Microbial Therapy and Breast Cancer Management: Exploring Mechanisms, Clinical Efficacy, and Integration within the One Health Approach

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1110 - 1110

Published: Jan. 16, 2024

This comprehensive review elucidates the profound relationship between human microbiome and breast cancer management. Recent findings highlight significance of microbial alterations in tissue, such as gut breast, their role influencing risk, development, progression, treatment outcomes. We delve into how can modulate systemic inflammatory responses estrogen levels, thereby impacting initiation therapeutic drug efficacy. Furthermore, we explore unique diversity within indicating potential imbalances brought about by highlighting specific microbes promising targets. Emphasizing a holistic One Health approach, this underscores importance integrating insights from human, animal, environmental health to gain deeper understanding complex microbe-cancer interplay. As field advances, strategic manipulation its metabolites presents innovative prospects for enhancement diagnostics therapeutics. However, rigorous clinical trials remain essential confirm microbiota-based interventions

Language: Английский

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Breast Cancer: Extracellular Matrix and Microbiome Interactions

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7226 - 7226

Published: June 30, 2024

Breast cancer represents the most prevalent form of and leading cause cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to appearance progression this disease. Despite advancements in breast treatment, a significant portion patients with distant metastases still experiences no cure. The extracellular matrix potential target for enhanced serum biomarkers cancer. Furthermore, degradation epithelial–mesenchymal transition constitute primary stages local invasion during tumorigenesis. Additionally, microbiome influence on diverse physiological processes. is emerging microbial dysbiosis element development various cancers, including Thus, better understanding interactions could provide novel alternatives treatment management. In review, we summarize current evidence regarding intricate relationship between microbiome. We discuss arising associations future perspectives field.

Language: Английский

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Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2644 - 2644

Published: Aug. 10, 2024

Breast cancer (BC) is one of the most common cancers worldwide and a leading cause cancer-related deaths among women. The escalating incidence BC underscores necessity multi-level treatment. complex heterogeneous disease involving many genetic, lifestyle, environmental factors. Growing evidence suggests that nutrition intervention an evolving effective prevention treatment strategy for BC. In addition, human microbiota, particularly gut now widely recognized as significant player contributing to health or status. It also associated with risk development This review will focus on in BC, including dietary patterns, bioactive compounds, nutrients affect therapeutic responses both animal studies. Additionally, this paper examines impacts these interventions modulating composition functionality microbiome, highlighting microbiome-mediated mechanisms combination factors microbes discussed. Insights from emphasize comprehensive management focuses nutrition–microbiome axis.

Language: Английский

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SEMdag: Fast learning of Directed Acyclic Graphs via node or layer ordering

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317283 - e0317283

Published: Jan. 8, 2025

A Directed Acyclic Graph (DAG) offers an easy approach to define causal structures among gathered nodes: linkages are represented by arrows between the variables, leading from cause effect. Recently, industry and academics have paid close attention DAG structure learning observable data, many techniques been put out address problem. We provide a two-step approach, named SEMdag() , that can be used quickly learn high-dimensional linear SEMs. It is included in R package SEMgraph employs two-stage order-based search using previous knowledge (Knowledge-based, KB) or data-driven method (Bottom-up, BU), under premise SEM with equal variance error terms assumed. evaluated our framework’s for finding plausible DAGs against six well-known discovery (ARGES, GES, PC, LiNGAM, CAM, NOTEARS). conducted series of experiments observed expression (or RNA-seq) taking into account pair training testing datasets four distinct diseases: Amyotrophic Lateral Sclerosis (ALS), Breast cancer (BRCA), Coronavirus disease (COVID-19) ST-elevation myocardial infarction (STEMI). The results show procedure recover graph good prediction performance conventional supervised algorithm (RF): scenario where initial sparse, BU may better choice than KB one; case denser, both report high performance, highest score based on topological layers. Besides its superior predictive compared research, user flexibility algorithms handle dimensional issues less computing load. function implemented easily available at https://CRAN.R-project.org/package=SEMgraph .

Language: Английский

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Interactions between the tumor microbiota and breast cancer

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 24, 2025

Breast cancer is the most common malignancy in women worldwide. Changes microbiota and their metabolites affect occurrence development of breast cancer; however, specific mechanisms are not clear. Gut microbes influence by regulating tumor immune response, estrogen metabolism, chemotherapy, immunotherapy effects. It was previously thought that there were no microorganisms tissue, but it now can outcome disease. This review builds on existing research to comprehensively analyze role gut intratumoral metastasis cancer. We also explore potential function as biomarkers for prognosis therapeutic highlighting need further clarify causal relationship between hope provide new ideas directions methods treatment.

Language: Английский

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A Systematic Review and Meta-Analysis of 16S rRNA and Cancer Microbiome Atlas Datasets to Characterize Microbiota Signatures in Normal Breast, Mastitis, and Breast Cancer

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 467 - 467

Published: Feb. 19, 2025

The breast tissue microbiome has been increasingly recognized as a potential contributor to cancer development and progression. However, inconsistencies in microbial composition across studies have hindered the identification of definitive signatures. We conducted systematic review meta-analysis 11 using 16S rRNA sequencing characterize bacterial 1260 fresh samples, including normal, mastitis-affected, benign, cancer-adjacent, cancerous tissues. Studies published until 31 December 2023 were included if they analyzed human Illumina short-read with sufficient metadata, while non-human non-breast tissues, non-English articles, those lacking metadata or alternative methods excluded. also incorporated data from Cancer Genome Atlas (TCGA-BRCA) cohort enhance our analyses. Our identified Proteobacteria, Firmicutes, Actinobacteriota, Bacteroidota dominant phyla tissue, Staphylococcus Corynebacterium frequently detected studies. While diversity was similar between cancer-adjacent both exhibited lower compared normal mastitis-affected Variability genera observed primer sets studies, emphasizing need for standardized methodologies research. An analysis TCGA-BRCA confirmed dominance Corynebacterium, which associated proliferation-related gene expression programs. Notably, high abundance 4.1-fold increased mortality risk. These findings underscore clinical relevance tumor progression emphasize importance methodological consistency. Future establish causal relationships, elucidate underlying mechanisms, assess microbiome-targeted interventions are warranted.

Language: Английский

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Bacterial metabolites: Effects on the development of breast cancer and therapeutic efficacy (Review)

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 9

Published: March 4, 2025

Evidence suggests that various gut metabolites significantly impact breast cancer (BC) and its treatment. However, the underlying mechanisms remain poorly understood require further investigation. In present study, current literature was reviewed to evaluate roles of microbial in development BC response Microbial metabolites, including secondary bile acids, short‑chain fatty amino acid lipopolysaccharide, nisin pyocyanin, serve crucial microenvironment. promote invasion, metastasis recurrence by facilitating cellular movement, epithelial‑mesenchymal transition, stem cell function diapedesis. Furthermore, certain such as trimethylamine N‑oxide L‑norvaline, can alter pharmacokinetics chemotherapeutic drugs. The review highlights possible involvement bacteriocins carcinogenesis, metastasis. These could provide new insights for treatment strategies are considered potential therapeutic targets.

Language: Английский

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Therapeutic potential of microbiome modulation in reproductive cancers

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 6, 2025

Language: Английский

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Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 990 - 990

Published: April 18, 2025

Estrogen receptors (ERs) play a critical role in breast cancer (BC) development and progression, with ERα being oncogenic ERβ exhibiting tumor-suppressive properties. The interaction between ER signaling other molecular pathways, such as PI3K/AKT/mTOR, influences tumor growth endocrine resistance. Emerging research highlights the of prebiotics modulating gut microbiota, which may influence estrogen metabolism, immune function, therapeutic responses BC. This review explores impact on receptor modulation, microbiota composition, regulation, metabolic pathways cancer. potential adjunctive therapies to enhance treatment efficacy mitigate chemotherapy-related side effects is discussed. A comprehensive analysis recent preclinical clinical studies was conducted, examining reprogramming short-chain fatty acids (SCFAs) derived from prebiotic fermentation epigenetic regulation resistance also evaluated. Prebiotics were found modulate microbiota-estrogen axis, reduce inflammation, responses. SCFAs demonstrated selective downregulation reprogramming, suppressing growth. Synbiotic interventions effects, improving quality life patients. offer promising avenue for prevention therapy by pathways. Future trials are needed validate their treatments management.

Language: Английский

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Harnessing Micronutrient Power: Vitamins, Antioxidants and Probiotics in Breast Cancer Prevention

Anticancer Research, Journal Year: 2024, Volume and Issue: 44(6), P. 2287 - 2295

Published: May 31, 2024

Breast cancer remains a global health challenge, prompting search for preventive strategies beyond conventional approaches. This review explores the potential of specific micronutrients, including antioxidants, vitamins, and probiotics, in breast prevention. Through an extensive literature encompassing PubMed up to March 2024, 14 micronutrients emerged with promising roles These include five vitamins: folate, vitamin D, B6, beta carotene, C nine other micronutrients: curcumin, piperine, epigallocatechin-3-gallate, quercetin, sulforaphane, indole-3-carbinol, lactobacillus, n-3 polyunsaturated fatty acids lycopene. Understanding efficacy these could pave way personalized interventions, offering new avenues reducing incidence improving public outcomes.

Language: Английский

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