Twenty years of microplastics pollution research—what have we learned?

Science, Journal Year: 2024, Volume and Issue: 386(6720)

Published: Sept. 19, 2024

Twenty years after the first publication that used term microplastic, we review current understanding, refine definitions, and consider future prospects. Microplastics arise from multiple sources, including tires, textiles, cosmetics, paint, fragmentation of larger items. They are widely distributed throughout natural environment, with evidence harm at levels biological organization. pervasive in food drink have been detected human body, emerging negative effects. Environmental contamination could double by 2040, wide-scale has predicted. Public concern is increasing, diverse measures to address microplastic pollution being considered international negotiations. Clear on efficacy potential solutions now needed issue minimize risks unintended consequences.

Language: Английский

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Effects of plastic particles on aquatic invertebrates and fish – A review

Environmental Toxicology and Pharmacology, Journal Year: 2022, Volume and Issue: 96, P. 104013 - 104013

Published: Nov. 1, 2022

Language: Английский

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Toxicity of micro/nanoplastics in the environment: Roles of plastisphere and eco-corona

Soil & Environmental Health, Journal Year: 2023, Volume and Issue: 1(1), P. 100002 - 100002

Published: Feb. 28, 2023

Micro/nanoplastics (MPs/NPs) are a growing threat to environmental health as these particles dispersed remote locations. However, the migration process of NPs differs from MPs due their differences in sizes and physicochemical properties, thereby inducing different behaviours fates. While provide surfaces host microorganisms form plastisphere, smaller than microorganisms, which often encapsulated by protein or organic matter unique eco-corona. Both plastisphere eco-corona alter physiochemical property MPs/NPs, changing toxicity. To fully understand toxicity MPs/NPs after forming eco-corona, this review aims evaluate roles toxicities environment. Specifically, discusses formation on NPs, summarizes biochemical mechanisms assesses potential threats humans. Finally, perspectives provided better manage plastic pollution protect environment human health.

Language: Английский

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Ferroptosis Induced by Pollutants: An Emerging Mechanism in Environmental Toxicology

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(5), P. 2166 - 2184

Published: Jan. 26, 2024

Environmental pollutants have been recognized for their ability to induce various adverse outcomes in both the environment and human health, including inflammation, apoptosis, necrosis, pyroptosis, autophagy. Understanding these biological mechanisms has played a crucial role risk assessment management efforts. However, recent identification of ferroptosis as form programmed cell death emerged critical mechanism underlying pollutant-induced toxicity. Numerous studies demonstrated that fine particulates, heavy metals, organic substances can trigger ferroptosis, which is closely intertwined with lipid, iron, amino acid metabolism. Given growing evidence linking severe diseases such heart failure, chronic obstructive pulmonary disease, liver injury, Parkinson's Alzheimer's cancer, it imperative investigate ferroptosis. In this review, we comprehensively analyze pathways intricate signaling molecules elucidate integration into driving braking axes. Furthermore, discuss potential hazards associated organs four representative animal models. Finally, provide an outlook on future research directions strategies aimed at preventing By enhancing our understanding novel developing effective preventive measures, mitigate effects environmental safeguard health.

Language: Английский

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Microplastic aging processes: Environmental relevance and analytical implications

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 172, P. 117566 - 117566

Published: Jan. 30, 2024

The analysis of microplastics (MPs) in terrestrial environments and the evaluation their environmental risk has gained great attention, owing to increasing evidence for widespread presence soils freshwater sediments globally. Once environment, MPs undergo abiotic biotic processes which alter properties integrity: this process is called "aging" implications fate these contaminants, morphology surface chemistry. Aging may also affect analytical assessment samples: samples likely contain aged MPs, while methods are generally established using pristine plastics validation. This can lead uncertainties quantification characterization. critical review summarizes current trends simulation characterization MP aging laboratory conditions, highlighting limitations knowledge gaps. It discusses challenges induced by samples, providing directions toward possible solutions.

Language: Английский

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Adsorption behavior of triazine pesticides on polystyrene microplastics aging with different processes in natural environment

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124319 - 124319

Published: June 4, 2024

Language: Английский

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Micro- and nano-plastics pollution in the marine environment: Progresses, drawbacks and future guidelines

Chemosphere, Journal Year: 2025, Volume and Issue: 374, P. 144211 - 144211

Published: Feb. 19, 2025

Language: Английский

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Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 860, P. 160403 - 160403

Published: Nov. 20, 2022

Micro- and nanoplastics (MNPs) are ubiquitous in the environment have recently been found human lungs, blood placenta. However, data on possible effects of MNPs health is extremely scarce. The potential toxicity during pregnancy, a period increased susceptibility to environmental insults, particular concern. placenta provides unique interface between maternal fetal circulation which essential for utero survival healthy pregnancy. Placental toxicokinetics still largely unexplored limited studies performed up now focus mainly polystyrene particles. Practical ethical considerations limit research options humans, extrapolation from animal challenging due marked differences species. Nevertheless, diverse vitro ex vivo placental models exist e.g., plasma membrane vesicles, mono-culture co-culture cells, placenta-on-a-chip, villous tissue explants, perfusion that can be used advance this area. objective concise review recapitulate different models, summarize current understanding uptake, transport define knowledge gaps. Moreover, we provide perspectives future urgently needed assess hazards risks MNP exposure health.

Language: Английский

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Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 259, P. 115018 - 115018

Published: May 20, 2023

The increasing demand for plastic in our daily lives has led to global pollution. improper disposal of resulted a massive amount atmospheric microplastics (MPs), which further the production nanoplastics (NPs). Because its intimate relationship with environment and human health, microplastic nanoplastic contamination is becoming problem. are microscopic light, they may penetrate deep into lungs. Despite several studies demonstrating abundance air, potential risks remain unknown. small size, characterization presented significant challenges. This paper describes sampling procedures nanoplastics. study also examines numerous harmful effects particles on health other species. There void research toxicity airborne upon inhalation, toxicological future. Further needed determine influence pulmonary diseases.

Language: Английский

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Doped Graphene To Mimic the Bacterial NADH Oxidase for One-Step NAD⁺ Supplementation in Mammals

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(5), P. 3108 - 3120

Published: Jan. 26, 2023

Nicotinamide adenine dinucleotide (NAD) is a critical regulator of metabolic networks, and declining levels its oxidized form, NAD+, are closely associated with numerous diseases. While supplementing cells precursors needed for NAD+ synthesis has shown poor efficacy in combatting decline, an alternative strategy the development synthetic materials that catalyze oxidation NADH into thereby taking over natural role oxidase (NOX) present bacteria. Herein, we discovered metal-nitrogen-doped graphene (MNGR) can NAD+. Among MNGR different transition metals, Fe-, Co-, Cu-NGR displayed strong catalytic activity combined >80% conversion similar specificity to NOX abstracting hydrogen from pyridine ring nicotinamide, higher selectivity than 51 other nanomaterials. The NOX-like FeNGR functioned well diverse cell lines. As proof concept vivo application, showed could specifically target liver remedy flux anomaly obesity mice NAD+-deficient cells. Overall, our study provides distinct insight exploration drug candidates by design mimic functions unique enzymes (e.g., NOX)

Language: Английский

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