Synthesis and Characterization of Carbonaceous Materials for Medical Applications: A comprehensive Review DOI Open Access
Ebenezer C. Nnadozie,

Kennedy Izuchukwu Ogunwa,

Vitalis Ikenna Chukwuike

et al.

Published: June 26, 2024

Carbonaceous materials have gained significant attention in recent years for their various applications the field of medicine and biotechnology. This comprehensive review explores synthesis characterization carbon-based potentials medical applications. The paper delves into methods fabrication nanoparticles, such as carbon nanotubes, biochar, graphene, while highlighting unique properties. Characterization techniques, microscopy, spectroscopy, surface analysis, are discussed to provide insights chemical structural properties these materials. Furthermore, examined wide-ranging applications, encompassing tissue engineering, drug delivery, biosensing, imaging, showcasing versatility promising contributions carbonaceous healthcare industry. outlines current challenges prospects field, emphasizing growing significance valuable tools advancing science technology, well public health.

Language: Английский

The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings DOI Creative Commons
Jin Yang, Junyi Liang,

Niyuan Hu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(10)

Published: Oct. 1, 2024

Alzheimer's disease (AD) is characterized by progressive cognitive decline and neuronal loss, commonly linked to amyloid-β plaques, neurofibrillary tangles, neuroinflammation. Recent research highlights the gut microbiota as a key player in modulating neuroinflammation, critical pathological feature of AD. Understanding role this process essential for uncovering new therapeutic avenues gaining deeper insights into AD pathogenesis.

Language: Английский

Citations

8
Microglia and Gut Microbiota: A Double-Edged Sword in Alzheimer's Disease DOI

Nargis Bano,

Sameera Khan,

Shakir Ahamad

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102515 - 102515

Published: Sept. 1, 2024

Language: Английский

Citations

8
Crosstalk between peripheral inflammation and brain: focus on the responses of microglia and astrocytes to peripheral challenge DOI
Maria Concetta Geloso,

Luca Zupo,

Valentina Corvino

et al.

Neurochemistry International, Journal Year: 2024, Volume and Issue: unknown, P. 105872 - 105872

Published: Oct. 1, 2024

Language: Английский

Citations

6
Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases DOI Open Access
Ewelina Młynarska, Paulina Jakubowska, Weronika Frąk

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3570 - 3570

Published: Oct. 21, 2024

Recent research highlights the growing interest in impact of nutrition on cognitive health and function disease, as dietary habits are increasingly recognized crucial factors relation to brain function. This focus is especially important given rising prevalence neurodegenerative diseases decline associated with poor choices. Links now being sought between microbiota gut-brain axis. Mechanisms proposed that include low-grade chronic neuroinflammation, influence short-chain fatty acids, or disruption glial cells transmitters brain.

Language: Английский

Citations

4
Systems Pharmacology Approach and Experiment Evaluation Reveal Pterocarpus Mildbraedii (Fabaceae) Intervention for Counteracting Behavioral Changes and Neuroinflammatory and Oxidative Stress Markers Against Lps-Induced Alzheimer's Disease in Rats DOI
Mengue Ngadena Yolande Sandrine, Pascal Emmanuel Owona,

Armand Fils Ella

et al.

Published: Jan. 1, 2025

Ethnopharmacological relevance: Pterocarpus mildbraedii was believed to have multiple benefits, including antioxidant, antipyretic, antalgic, anti-convulsant, and anxiolytic effects. Previous studies reported that water extract (Pm) contained secondary metabolites able cross the BBB. However, Pm's systemic mechanism targets for neuroinflammation remain largely unexplored.Aim of study: This research used a systems pharmacology approach experiment evaluation reveal potential protective effects Pm against neuroinflammation, oxidative stress, behavioral changes in an LPS-induced Alzheimer's disease (AD) rat model.Materials methods: integrated network analysis experimental verification evaluate pharmacological PM AD systematically. Swiss Target Prediction, GeneCards, STRING databases were employed identify targets. The interaction between active components hub confirmed via molecular docking. GO KEGG pathway analyses also carried out. Further, vitro bioassays explore anti-inflammatory antioxidant activities and, finally, vivo neuroinflammatory stress markers.Results: Network docking revealed primarily regulates signaling pathways such as ESR1, ESR2, BACE1, MAPK1, TLR4, IL6, GSK3B through like liquiritigenin pterocarptriol. identified significant action AD, nitrogen metabolism VEGF pathway. In vitro, demonstrated their properties, along with inhibitory on AchE BchE. Behavioral tests showed LPS exposure impaired exploratory behavior, spatial learning, increased anxiety rats, correlating brain, marked by elevated MDA NO levels, decreased CAT, SOD, GSH levels. raised TNF-α IL-6 levels while reducing dopamine, serotonin, AChE activity. Notably, treatment significantly mitigated improved activity, restored neurotransmitter animals.Conclusion: paper established P. could inhibit its components, targets, pathways. milbraedii may be candidate treatment.

Language: Английский

Citations

0
Microbial Trojan Horses: Virulence Factors as Key Players in Neurodegenerative Diseases DOI Creative Commons
Matheus V. Coste Grahl, Kelvin Siqueira Hohl,

Thiago Smaniotto

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 687 - 687

Published: Feb. 4, 2025

Changes in population demographics indicate that the elderly will reach 2.1 billion worldwide by 2050. In parallel, there be an increase neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This review explores dysbiosis occurring these pathologies how virulence factors contribute to worsening or development of clinical conditions, it summarizes existing potential ways combat microorganisms related diseases. Microbiota imbalances can progression increasing intestinal permeability, exchanging information through innervation, even acting a Trojan horse affecting immune cells. The microbiota produce protect themselves from host defenses, many which These are expressed according genetic composition each microorganism, leading wide range considered. Among main LPS, urease, curli proteins, amyloidogenic VacA, CagA. also packed into bacterial outer membrane vesicles, transport RNA, DNA, enabling distal communication impacts various diseases, including

Language: Английский

Citations

0
Chaihuang Qingyi Huoxue granule ameliorates severe acute pancreatitis by modulating gut microbiota and repairing the intestinal mucosal barrier DOI Creative Commons
Xiaobin Zhang, Xiaoqun Zeng,

Wen Guo

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 18, 2025

During severe acute pancreatitis (SAP), damage to the intestinal mucosal barrier and translocation of pathogenic bacteria are key mechanisms that accelerate disease progression SAP. Chaihuang Qingyi Huoxue Granule (CH) is a herbal formula used in clinical treatment This study aims investigate role CH regulating gut microbiota SAP rats. Sodium taurocholate (3.5%) was retrogradely perfused into biliopancreatic duct establish model (4.4 g/kg) administered by gavage. Serum amylase, lipase, endotoxin levels were measured. Hematoxylin-eosin (HE) staining observe morphological changes pancreas colon. The expression zona occludens-1 (ZO-1) occludin colon examined immunohistochemistry (IHC) western blot. 16S rDNA gene sequencing analyze content short-chain fatty acids (SCFAs) contents rats determined gas chromatography-mass spectrometry (GC-MS). reduced serum rats, alleviated pathological colon, restored ZO-1 occludin. Moreover, dysbiosis with diversity structure. At phylum level, relative abundance Firmicutes Bacteroidetes increased, while Proteobacteria decreased. genus Ruminococcus 1, Parabacteroides, Prevotellaceae UCG-001, Lachnospiraceae NK4A136 group, Lactobacillus Escherichia-Shigella, Enterococcus, Enterobacter In addition, increased SCFAs ameliorates maintaining homeostasis microbiota, increasing SCFAs, repairing barrier.

Language: Английский

Citations

0
Semaglutide Ameliorates Neuroinflammation Caused by Enterogenous Pyrogen in APP/PS1 Mice DOI Creative Commons
Yuan Yuan,

Jiawei Zhang,

Ziyao Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Background and purpose: Alzheimer's disease (AD) is a neurodegenerative characterized by progressive cognitive dysfunction, which common in the elderly. In recent years, it has been reported that glucagon-like peptide 1 (GLP-1) analogues have neuroprotective function. However, mechanism of GLP-1 improving neurological function not fully clarified. This study attempts to clarify alleviating AD phenotype. Methods: this study, modified once-weekly analogue, Semaglutide, was used treat 8-month-old amyloid precursor protein / presenilin (APP/PS1) transgenic mice. By means ethology, molecular biology 16s rRNA amplicon sequencing, confirmed Semaglutide alleviated phenotype APP/PS1 Results: improved behavioral performance mice, reduced neuronal damage aggregation amyloid-β (Aβ) plaques, enhanced synaptic plasticity. also attenuated pyroptosis mediated NOD-like receptor thermal domain associated 3 (NLRP3), inflammatory reaction toll-like 4 (TLR4) mitochondrial microglia as well structure blood-brain barrier (BBB) Conclusion: may repair alleviate central nervous system injury caused displacement pyrogen gut

Language: Английский

Citations

0
Research Progress of Bile Acids in Neurodegenerative Diseases DOI

念 陈

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1718 - 1724

Published: Jan. 1, 2025

Language: Английский

Citations

0
Microbiome functional gene pathways predict cognitive performance in older adults with Alzheimers disease DOI Creative Commons
Abigail L. Zeamer,

YuShuan Lai,

Victoria Sanborn

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

ABSTRACT Disturbances in the gut microbiome is increasing correlated with neurodegenerative disorders, including Alzheimer’s Disease. The may fact influence disease pathology AD by triggering or potentiating systemic and neuroinflammation, thereby driving along “microbiota-gut-brain-axis”. Currently, drivers of cognitive decline symptomatic progression remain unknown understudied. Changes composition offer clues to potential physiologic neuropathologic changes that contribute decline. Here, we recruited a cohort 260 older adults (age 60+) living community followed them over time, tracking objective measures cognition, clinical information, microbiomes. Subjects were classified as healthy controls having mild impairment based on performance. Those diagnosis Diseases confirmed using serum biomarkers. Using metagenomic sequencing, found relative species abundances well cognition status (MCI AD). Furthermore, gene pathways analyses suggest certain microbial metabolic either be maintaining function. Specifically, genes involved urea cycle production methionine cysteine predicted worse Our study suggests predict

Language: Английский

Citations

0