The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes DOI
Yuchong He,

Ruocheng Yin

Journal of Applied Toxicology, Journal Year: 2023, Volume and Issue: 44(1), P. 66 - 85

Published: June 29, 2023

Abstract Microplastics (MPs) and nanoplastics (NPs) are extensively distributed in the environment. However, a comprehensive review in‐depth discussion on effects of MPs NPs to reproductive capacity transgenerational toxicity mammals, especially humans, is lacked. It suggested that microplastics could accumulate mammalian organs exert toxic system for both sexes. For males, damage consists abnormal testicular sperm structure, decreased vitality, endocrine disruption, which were caused by oxidative stress, inflammation, apoptosis cells, autophagy, cytoskeleton, hypothalamic‐pituitary‐testicular axis. females, includes ovary uterus structure granulosa cell apoptosis, hypothalamic‐pituitary‐ovary axis abnormalities, tissue fibrosis. toxicity, premature mortality existed rodent offspring after maternal exposure microplastics. Among surviving offspring, metabolic disorders, dysfunction, immune, neurodevelopmental, cognitive disorders detected, these events directly correlated with translocation NPs. Studies human‐derived cells or organoids demonstrated studies sexes yet phase exploring suitable experimental models, more detailed research threat human fertility still urgently needed. Further will help assess public health risks.

Language: Английский

A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals DOI Creative Commons
Sana Ullah,

Shahid Ahmad,

Xinle Guo

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 16, 2023

Over the years, vaste expansion of plastic manufacturing has dramatically increased environmental impact microplastics [MPs] and nanoplastics [NPs], making them a threat to marine terrestrial biota because they contain endocrine disrupting chemicals [EDCs] other harmful compounds. MPs NPs have deleteriouse impacts on mammalian components such as hypothalamus, pituitary, thyroid, adrenal, testes, ovaries. absorb act transport medium for bisphenols, phthalates, polybrominated diphenyl ether, polychlorinated biphenyl organotin, perfluorinated compounds, dioxins, polycyclic aromatic hydrocarbons, organic contaminants, heavy metals, which are commonly used additives in production. As EDCs not covalently bonded plastics, can easily leach into milk, water, liquids affecting system mammals upon exposure. The toxicity induced by is size-dependent, smaller particles better absorption capacity larger surface area, releasing more EDC toxic chemicals. Various contained or carried share structural similarities with specific hormone receptors; hence interfere normal receptors, altering hormonal action glands. This review demonstrates size-dependent MPs’ bioaccumulation, distribution, translocation potential hazards gland. We reviewed that disrupt hypothalamic-pituitary axes, including hypothalamic-pituitary-thyroid/adrenal/testicular/ovarian axis leading oxidative stress, reproductive toxicity, neurotoxicity, cytotoxicity, developmental abnormalities, decreased sperm quality, immunotoxicity. direct consequences testis, ovaries documented. Still, studies need be out identify effects adrenal

Language: Английский

Citations

121
Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice DOI
Hao Wu,

Tong Xu,

Ting Chen

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 838, P. 155825 - 155825

Published: May 19, 2022

Language: Английский

Citations

118
Evaluation of Neurotoxicity in BALB/c Mice following Chronic Exposure to Polystyrene Microplastics DOI

Haibo Jin,

Chen Yang,

Chengyue Jiang

et al.

Environmental Health Perspectives, Journal Year: 2022, Volume and Issue: 130(10)

Published: Oct. 1, 2022

Background: The toxicity of microplastics (MPs) has attracted wide attention from researchers. Previous studies have indicated that MPs produce toxic effects on a variety organs in aquatic organisms and mammals. However, the exact neurotoxicity mammals is still unclear. Objectives: We aimed to confirm chronic exposure polystyrene (PS-MPs) at environmental pollution concentrations. Methods: In present study, mice were provided drinking water containing 100μg/L 1,000μg/L PS-MPs with diameters 0.5, 4, 10μm for 180 consecutive days. After period, anesthetized gain brain tissues. accumulation tissues, integrity blood–brain barrier, inflammation, spine density detected. evaluated learning memory ability by Morris maze novel object recognition tests. Results: observed various particle (0.5, 10μm) brains exposed mice. Meanwhile, also exhibited disruption higher level dendritic density, an inflammatory response hippocampus. addition, cognitive deficits compared control as determined using tests, respectively. There was concentration-dependent trend, but no size-dependent differences seen MPs. Conclusions: Collectively, our results suggested can lead dysfunctions induce neurotoxic mice, findings which wide-ranging implications public regarding potential risks https://doi.org/10.1289/EHP10255

Language: Английский

Citations

105
Raman Microspectroscopy evidence of microplastics in human semen DOI Creative Commons
Luigi Montano, Elisabetta Giorgini, Valentina Notarstefano

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 901, P. 165922 - 165922

Published: July 31, 2023

The presence of microplastics (MPs) in human fluids and organs is a great concern, since, as highlighted by recent studies on animal models, they could cause alterations several physiological functions, including reproduction. In this study, semen samples collected from men living polluted area the Campania Region (Southern Italy), were analyzed to assess MPs. N. 16 pigmented microplastic fragments (ranging 2 6 μm size) with spheric or irregular shapes found six out ten samples. All detected MPs characterized terms morphology (size, colour, shape) chemical composition Raman Microspectroscopy. Chemical showed polypropylene (PP), polyethylene (PE), terephthalate (PET), polystyrene (PS), polyvinylchloride (PVC), polycarbonate (PC), polyoxymethylene (POM) acrylic, suggesting ingestion and/or inhalation route exposure environmental work, we propose for first time mechanism which pass into most likely through epididymis seminal vesicles, are susceptible inflammation.

Language: Английский

Citations

105
Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut–Liver Axis DOI

Kai-Kai Zhang,

Jian-Zheng Yang, Lijian Chen

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 15125 - 15145

Published: July 24, 2023

Dietary pollution by polystyrene microplastics (MPs) can cause hepatic injuries and microbial dysbiosis. Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, exerts beneficial effects on liver modulating gut microbiota. However, role of microbiota MPs-induced protective effect EGCG have not been clarified. Here, 5 μm MPs were orally administered to mice induce injuries. Subsequently, antibiotic cocktail (ABX) fecal transplant (FMT) experiments performed investigate underlying mechanisms. Additionally, was explore its protection against Our results showed that activated systemic inflammation, promoted fibrosis, altered metabolome; meanwhile, damaged homeostasis disturbing microbiome, promoting colonic impairing intestinal barrier. Notably, reduced abundance probiotics Akkermansia, Mucispirillum, Faecalibaculum while increasing pathogenic Tuzzerella. Interestingly, elimination mitigated inflammation barrier impairment. Moreover, ABX ameliorated but fibrosis. Correspondingly, from MPs-administered induced colonic, systemic, their profibrosis observed. Finally, elevated effectively repressed inflammation. remodeling metabolome also attenuated EGCG. These findings illustrated contributed injuries, could serve as a potential prevention strategy for these adverse consequences.

Language: Английский

Citations

83
Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice DOI Creative Commons

Tianxin Zhao,

Lianju Shen,

Xin Ye

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 445, P. 130544 - 130544

Published: Dec. 5, 2022

Polystyrene microplastics (PS-MPs) can threaten human health, especially male fertility. However, most existing studies have focused on the adulthood stage of reproduction toxicity caused by relatively short-term PS-MP exposure. This study aimed to investigate toxic effect PS-MPs testicular development and reproductive function upon prenatal postnatal Pregnant mice their offspring were exposed 0, 0.5 mg/L, 5 50 mg/L through daily drinking water from gestational day 1 (PND) 35 or PND70. We found that exposure induced testis disorder PND35 spermatogenesis dysfunction By combining RNA sequencing results bioinformatics analysis, hormone-mediated signaling pathway, G1/S transition mitotic cell cycle, coregulation androgen receptor activity, Hippo pathway shown be involved in PND35. The meiotic regulation immune effector process, neutrophil degranulation, inflammation mediated chemokine cytokine pathways associated with disturbed These findings show resulted subfertility, which may regulated involve an reaction.

Language: Английский

Citations

77
Recent progress of microplastic toxicity on human exposure base on in vitro and in vivo studies DOI

Zhengguo Liu,

Xue‐yi You

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 903, P. 166766 - 166766

Published: Sept. 2, 2023

Language: Английский

Citations

69
Exposure to nanoplastics induces mitochondrial impairment and cytomembrane destruction in Leydig cells DOI Creative Commons

Zhangbei Sun,

Yiqian Wen,

Fan Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 255, P. 114796 - 114796

Published: March 20, 2023

Plastic particle pollution poses an emerging threat to ecological and human health. Laboratory animal studies have illustrated that nano-sized plastics can accumulate in the testis cause testosterone deficiency spermatogenic impairment. In this study, TM3 mouse Leydig cells were vitro exposed polystyrene nanoparticles (PS-NPs, size 20 nm) at dosages of 50, 100 150 μg/mL investigate their cytotoxicity. Our results demonstrated PS-NPs be internalized into led a concentration-dependent decline cell viability. Furthermore, stimulation amplified ROS generation initiated cellular oxidative stress apoptosis. Moreover, treatment affected mitochondrial DNA copy number collapsed membrane potential, accompanied by disrupted energy metabolism. The also displayed down-regulated expression steroidogenesis-related genes StAR, P450scc 17β-HSD, along with decrease secretion. addition, destructed plasma integrity, as presented increase lactate dehydrogenase release depolarization potential. summary, these data indicated exposure produced cytotoxic effect on inducing injury, impairment, apoptosis, cytomembrane destruction. provide new insights male reproductive toxicity caused NPs.

Language: Английский

Citations

55
Reproductive toxicity of PFOA, PFOS and their substitutes: A review based on epidemiological and toxicological evidence DOI

Wenshan Shi,

Zengli Zhang, Mei Li

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118485 - 118485

Published: Feb. 17, 2024

Language: Английский

Citations

37
Microplastics exposure: implications for human fertility, pregnancy and child health DOI Creative Commons

Rewa E. Zurub,

Yusmaris Cariaco, Michael G. Wade

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Plastics found in our everyday environment are becoming an increasing concern for individual and population-level health, the extent of exposure potential toxic effects these contaminants on numerous human organ systems clear. Microplastics (MPs), tiny plastic particles, appear to have many same biological as their precursors compounded effect accumulation different organs. Recently, microplastic was observed placenta, raising important questions related health pregnancies offspring. These concerns particularly heightened considering developmental origins disease (DOHaD) framework, which postulates that utero can programme lifelong The current review examines state knowledge this topic highlights avenues future investigation.

Language: Английский

Citations

36