The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(5), P. 1919 - 1955

Published: Feb. 11, 2023

Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and mortality, any treatment targeting single session insufficient to tackle this. CHF characterized by reduced cardiac output resulting from neurohumoral dysregulation remodeling, which might be related oxidative stress, inflammation, endoplasmic reticulum apoptosis, autophagy, mitochondrial function, angiogenesis. These molecular mechanisms interact each other through crosstalk. Historically, Chinese medicinal herbs have been widely applied in the of CHF, therapeutic effects their ingredients scientifically confirmed over past decades. Traditional medicine (TCM) multiple components can confront different pathogenesis targets. This review analyzes commonly used TCM patent drugs decoctions that are applicable stages based on clinical trials. Diverse bioactive found treat via mechanisms. comprehensively covers key works underlying TCM, herbal synergistic constituent compatibility treating providing additional ideas address this threat.

Language: Английский

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MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products

Aging and Disease, Journal Year: 2024, Volume and Issue: 15(2), P. 640 - 640

Published: Jan. 1, 2024

Various diseases, including cancers, age-associated disorders, and acute liver failure, have been linked to the oncogene, MYC. Animal testing clinical trials shown that sustained tumor volume reduction can be achieved when MYC is inactivated, different combinations of therapeutic agents inhibitors are currently being developed. In this review, we first provide a summary multiple biological functions oncoprotein in cancer treatment, highlighting equilibrium points MYC/MAX, MIZ1/MYC/MAX, MAD (MNT)/MAX complexes further potential treatment could used restrain oncogene expression its tumorigenesis. We also discuss multifunctional capacity various cellular processes, influences on immune response, metabolism, cell cycle, apoptosis, autophagy, pyroptosis, metastasis, angiogenesis, multidrug resistance, intestinal flora. Moreover, summarize therapy patent landscape emphasize as druggable target, using herbal medicine modulators. Finally, describe pending challenges future perspectives biomedical research, involving development approaches modulate or targeted genes. Patients with cancers driven by signaling may benefit from therapies targeting these pathways, which delay cancerous growth recover antitumor responses.

Language: Английский

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Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

Hydroxysafflor yellow A (HSYA), a natural pigment with chalcone structure extracted from Carthamus tinctorius L. (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes. However, no study reported the anticancer mechanisms of principal bioactive compound in safflower. This review discusses recent developments physicochemical properties sources, pharmacological effects mechanisms, pharmacokinetic progress, safety HSYA, focusing involvement HSYA regulation related pathways apoptosis, autophagy, tumor immune microenvironment variety cancers. can serve as theoretical basis for further research development insights into signaling pathways.

Language: Английский

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Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114866 - 114866

Published: May 12, 2023

Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial some cardiovascular diseases, especially in Asia, North America, Europe other parts of world. This comprehensive review aims update biomedical potential ART its derivatives for treating human diseases highlighting pharmacokinetic pharmacological properties based on results experimental studies vitro vivo. Cellular molecular mechanisms action, tested doses toxic effects artemisinin were also described. The analysis data an up-to-date literature search showed that display anticancer along with wide range activities antibacterial, antiviral, antimalarial, antioxidant cardioprotective effects. These compounds have great discovering new drugs adjunctive therapies cancer various diseases. Detailed translational are however needed fully understand these compounds.

Language: Английский

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Research progress of natural silk fibroin and the application for drug delivery in chemotherapies

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 4, 2023

Silk fibroin has been widely used in biological fields due to its biocompatibility, mechanical properties, biodegradability, and safety. Recently, silk as a drug carrier was developed rapidly achieved remarkable progress cancer treatment. The fibroin-based delivery system could effectively kill tumor cells without significant side effects resistance. However, few studies have reported on systems for antitumor therapy. advancement of research applications therapy are highlighted this study. applications, private opinions, future prospects carriers discussed understand better the development anti-cancer systems, which may also contribute advancing innovation.

Language: Английский

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Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Hand.-Mazz. herb pair

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

The Prunella vulgaris L. (PVL) and Taraxacum mongolicum Hand.-Mazz. (TH) herb pair, which is commonly used in traditional Chinese medicine (TCM), has been applied for the treatment of breast cancer. Although its efficacy validated, synergistic anti-breast cancer compound combinations within this pair their underlying mechanisms action remain unclear. This study aimed to identify validate PVL-TH using large-scale biomedical data, artificial intelligence experimental methods. first step was investigate effects various PVL TH extracts vitro cellular assays most effective superior extracts. These were subjected liquid chromatography-mass spectrometry (LC-MS) analysis constituent compounds. A deep learning-based prediction model, DeepMDS, predict multi-compound combinations. predicted experimentally validated at actual content ratios found Preliminary bioinformatics analyses conducted explore these We also compared from different geographical origins analyzed contents compounds assess representation anti-tumor effect corresponding TCM. results revealed that LC-MS identified 27 21 (50% ethanol extracts) TH, respectively. Based on compounds, DeepMDS model such as F973 (caffeic acid, rosmarinic p-coumaric esculetin), T271 (chlorogenic cichoric caffeic acid), T1685 scopoletin) single PVL, combinations, concentrations extracts, demonstrated activity could regulate tumor-related pathways synergistically, inhibiting tumor cell growth, inducing apoptosis, blocking cycle progression. Furthermore, concentration ratio total closely associated with origins. combination represent pair. provides insights into exploring representative complex

Language: Английский

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Traditional Chinese medicine in the era of immune checkpoint inhibitor: theory, development, and future directions

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: May 20, 2023

Abstract Immune checkpoint inhibitors (ICIs) have revolutionized cancer management and been widely applied; however, they still some limitations in terms of efficacy toxicity. There are multiple treatment regimens Traditional Chinese Medicine (TCM) that play active roles combination with Western medicine the field oncology treatment. TCM ICIs works by regulating tumor microenvironment modulating gut microbiota. Through targets means, enhances ICIs, reverses resistance, effectively prevents treats ICI-related adverse events based on basic clinical studies. However, there few conclusions this topic. This review summarizes development treatment, mechanisms underlying existing studies, ongoing trials, prospects for future development.

Language: Английский

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Rapid identification of the compounds of Bushen Huoxue Prescription based on offline two‐dimensional liquid chromatography with high‐resolution mass spectrometry and molecular network technology

Journal of Separation Science, Journal Year: 2024, Volume and Issue: 47(2)

Published: Jan. 1, 2024

The comprehensive and efficient characterization of components in traditional Chinese medicine is crucial for elucidating its active constituents uncovering mechanism. Identifying the compounds Bushen Huoxue Prescription (BHP) difficult because complex composition large difference concentration among compounds. In this study, a hydrophilic interaction liquid chromatography coupled with reversed‐phase LC (HILIC × RPLC) offline 2D‐LC tandem high‐resolution mass spectrometry method was established to analyze total BHP. Database screening molecular networking were performed identify contrast conventional 1D chromatography, 2D increased peak capacity, enriched trace ingredients, prevented masking high‐abundance A 165 identified, 14 potential needed be further identified. This study provided an effective comprehensively analyzing system

Language: Английский

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Exploring the mechanism of Taohong Siwu Decoction on the treatment of blood deficiency and blood stasis syndrome by gut microbiota combined with metabolomics

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: April 23, 2023

Abstract Background Taohong Siwu Decoction (THSWD) is a prescription which included in the “List of Ancient Classic Prescriptions (First Batch)” issued by National Administration Traditional Chinese Medicine (TCM) and Medical Products People’s Republic China. THSWD effective widely applied clinically for many diseases caused blood deficiency stasis syndrome TCM, such as primary dysmenorrhea, menopausal syndrome, coronary heart disease, angina pectoris, diabetes. Methods The TCM model was prepared ice water bath combined with cyclophosphamide, rats were randomly divided into control group, deficiency, positive treatment group. Pharmacodynamics measured routine, coagulation, other related indexes rats. UHPLC-MS technology used to analyze changes fingerprints metabolites plasma mass spectrometry information public database retrieval, find potential biomarkers screening metabolites. At same time, 16S rDNA sequencing identify intestinal flora, statistical analysis differences strain diversity between groups. Results administration can significantly improve physical signs, hematopoietic factors model, symptoms deficiency. results general pharmacological studies showed groups improved viscosity coagulation-related modeling, coagulation function significantly. metabolomic found that compared exerted better effects on β-alanine, taurine, l -tyrosine, -arginine, Eugenol, sodium deoxycholate, deethylatrazine. Twenty-three differential intervention effects, mainly involved eight metabolic pathways, including amino acid metabolism, taurine hypotaurine vitamin nucleotide metabolism. Gut microbiota data that, relative abundance value Firmicutes Bacteroidota group reduced, while Actinobacteria, Spirochaetota, Proteobacteria, Campilobacterota, pathogenic bacteria increased. Following intervention, beneficial increased, decreased. Correlation gut two are closely related. affected host system through mutual adjustment these factors, Conclusion disease cyclophosphamide lead pharmacology, metabolomics, microbiota. stasis. mechanism regulation platelet

Language: Английский

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Baicalein promotes KDM4E to induce BICD1 and inhibit triple‐negative breast cancer progression by blocking PAR1 signaling

Molecular Carcinogenesis, Journal Year: 2024, Volume and Issue: 63(7), P. 1288 - 1302

Published: April 12, 2024

Abstract Baicalein has been implicated in the chemotherapy overcoming triple‐negative breast cancer (TNBC). However, many unanswered questions remain regarding its role treating TNBC. Here, we sought to demonstrate molecular pathway mediated by baicalein Lysine‐specific demethylase 4E (KDM4E), reduced TNBC cells, was identified as a target protein of baicalein, and enhanced expression stability KDM4E cells. Knockdown attenuated inhibitory effect on cell activity, demonstrated intensified mobility, viability, apoptosis resistance activated bicaudal D homolog 1 (BICD1) reducing deposition histone H3 lysine 9 trimethylation (H3K9me3) promoter, whereas BICD1 promoted protease‐activated receptor‐1 (PAR1) endocytosis blocked PAR1 signaling through physical interaction with PAR1. strengthened PAR1‐dependent activity cells response thrombin activation, progression combined overexpression BICD1. Taken together, our data indicate that baicalein‐promoted signaling, thereby inhibiting progression.

Language: Английский

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