Propolis: A Natural Substance with Multifaceted Properties and Activities

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1519 - 1519

Published: Feb. 11, 2025

Propolis (bee glue) is a complex mixture of resins, waxes, and gums, it resinous exudate manufactured by honey bees to maintain the integrity hive defend against external threats. This multifunctional material exhibits several striking properties. The anti-inflammatory properties propolis have made subject traditional medicine over time, from ancient Egyptian mummification modern complementary medicine. with rich phytochemicals, such as polyphenols flavonoids, exhibit anti-inflammatory, antioxidant, anticancer effects. review describes multiple uses propolis, highlighting role an exceptional natural resource high therapeutic potential.

Language: Английский

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Propolis and Their Active Constituents for Chronic Diseases

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 259 - 259

Published: Jan. 18, 2023

Propolis is a mass of chemically diverse phytoconstituents with gummy textures that are naturally produced by honeybees upon collection plant resins for utilization in various life processes beehives. Since ancient times, propolis has been unique traditional remedy globally utilized several purposes, and it secured value pharmaceutical nutraceutical areas recent years. The chemical composition comprises constituents deviations the precise honeybee species, source used production bees, climate conditions harvesting season. Over 300 molecular structures have discovered from propolis, important classes include phenolic acids, flavonoids, terpenoids, benzofurans, benzopyrene chalcones. also reported to pharmacological activities, such as antidiabetic, anti-inflammatory, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral, antifungal, anticaries. As chronic diseases risen global health threat, abundant research conducted track its alternative therapies diseases. Several clinical trials revealed potency preventing curing some This review explores beneficial effect active credible mechanisms computational studies on

Language: Английский

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PeruNPDB: the Peruvian Natural Products Database for in silico drug screening

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 10, 2023

Abstract Since the number of drugs based on natural products (NPs) represents a large source novel pharmacological entities, NPs have acquired significance in drug discovery. Peru is considered megadiverse country with many endemic species plants, terrestrial, and marine animals, microorganisms. databases major impact discovery development. For this reason, several countries such as Mexico, Brazil, India, China initiatives to assemble maintain that are representative their diversity ethnopharmacological usage. We describe assembly, curation, chemoinformatic evaluation content coverage chemical space, well physicochemical attributes initial version Peruvian Natural Products Database (PeruNPDB), which contains 280 products. Access PeruNPDB available for free ( https://perunpdb.com.pe/ ). The PeruNPDB’s collection intended be used variety tasks, virtual screening campaigns against various disease targets or biological endpoints. This emphasizes biodiversity protection both directly indirectly human health.

Language: Английский

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Propolis in the management of cardiovascular disease

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131219 - 131219

Published: March 30, 2024

Language: Английский

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Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 390 - 390

Published: Feb. 24, 2024

Aging populations worldwide are placing age-related diseases at the forefront of research agenda. The therapeutic potential natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular molecular-level changes associated with diseases. With this in mind, scientists have introduced a contextual framework guide future aging research, called hallmarks aging. This encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, altered intercellular communication. Propolis, rich array bioactive compounds, functions as potent functional food, modulating metabolism, gut microbiota, immune response, offering significant health benefits. Studies emphasize propolis' properties, such antitumor, cardioprotective, neuroprotective effects, well ability mitigate oxidative stress, DNA damage, pathogenic bacteria growth. article underscores current scientific evidence supporting role controlling molecular characteristics linked hallmarks, hypothesizing geroscience research. aim is discover novel strategies improve quality life older individuals, addressing existing deficits perspectives area.

Language: Английский

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Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings

BDJ Open, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 25, 2025

Abstract Background and objectives Gingivitis periodontitis are common periodontal diseases that can significantly harm overall oral health, affecting the teeth their supporting tissues, along with surrounding anatomical structures, if left untreated, leading to total destruction of alveolar bone connective tooth loss, other more serious systemic health issues. Numerous studies have shown propolis help reduce gum inflammation, inhibit growth pathogenic bacteria, promote tissue regeneration, but varying degrees success reported. For this reason, comprehensive systematic review aims at finding out truth concerning efficacy mouthwashes in treating gingivitis periodontitis, as its main objective. Data sources Research findings from 6 different databases: China National Knowledge Infrastructure (CNKI), PubMed®, Europe PMC, Cochrane Central Register Controlled Trials (CENTRAL), BioMed Central, Google Scholar, were retrieved examined addition a manual search references lists. Study selection synthesis The PICOS framework was used select exclude studies. focus on clinical randomized controlled trials (RCTs) effectiveness propolis-containing comparison propolis-free ones for treatment employing related indices. Animal studies, microbiological in-vitro retrospective case-control cohorts, case reports, series, reviews, letters, editorials, meta-analyses, non-clinical (non-RCTs), all excluded. A meta-analysis not performed data only studied qualitatively due obvious heterogeneity amongst selected extracted, then revised Cochrane’s risk bias tool (RoB 2.0) utilised by two authors, independently, evaluate each study. Results At first, 151 results reached, after removing duplicates, 99 records remained, later screened, assessed, full details based set criteria. Out these articles, ten included review, encompassing 453 patients an age range (13–70) years old. Propolis protocols application intervention whereas placebo or rest tested such as, chlorhexidine, sodium fluoride cetylpyridinium chloride, sterile distilled water, hydrogen peroxide, which compared. Treatment duration extended 14 days 3 months follow-up period differed months. In general, decreased plaque accumulations gingival inflammation employed On hand, aforementioned than deemed equally effective even superior some As assessment bias, four assigned having low bias. Two concerns, while identified high Conclusions Despite fact has positive effects terms controlling especially when mechanical methods, lack certainty power evidence is no agreed gold standards. These conclusions come, sure, within limitations like substantial variability presence demonstrate propolis-based showed promising outcomes reducing inflammation. However, it highly recommended conduct rigorous patient-reported outcome measures, periods, larger samples sizes, better-designed methodologies, typified use, implementation similar indices order obtain reliable, conclusive, generalisable results. Prospero Registration Number CRD42024524523.

Language: Английский

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Biological Activity and Chemical Composition of Propolis from Various Regions of Poland

Molecules, Journal Year: 2022, Volume and Issue: 28(1), P. 141 - 141

Published: Dec. 24, 2022

Propolis is one of the bee products, with multiple biological properties used in numerous applications. The research objective was to determine chemical composition and (antibacterial, antifungal, antiviral, antioxidant, cytoprotective activity) propolis extracts collected from various regions Poland. results indicated that total content phenols (116.16–219.41 mg GAE/g EEP) flavonoids (29.63–106.07 QE/g depended on their geographic origin. high epicatechin, catechin, pinobanksin, myricetin, acids: vanillic syringic samples confirmed by chromatographic analysis. Moreover, presence caffeic acid phenethyl ester all samples. origin also influenced its extracts. were characterized moderate DPPH free radical scavenging activity (29.22–35.14%), relatively low ferrous iron chelating (9.33–32.32%). showed protection human red blood cells against radicals generated 2,2’-azobis(2-methylpropionamidine) dihydrochloride (AAPH). exhibited diversified tested pathogenic bacteria limited fungal strains. selected only 2 5 examined HPV (human papillomaviruses) geographical distribution.

Language: Английский

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Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 341 - 341

Published: Jan. 31, 2023

Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during throughout lifespan. These lead to a perturbated in-utero environment that impacts critical phases of the fetus’s life correlates an increased risk chronic pathological conditions, such as diabetes, obesity, cardiovascular diseases, in both mother’s adult offspring’s life. The dietary intake naturally occurring antioxidants promotes benefits disease prevention. In this regard, maternal polyphenolic is linked reduced obesity cardio-metabolic disorders, positively affecting fetus offspring. work, we will gather critically appraise current literature highlighting effect/s polyphenol antioxidant resveratrol on oxidative stress, inflammation, other molecular physiological phenomena associated with gestational preeclampsia, preterm labor. impact prenatal complications pregnancy-associated structures, placenta, also be discussed. Finally, draw conclusions from knowledge provide future perspectives potentially exploiting therapeutic tool conditions.

Language: Английский

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LC‐ESI‐MS/MS Chemical Characterization, Antioxidant and Antidiabetic Properties of Propolis Extracted with Organic Solvents from Eastern Anatolia Region

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(5)

Published: March 28, 2023

Geographic conditions (altitude, climate, and local flora) lead to significant differences in the chemical composition of propolis. Therefore, more research is needed for propolis different geographical regions. So, aim this study was evaluate phenolic profile, total content, antioxidant, antidiabetic properties Pülümür from Turkey. Methanol (MeOH), chloroform (CHCl3 ), hexane extracts were analyzed. LC-ESI-MS/MS analysis showed that most abundant compound caffeic acid MeOH extract (2943.12±11.12 μg phenolics/g extract), while on other hand, CHCl3 had highest content (125.75±1.02 mg GAE/g extract). Antioxidant activity measured using ABTS DPPH assays, whereas (IC50 =6.35±0.11 28.84±0.10 μg/mL, respectively) =5.04±0.07 28.80±0.09 relatively high antioxidant activity. The better than standard compound, acarbose =0.544 0.805 mg/mL, respectively).

Language: Английский

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Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis

Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(9)

Published: Sept. 14, 2023

Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring that, ultimately, affect lung compliance capacity. As result of its broad range biological activities, including antioxidant, anti-inflammatory, antiapoptotic, many others, resveratrol has been shown to be an effective treatment for respiratory system disease, infectious cancer. This work reviews the known molecular therapeutic targets potential mechanisms action attenuating PF cancer, COVID-19, diseases (ILDs) etiologies, idiopathic pneumonia, ILDs associated with systemic disorders, such as rheumatoid arthritis, sclerosis, Schrödinger’s syndrome, lupus erythematosus, hypertension. The current issues controversies related possible use pharmaceutical drug or supplement also discussed.

Language: Английский

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