Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(11), P. 1552 - 1552
Published: Nov. 4, 2022
The
purpose
of
this
study
was
to
review
the
physicochemical
characterization
Romanian
honey
and
propolis
their
antifungal
effect
on
different
strains.
As
an
indicator
environmental
pollution,
lead
exceeded
allowed
limits
in
two
areas.
relationship
between
acidity
electrical
conductivity
polyfloral
antioxidant
activity
with
total
content
phenolics
flavonoids
investigated.
13
samples
from
North-West
Central
Romania
12
Alba
County
investigated
against
six
fungal
strains:
Aspergillus
niger,
flavus,
Candida
albicans,
Penicillium
chrysogenum,
Rhizopus
stolonifer,
Fusarium
oxysporum.
All
exhibited
effect.
most
sensitive
strains
were
P.
chrysogenum
R.
stolonifer
for
F.
oxisporumn
propolis.
A
two-way
analysis
variance
used
evaluate
correlations
diameter
inhibition
zones
extracts.
Statistical
demonstrated
that
zone
influenced
by
strain
type
geographical
origin
Pearson's
correlation
coefficient
shows
a
significant
positive
linear
flavonoid
phenol
concentration
propolis,
respectively.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1519 - 1519
Published: Feb. 11, 2025
Propolis
(bee
glue)
is
a
complex
mixture
of
resins,
waxes,
and
gums,
it
resinous
exudate
manufactured
by
honey
bees
to
maintain
the
integrity
hive
defend
against
external
threats.
This
multifunctional
material
exhibits
several
striking
properties.
The
anti-inflammatory
properties
propolis
have
made
subject
traditional
medicine
over
time,
from
ancient
Egyptian
mummification
modern
complementary
medicine.
with
rich
phytochemicals,
such
as
polyphenols
flavonoids,
exhibit
anti-inflammatory,
antioxidant,
anticancer
effects.
review
describes
multiple
uses
propolis,
highlighting
role
an
exceptional
natural
resource
high
therapeutic
potential.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(2), P. 259 - 259
Published: Jan. 18, 2023
Propolis
is
a
mass
of
chemically
diverse
phytoconstituents
with
gummy
textures
that
are
naturally
produced
by
honeybees
upon
collection
plant
resins
for
utilization
in
various
life
processes
beehives.
Since
ancient
times,
propolis
has
been
unique
traditional
remedy
globally
utilized
several
purposes,
and
it
secured
value
pharmaceutical
nutraceutical
areas
recent
years.
The
chemical
composition
comprises
constituents
deviations
the
precise
honeybee
species,
source
used
production
bees,
climate
conditions
harvesting
season.
Over
300
molecular
structures
have
discovered
from
propolis,
important
classes
include
phenolic
acids,
flavonoids,
terpenoids,
benzofurans,
benzopyrene
chalcones.
also
reported
to
pharmacological
activities,
such
as
antidiabetic,
anti-inflammatory,
antioxidant,
anticancer,
immunomodulatory,
antibacterial,
antiviral,
antifungal,
anticaries.
As
chronic
diseases
risen
global
health
threat,
abundant
research
conducted
track
its
alternative
therapies
diseases.
Several
clinical
trials
revealed
potency
preventing
curing
some
This
review
explores
beneficial
effect
active
credible
mechanisms
computational
studies
on
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: May 10, 2023
Abstract
Since
the
number
of
drugs
based
on
natural
products
(NPs)
represents
a
large
source
novel
pharmacological
entities,
NPs
have
acquired
significance
in
drug
discovery.
Peru
is
considered
megadiverse
country
with
many
endemic
species
plants,
terrestrial,
and
marine
animals,
microorganisms.
databases
major
impact
discovery
development.
For
this
reason,
several
countries
such
as
Mexico,
Brazil,
India,
China
initiatives
to
assemble
maintain
that
are
representative
their
diversity
ethnopharmacological
usage.
We
describe
assembly,
curation,
chemoinformatic
evaluation
content
coverage
chemical
space,
well
physicochemical
attributes
initial
version
Peruvian
Natural
Products
Database
(PeruNPDB),
which
contains
280
products.
Access
PeruNPDB
available
for
free
(
https://perunpdb.com.pe/
).
The
PeruNPDB’s
collection
intended
be
used
variety
tasks,
virtual
screening
campaigns
against
various
disease
targets
or
biological
endpoints.
This
emphasizes
biodiversity
protection
both
directly
indirectly
human
health.
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 390 - 390
Published: Feb. 24, 2024
Aging
populations
worldwide
are
placing
age-related
diseases
at
the
forefront
of
research
agenda.
The
therapeutic
potential
natural
substances,
especially
propolis
and
its
components,
has
led
to
these
products
being
promising
agents
for
alleviating
several
cellular
molecular-level
changes
associated
with
diseases.
With
this
in
mind,
scientists
have
introduced
a
contextual
framework
guide
future
aging
research,
called
hallmarks
aging.
This
encompasses
various
mechanisms
including
genomic
instability,
epigenetic
changes,
mitochondrial
dysfunction,
inflammation,
impaired
nutrient
sensing,
altered
intercellular
communication.
Propolis,
rich
array
bioactive
compounds,
functions
as
potent
functional
food,
modulating
metabolism,
gut
microbiota,
immune
response,
offering
significant
health
benefits.
Studies
emphasize
propolis'
properties,
such
antitumor,
cardioprotective,
neuroprotective
effects,
well
ability
mitigate
oxidative
stress,
DNA
damage,
pathogenic
bacteria
growth.
article
underscores
current
scientific
evidence
supporting
role
controlling
molecular
characteristics
linked
hallmarks,
hypothesizing
geroscience
research.
aim
is
discover
novel
strategies
improve
quality
life
older
individuals,
addressing
existing
deficits
perspectives
area.
BDJ Open,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 25, 2025
Abstract
Background
and
objectives
Gingivitis
periodontitis
are
common
periodontal
diseases
that
can
significantly
harm
overall
oral
health,
affecting
the
teeth
their
supporting
tissues,
along
with
surrounding
anatomical
structures,
if
left
untreated,
leading
to
total
destruction
of
alveolar
bone
connective
tooth
loss,
other
more
serious
systemic
health
issues.
Numerous
studies
have
shown
propolis
help
reduce
gum
inflammation,
inhibit
growth
pathogenic
bacteria,
promote
tissue
regeneration,
but
varying
degrees
success
reported.
For
this
reason,
comprehensive
systematic
review
aims
at
finding
out
truth
concerning
efficacy
mouthwashes
in
treating
gingivitis
periodontitis,
as
its
main
objective.
Data
sources
Research
findings
from
6
different
databases:
China
National
Knowledge
Infrastructure
(CNKI),
PubMed®,
Europe
PMC,
Cochrane
Central
Register
Controlled
Trials
(CENTRAL),
BioMed
Central,
Google
Scholar,
were
retrieved
examined
addition
a
manual
search
references
lists.
Study
selection
synthesis
The
PICOS
framework
was
used
select
exclude
studies.
focus
on
clinical
randomized
controlled
trials
(RCTs)
effectiveness
propolis-containing
comparison
propolis-free
ones
for
treatment
employing
related
indices.
Animal
studies,
microbiological
in-vitro
retrospective
case-control
cohorts,
case
reports,
series,
reviews,
letters,
editorials,
meta-analyses,
non-clinical
(non-RCTs),
all
excluded.
A
meta-analysis
not
performed
data
only
studied
qualitatively
due
obvious
heterogeneity
amongst
selected
extracted,
then
revised
Cochrane’s
risk
bias
tool
(RoB
2.0)
utilised
by
two
authors,
independently,
evaluate
each
study.
Results
At
first,
151
results
reached,
after
removing
duplicates,
99
records
remained,
later
screened,
assessed,
full
details
based
set
criteria.
Out
these
articles,
ten
included
review,
encompassing
453
patients
an
age
range
(13–70)
years
old.
Propolis
protocols
application
intervention
whereas
placebo
or
rest
tested
such
as,
chlorhexidine,
sodium
fluoride
cetylpyridinium
chloride,
sterile
distilled
water,
hydrogen
peroxide,
which
compared.
Treatment
duration
extended
14
days
3
months
follow-up
period
differed
months.
In
general,
decreased
plaque
accumulations
gingival
inflammation
employed
On
hand,
aforementioned
than
deemed
equally
effective
even
superior
some
As
assessment
bias,
four
assigned
having
low
bias.
Two
concerns,
while
identified
high
Conclusions
Despite
fact
has
positive
effects
terms
controlling
especially
when
mechanical
methods,
lack
certainty
power
evidence
is
no
agreed
gold
standards.
These
conclusions
come,
sure,
within
limitations
like
substantial
variability
presence
demonstrate
propolis-based
showed
promising
outcomes
reducing
inflammation.
However,
it
highly
recommended
conduct
rigorous
patient-reported
outcome
measures,
periods,
larger
samples
sizes,
better-designed
methodologies,
typified
use,
implementation
similar
indices
order
obtain
reliable,
conclusive,
generalisable
results.
Prospero
Registration
Number
CRD42024524523.
Molecules,
Journal Year:
2022,
Volume and Issue:
28(1), P. 141 - 141
Published: Dec. 24, 2022
Propolis
is
one
of
the
bee
products,
with
multiple
biological
properties
used
in
numerous
applications.
The
research
objective
was
to
determine
chemical
composition
and
(antibacterial,
antifungal,
antiviral,
antioxidant,
cytoprotective
activity)
propolis
extracts
collected
from
various
regions
Poland.
results
indicated
that
total
content
phenols
(116.16–219.41
mg
GAE/g
EEP)
flavonoids
(29.63–106.07
QE/g
depended
on
their
geographic
origin.
high
epicatechin,
catechin,
pinobanksin,
myricetin,
acids:
vanillic
syringic
samples
confirmed
by
chromatographic
analysis.
Moreover,
presence
caffeic
acid
phenethyl
ester
all
samples.
origin
also
influenced
its
extracts.
were
characterized
moderate
DPPH
free
radical
scavenging
activity
(29.22–35.14%),
relatively
low
ferrous
iron
chelating
(9.33–32.32%).
showed
protection
human
red
blood
cells
against
radicals
generated
2,2’-azobis(2-methylpropionamidine)
dihydrochloride
(AAPH).
exhibited
diversified
tested
pathogenic
bacteria
limited
fungal
strains.
selected
only
2
5
examined
HPV
(human
papillomaviruses)
geographical
distribution.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 341 - 341
Published: Jan. 31, 2023
Adverse
pregnancy
outcomes
are
considered
significant
health
risks
for
pregnant
women
and
their
offspring
during
throughout
lifespan.
These
lead
to
a
perturbated
in-utero
environment
that
impacts
critical
phases
of
the
fetus’s
life
correlates
an
increased
risk
chronic
pathological
conditions,
such
as
diabetes,
obesity,
cardiovascular
diseases,
in
both
mother’s
adult
offspring’s
life.
The
dietary
intake
naturally
occurring
antioxidants
promotes
benefits
disease
prevention.
In
this
regard,
maternal
polyphenolic
is
linked
reduced
obesity
cardio-metabolic
disorders,
positively
affecting
fetus
offspring.
work,
we
will
gather
critically
appraise
current
literature
highlighting
effect/s
polyphenol
antioxidant
resveratrol
on
oxidative
stress,
inflammation,
other
molecular
physiological
phenomena
associated
with
gestational
preeclampsia,
preterm
labor.
impact
prenatal
complications
pregnancy-associated
structures,
placenta,
also
be
discussed.
Finally,
draw
conclusions
from
knowledge
provide
future
perspectives
potentially
exploiting
therapeutic
tool
conditions.
Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
20(5)
Published: March 28, 2023
Geographic
conditions
(altitude,
climate,
and
local
flora)
lead
to
significant
differences
in
the
chemical
composition
of
propolis.
Therefore,
more
research
is
needed
for
propolis
different
geographical
regions.
So,
aim
this
study
was
evaluate
phenolic
profile,
total
content,
antioxidant,
antidiabetic
properties
Pülümür
from
Turkey.
Methanol
(MeOH),
chloroform
(CHCl3
),
hexane
extracts
were
analyzed.
LC-ESI-MS/MS
analysis
showed
that
most
abundant
compound
caffeic
acid
MeOH
extract
(2943.12±11.12
μg
phenolics/g
extract),
while
on
other
hand,
CHCl3
had
highest
content
(125.75±1.02
mg
GAE/g
extract).
Antioxidant
activity
measured
using
ABTS
DPPH
assays,
whereas
(IC50
=6.35±0.11
28.84±0.10
μg/mL,
respectively)
=5.04±0.07
28.80±0.09
relatively
high
antioxidant
activity.
The
better
than
standard
compound,
acarbose
=0.544
0.805
mg/mL,
respectively).
Frontiers in Bioscience-Landmark,
Journal Year:
2023,
Volume and Issue:
28(9)
Published: Sept. 14, 2023
Pulmonary
fibrosis
(PF)
is
a
feared
component
in
over
200
interstitial
pulmonary
diseases,
which
are
characterized
by
increased
alveolar
wall
thickness,
excessive
scarring,
and
aberrant
extracellular
matrix
restructuring
that,
ultimately,
affect
lung
compliance
capacity.
As
result
of
its
broad
range
biological
activities,
including
antioxidant,
anti-inflammatory,
antiapoptotic,
many
others,
resveratrol
has
been
shown
to
be
an
effective
treatment
for
respiratory
system
disease,
infectious
cancer.
This
work
reviews
the
known
molecular
therapeutic
targets
potential
mechanisms
action
attenuating
PF
cancer,
COVID-19,
diseases
(ILDs)
etiologies,
idiopathic
pneumonia,
ILDs
associated
with
systemic
disorders,
such
as
rheumatoid
arthritis,
sclerosis,
Schrödinger’s
syndrome,
lupus
erythematosus,
hypertension.
The
current
issues
controversies
related
possible
use
pharmaceutical
drug
or
supplement
also
discussed.