Cancer Immunology Research,
Journal Year:
2024,
Volume and Issue:
12(12), P. 1691 - 1702
Published: Aug. 26, 2024
Abstract
Ferroptosis
is
an
iron-dependent
form
of
cell
death
that
influences
cancer
immunity.
Therapeutic
modulation
ferroptosis
considered
a
potential
strategy
to
enhance
the
efficacy
other
therapies,
including
immunotherapies
such
as
chimeric
antigen
receptor
(CAR)
T-cell
therapy.
In
this
study,
we
demonstrated
IFNκ
influenced
induction
ferroptosis.
could
sensitivity
tumor
cells
induced
by
small
molecule
compound
erastin
and
polyunsaturated
fatty
acid
arachidonic
acid.
Mechanistically,
in
combination
with
immunogenic
via
IFNAR/STAT1/ACSL4
axis.
Moreover,
CAR
T
engineered
express
showed
increased
antitumor
efficiency
against
H460
(antigen
positive)
H322
(antigen-negative)
both
vitro
vivo.
We
conclude
cytokine
be
harnessed
function
inducing
Aging,
Journal Year:
2024,
Volume and Issue:
16(4), P. 3404 - 3419
Published: Feb. 12, 2024
Background:
Traumatic
Brain
Injury
(TBI)
has
high
disability
and
mortality
rate.
Oxidative
stress
ferroptosis
are
important
pathophysiological
characteristics
after
TBI.
Orexin-A
(OXA)
can
alleviate
neuronal
damage
in
diverse
neurological
disorders.
Nevertheless,
the
role
mechanism
of
OXA
TBI
stay
unknown.
Objectives:
The
research
investigated
protection
influence
on
its
potential
mechanisms.
Methods:
Male
Sprague-Dawley
rats
were
randomly
grouped
into:
sham,
TBI,
+
normal
saline
(NS)
TBI+OXA
groups.
model
was
constructed
rat
via
modified
Feeneyâs
approach,
treatment
administered
following
construction
model.
Results:
Relative
to
TBI+NS
group,
group
displayed
greatly
recovered
tissue
deficits.
Additionally,
eased
oxidative
as
well
cerebral
cortex
Furthermore,
increased
Nrf2
expression
regulating
factors
HO-1
NQO1
rats.
Conclusions:
Our
found
may
restrain
Nrf2/HO-1
signaling
pathway
activation,
thereby
reducing
brain
injury
Cancer Immunology Research,
Journal Year:
2024,
Volume and Issue:
12(12), P. 1691 - 1702
Published: Aug. 26, 2024
Abstract
Ferroptosis
is
an
iron-dependent
form
of
cell
death
that
influences
cancer
immunity.
Therapeutic
modulation
ferroptosis
considered
a
potential
strategy
to
enhance
the
efficacy
other
therapies,
including
immunotherapies
such
as
chimeric
antigen
receptor
(CAR)
T-cell
therapy.
In
this
study,
we
demonstrated
IFNκ
influenced
induction
ferroptosis.
could
sensitivity
tumor
cells
induced
by
small
molecule
compound
erastin
and
polyunsaturated
fatty
acid
arachidonic
acid.
Mechanistically,
in
combination
with
immunogenic
via
IFNAR/STAT1/ACSL4
axis.
Moreover,
CAR
T
engineered
express
showed
increased
antitumor
efficiency
against
H460
(antigen
positive)
H322
(antigen-negative)
both
vitro
vivo.
We
conclude
cytokine
be
harnessed
function
inducing
