Pyroptosis in inflammatory diseases and cancer

Theranostics, Journal Year: 2022, Volume and Issue: 12(9), P. 4310 - 4329

Published: Jan. 1, 2022

Pyroptosis is a lytic and inflammatory type of programmed cell death that usually triggered by inflammasomes executed gasdermin proteins. The main characteristics pyroptosis are swelling, membrane perforation, the release contents. In normal physiology, plays critical role in host defense against pathogen infection. However, excessive may cause immoderate continuous responses involves occurrence diseases. Attractively, as immunogenic death, can serve new strategy for cancer elimination inducing pyroptotic activating intensely antitumor immunity. To make good use this double-edged sword, molecular mechanisms, therapeutic implications related diseases need to be fully elucidated. review, we first systematically summarize signaling pathways then present available evidences indicating cancer. Based on this, focus recent progress strategies inhibit treatment diseases, those induce therapy. Overall, should shed light future directions provide novel ideas using powerful tool fight

Language: Английский

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Microenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(24)

Published: Oct. 27, 2021

The absence of tumor antigens leads to a low response rate, which represents major challenge in immune checkpoint blockade (ICB) therapy. Pyroptosis, releases and damage-associated molecular patterns (DAMPs) that induce antitumor immunity boost ICB efficiency, potentially injury when occurring normal tissues. Therefore, strategy highly efficient agent tumor-specific pyroptosis but reduce tissues is urgently required. Here, smart microenvironmental reactive oxygen species (ROS)/glutathione (GSH) dual-responsive nano-prodrug (denoted as MCPP) with high paclitaxel (PTX) photosensitizer purpurin 18 (P18) loading rationally designed. ROS/GSH system facilitates the microenvironment achieves optimal drug release tumors. ROS generated by P18 after laser irradiation controlled induces cell PTX chemo-photodynamic Pyroptotic cells DAMPs, thus initiating adaptive immunity, boosting achieving regression, generating immunological memory, preventing recurrence. Mechanistically, therapy control-release synergistically gasdermin E (GSDME)-related pyroptosis. It speculated inspired using presented can be trigger augment efficiency.

Language: Английский

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ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(10)

Published: Jan. 11, 2023

Although zeolitic imidazolate framework-8 (ZIF-8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF-8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase-1/gasdermin D (GSDMD)-dependent pathway. The pyroptotic cell death is accompanied necrosis and immunogenic (ICD) simultaneously for efficient situ immunity initiation. Meanwhile, carbonyl cyanide m-chlorophenyl hydrazone (CCCP), mitochondrial depolarizing agent, successfully loaded into NPs found to further enhance process. Collectively, obtained Pluronic F127-modified CCCP-incorporated (F127 ZIF-8CCCP NPs) activate antitumor reprogram immunosuppressive microenvironment (TME), realizing high-efficiency growth inhibition. This work will facilitate biomedicine applications of provide good inspiration pyroptosis-induced cancer therapy.

Language: Английский

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Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 273 - 285

Published: March 12, 2022

Language: Английский

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A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(8)

Published: Nov. 29, 2021

An ideal cancer treatment should not only destroy primary tumors but also improve the immunogenicity of tumor microenvironment to achieve a satisfactory anti-tumor immune effect. We designed carbonic anhydrase IX (CAIX)-anchored rhenium(I) photosensitizer, named CA-Re, that performs type-I and type-II photodynamic therapy (PDT) with high efficiency under hypoxia (nanomolar-level phototoxicity), evokes gasdermin D (GSDMD) mediated pyroptotic cell death effectively stimulate immunogenicity. CA-Re could disrupt self-report loss membrane integrity simultaneously. This promoted maturation antigen-presenting ability dendritic cells (DCs), fully activated T dependent adaptive response in vivo, eventually eliminating distant at same time as destroying tumors. To best our knowledge, is first metal complex-based pyroptosis inducer.

Language: Английский

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Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Drug Delivery, Journal Year: 2022, Volume and Issue: 29(1), P. 2130 - 2161

Published: July 10, 2022

Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by inability drug to be solely delivered tumor when treating cancer with chemotherapy. Natural products attracted more and attention due antitumor effect multiple ways, abundant resources less effects. Therefore, combination natural active ingredients chemotherapy may an effective strategy, which can inhibit growth multidrug resistance, reduce drugs. Nano-drug co-delivery system (NDCDS) play important role This review provides comprehensive summary research status application prospect nano-delivery strategies drugs, aiming provide basis development anti-tumor

Language: Английский

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Engineering Multienzyme‐Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(13)

Published: Dec. 17, 2021

The engineering of a series multienzyme-mimicking covalent organic frameworks (COFs), COF-909-Cu, COF-909-Fe, and COF-909-Ni, as pyroptosis inducers, remodeling the tumor microenvironment to boost cancer immunotherapy, is reported. Mechanistic studies reveal that these COFs can serve hydrogen peroxide (H

Language: Английский

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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

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Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: March 15, 2023

Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a significant challenge in augmenting effect cancer immunotherapy. Pyroptosis, lytic programmed cell-death pathway unlike apoptosis, considered type immunogenic cell death (ICD) that can intensify ICD process cells, releasing dramatically increased tumor-associated antigens damage-associated molecular patterns promote Herein, membrane-targeted aggregation-induced emission photosensitive dimer found be able achieve highly efficient under synergistic photodynamic photothermal therapy. The efficiently produce type-I reactive oxygen species (ROS) by therapy hypoxic tissue, leading pyroptosis direct membrane damage, which further reinforced its effect. Furthermore, enhanced based on completely eliminate primary seventh day treatment also boost systemic antitumor immunity generating immune memory, demonstrated superior therapeutic effects both solid tumors metastatic when healing 4T1 mouse models with poor immunogenicity.

Language: Английский

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