Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 8, 2024
Abstract
Mitochondria
occupy
a
central
role
in
the
biology
of
most
eukaryotic
cells,
functioning
as
hub
oxidative
metabolism
where
sugars,
fats,
and
amino
acids
are
ultimately
oxidized
to
release
energy.
This
crucial
function
fuels
variety
cellular
activities.
Disruption
mitochondrial
is
common
feature
many
diseases,
including
cancer,
neurodegenerative
conditions
cardiovascular
diseases.
Targeting
tumor
cell
with
multifunctional
nanosystems
emerges
promising
strategy
for
enhancing
therapeutic
efficacy
against
cancer.
review
comprehensively
outlines
pathways
metabolism,
emphasizing
their
critical
roles
energy
production
metabolic
regulation.
The
associations
between
aberrant
initiation
progression
cancer
highlighted,
illustrating
how
these
disruptions
contribute
oncogenesis
sustainability.
More
importantly,
innovative
strategies
employing
nanomedicines
precisely
target
therapy
fully
explored.
Furthermore,
key
challenges
future
directions
this
field
identified
discussed.
Collectively,
provides
comprehensive
understanding
current
state
potential
nanomedicine
targeting
offering
insights
developing
more
effective
therapies.
Biology,
Journal Year:
2023,
Volume and Issue:
12(4), P. 558 - 558
Published: April 6, 2023
Background:
Senescence
is
a
cellular
aging
process
in
all
multicellular
organisms.
It
characterized
by
decline
functions
and
proliferation,
resulting
increased
damage
death.
These
conditions
play
an
essential
role
significantly
contribute
to
the
development
of
age-related
complications.
Humanin
mitochondrial-derived
peptide
(MDP),
encoded
mitochondrial
DNA,
playing
cytoprotective
preserve
function
cell
viability
under
stressful
senescence
conditions.
For
these
reasons,
humanin
can
be
exploited
strategies
aiming
counteract
several
processes
involved
aging,
including
cardiovascular
disease,
neurodegeneration,
cancer.
Relevance
disease:
appears
decay
organ
tissue
function,
it
has
also
been
related
diseases,
such
as
conditions,
cancer,
diabetes.
In
particular,
senescent
cells
produce
inflammatory
cytokines
other
pro-inflammatory
molecules
that
participate
diseases.
Humanin,
on
hand,
seems
contrast
known
diseases
promoting
death
damaged
or
malfunctioning
contributing
inflammation
often
associated
with
them.
Both
humanin-related
mechanisms
are
complex
have
not
fully
clarified
yet.
Further
research
needed
thoroughly
understand
disease
identify
potential
interventions
target
them
order
prevent
treat
Objectives:
This
systematic
review
aims
assess
underlying
link
connecting
senescence,
humanin,
disease.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(37)
Published: Feb. 9, 2024
Abstract
The
diagnosis
and
treatment
of
solid
tumors
have
undergone
significant
advancements
marked
by
a
trend
toward
increased
specificity
integration
imaging
therapeutic
functions.
multifaceted
nature
inorganic
oxide
nanomaterials
(IONs),
which
boast
optical,
magnetic,
ultrasonic,
biochemical
modulatory
properties,
makes
them
ideal
building
blocks
for
developing
multifunctional
nanoplatforms.
A
promising
class
materials
that
emerged
in
this
context
are
peptide‐functionalized
(PFIONs),
demonstrated
excellent
performance
therapy,
making
potential
candidates
advancing
tumor
treatment.
Owing
to
the
functionalities
peptides
targeting,
penetration,
responsiveness,
well‐designed
PFIONs
can
specifically
accumulate
release
or
agents
at
sites,
enabling
precise
effective
This
review
provides
an
overview
recent
advances
use
tumors,
highlighting
superiority
as
well
synergistic
Moreover,
discusses
challenges
prospects
depth,
aiming
promote
intersection
interdisciplinary
facilitate
their
clinical
translation
development
personalized
diagnostic
systems
optimizing
material
systems.
Abstract
Reactive
oxygen
species
(ROS)
serve
as
typical
metabolic
byproducts
of
aerobic
life
and
play
a
pivotal
role
in
redox
reactions
signal
transduction
pathways.
Contingent
upon
their
concentration,
ROS
production
not
only
initiates
or
stimulates
tumorigenesis
but
also
causes
oxidative
stress
(OS)
triggers
cellular
apoptosis.
Mounting
literature
supports
the
view
that
are
closely
interwoven
with
pathogenesis
cluster
diseases,
particularly
those
involving
cell
proliferation
differentiation,
such
myelodysplastic
syndromes
(MDS)
chronic/acute
myeloid
leukemia
(CML/AML).
OS
caused
by
excessive
at
physiological
levels
is
likely
to
affect
functions
hematopoietic
stem
cells,
growth
self-renewal,
which
may
contribute
defective
hematopoiesis.
We
review
herein
eminent
hematological
niche
profound
influence
on
progress
MDS.
highlight
targeting
practical
reliable
tactic
for
MDS
therapy.
Graphical
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9975 - 9975
Published: Sept. 16, 2024
Mitochondria
are
a
unique
type
of
semi-autonomous
organelle
within
the
cell
that
carry
out
essential
functions
crucial
for
cell's
survival
and
well-being.
They
location
where
eukaryotic
cells
energy
metabolism.
Aside
from
producing
majority
ATP
through
oxidative
phosphorylation,
which
provides
cellular
functions,
mitochondria
also
participate
in
other
metabolic
processes
cell,
such
as
electron
transport
chain,
citric
acid
cycle,
β-oxidation
fatty
acids.
Furthermore,
regulate
production
elimination
ROS,
synthesis
nucleotides
amino
acids,
balance
calcium
ions,
process
death.
Therefore,
it
is
widely
accepted
mitochondrial
dysfunction
factor
causes
or
contributes
to
development
advancement
various
diseases.
These
include
common
systemic
diseases,
aging,
diabetes,
Parkinson's
disease,
cancer,
well
rare
disorders,
like
Kearns-Sayre
syndrome,
Leigh
myopathy.
This
overview
outlines
mechanisms
by
involved
numerous
illnesses
physiological
activities.
Additionally,
new
discoveries
regarding
involvement
both
disorders
maintenance
good
health.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 16, 2025
Mitochondrial
morphology
and
function
are
intrinsically
linked,
indicating
the
opportunity
to
predict
functions
by
analyzing
morphological
features
in
live-cell
imaging.
Herein,
we
introduce
MoDL,
a
deep
learning
algorithm
for
mitochondrial
image
segmentation
prediction.
Trained
on
dataset
of
20,000
manually
labeled
mitochondria
from
super-resolution
(SR)
images,
MoDL
achieves
superior
accuracy,
enabling
comprehensive
analysis.
Furthermore,
predicts
employing
an
ensemble
strategy,
powered
extended
training
over
100,000
SR
each
annotated
with
functional
data
biochemical
assays.
By
leveraging
this
large
alongside
fine-tuning
retraining,
demonstrates
ability
precisely
heterogeneous
unseen
cell
types
through
small
sample
size
training.
Our
results
highlight
MoDL's
potential
significantly
impact
research
drug
discovery,
illustrating
its
utility
exploring
complex
relationship
between
form
within
wide
range
biological
contexts.
