Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription DOI Creative Commons
Jingjie Zhang, Xianmei Meng, Yiting Zhou

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 19, 2023

Abstract Numerous mechanisms have shown that long noncoding RNAs (lncRNAs) promote the development of colorectal cancer (CRC), but role lnc-LRRTM4 in progression CRC remains unclear. In this article, we found was highly expressed tissues and cell lines could proliferation metastasis cells. These consequences were achieved by directly binding to promoter LRRTM4 induce its transcription. Moreover, enhanced growth cells vivo promoting cycle reducing apoptosis. Taken together, our results revealed promotes cells, suggesting it may be a potential diagnostic therapeutic target for CRC.

Language: Английский

PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner in hepatocellular carcinoma DOI Creative Commons
Jiarui Li, Yilan Li, Denghui Wang

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: May 14, 2024

Abstract Background Sorafenib is a standard first-line treatment for advanced hepatocellular carcinoma (HCC), yet its effectiveness often constrained. Emerging studies reveal that sorafenib triggers ferroptosis, an iron-dependent regulated cell death (RCD) mechanism characterized by lipid peroxidation. Our findings isolate the principal target responsible ferroptosis in HCC cells and outline approach to potentially augment sorafenib's therapeutic impact on HCC. Methods We investigated gene expression alterations following sgRNA-mediated knockdown induced erastin using CRISPR screening-based bioinformatics analysis. Gene set enrichment analysis (GSEA) "GDCRNATools" package facilitated correlation studies. employed tissue microarrays cDNA validation. Ubiquitination assay, Chromatin immunoprecipitation (ChIP) RNA (RIP) dual-luciferase reporter assay were utilized delineate specific mechanisms underlying cells. Results study has revealed pleiomorphic adenoma 1 (PLAG1), implicated pleomorphic adenoma, confers resistance treated with sorafenib. leads opposite trend of protein mRNA levels PLAG1, which not caused affecting stability or ubiquitination PLAG1 protein, but regulation at transcriptional level upstream competitive endogenous long non-coding (lncRNA) plasmacytoma variant translocation (PVT1). Data from 139 patients showed significant positive between GPX4 tumor samples, instrumental redox homeostasis driving glutathione peroxidase 4 (GPX4), enzyme reduces peroxides (LPOs), further inhibition. Conclusions Ferroptosis promising cancer therapy, especially resistant chemotherapy immunotherapy. indicate holds promise may enhance efficacy treating

Language: Английский

Citations

14
Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers DOI
Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi

et al.

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(2)

Published: March 1, 2024

A significant portion of human cancers are caused by oncoviruses (12%-25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one which involves modifying the gene expression patterns leading rewiring genes resulting changes cellular processes signalling pathways. In recent studies, a specific mode regulation known as circular RNA (circRNA)-mediated competing endogenous (ceRNA) networks has emerged key player this context. CircRNAs, class non-coding molecules, can interact with other such mRNAs microRNAs (miRNAs), through process ceRNA crosstalk. This interaction occurs when circRNAs, acting sponges, sequester miRNAs, thereby preventing them from binding target modulating expression. By cell genome, have ability manipulate activity influencing that profoundly impact proliferation, differentiation, apoptosis, immune responses. review focuses on comprehensive evaluation latest findings involvement virus-induced reprogramming circRNA-mediated development pathophysiology viral cancers, including cervical cancer, gastric nasopharyngeal carcinoma, Kaposi's sarcoma, hepatocellular diffuse large B lymphoma. Understanding these mechanisms improve our knowledge how contribute identify potential targets for developing optimised therapies diagnostic tools cancers.

Language: Английский

Citations

13
HIF-1α-activated long non-coding RNA KDM4A-AS1 promotes hepatocellular carcinoma progression via the miR-411-5p/KPNA2/AKT pathway DOI Creative Commons
Tianxiang Chen, Runkun Liu,

Yongshen Niu

et al.

Cell Death and Disease, Journal Year: 2021, Volume and Issue: 12(12)

Published: Dec. 13, 2021

Abstract Hepatocellular carcinoma (HCC) is the most common type of liver cancer with poor clinical outcomes. Long non-coding RNAs (lncRNAs) are extensively involved in tumorigenesis and progression HCC. However, more investigations should be carried out on novel lncRNAs their effects Here we identified a lncRNA KDM4A-AS1, which was aberrantly overexpressed HCC tissues, associated unfavorable features prognosis patients. KDM4A-AS1 promoted cell proliferation, migration, invasion vitro contributed to growth lung metastasis vivo. Mechanistically, inversely modulated by miR-411-5p at post-transcriptional level facilitated Karyopherin α2 (KPNA2) expression competitively binding miR-411-5p, thereby activating AKT pathway. KPNA2 silencing, overexpression, inhibitor (MK2206) consistently reversed KDM4A-AS1-enhanced mobility, EMT cells. as hypoxia-responsive gene transactivated hypoxia-inducible factor 1α (HIF-1α) In turn, regulated HIF-1α through KPNA2/AKT signaling Hence, this study revealed lncRNA, via KDM4A-AS1/KPNA2/HIF-1α loop. Our findings provide promising prognostic therapeutic target for

Language: Английский

Citations

51
LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma DOI Creative Commons
Lianyuan Tao, Deyu Li,

Sengmao Mu

et al.

Laboratory Investigation, Journal Year: 2022, Volume and Issue: 102(5), P. 494 - 504

Published: March 9, 2022

Language: Английский

Citations

34
PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling DOI Creative Commons
Hualin Chen, Wenjie Yang, Yingjie Li

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(7)

Published: July 15, 2023

Abstract PLAGL2 is upregulated in various tumors, including bladder cancer (BCa). However, the mechanisms underlying tumorigenic effects of BCa remain unclear. In our study, we proved that was overexpressed tissues and correlated with decreased survival. Functionally, deficiency significantly suppressed proliferation metastasis cells vitro vivo. RNA sequencing, qRT‒PCR, immunoblotting, immunofluorescence staining, luciferase reporter, ChIP assays revealed disrupted Hippo pathway increased YAP1/TAZ activity by transactivating RACGAP1. Further investigations demonstrated activated signaling via RACGAP1-mediated RhoA activation. Importantly, inhibitor simvastatin or verteporfin abrogated proproliferative prometastatic enhanced PLAGL2. These findings suggest promotes progression RACGAP1/RhoA GTPase/YAP1 signaling. Hence, core nodes may be promising therapeutic targets for BCa.

Language: Английский

Citations

19
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1 DOI Creative Commons

Yingnan Yang,

Siying Jia,

Ning Zhu

et al.

Biology Direct, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 24, 2024

Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC). OTU deubiquitinase 5 (OTUD5), a DUB family member, has been recognized as critical regulator bladder cancer, breast cancer HCC. However, expression biological function OTUD5 HCC are still controversial.

Language: Английский

Citations

6
Development and validation of ferroptosis-related lncRNAs signature for hepatocellular carcinoma DOI Creative Commons
Jiaying Liang, Yaofeng Zhi,

Wenhui Deng

et al.

PeerJ, Journal Year: 2021, Volume and Issue: 9, P. e11627 - e11627

Published: June 11, 2021

Hepatocellular carcinoma (HCC) with high heterogeneity is one of the most frequent malignant tumors throughout world. However, there no research to establish a ferroptosis-related lncRNAs (FRlncRNAs) signature for patients HCC. Therefore, this study was designed novel FRlncRNAs predict survival HCC.The expression profiles were acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. co-expressed genes utilized signature. Cox regression used construct three in TCGA cohort, which verified GEO validation cohort.Three differently expressed significantly associated prognosis HCC identified, composed According signature, could be divided into low- high-risk groups. Patients group displayed shorter overall (OS) contrasted those low-risk (P < 0.001 cohort P = 0.045 cohort). This serve as independent predictor (multivariate HR > 1, 0.001), certain extent (univariate 0.05). Meanwhile, it also useful tool predicting among each stratum gender, age, grade, stage, etiology,etc. connected immune cell infiltration (i.e., Macrophage, Myeloid dendritic cell, Neutrophil etc.) checkpoint blockade targets (PD-1, CTLA-4, TIM-3).The might potential therapeutic patients, their prognostic prediction

Language: Английский

Citations

34
The Role of Long Non-Coding RNA and microRNA Networks in Hepatocellular Carcinoma and Its Tumor Microenvironment DOI Open Access
Tingting Shi, Asahiro Morishita, Hideki Kobara

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10630 - 10630

Published: Sept. 30, 2021

Hepatocellular carcinoma (HCC) is a common liver malignancy with high morbidity and poor prognosis. Long non-coding RNAs (lncRNAs) are involved in crucial biological processes of tumorigenesis progression, play four major regulatory roles, namely signal, decoy, guide, scaffold, to regulate gene expression. Through these processes, lncRNAs can target microRNAs (miRNAs) form lncRNA miRNA networks, which cancer cell proliferation, metastasis, drug resistance, the tumor microenvironment. Here, we summarize multifaceted functions networks pathogenesis HCC, potential use diagnostic or prognostic biomarkers, novel therapeutic targets HCC. This review also highlights effects microenvironment

Language: Английский

Citations

28
A Review of the Regulatory Mechanisms of N-Myc on Cell Cycle DOI Creative Commons
Hongli Li, Lulu Dong, Min-Jie Jin

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1141 - 1141

Published: Jan. 23, 2023

Neuroblastoma has obvious heterogeneity. It is one of the few undifferentiated malignant tumors that can spontaneously degenerate into completely benign tumors. However, for its high-risk type, even with various intensive treatment options, prognosis still unsatisfactory. At same time, a large number research data show abnormal amplification and high-level expression MYCN gene are positively correlated progression, poor prognosis, mortality neuroblastoma. In this context, article explores role N-Myc, product on target genes related to cell cycle reveals regulatory network in promoting tumor proliferation progression. We hope it provide ideas direction development drugs targeting N-Myc downstream genes.

Language: Английский

Citations

11
The Role of microRNAs in Hepatocellular Cancer: A Narrative Review Focused on Tumor Microenvironment and Drug Resistance DOI Creative Commons
Ali Tavakoli Pirzaman,

Ali Alishah,

Bahareh Babajani

et al.

Technology in Cancer Research & Treatment, Journal Year: 2024, Volume and Issue: 23

Published: Jan. 1, 2024

Globally, hepatic cancer ranks fourth in terms of cancer-related mortality and is the sixth most frequent kind cancer. Around 80% liver cancers are hepatocellular carcinomas (HCC), which leading cause death. It well known that HCC may develop resistance to available chemotherapy treatments very fast. One biggest obstacles providing patients with appropriate care drug resistance. According reports, more than 90% cancer-specific fatalities caused by treatment By binding 3'-untranslated region target messenger RNAs (mRNAs), microRNAs (miRNAs), a group noncoding around 17 25 nucleotides long, regulate gene expression. Moreover, they play role control signaling pathways, cell proliferation, As result, miRNAs an important microenvironment changing immune phenotypes, hypoxic conditions, acidification, as angiogenesis extracellular matrix components. changes miRNA levels can effectively resist cells affecting various cellular processes such autophagy, apoptosis, membrane transporter activity. In current work, we narratively reviewed HCC, special focus on tumor

Language: Английский

Citations

4