Odontology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Language: Английский
IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 26, 2024
Chronic inflammatory processes in the oral mucosa and periodontitis are common disorders caused by microflora microbial biofilms. These factors activate both innate adaptive immune systems, leading to production of pro-inflammatory cytokines. Cytokines known play a crucial role pathogenesis gingivitis have been proposed as biomarkers for diagnosis follow-up these diseases. They can stromal cells, local inflammation tissue damage. This damage include destruction periodontal ligaments, gingiva, alveolar bone. Studies reported increased levels cytokines, such interleukin-1beta (IL-1beta), tumor necrosis factor (TNF), IL-6, IL-17, IL-23, patients with periodontitis. In experimental models periodontitis, TNF IL-23/IL-17 axis pivotal disease pathogenesis. Inactivation pathways through neutralizing antibodies, genetic engineering or IL-10 function has demonstrated reduce activity. review discusses cytokines particular emphasis on their mediating destruction. It also explores new therapeutic interventions that offer potential research clinical therapy chronic
Language: Английский
Citations
14
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 1, 2024
Alzheimer’s disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% cases, may arise due to influence environmental factors. It was reported that periodontitis, common oral ailment, shares several risk factors with including advanced age, smoking, diabetes, and hypertension, among others. Periodontitis an inflammatory triggered dysbiosis microorganisms, whereas neuroinflammation. Many studies have indicated chronic inflammation can instigate brain AD-related pathologies, amyloid-β plaques, Tau protein hyperphosphorylation, neuroinflammation, neurodegeneration. The potential involvement periodontal pathogens and/or their virulence in onset progression AD oral-brain axis has garnered significant attention researchers ongoing investigations. This review updated potentially associated elucidating impact on central nervous system, immune response, related pathological processes provide valuable insights future research axis.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2612 - 2612
Published: Feb. 23, 2024
Periodontitis is an inflammatory condition affecting the supporting structures of teeth. Periodontal conditions may increase susceptibility individuals to various systemic illnesses, including Alzheimer’s disease. disease a neurodegenerative characterized by gradual onset and progressive deterioration, making it primary cause dementia, although exact remains elusive. Both periodontitis share risk factors clinical studies comparing associations occurrence among with have suggested potential correlation between these conditions. Brains substantiated existence microorganisms related periodontitis, especially Porphyromonas gingivalis, which produces neurotoxic gingipains present capability breach blood–brain barrier. Treponema denticola induce tau hyperphosphorylation lead neuronal apoptosis. Lipopolysaccharides—components bacterial cell membranes mediators inflammation—also impact on brain function. Further research could unveil therapeutic approaches targeting periodontal pathogens potentially alleviate AD progression.
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 14, 2025
Porphyromonas gingivalis ( P. ) is a gram-negative bacterium and the main causative agent of periodontitis, disease closely associated with development periodontal disease. The progression chronic infectious disease, intricately linked to inflammatory immune response. Inflammatory cytokines act on tissues via immunomodulation, resulting in destruction tissue. Recent studies have established connections between periodontitis various systemic diseases, including cardiovascular tumors, neurodegenerative diseases. Neurodegenerative diseases are neurological disorders caused by system dysfunction, Alzheimer’s Parkinson’s One characteristics an impaired response, which mediates neuroinflammation through microglial activation. Some shown association as primary culprit. can cross blood-brain barrier (BBB) or mediate injury variety pathways, gut-brain axis, thereby affecting neuronal growth survival participating onset However, comprehensive systematic summaries origin lacking. This article reviews summarizes relationship its possible regulatory mechanisms. review offers new perspectives into understanding highlights innovative approaches for investigating developing tailored medications treating conditions, particularly from viewpoint their .
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 25, 2025
Sterile systemic inflammation may contribute to neuroinflammation and accelerate the progression of neurodegenerative diseases. The double-stranded RNA-dependent protein kinase (PKR) is a key signaling molecule that regulates immune responses by regulating macrophage activation, various inflammatory pathways, inflammasome formation. This study aims role PKR in sterile inflammation-triggered cognitive dysfunctions. Here, laparotomy mouse model was used neuroimmune triggered inflammation. Our revealed genetic deletion mice potently attenuated laparotomy-induced peripheral neural deficits. Furthermore, intracerebroventricular injection rAAV-DIO-PKR-K296R inhibit cholinergic neurons ChAT-IRES-Cre-eGFP rescued changes metabolites brain glucose metabolism, particularly phosphoenolpyruvate succinate levels, impairment short-term spatial working memory. results demonstrated critical neuroinflammation, metabolism dysfunctions model. could be novel pharmacological target for treating inflammation-induced
Language: Английский
Citations
1
Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(3), P. 100 - 100
Published: Feb. 26, 2025
Periodontitis and diabetes mellitus are two highly prevalent chronic conditions that share a bidirectional relationship, significantly impacting public health. Periodontitis, gum inflammation caused by microbial dysbiosis, aggravates glycemic control in diabetics, while uncontrolled heightens periodontitis severity. These create vicious cycle, where dysbiosis mutually drive disease progression, exacerbating systemic The underlying mechanisms involve inflammation, immune dysfunction, with both diseases contributing to chain of exacerbates This relationship is significant because managing one condition can impact the other. In diabetic individuals, interventions such as periodontal therapy have shown effectiveness improving control, underscoring potential integrated strategies for these simultaneously. this review, we highlight importance deeper understanding molecular immunological interactions between essential developing therapeutic approaches, enhance quality life patient significantly.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15135 - 15135
Published: Oct. 13, 2023
Progressive supranuclear palsy (PSP) is an atypical parkinsonian syndrome based on tau pathology; its clinical phenotype differs, but PSP with Richardson's (PSP-RS) and the parkinsonism predominant (PSP-P) variant remain two most common manifestations. Neuroinflammation involved in course of disease may cause neurodegeneration. However, up-to-date cytokine profile has not been assessed different phenotypes. This study aimed to evaluate possible differences neuroinflammatory patterns between Serum cerebrospinal fluid (CSF) concentrations interleukin-1 beta (IL-1β) IL-6 were analyzed using enzyme-linked immunosorbent assay (ELISA) kits 36 participants-12 healthy controls 24 patients a diagnosis PSP-12 PSP-RS 12 PSP-P. Disease duration among ranged from three six years. All participants underwent basic biochemical testing, neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) values calculated. Due lack neuropathological examinations, as all alive, total levels CSF. Tau significantly higher PSP-P groups compared controls. The lowest serum CSF interleukins observed patients, whereas had interleukin concentrations. Furthermore, there was significant correlation PLR patients. results indicate existence distinct or neuroprotective role increased inflammatory activity, which could PSPS phenotypes course. causality correlations described requires further studies be confirmed.
Language: Английский
Citations
18
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5753 - 5753
Published: May 25, 2024
Periodontitis, a prevalent inflammatory condition, affects the supporting structures of teeth, leading to significant oral health challenges. Traditional treatments have primarily focused on mechanical debridement, antimicrobial therapy, and surgery, which often fail restore lost periodontal structures. Emerging as novel approach in regenerative medicine, extracellular vesicle (EV) including exosomes, leverages nano-sized vesicles known for facilitating intercellular communication modulating physiological pathological processes. This study is proof-of-concept type that evaluates clinical efficacy EV therapy non-surgical treatment stage I–III periodontitis, focusing its anti-inflammatory potential. The research involved seven patients undergoing healthy individuals. Clinical parameters, plaque index, bleeding probing, probing depth, attachment level, were assessed alongside cytokine levels gingival crevicular fluid. found improvements marked reduction pro-inflammatory cytokines post-treatment, matching subjects, underscoring therapy’s ability not only attenuate inflammation enhance tissue regeneration, but also highlighting potential restoring health. investigation illuminates promising role treatment, advocating shift towards therapies halt disease progression promote structural functional restoration tissues.
Language: Английский
Citations
6
Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15
Published: Aug. 15, 2023
The association between inflammatory biomarkers and individual delirium symptoms remains controversial in observational studies. We investigated the relationship risk of developing delirium.A bidirectional two-sample Mendelian randomization (MR) was performed. Genetic instruments associated with peripheral tumor necrosis factor-a (TNF-a) C-reactive protein (CRP), interleukin (IL)-1α, IL-1β, IL-2, IL-8, IL-6, soluble IL-6 receptor alpha (sIL-6Rα), gp130 were identified three different large summary genome-wide studies (GWAS) conducted European population. Summary-level statistics for not induced by alcohol other psychoactive substances obtained from FinnGen consortium (2,612 cases 325,306 controls). estimated causal effects performed using instruments' variants at significant level (P < 5e-8 P 5e-6), applying a linkage disequilibrium clumping approach threshold r2 0.001 each exposures. Reverse causation also inverse-variance weighted method (IVW), MR-Egger method, median regression, MR Pleiotropy RESidual Sum used analyses.At 5e-8, 0.001), genetically predicted sIL-6Rα significantly decreased less than single-nucleotide polymorphisms (SNPs) all GWAS data sources (ORWaldratio = 0.89, 95% CI: 0.79-0.96, PWaldratio 0.0016; ORIVW 0.88, 0.79-0.97, PIVW 0.008; 0.80-0.96, 0.004). became non-significant when more liberal 5e-6 applied (all > 0.05). At two significance levels we found no evidence TNF-α, CRP, IL-1α, on intercept MR-PRESSO results indicated that SNP had possible pleiotropy Regarding reverse, an effect these could be 0.05).The this analysis did support sIL-6Rα, gp130, IL-8 causally delirium. More research is needed to explore role factors pathogenesis
Language: Английский
Citations
15