Cellular Oncology, Journal Year: 2023, Volume and Issue: 46(6), P. 1605 - 1623
Published: July 12, 2023
Language: Английский
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 26, 2025
Lung cancer (LC) is a highly prevalent and deadly type of characterized by intricate molecular pathways that drive tumor development, metastasis, resistance to conventional treatments. Recently, ferroptosis, controlled mechanism cell death instigated iron-dependent lipid peroxidation, has gained attention for its role in LC progression treatment. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) long noncoding (lncRNAs), are emerging key modulators significantly influencing biology. This review explores how ncRNAs control ferroptotic affect growth, therapy LC. By understanding the dual functions both activating inhibiting we aim uncover new therapeutic targets strategies These insights provide promising direction development ncRNA-based treatments designed induce potentially improving outcomes patients with
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 374 - 374
Published: March 6, 2025
Introduction: Non-small cell lung cancer (NSCLC) is a lethal type of (LC) with 5-year survival rate 19%. Because drug resistance typically develops following chemotherapy, radiotherapy, and immunotherapy, novel NSCLC therapeutic strategy urgently demanded. Gambogenic acid (GNA), major bioactive ingredient isolated from gamboge, has multipotent antitumor effects, although activity against unknown. Methods: CCK8, ethynyl deoxyuridine (EdU), the plate colony formation assay, transwell wound healing (WH) assay were used to study effect GNA on proliferation migration ability NSCLC. Flow cytometry was detect apoptosis cycle. Proteomic analysis LiP-SMap downstream target GNA. Ferroptosis inhibitor ferrostatin-1 ferroptosis. Overexpressing GCH1 for rescue experiment. Subcutaneous tumor pulmonary metastasis in mouse model growth metastasis. Results: The results present showed that inhibited cells dose- time-dependent manner, which arrested cycle G0/G1 phase. In vivo data revealed found significantly expression GTP cyclohydrolase 1 (GCH1). interacted ILE248 ARG249 GCH1. overexpression had similar role ferroptosis restored after treatment. Also, promoted reactive oxygen species (ROS) accumulation, reduced mitochondrial membrane potential. or treatment reversed regulation ROS accumulation potential inhibition. Conclusions: Taken together, these findings confirmed suppressed malignant progression by inducing GCH1-mediated
Language: Английский
Citations
1
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(2), P. 342 - 349
Published: July 7, 2023
Abstract Circular RNAs (circRNAs) are a class of covalently closed single-stranded that expressed during the development specific cells and tissues. CircRNAs play crucial roles in physiological pathological processes by sponging microRNAs, modulating gene transcription, controlling activity certain RNA-binding proteins, producing functional peptides. A key focus research at present is functionality circRNAs nervous system several advances have emerged over last 2 years. However, precise role has yet to be comprehensively reviewed. In this review, we first summarize recently described brain development, maturity, aging. Then, on involvement various diseases central system, such as cancer, chronic neurodegenerative diseases, acute injuries neuropathic pain. better understanding will help us develop potential diagnostic, prognostic, therapeutic strategies treat system.
Language: Английский
Citations
21
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1178 - 1189
Published: May 21, 2024
As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), unique non-coding molecule, seems to be one most alluring target molecules involved in pathophysiology many kinds cancers. CircRNAs have been identified as prospective targets and biomarkers for diagnosis treatment numerous disorders, particularly malignancies. Recent research has established clinical link between temozolomide (TMZ) resistance certain circRNA dysregulations glioma tumors. may play therapeutic role controlling or overcoming TMZ provide guidance novel kind individualized therapy. To address biological characteristics circRNAs their potential induce TMZ, this review highlighted summarized possible roles that molecular pathways drug resistance, including Ras/Raf/ERK PI3K/Akt signaling pathway metabolic processes gliomas.
Language: Английский
Citations
8
Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 122 - 122
Published: Feb. 15, 2024
Ferroptosis is a non-apoptotic mode of cell death driven by membrane lipid peroxidation and characterized elevated intracellular levels Fe
Language: Английский
Citations
7
Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122613 - 122613
Published: May 14, 2024
Language: Английский
Citations
7
PubMed, Journal Year: 2024, Volume and Issue: 23, P. 570 - 599
Published: Jan. 1, 2024
Cancer poses intricate challenges to treatment due its complexity and diversity. Ferroptosis circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators pivotal influencers ferroptosis in cell lines. The results underscore significance modulating pathways that impact crucial aspects development, including survival, proliferation, metastasis. A detailed analysis delineates these pathways, shedding light on mechanisms through which influence ferroptosis. Building upon recent experimental findings, study evaluates potential targeting induce By identifying specific associated with etiology cancer, this paves way for development targeted therapeutics exploit vulnerabilities cells. This review consolidates existing understanding circRNAs, emphasizing role therapy providing impetus ongoing research dynamic field. See also graphical abstract(Fig. 1).
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13336 - 13336
Published: Aug. 28, 2023
As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which different from other death forms morphologically, biochemically, immunologically. Ferroptosis metabolism, antioxidant defense systems as well various transcription factors related signal pathways. Emerging evidence has highlighted that associated with many physiological pathological processes, including cancer, neurodegeneration diseases, cardiovascular ischemia/reperfusion injury. Noncoding RNAs are group functional RNA molecules not translated into proteins, can regulate gene expression in manners. An increasing number studies have shown noncoding RNAs, especially miRNAs, lncRNAs, circRNAs, interfere the progression modulating ferroptosis-related genes or proteins directly indirectly. In this review, we summarize basic mechanisms regulations focus on recent mechanism for types ncRNAs to conditions, will deepen our understanding regulation provide new insights employing ferroptosis-associated therapeutic strategies.
Language: Английский
Citations
16
Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23507 - e23507
Published: Dec. 13, 2023
Ferroptosis is a regulatory cell death (RCD) caused by iron-dependent lipid peroxidation, which the backbone of regulating various diseases such as tumor, nervous system and so on. Despite ferroptosis without specific detection methods currently, there are numerous types technology commonly used, including flow cytometry, activity assay, microscopic imaging, western blotting, quantitative polymerase chain reaction (qPCR). In addition, could be detected quantifying oxygen-free radicals reactive oxygen species (ROS), metabolite (malondialdehyde ((MDA)), related pathways observing mitochondrial damage. face methods, how to choose appropriate based on experimental purposes has become problem that needs solved at present. this review, we summarized used critical substances in process ferroptosis, hope facilitating comprehensive study with view providing guidance for subsequent research.
Language: Английский
Citations
15
Molecular Therapy — Nucleic Acids, Journal Year: 2023, Volume and Issue: 32, P. 432 - 444
Published: April 7, 2023
Glioblastoma multiforme (GBM) is the deadliest primary central nervous system tumor. miRNAs (miRs), a class of non-coding RNAs, are considered pivotal post-transcriptional regulators cell signaling pathways. miR-21 reliable oncogene that promotes tumorigenesis cancer cells. We first performed an in silico analysis on 10 microarray datasets retrieved from TCGA and GEO databases to elucidate top differentially expressed miRs. Furthermore, we generated circular decoy, CM21D, using tRNA-splicing mechanism GBM models, U87 C6. The inhibitory efficacy CM21D with linear form, LM21D, was compared under vitro conditions intracranial C6 rat glioblastoma model. significantly overexpressed samples confirmed models qRT-PCR. more efficient than LM21D at inducing apoptosis, inhibiting proliferation migration, interrupting cycle by restoring expression target genes RNA protein levels. Moreover, suppressed tumor growth effectively C6-rat model (p < 0.001). Our findings validate as promising therapeutic for GBM. introduced sponging reduced can be potential RNA-base therapy inhibit cancers.
Language: Английский
Citations
14