The Impact of Ozone on Periodontal Cell Line Viability and Function

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 72 - 72

Published: Jan. 23, 2025

Periodontal diseases, including gingivitis and periodontitis, are chronic inflammatory conditions of the teeth’ supporting structures that can lead to progressive tissue destruction loss if left untreated. Basic treatments like scaling root planing, alone or combined with antimicrobial agents, standard care. However, increasing prevalence antibiotic resistance need for new ideas in therapy, adjunctive ozone therapy have gained attention. Ozone (O3), a triatomic oxygen molecule, is used because its strong antimicrobial, anti-inflammatory, regenerative activity and, hence, as potential tool periodontal therapy. This review use disease breaks down multifaceted mechanism which includes selective action against biofilm-associated pathogens, immunomodulatory effects on host cells, stimulation repair. O3 disrupts microbial biofilms, enhances immune cell function, promotes healing by activating Nuclear Factor Erythroid 2-Related 2 (Nrf2) Mitogen-Activated Protein Kinase (MAPK) signaling pathways regulate oxidative stress, inflammation, apoptosis. Additional findings include ability upregulate growth factors extracellular matrix proteins, significant regeneration. also discusses application lines, emphasizing impact viability, proliferation, differentiation. Advances techniques, properties O3, demonstrated clinical benefits. Challenges, standardized dosages, effective delivery systems, long-term studies, addressed ensure safe integration. dual capabilities, offers an innovative approach treatment. Future research focusing optimized protocols evidence-based guidelines essential fully realize enhancing health improving patient outcomes.

Language: Английский

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New Insights in Natural Bioactive Compounds for Periodontal Disease: Advanced Molecular Mechanisms and Therapeutic Potential

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 807 - 807

Published: Feb. 10, 2025

Periodontal disease is a chronic inflammatory condition that destroys the tooth-supporting structures due to host's immune response microbial biofilms. Traditional periodontal treatments, such as scaling and root planing, pharmacological interventions, surgical procedures, have significant limitations, including difficulty accessing deep pockets, biofilm recolonization, development of antibiotic resistance. In light these challenges, natural bioactive compounds derived from plants, herbs, other sources offer promising alternative their anti-inflammatory, antioxidant, antimicrobial, tissue-regenerative properties. This review focuses on molecular mechanisms through which compounds, curcumin, resveratrol, epigallocatechin gallate (EGCG), baicalin, carvacrol, berberine, essential oils, Gum Arabic, exert therapeutic effects in disease. Bioactive inhibit critical pathways like NF-κB, JAK/STAT, MAPK while activating protective Nrf2/ARE, reducing cytokine production oxidative stress. They also activity matrix metalloproteinases (MMPs), preventing tissue degradation promoting healing. addition, demonstrated potential disrupt bacterial biofilms by interfering with quorum sensing, targeting cell membranes, enhancing efficacy.Bioactive modulate system shifting balance pro-inflammatory anti-inflammatory responses efferocytosis, helps resolve inflammation supports regeneration. However, despite challenges related poor bioavailability, stability oral cavity, absence large-scale clinical trials need be addressed. Future strategies should prioritize advanced delivery systems nanoparticles hydrogels enhance bioavailability sustain release, alongside long-term studies assess human populations. Furthermore, combining traditional treatments could provide synergistic benefits managing aims explore disease, emphasizing action offering insights into integration conventional therapies for more comprehensive approach health.

Language: Английский

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Therapeutic Potential of Extracellular Vesicles in Oral Inflammation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3031 - 3031

Published: March 26, 2025

The therapeutic potential of extracellular vesicles (EVs) in reducing oral inflammation is thoroughly examined this review, with an emphasis on gingivitis, periodontitis, and mucositis. It explains the complex relationship between microbial dysbiosis host immune responses aetiology inflammation. Pathophysiological mechanisms periodontitis are examined, emphasising roles played by periodontal pathogens inflammatory mediators disease's chronic course systemic effects. Preclinical research providing new evidence that EVs originating from various cellular sources control cell dynamics towards a pro-healing phenotype, promote tissue regeneration, have immunomodulatory qualities. EV-based therapies appear to be promising technique benefits over traditional methods for treatment illnesses specifically altering signalling pathways. This review highlights improve patient outcomes health emphasises need additional clinical clarify efficacy underlying therapy.

Language: Английский

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Causal Relationship between Mitochondrial Biological Function and Periodontitis: Evidence from a Mendelian Randomization Study

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7955 - 7955

Published: July 21, 2024

A growing number of studies indicate that mitochondrial dysfunction serves as a pathological mechanism for periodontitis. Therefore, this two-sample Mendelian randomization (MR) study was carried out to explore the causal associations between biological function and periodontitis, because specific nature relationship remains inconclusive in existing MR studies. Inverse variance weighting, randomization-Egger, weighted mode, simple median analyses were performed assess relationships exposure factors The results present revealed association periodontitis medium-chain acyl-CoA dehydrogenase (MCAD), malonyl-CoA decarboxylase (MLYCD), glutaredoxin 2 (Grx2), oligoribonuclease (ORN), pyruvate carboxylase (PC). Notably, MCAD MLYCD are causally linked serve protective factors. However, Grx2, ORN, PC risk Our established such insights may provide promising approach treating via regulation.

Language: Английский

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A Macroscopic Exploration of the Ideoscape on Exosomes for Bone Regeneration

Osteology, Journal Year: 2024, Volume and Issue: 4(4), P. 159 - 178

Published: Oct. 8, 2024

Background: Exosomes, nanoscale extracellular vesicles, play a crucial role in tissue physiology and regeneration. This study uses infometric techniques to explore the structure of exosome-based bone regeneration research. Methods: We applied BERTopic, an advanced topic modeling algorithm, comprehensive corpus scientific literature on exosomes regeneration, identifying key themes such as stem cell studies, healing, regenerative applications, with orthopedics dentistry emerging dominant subfields. To further investigate ‘ideoscape’, i.e., conceptual landscape that maps how ideas, methods, are interconnected across field, we extracted significant concepts from abstracts using GPT 3.5 turbo created knowledge graphs. Results: Our analysis revealed rapid growth field dental which has outpaced other topics by twofold. highlighted central periodontal cells their cellular processes—proliferation, migration, differentiation—along clinical applications. approach provided clear visualization field’s intellectual structure, showing interconnected. findings offer view evolving trends revealing not only most active research areas but also gaps opportunities for investigation. Conclusions: exemplifies utility combining graph creation map trends, offering flexible largely automated tool researchers vast bodies guide future directions.

Language: Английский

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Interleukin-6 Receptor Gene rs1800795 Polymorphism and Expression of Interleukin-6 in Gingival Tissue in Patients with Periodontitis

Microorganisms, Journal Year: 2024, Volume and Issue: 12(10), P. 1954 - 1954

Published: Sept. 27, 2024

Periodontitis is a multifactorial inflammatory disease. This chronic periodontal disease caused by bacterial infection in the gums, which triggers host response. To eliminate infection, immune response mechanisms are activated, leading to inflammation and damage tissues. process involves many cytokines, including IL-6, cytokine with antibacterial properties. An ongoing tissues leads its excessive production, increases inflammation. In this study, we examined

Language: Английский

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