Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Jan. 20, 2024
Language: Английский
Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 168(5), P. 910 - 954
Published: Jan. 6, 2024
Although we have learned much about how the brain fuels its functions over last decades, there remains still to discover in an organ that is so complex. This article lays out major gaps our knowledge of interrelationships between metabolism and function, including biochemical, cellular, subcellular aspects functional imaging adult brain, as well during development, aging, disease. The focus on unknowns substrates associated transporters, roles insulin lipid droplets, emerging role microglia, mysteries cofactor signaling molecule NAD
Language: Английский
Citations
36
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Jan. 2, 2025
Abstract Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is restrained cellular defences. Ferroptosis increasingly implicated in a host of diseases, and unlike other cell death programs the physiological initiation conceived to occur not an endogenous executioner, but withdrawal guardians that otherwise constantly oppose induction. Here, we profile key ferroptotic defence strategies including regulation, modulation enzymes metabolite systems: glutathione reductase (GR), suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase (NQO1), Dihydrofolate (DHFR), retinal reductases dehydrogenases (RDH) thioredoxin (TR). A common thread uniting all metabolites combat lipid during dependence on reductant, nicotinamide adenine dinucleotide phosphate (NADPH). We will outline how cells control central carbon metabolism produce NADPH necessary precursors defend against ferroptosis. Subsequently discuss evidence for dysregulation different disease contexts glucose-6-phosphate dehydrogenase deficiency, cancer neurodegeneration. Finally, several anti-ferroptosis therapeutic spanning use radical trapping agents, dependent redox support highlight current landscape clinical trials focusing
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1645 - 1645
Published: Feb. 14, 2025
The relationship between neuroinflammation and depression is a complex area of research that has garnered significant attention in recent years. Neuroinflammation, characterized by the activation glial cells release pro-inflammatory cytokines, been implicated pathophysiology depression. bidirectional; not only can inflammation contribute to onset depressive symptoms, but itself also exacerbate inflammatory responses, creating vicious cycle complicates treatment recovery. present comprehensive review aimed explore current findings on interplay depression, as well mechanisms, risk factors, therapeutic implications. mechanisms which induces depressive-like behaviors are diverse. Neuroinflammation increase activate hypothalamus-pituitary-adrenal (HPA) axis, impair serotonin synthesis, all symptoms. Furthermore, microglia linked mediators disrupt neuronal function mood disorders. Stress-induced neuroinflammatory responses lead cytokines affect brain influence behavior mood. Understanding these crucial for developing targeted therapies mitigate effects
Language: Английский
Citations
4
Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 81, P. 101734 - 101734
Published: Sept. 14, 2022
Language: Английский
Citations
52
Acta Pharmacologica Sinica, Journal Year: 2022, Volume and Issue: 43(10), P. 2482 - 2494
Published: March 15, 2022
Language: Английский
Citations
51
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(4), P. 833 - 845
Published: Aug. 14, 2023
A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.
Language: Английский
Citations
31
Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(8)
Published: Aug. 8, 2023
Abstract Cervical cancer is one of the leading causes death in women. Mitochondrial-mediated ferroptosis (MMF) a recently discovered form cell death. However, role and underlying mechanism MMF cervical remain elusive. Here, using an unbiased screening for mitochondrial transmembrane candidates, we identified carrier 1 ( MTCH1 ) as central mediator cancers. -deficiency disrupted oxidative phosphorylation while elevated reactive oxygen species (ROS) by decreasing NAD + levels. This autonomous event initiated mitochondria-to-nucleus retrograde signaling involving reduced FoxO1 nuclear translocation subsequently downregulation transcription activity key anti-ferroptosis enzyme glutathione peroxidase 4 (GPX4), thereby elevating ROS ultimately triggering ferroptosis. Strikingly, targeting combination with Sorafenib effectively synergistically inhibited growth nude mouse xenograft model actively inducing In conclusion, these findings enriched our understanding mechanisms which governed though to FoxO1-GPX4 axis, provided potential therapeutic target treating cancer.
Language: Английский
Citations
29
Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 208, P. 110888 - 110888
Published: Jan. 29, 2024
Neuroinflammation induced by chronic cerebral hypoperfusion (CCH) plays a crucial role in the pathophysiologic mechanisms of vascular dementia (VD). A growing body research has found that intestinal microbiota is associated with variety central nervous system disorders and there relationship between dysbiosis cognitive dysfunction inflammatory responses. Baicalein belongs to class flavonoids biological functions, including anti-inflammatory, antioxidant anti-apoptotic. significant improvement memory learning, can be used as potential drug for protection treatment disorders. Whether baicalein an ameliorative effect on impairment VD, whether its mechanism related inhibition response regulation not been reported. We bilateral common carotid artery occlusion (BCCAO) establish VD rat model. Morris water maze (MWM) test showed improved rats. applied HE staining, immunofluorescence ELISA observe significantly CCH-induced neuronal damage CA1 region hippocampus, reduced glial cell activation release pro-inflammatory factors. Western blot inhibited TLR4/MyD88/NF-κB signaling pathway 16 S rDNA sequencing analyze composition microbiota. The results modulated diversity microbiota, suppressed relative abundance inflammation-associated In conclusion, this study ameliorated impairment, attenuated hippocampal responses, pathway,
Language: Английский
Citations
15
Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122749 - 122749
Published: Aug. 6, 2024
Language: Английский
Citations
11
Biotechnology and Applied Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 26, 2025
ABSTRACT The PnuC gene plays a crucial role in the complex processes related to absorption and synthesis of nicotinamide mononucleotide (NMN) precursor. NMN, adenine dinucleotide (NAD + ) precursor, is important for cellular energy metabolism, DNA repair, antiaging. This study focuses on elucidating precursor mechanism specific function encoding membrane transport proteins, as well its impact regulation dynamics NMN within cell. understanding aims provide insights into potential effects metabolic balance, illustrated through two NAD biosynthesis pathways based renewable readily available cytoplasmic resources, assessing expression clarifying interactions mechanisms. Enhanced analysis has initiated discussions applications treating aging‐related diseases dysfunctions, contributing health maintenance.
Language: Английский
Citations
1