Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(5), P. 299 - 315
Published: March 7, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)
Published: March 29, 2021
Abstract Currently, pyroptosis has received more and attention because of its association with innate immunity disease. The research scope expanded the discovery gasdermin family. A great deal evidence shows that can affect development tumors. relationship between tumors is diverse in different tissues genetic backgrounds. In this review, we provide basic knowledge pyroptosis, explain tumors, focus on significance tumor treatment. addition, further summarize possibility as a potential treatment strategy describe side effects radiotherapy chemotherapy caused by pyroptosis. brief, double-edged sword for rational use dual effect will help us explore formation ideas patients to develop new drugs based
Language: Английский
Citations
1577
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: June 20, 2022
Abstract In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not ICIs, partly caused absence of tumor-infiltrating lymphocytes (TILs), significantly limits application ICIs. Converting these “cold” into “hot” may ICIs is an unsolved question immunotherapy. Since it a general characteristic cancers resist apoptosis, induction non-apoptotic regulated cell death (RCD) emerging as new treatment strategy. Recently, several studies have revealed interaction between RCD and antitumor immunity. Specifically, autophagy, ferroptosis, pyroptosis, necroptosis exhibit synergistic responses while possibly exerting inhibitory effects on responses. Thus, targeted therapies (inducers inhibitors) against combination with exert potent activity, resistant This review summarizes multilevel relationship immunity RCD, including necroptosis, potential targeting improve efficacy malignancy.
Language: Английский
Citations
614
Theranostics, Journal Year: 2021, Volume and Issue: 11(11), P. 5365 - 5386
Published: Jan. 1, 2021
Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has greatly improved the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend on infiltration T cells capable recognizing and killing cells. ICIs are not effective in "cold tumors", which characterized lack T-cell infiltration. To realize full potential immunotherapy solve this obstacle, it is essential to understand drivers into tumors. We present a critical review our understanding mechanisms underlying including impaired priming deficient homing beds. "Hot tumors" with significant associated better ICI efficacy. In review, we summarize multiple strategies that promote transformation "hot discuss these lead increased Finally, application nanomaterials provide an outlook future emerging field. The combination nanomedicines enhances cross-presentation antigens promotes A deeper opens new possibilities for development cell-based therapies improve effectiveness.
Language: Английский
Citations
540
Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)
Published: Dec. 8, 2022
Abstract Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various activities, including clearance aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target development cancer medications recent years. However, because tumor show avoidance apoptosis, which causes treatment resistance recurrence, numerous studies been devoted alternative mortality processes, namely necroptosis, pyroptosis, ferroptosis, cuproptosis; these modalities extensively studied shown be crucial therapy effectiveness. Furthermore, evidence suggests that undergoing may alter immunogenicity microenvironment (TME) some extent, rendering it more suitable inhibiting progression metastasis. In addition, other components TME undergo abovementioned forms induce immune attacks on cells, resulting enhanced antitumor responses. Hence, this review discusses molecular processes features cuproptosis effects novel proliferation Importantly, introduces complex affect biology. It also summarizes potential agents nanoparticles or inhibit their therapeutic based from vivo vitro reports clinical trials inducers evaluated treatments patients. Lastly, we summarized impact modulating drug advantages adding modulators over conventional treatments.
Language: Английский
Citations
500
Cancer Communications, Journal Year: 2022, Volume and Issue: 42(2), P. 88 - 116
Published: Feb. 1, 2022
Abstract The hallmark of tumorigenesis is the successful circumvention cell death regulation for achieving unlimited replication and immortality. Ferroptosis a newly identified type dependent on lipid peroxidation which differs from classical programmed in terms morphology, physiology biochemistry. broad spectrum injury tumor tolerance are main reasons radiotherapy chemotherapy failure. effective rate immunotherapy as new treatment method less than 30%. can be seen radiotherapy, chemotherapy, immunotherapy; therefore, ferroptosis activation may potential strategy to overcome drug resistance mechanism traditional cancer treatments. In this review, characteristics causes by briefly described. addition, three metabolic regulations its crosstalk with signaling pathways summarized. Collectively, these findings suggest vital role based interaction immunotherapy, thus, indicating remarkable treatment.
Language: Английский
Citations
428
Journal of Experimental & Clinical Cancer Research, Journal Year: 2021, Volume and Issue: 40(1)
Published: May 3, 2021
Abstract Background Unraveling the mystery of cell death is one most fundamental progresses life sciences during past decades. Regulated (RCD) or programmed (PCD) not only essential in embryonic development, but also plays an important role occurrence and progression diseases, especially cancers. Escaping hallmarks cancer. Main body Pyroptosis inflammatory usually caused by microbial infection, accompanied activation inflammasomes maturation pro-inflammatory cytokines interleukin-1β (IL-1β) interleukin-18 (IL-18). Gasdermin family proteins are executors pyroptosis. Cytotoxic N-terminal gasdermins generated from caspases granzymes proteases mediated cleavage gasdermin oligomerizes forms pore across membrane, leading to release IL-1β, IL-18. exerts tumor suppression function evokes anti-tumor immune responses. Therapeutic regimens, including chemotherapy, radiotherapy, targeted therapy therapy, induce pyroptosis cancer, which potentiate local systemic immunity. On other hand, normal cells attributes side effects anti-cancer therapies. Conclusion In this review, we focus on regulatory mechanisms suppressive We discuss attribution reprogramming microenvironments restoration immunity its potential application cancer therapy.
Language: Английский
Citations
359
Cell Death Discovery, Journal Year: 2021, Volume and Issue: 7(1)
Published: April 7, 2021
Abstract Ovarian cancer (OC) is a highly malignant gynaecological tumour that has very poor prognosis. Pyroptosis been demonstrated in recent years to be an inflammatory form of programmed cell death. However, the expression pyroptosis-related genes OC and their correlations with prognosis remain unclear. In this study, we identified 31 pyroptosis regulators were differentially expressed between normal ovarian tissues. Based on these (DEGs), all cases could divided into two subtypes. The prognostic value each gene for survival was evaluated construct multigene signature using Cancer Genome Atlas (TCGA) cohort. By applying least absolute shrinkage selection operator (LASSO) Cox regression method, 7-gene built classified patients TCGA cohort low- or high-risk group. low-risk group showed significantly higher possibilities than those ( P < 0.001). Utilizing median risk score from cohort, Gene Expression Omnibus (GEO) subgroups, had increased overall (OS) time = 0.014). Combined clinical characteristics, found independent factor predicting OS patients. ontology (GO) Kyoto Encylopedia Genes Genomes (KEGG) analyses indicated immune-related enriched immune status decreased conclusion, play important roles immunity can used predict OCs.
Language: Английский
Citations
353
Theranostics, Journal Year: 2021, Volume and Issue: 11(18), P. 8813 - 8835
Published: Jan. 1, 2021
In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated remarkable achievements. However, emerging evidence has shown that chemoresistance is mediated by impairing or bypassing apoptotic cell death. Several novel types of programmed death, such as ferroptosis, necroptosis, pyroptosis, recently been reported to play significant roles in the modulation cancer progression are considered a promising strategy for treatment. Thus, switch between pyroptosis also discussed. Cancer immunotherapy gained increasing attention due breakthroughs immune checkpoint inhibitors; moreover, highly correlated with immunity tumor microenvironment. Compared necroptosis primary mechanism host defense crucial bridging innate adaptive immunity. Furthermore, exerts benefits on immunotherapies, including inhibitors (ICIs) chimeric antigen receptor T-cell therapy (CAR-T). Hence, this review, we elucidate role We summarize potential small molecules nanomaterials target pyroptotic death mechanisms their therapeutic effects cancer.
Language: Английский
Citations
320
International Journal of Surgery, Journal Year: 2022, Volume and Issue: 107, P. 106936 - 106936
Published: Sept. 20, 2022
Postoperative progression and chemotherapy resistance is the major cause of treatment failure in patients with triple-negative breast cancer (TNBC). Currently, there a lack an ideal predictive model for drug sensitivity postoperative TNBC patients. Diverse programmed cell death (PCD) patterns play important role tumor progression, which has potential to be prognostic indicator after surgery.Twelve PCD (apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, entotic death, netotic parthanatos, lysosome-dependent autophagy-dependent alkaliptosis, oxeiptosis) were analyzed construction. Bulk transcriptome, single-cell genomics, clinical information collected from TCGA-BRCA, METABRIC, GSE58812, GSE21653, GSE176078, GSE75688, KM-plotter cohorts validate model.The machine learning algorithm established index (CDI) 12-gene signature. Validated five independent datasets, high CDI had worse prognosis surgery. Two molecular subtypes distinct vital biological processes identified by unsupervised clustering model. A nomogram performance was constructed incorporating features. Furthermore, associated immune checkpoint genes key microenvironment components integrated analysis bulk transcriptome. are resistant standard adjuvant regimens (docetaxel, oxaliplatin, etc.); however, they might sensitive palbociclib (an FDA-approved luminal cancer).Generally, we novel comprehensively analyzing diverse patterns, can accurately predict user-friendly website created facilitate application this prediction (https://tnbc.shinyapps.io/CDI_Model/).
Language: Английский
Citations
271
Advanced Science, Journal Year: 2021, Volume and Issue: 8(24)
Published: Oct. 27, 2021
The absence of tumor antigens leads to a low response rate, which represents major challenge in immune checkpoint blockade (ICB) therapy. Pyroptosis, releases and damage-associated molecular patterns (DAMPs) that induce antitumor immunity boost ICB efficiency, potentially injury when occurring normal tissues. Therefore, strategy highly efficient agent tumor-specific pyroptosis but reduce tissues is urgently required. Here, smart microenvironmental reactive oxygen species (ROS)/glutathione (GSH) dual-responsive nano-prodrug (denoted as MCPP) with high paclitaxel (PTX) photosensitizer purpurin 18 (P18) loading rationally designed. ROS/GSH system facilitates the microenvironment achieves optimal drug release tumors. ROS generated by P18 after laser irradiation controlled induces cell PTX chemo-photodynamic Pyroptotic cells DAMPs, thus initiating adaptive immunity, boosting achieving regression, generating immunological memory, preventing recurrence. Mechanistically, therapy control-release synergistically gasdermin E (GSDME)-related pyroptosis. It speculated inspired using presented can be trigger augment efficiency.
Language: Английский
Citations
262