Chronic Occupational Exposure to Traffic Pollution Is Associated with Increased Carotid Intima-Media Thickness in Healthy Urban Traffic Control Police DOI Open Access
Abdulrazak O. Balogun, M. Margaret Weigel, Edmundo Estévez

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(17), P. 6701 - 6701

Published: Sept. 1, 2023

Urban traffic officers in many low- and middle-income countries are exposed to high levels of traffic-related air pollutants (TRAP) while working vehicle control on heavily congested streets. The impact chronic TRAP exposure the cardiovascular health, including carotid intima-media thickness (CIMT), this outdoor occupational group remains unclear. This cross-sectional study compared average mean maximum CIMT measurements two groups relatively young, healthy police (32 ± 7 years; 77% male) Quito, Ecuador, who were without clinical evidence serious or other disease. Previously published background data PM10 (a surrogate) indicated that street pollutant several orders magnitude higher at intersections worked by those only an office. Accordingly, permanently assigned daily duties requiring them stand 0-3 m from trafficked (n = 61). 54) consisted same organization office inside administration building. Mean measured with ultrasound. General linear models used compare groups, adjusting for covariates. adjusted measures increased 11.5% 10.3%, respectively, (p 0.0001). These findings suggest is associated police. important since even small increases arterial thickening over time may promote earlier progression disease premature mortality risk.

Language: Английский

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study DOI Creative Commons
Yanlin Wu, Zhengjun Lin, Changchun Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 2, 2023

Abstract Epigenetics regulates gene expression and has been confirmed to play a critical role in variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism others. The term ‘epigenetics’ was firstly proposed 1942 with the development technologies, exploration epigenetics made great progresses. There are four main epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodelling, noncoding RNA (ncRNA), which exert different effects on diseases. Genetic non-genetic factors, ageing, diet, exercise, interact jointly affect formation phenotype. Understanding could be applied diagnosing treating diseases clinic, biomarkers, drugs, editing. In this review, we introduce brief history well milestone events since proposal ‘epigenetics’. Moreover, summarise research methods general mechanisms modulation. Furthermore, interaction between genetic or factors. Finally, clinical trials applications

Language: Английский

Citations

191
Diabetes mellitus—Progress and opportunities in the evolving epidemic DOI
E. Dale Abel, Anna L. Gloyn, Carmella Evans‐Molina

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(15), P. 3789 - 3820

Published: July 1, 2024

Language: Английский

Citations

48
Impact of climate change on immune responses and barrier defense DOI Creative Commons
Chrysanthi Skevaki, Kari C. Nadeau, Marc E. Rothenberg

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 153(5), P. 1194 - 1205

Published: Feb. 2, 2024

Climate change is not just jeopardizing the health of our planet, but it increasingly impacting immune health.There an expanding body evidence that climaterelated exposures, such as air pollution, heat, wildfires, extreme weather events, and biodiversity loss significantly disrupt functioning human system.These exposures manifest in a broad range stimuli including antigens, allergens, heat stress, pollutants, microbiota changes, other toxic substances.Such pose direct indirect threat to body's primary line defense, epithelial barrier, affecting its physical integrity functional efficacy.Furthermore, these climate-related environmental stressors can hyper-stimulate innate system influence adaptive immunity, notably terms developing preserving tolerance.The or failure tolerance instigate wide spectrum non-communicable diseases autoimmune conditions, allergy, respiratory illnesses, metabolic diseases, obesity, others.As continues unravel, there need for additional research climate immunology covers diverse environments different global settings, employing modern biological epidemiological tools.

Language: Английский

Citations

24
Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study DOI Creative Commons

Jing Qian,

Jiahao Zhu,

Yifan Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117770 - 117770

Published: Jan. 1, 2025

Language: Английский

Citations

2
Exposure to outdoor and indoor air pollution and risk of overweight and obesity across different life periods: A review DOI Creative Commons
Xiaoyi Shi, Yuxin Zheng,

Haiwen Cui

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 242, P. 113893 - 113893

Published: July 31, 2022

Due to the highly evolved industrialization and modernization, air quality has deteriorated in most countries. As reported by World Health Organization (WHO), pollution is now considered as one of major threats global health a principal risk factor for noncommunicable diseases. Meanwhile, increasing worldwide prevalence overweight obesity attracting more public attentions. Recently, accumulating epidemiological studies have provided evidence that may be partially attributable environmental exposure pollution. This review summarizes correlation between various outdoor indoor pollutants (mainly particulate matter (PM), nitrogen oxides (NOx), ozone (O3), polycyclic aromatic hydrocarbons (PAHs)) outcomes recent years. Moreover, it discusses multiple effects during periods throughout life sex differences populations. also describes potential mechanism underlying increased caused pollution, including inflammation, oxidative stress, metabolic imbalance, intestinal flora disorders epigenetic modifications. Finally, this proposes macro- micro-measures prevent negative on prevalence.

Language: Английский

Citations

58
Environmental Pollution and the Risk of Developing Metabolic Disorders: Obesity and Diabetes DOI Open Access

William Junior Khalil,

Meriem Akeblersane,

Ana Saad Khan

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8870 - 8870

Published: May 17, 2023

To meet the increased need for food and energy because of economic shift brought about by Industrial Revolution in 19th century, there has been an increase persistent organic pollutants (POPs), atmospheric emissions metals environment. Several studies have reported a relationship between these obesity, diabetes (type 1, type 2 gestational). All major are considered to be endocrine disruptors their interactions with various transcription factors, receptors tissues that result alterations metabolic function. POPs impact adipogenesis, thereby increasing prevalence obesity exposed individuals. Metals glucose regulation disrupting pancreatic β-cells, causing hyperglycemia impaired insulin signaling. Additionally, positive association observed concentration chemicals (EDCs) 12 weeks prior conception fasting levels. Here, we evaluate what is currently known regarding link environmental disorders. In addition, indicate where further research required improve our understanding specific effects on disorders which would enable implementation changes prevention.

Language: Английский

Citations

37
Exposure to air pollution and gains in body weight and waist circumference among middle-aged and older adults DOI
Yaqi Wang,

Huiyue Tan,

Hao Zheng

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 869, P. 161895 - 161895

Published: Jan. 26, 2023

Language: Английский

Citations

27
Association of volatile organic compound exposure with metabolic syndrome and its components: a nationwide cross-sectional study DOI Creative Commons
Rui Dong,

Dongchun Chang,

Chao Shen

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 2, 2024

Abstract Background Metabolic syndrome (MetS) is a health issue consisting of multiple metabolic abnormalities. The impact exposure to volatile organic compounds (VOCs) on MetS and its components remains uncertain. This study aimed assess the associations individual urinary metabolites VOC (mVOCs) mVOC mixtures with among general adult population in United States. Methods A total 5345 participants eligible data were filtered from 2011–2020 cycles National Health Nutrition Examination Survey. Multivariate logistic regression models applied mVOCs components. least absolute shrinkage selection operator (LASSO) constructed identify more relevant mVOCs. weight quantile sum model was further explore links between co-exposure Results results indicated positive MetS, including CEMA, DHBMA, HMPMA. CEMA found be positively correlated all MetS. HMPMA associated elevated triglyceride (TG), reduced high-density lipoprotein, fasting blood glucose (FBG) impairment; 3HPMA an risk high TG FBG DHBMA had pressure. LASSO-selected increased TG, pressure, impairment. Conclusion Positive certain observed by utilizing statistical large-scale national data. These findings may serve as theoretical basis for future experimental mechanistic studies have important implications public health.

Language: Английский

Citations

11
Association between solid cooking fuels exposure and metabolic syndrome: Evidence from China DOI Creative Commons

Jiaming Xue,

Shuai Chen,

Yicheng Jiang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117648 - 117648

Published: Jan. 1, 2025

Epidemiological evidence connecting cooking fuel use to metabolic syndrome (MetS) is lacking. Solid usage and MetS prevalence were prospectively investigated in this study. We included participants 2011 2015 from the China Health Retirement Longitudinal Study (CHARLS) data. Through cross-sectional longitudinal studies, we found that of solid fuels reduced risk compared with clean (cross-sectional study: 2011: Odds ratio (OR): 0.819, 95 %confidence interval (CI): 0.747-0.897, P < 0.001; 2015: OR: 0.766, %CI: 0.708-0.851, 0.736, 0.652-0.831, 0.001).This impact ceases exist whenever a switch type occurs (Non persistent clean: 0.937, 0.837-1.050, = 0.262; Persistent solid: 0.767, 0.691-0.853, 0.001). Moreover, biomass (crop residue wood burning) combustion (OR: 0.653, 0.573-0.743, 0.001), while coal had no effect on 1.092, 0.907-1.315, 0.352). Based mediation analysis, triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) mediated 61.3 % 39.8 reduction observed fuel. In summary, our research showed household associated less risk. Among them, may play an important role.

Language: Английский

Citations

1
The Biological and Molecular Action of Ozone and Its Derivatives: State-of-the-Art, Enhanced Scenarios, and Quality Insights DOI Open Access
Valter Travagli, Eugenio Luigi Iorio

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8465 - 8465

Published: May 9, 2023

The ultimate objective of this review is to encourage a multi-disciplinary and integrated methodological approach that, starting from the recognition some current uncertainties, helps deepen molecular bases ozone treatment effects on human animal well-being optimize their performance in terms reproducibility results, quality, safety. In fact, common therapeutic treatments are normally documented by healthcare professionals’ prescriptions. same applies medicinal gases (whose uses based pharmacological effects) that intended for patients treatment, diagnostic, or preventive purposes have been produced inspected accordance with good manufacturing practices pharmacopoeia monographs. On contrary, it responsibility professionals, who thoughtfully choose use as product, achieve following objectives: (i) understand basis mechanism action; (ii) adjust according clinical responses obtained principles precision medicine personalized therapy; (iii) ensure all quality standards.

Language: Английский

Citations

19