Lu Liu,

Hongjing Zhang

et al.

European Journal of Radiology, Journal Year: 2025, Volume and Issue: 184, P. 111993 - 111993

Published: Feb. 9, 2025

Language: Английский

Citations

0
Radiation-Induced Brain Injury with Special Reference to Astrocytes as a Therapeutic Target DOI Creative Commons
Caiping Wang,

Xingjuan Fan,

Yunwei Shi

et al.

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(3)

Published: March 21, 2025

Radiotherapy is one of the primary modalities for oncologic treatment and has been utilized at least once in over half newly diagnosed cancer patients. Cranial radiotherapy significantly enhanced long-term survival rates patients with brain tumors. However, radiation-induced injury, particularly hippocampal neuronal damage along impairment neurogenesis, inflammation, gliosis, adversely affects quality life these Astrocytes, a type glial cell that are abundant brain, play essential roles maintaining homeostasis function. Despite their importance, pathophysiological changes astrocytes induced by radiation have not thoroughly investigated, no systematic or comprehensive review addressing effects on related diseases conducted. In this paper, we current studies neurophysiological following exposure. We describe astrocytes, including astrogliosis, astrosenescence, associated cellular molecular mechanisms. Additionally, summarize impairments neurogenesis blood-brain barrier (BBB). Based research, propose may serve as potential therapeutic targets treating injury (RIBI) subsequent neurological neuropsychiatric disorders.

Language: Английский

Citations

0
The Mevalonate Pathway in the Radiation Response of Cancer DOI
Linda Azizi, Hannah Hausman,

A. Meyer

et al.

International Journal of Radiation Oncology*Biology*Physics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Development and Validation of an Early Recurrence Prediction Model for High-Grade Glioma Integrating Temporalis Muscle and Tumor Features: Exploring the Prognostic Value of Temporalis Muscle DOI
Quanwei Zhu, Xiaocong Hu,

Qihui Ye

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

This study aimed to develop and validate a predictive model for early recurrence of high-grade glioma (HGG) within 180 days, assess the prognostic value preoperative postoperative temporalis muscle metrics (area thickness), explore their significance in follow-up. Seventy-one molecularly confirmed HGG patients were included, with data sourced from local TCIA (The Cancer Imaging Archive) RHUH-GBM (Río Hortega University Hospital Glioblastoma) dataset. Tumor segmentation was performed using deep learning, radiomic features extracted following comparison manual segmentation. Feature selection conducted mutual information recursive feature elimination. A comprehensive integrating 3D tumor radiomics developed compared tumor-only identify optimal framework. SHAP analysis used evaluate interpretability importance. The TM_Tumor_HistGradientBoosting model, incorporating 16 including metrics, outperformed accuracy (0.89), recall (0.87), F1 score (0.88). highlighted that cross-sectional area strongly associated risk, while thickness significantly contributed prediction. Combining MRI substantially improved prediction HGG. Temporalis serve as objective sustainable indicators significant clinical

Language: Английский

Citations

0
Oxidative stress induced paclitaxel-derived carbon dots inhibit glioblastoma proliferation and EMT process DOI Creative Commons
Haiyang Yan,

Huimin Miao,

James C. Hu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Glioblastoma represents the most prevalent and deadly form of brain tumor with limited therapeutic drugs. The existence blood-brain barrier (BBB) hinders drugs permeate to efficiently. Nowadays, nano-formulations, particularly carbon dots, have emerged as promising candidates for targeting treating diseases. In this study, we report synthesis a novel PTX-CDs, using one-step hydrothermal method paclitaxel (PTX) precursor. PTX-CDs shows increased water solubility by about 1000 times in comparison PTX. Moreover, effectively penetrates BBB exerts significant anticancer effects. detail, accumulates mitochondria cells without adding extra targeted molecules, resulting damage mitochondrial membrane potential reactive oxygen species (ROS) level. Transcriptome profiling revealed that disturbs cell-cycle inducing arrest at G2/M phase, thereby inhibiting cell proliferation. further decreased invasion epithelial-mesenchymal transition (EMT) process glioblastoma cells. significantly inhibited growth intracranial tumors orthotopic mice model prolonged survival tumor-bearing mice. This study presents viable strategy develop CDs-based agent conventional chemotherapeutic

Language: Английский

Citations

0
Donor Substitution Engineering of Hemicyanine Nanoparticles to Reprogram the Tumor Microenvironment and Enhance Fn14‐Targeted BiTE for Glioblastoma Photoimmunotherapy DOI

Gaowei Li,

Shichao Jiang, Zongliang Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Glioblastoma (GBM) is a highly malignant intracranial tumor with limited treatment options. Bispecific T‐cell engagers (BiTEs) are being explored for GBM treatment, but their success hindered by inadequate T cell infiltration and activation due to the acidic immunosuppressive microenvironment. Photothermal immunotherapy lyses tumors activates immune responses, complementing BiTEs. This study innovatively employs donor engineering strategy develop hemicyanine dyes (Hcys) that emit from near‐infrared (NIR) I NIR II. The Hcy excellent properties encapsulated in an amphiphilic micelle, forming nano assembly lactate oxidase (PLH1100). PLH1100 exhibits spectral absorption at 980 nm, photothermal conversion efficiency of 58.7%, capability NIR‐II imaging. Besides ablation, regulates lactic acid metabolism immunogenic death, improving microenvironment promoting activation. Further studies demonstrate effectively kills human murine cells, inhibits orthotopic U87 growth BALB/c‐nu mice, enhances efficacy Fn14‐targeted BiTE GL261 C57BL/6 achieving synergistic “1+1>2” therapeutic effect. Collectively, this work opens new pathway using Hcy‐based molecules combined drugs therapy, significant clinical potential.

Language: Английский

Citations

3