Journal of Controlled Release,
Journal Year:
2023,
Volume and Issue:
356, P. 463 - 480
Published: March 15, 2023
Complexity
and
difficulties
in
wound
management
are
pressing
concerns
that
affect
patients'
quality
of
life
may
result
tissue
infection,
necrosis,
loss
local
systemic
functions.
Hence,
novel
approaches
to
accelerate
healing
being
actively
explored
over
the
last
decade.
Exosomes
as
important
mediators
intercellular
communications
promising
natural
nanocarriers
due
their
biocompatibility,
low
immunogenicity,
drug
loading
targeting
capacities,
innate
stability.
More
importantly,
exosomes
developed
a
versatile
pharmaceutical
engineering
platform
for
repair.
This
review
provides
an
overview
biological
physiological
functions
derived
from
variety
origins
during
phases,
strategies
exosomal
engineering,
therapeutic
applications
skin
regeneration.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(9), P. 8530 - 8550
Published: April 28, 2023
Exosomes
(EXs)
shed
by
mesenchymal
stem
cells
(MSCs)
are
potent
therapeutic
agents
that
promote
wound
healing
and
regeneration,
but
when
used
alone
in
vivo,
their
potency
is
diminished
rapid
clearance
bioactivity
loss.
Inspired
the
biotin-avidin
interaction,
we
developed
a
simple
yet
versatile
method
for
immobilization
of
MSC-derived
EXs
(MSC-EXs)
into
hydrogels
achieved
sustained
release
regenerative
purposes.
First,
biotin-modified
gelatin
methacryloyl
(Bio-GelMA)
was
fabricated
grafting
NHS-PEG12-biotin
onto
amino
groups
GelMA.
Biotin-modified
MSC-EXs
(Bio-EXs)
were
then
synthesized
using
an
situ
self-assembling
biotinylation
strategy,
which
provided
sufficient
binding
sites
MSC-EX
delivery
with
little
effect
on
cargo
composition.
Thereafter,
Bio-EXs
immobilized
Bio-GelMA
via
streptavidin
to
generate
Bio-GelMA@Bio-EX
hydrogels.
An
vitro
analysis
demonstrated
could
be
taken
up
macrophages
exerted
immunomodulatory
effects
similar
those
MSC-EXs,
7
days.
After
subcutaneous
transplantation,
more
constant
retention
observed
28
When
placed
artificial
periodontal
multitissue
defect,
functionalized
exhibited
optimized
performance
regrow
complex
tissues,
including
acellular
cementum,
ligaments
(PDLs),
alveolar
bone.
In
this
context,
robust
promoted
macrophage
polarization
toward
M2
phenotype.
Our
findings
demonstrate
delivered
aid
system
exhibit
macrophage-modulating
repair-promoting
functions
suggest
universal
approach
development
MSC-EX-functionalized
biomaterials
advanced
therapies.
International Journal of Biological Sciences,
Journal Year:
2023,
Volume and Issue:
19(5), P. 1430 - 1454
Published: Jan. 1, 2023
Exosomes,
as
therapeutically
relevant
cell-secreted
extracellular
vesicles,
have
attracted
enormous
interest
because
they
participate
in
intercellular
communication
and
facilitate
wound
healing.Stem
cell-derived
exosomes
exhibit
similar
biological
effects
to
source
cells
with
the
exception
of
low
immunogenicity
no
tumorigenicity,
well
superior
efficacy
promoting
healing.Exosomes
accelerate
healing
by
angiogenesis
cell
proliferation,
balancing
inflammatory
responses.Particularly,
when
are
genetically
modified
or
used
combination
materials,
can
better
comprehensive
therapeutic
properties,
such
enriching
active
ingredients,
targeted
delivery,
physiological
barrier
penetration,
which
not
available
traditional
single
products.Besides,
also
been
considered
for
diagnostic
uses
related
wounds,
repairing
complex
enhancing
graft
success,
treating
complications,
serving
biomarkers.However,
their
clinical
applications
still
face
challenges,
reliable
commercial
products
yet
available.This
review
will
focus
on
recent
research
advances
that
describe
characteristics
isolation
exosomes,
introduce
sources
suitable
repair
illustrate
value
engineered
development
directions
future,
provide
evidence
potential
application
healing,
discuss
risks,
solutions
future
applications.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(31), P. 21345 - 21364
Published: Jan. 1, 2023
Nanoparticle-modified
hydrogels
exhibit
substantial
promise
in
the
realm
of
wound
healing,
with
their
ability
to
expedite
tissue
regeneration,
mitigate
infection
risks,
and
facilitate
enhanced
therapeutic
outcomes.
Journal of Controlled Release,
Journal Year:
2023,
Volume and Issue:
356, P. 463 - 480
Published: March 15, 2023
Complexity
and
difficulties
in
wound
management
are
pressing
concerns
that
affect
patients'
quality
of
life
may
result
tissue
infection,
necrosis,
loss
local
systemic
functions.
Hence,
novel
approaches
to
accelerate
healing
being
actively
explored
over
the
last
decade.
Exosomes
as
important
mediators
intercellular
communications
promising
natural
nanocarriers
due
their
biocompatibility,
low
immunogenicity,
drug
loading
targeting
capacities,
innate
stability.
More
importantly,
exosomes
developed
a
versatile
pharmaceutical
engineering
platform
for
repair.
This
review
provides
an
overview
biological
physiological
functions
derived
from
variety
origins
during
phases,
strategies
exosomal
engineering,
therapeutic
applications
skin
regeneration.
