European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1—epidemiology, pathophysiology, and diagnosis

European Heart Journal, Journal Year: 2021, Volume and Issue: 43(11), P. 1033 - 1058

Published: Sept. 13, 2021

Abstract Aims Since its emergence in early 2020, the novel severe acute respiratory syndrome coronavirus 2 causing disease 2019 (COVID-19) has reached pandemic levels, and there have been repeated outbreaks across globe. The aim of this two-part series is to provide practical knowledge guidance aid clinicians diagnosis management cardiovascular (CVD) association with COVID-19. Methods results A narrative literature review available evidence performed, resulting information organized into two parts. first, reported here, focuses on epidemiology, pathophysiology, (CV) conditions that may be manifest patients second part, which will follow a later edition journal, addresses topics care pathways, treatment, follow-up CV Conclusion This comprehensive not formal guideline but rather document provides summary current practicing managing CVD recommendations are mainly result observations personal experience from healthcare providers. Therefore, provided here subject change increasing knowledge, prospective studies, changes pandemic. Likewise, should interfere by local national authorities.

Language: Английский

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COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 27, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated symptoms, named disease 2019 (COVID-19), have rapidly spread worldwide, resulting in the declaration of a pandemic. When several countries began enacting quarantine lockdown policies, pandemic as it is now known truly began. While most patients minimal approximately 20% verified subjects are suffering from serious medical consequences. Co-existing diseases, such cardiovascular disease, cancer, diabetes, others, been shown to make more vulnerable severe outcomes COVID-19 by modulating host–viral interactions immune responses, causing infection mortality. In this review, we outline putative signaling pathways at interface emphasizing clinical molecular implications concurring diseases outcomes. As evidence limited on co-existing COVID-19, findings preliminary, further research required for optimal management with comorbidities.

Language: Английский

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Evolution of SARS-CoV-2 Variants: Implications on Immune Escape, Vaccination, Therapeutic and Diagnostic Strategies

Viruses, Journal Year: 2023, Volume and Issue: 15(4), P. 944 - 944

Published: April 10, 2023

The COVID-19 pandemic caused by SARS-CoV-2 is associated with a lower fatality rate than its SARS and MERS counterparts. However, the rapid evolution of has given rise to multiple variants varying pathogenicity transmissibility, such as Delta Omicron variants. Individuals advanced age or underlying comorbidities, including hypertension, diabetes cardiovascular diseases, are at higher risk increased disease severity. Hence, this resulted in an urgent need for development better therapeutic preventive approaches. This review describes origin human coronaviruses, particularly well sub-variants. Risk factors that contribute severity implications co-infections also considered. In addition, various antiviral strategies against COVID-19, novel repurposed drugs targeting viral host proteins, immunotherapeutic strategies, discussed. We critically evaluate current emerging vaccines their efficacy, immune evasion new impact on diagnostic testing examined. Collectively, global research public health authorities, along all sectors society, prepare upcoming future coronavirus outbreaks.

Language: Английский

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COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(13), P. 2920 - 2920

Published: June 29, 2021

The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19).Scientific institutional websites databases were searched data collected organized, when plausible, angle discussion toward following clinical issues. (1) Are patients with COVID-19 at higher risk developing acute or late-onset dysfunction? (2) May underlying dysfunctions be considered factors for poor prognosis once infection has occurred? (3) there defined strategies manage despite pandemic-related constraints? Herein, authors only relevant more frequently observed disorders related hypothalamic-pituitary region, thyroid parathyroid glands, calcium-phosphorus homeostasis osteoporosis, adrenal gonads. Main. Data highlight basis some pathophysiological mechanisms anatomical alterations Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced dysfunctions. Some conditions, such as insufficiency cortisol excess, may worse progression occurred. These at-risk populations require adequate education avoid SARS-CoV-2 adequately medical therapy during pandemic, even emergencies. Endocrine management underwent a palpable restraint, especially procedures requiring obligate access healthcare facilities diagnostic therapeutic purposes. Strategies triage prioritize consultations, laboratory, instrumental evaluations, digital telehealth solutions should implemented better deal this probably long-term situation.

Language: Английский

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Physical activity and COVID-19. The basis for an efficient intervention in times of COVID-19 pandemic

Physiology & Behavior, Journal Year: 2021, Volume and Issue: 244, P. 113667 - 113667

Published: Dec. 1, 2021

Language: Английский

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Modification of subcutaneous white adipose tissue inflammation by omega-3 fatty acids is limited in human obesity-a double blind, randomised clinical trial

EBioMedicine, Journal Year: 2022, Volume and Issue: 77, P. 103909 - 103909

Published: March 1, 2022

BackgroundObesity is associated with enhanced inflammation. However, investigation in human subcutaneous white adipose tissue (scWAT) limited and the mechanisms by which inflammation occurs have not been well elucidated. Marine long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) anti-inflammatory actions may reduce scWAT inflammation.MethodsSubcutaneous biopsies were collected from individuals living obesity (n=45) normal weight (n=39) prior to following a 12-week intervention either 3 g/day of fish oil concentrate (providing 1.1 g eicosapentaenoic acid (EPA) + 0.8 docosahexaenoic (DHA)) or corn oil. ScWAT acid, oxylipin, transcriptome profiles assessed gas chromatography, ultra-pure liquid chromatography tandem mass spectrometry, RNA sequencing qRT-PCR, respectively.FindingsObesity was greater demonstrated lower concentrations specialised pro-resolving mediators (SPMs) hydroxy-DHA metabolites an altered differential expression genes involved LC PUFA activation, oxylipin synthesis, inflammation, immune response. Intervention PUFAs increased their respective including SPM precursor 14-hydroxy-DHA decreased arachidonic derived inflammatory response effect individuals.InterpretationDownregulated responsible for activation metabolism contribute profile limit effects obesity. There be need personalised supplementation based on status.FundingEuropean Commission Seventh Framework Programme (Grant Number 244995) Czech Academy Sciences (Lumina quaeruntur LQ200111901).

Language: Английский

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Anti-Obesity Effect of Combining White Kidney Bean Extract, Propolis Ethanolic Extract and CrPi3 on Sprague-Dawley Rats Fed a High-Fat Diet

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 310 - 310

Published: Jan. 20, 2024

Obesity has been associated with the occurrence and prevalence of various chronic metabolic diseases. The management obesity evolved to focus not only on reducing weight, but also preventing obesity-related complications. Studies have shown that bioactive components in natural products like white kidney bean extract (WKBE), propolis ethanolic (PEE), chromium picolinate (CrPi3) showed anti-obesity properties. However, no studies examined outcomes combining any these nutraceutical supplements. We compared effects HFD supplemented WKBE, WKBE+PEE, or WKBE+PEE+CrPi3 against control obese groups using Sprague-Dawley rats fed a 45% high-fat diet as an vivo model. Nutritional parameters, biochemical biomarkers cardiovascular disease, liver function, gut health were among comparable effects. Our findings three supplements had synergetic effect weight gain, food utilization rate, abdominal fat, serum lipids, arterial hepatic risk blood glucose level, addition improving renal function microbiota. attributed α-amylase inhibitor action flavonoids, polyphenol content PEE, which potentiated CrPi3 resulting further reduction normalization certain parameters.

Language: Английский

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The Impact of Diet Quality on COVID-19 Severity and Outcomes—A Scoping Review

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 1, 2025

The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the potential role of nutrition in modifying disease susceptibility and severity. This review aims to systematically evaluate current evidence on associations between dietary patterns, assessed using diet quality scores (DQS), severity outcomes. A comprehensive literature search identified 15 studies across diverse populations. Prospective cohort generally found higher associated with lower infection rates. Case-control consistently showed reduced odds severe illness adherence anti-inflammatory particularly Mediterranean diet. Cross-sectional data revealed DQS symptom burden improved prognostic biomarkers. An ecological study demonstrated inverse relationships national-level caseloads. Mediterranean, Dietary Approaches Stop Hypertension (DASH), plant-based were notably predictive favourable outcomes, even after adjusting for confounders. Conversely, consumption processed foods high saturated fats, sugars, additives was linked increased complications. Despite these findings, research gaps remain, including impacts specific components, effect modifiers populations, establishing causality through interventional trials. highlights observational supporting integration optimal into pandemic preparedness strategies. Further is needed strengthen findings inform evidence-based recommendations prevention management.

Language: Английский

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European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1—epidemiology, pathophysiology, and diagnosis

Cardiovascular Research, Journal Year: 2021, Volume and Issue: 118(6), P. 1385 - 1412

Published: Dec. 2, 2021

Since its emergence in early 2020, the novel severe acute respiratory syndrome coronavirus 2 causing disease 2019 (COVID-19) has reached pandemic levels, and there have been repeated outbreaks across globe. The aim of this two-part series is to provide practical knowledge guidance aid clinicians diagnosis management cardiovascular (CVD) association with COVID-19. A narrative literature review available evidence performed, resulting information organized into two parts. first, reported here, focuses on epidemiology, pathophysiology, (CV) conditions that may be manifest patients second part, which will follow a later edition journal, addresses topics care pathways, treatment, follow-up CV This comprehensive not formal guideline but rather document provides summary current practicing managing CVD recommendations are mainly result observations personal experience from healthcare providers. Therefore, provided here subject change increasing knowledge, prospective studies, changes pandemic. Likewise, should interfere by local national authorities.

Language: Английский

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Comorbidities, Associated Diseases, and Risk Assessment in COVID-19—A Systematic Review

International Journal of Clinical Practice, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 24

Published: Oct. 31, 2022

It is considered that COVID-19’s pandemic expansion responsible for the particular increase in deaths, especially among population with comorbidities. The health system often overwhelmed by large number of cases patients addressing it, regional limitation funds, and gravity at subjects suffering from this pathology. Several associated conditions including diabetes, cardiovascular illnesses, obesity, persistent lung condition, neurodegenerative diseases, etc., mortality risk hospitalization COVID-19. rapid identification increased death SARS-CoV-2 virus, stratification accordance allocation human, financial, logistical resources proportion must be a priority systems worldwide.

Language: Английский

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