Risk factors and clinical presentations of long COVID in Africa: A scoping review DOI Creative Commons
Enos Moyo, Munashe Chimene, Perseverance Moyo

et al.

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(12), P. 1982 - 1988

Published: Oct. 6, 2023

COVID-19-related complications can last for years, even in patients who are asymptomatic during the acute phase, a phenomenon referred to as long COVID. This scoping review aimed summarize risk factors and clinical symptoms of COVID Africa between 2020 2022. Five studies were included. Three used this retrospective cross-sectional studies, one was prospective cohort study while another case-control study. The identified several COVID, including being female, older than 40 having more four COVID-19 symptoms, concomitant conditions such asthma, hypertension, depression. General, respiratory, cardiovascular, otolaryngological, gastrointestinal, neurological among reported symptoms. To ensure that with diagnosed treated early, need be different population groups.

Language: Английский

Why does malaise/fatigue occur? Underlying mechanisms and potential relevance to treatments in rheumatoid arthritis DOI
Yoshiya Tanaka, Kei Ikeda, Yuko Kaneko

et al.

Expert Review of Clinical Immunology, Journal Year: 2024, Volume and Issue: 20(5), P. 485 - 499

Published: Jan. 15, 2024

Introduction Fatigue and malaise are commonly associated with a wide range of medical conditions, including rheumatoid arthritis (RA). Evidence suggests that fatigue can be overwhelming for patients, yet these symptoms remain inadequately-managed, largely due to an incomplete elucidation the underlying causes.

Language: Английский

Citations

4
Inflammation‐, immunothrombosis,‐ and autoimmune‐feedback loops may lead to persistent neutrophil self‐stimulation in long COVID DOI Creative Commons
Alain R. Thierry, Dominique Salmon

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(8)

Published: Aug. 1, 2024

Understanding the pathophysiology of long COVID is one most intriguing challenges confronting contemporary medicine. Despite observations recently made in relevant molecular, cellular, and physiological domains, it still difficult to say whether post-acute sequelae COVID-19 directly correspond consequences severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This work hypothesizes that neutrophils neutrophil extracellular traps (NETs) production are at interconnection three positive feedback loops which initiated phase SARS-CoV-2 infection, involve inflammation, immunothrombosis, autoimmunity. phenomenon could be favored by fact may bind penetrate neutrophils. The ensuing strong stimulation leads a progressive amplification an exacerbated uncontrolled NETs production, potentially persisting for months beyond continuous self-stimulation leads, turn, systemic micro-thromboses, autoantibodies, whose significant include persistence endothelial multiorgan damage, vascular complications.

Language: Английский

Citations

4
Long COVID: Clinical Findings, Pathology, and Endothelial Molecular Mechanisms DOI
H. Bradford Hawley

The American Journal of Medicine, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Language: Английский

Citations

11
SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway DOI Creative Commons
Rabab S. Hamad, Hayder M. Al‐kuraishy, Αθανάσιος Αλεξίου

et al.

Cell Stress and Chaperones, Journal Year: 2023, Volume and Issue: 28(6), P. 657 - 673

Published: Oct. 5, 2023

Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and extra-pulmonary manifestations due the development of oxidative stress (OS) hyperinflammation. The underlying cause for OS hyperinflammation in COVID-19 may be related inhibition nuclear factor erythroid 2-related (Nrf2), master regulator antioxidative responses cellular homeostasis. Nrf2 pathway inhibits expression pro-inflammatory cytokines cytokine storm COVID-19. activators can attenuate endothelial dysfunction (ED), renin-angiotensin system (RAS) dysregulation, immune thrombosis, coagulopathy. Hence, this review aimed reveal potential role its management As well, we tried revise mechanistic

Language: Английский

Citations

11
Risk factors and clinical presentations of long COVID in Africa: A scoping review DOI Creative Commons
Enos Moyo, Munashe Chimene, Perseverance Moyo

et al.

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(12), P. 1982 - 1988

Published: Oct. 6, 2023

COVID-19-related complications can last for years, even in patients who are asymptomatic during the acute phase, a phenomenon referred to as long COVID. This scoping review aimed summarize risk factors and clinical symptoms of COVID Africa between 2020 2022. Five studies were included. Three used this retrospective cross-sectional studies, one was prospective cohort study while another case-control study. The identified several COVID, including being female, older than 40 having more four COVID-19 symptoms, concomitant conditions such asthma, hypertension, depression. General, respiratory, cardiovascular, otolaryngological, gastrointestinal, neurological among reported symptoms. To ensure that with diagnosed treated early, need be different population groups.

Language: Английский

Citations

10