World Journal of Stem Cells,
Journal Year:
2024,
Volume and Issue:
16(12), P. 990 - 1001
Published: Dec. 12, 2024
In
this
editorial,
we
have
taken
an
in-depth
look
at
the
article
published
by
Wan
et
al
.
The
study
showed
that
preconditioning
mesenchymal
stem
cells
(MSCs)
protected
them
against
programmed
cell
death,
and
increased
their
survival
rate
therapeutic
potential.
Autophagy,
a
type
of
is
major
intracellular
degradation
recycling
pathway
crucial
for
maintaining
cellular
homeostasis,
self-renewal,
pluripotency.
We
explored
relationship
between
autophagy
MSCs
to
determine
role
in
applications
MSCs.
Respiratory Research,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: March 15, 2025
Pulmonary
hypertension
(PH)
is
a
progressive
and
life-threatening
cardiopulmonary
disease
that
not
uncommon.
The
modulation
of
the
pulmonary
artery
(PA)
involves
various
fatty
acids,
including
omega-6
polyunsaturated
acids
(ω-6
PUFAs)
ω-6
PUFAs-derived
oxylipins.
These
lipid
mediators
are
produced
through
cyclooxygenase
(COX),
lipoxygenase
(LOX),
cytochrome
P450
(CYP450),
non-enzymatic
pathways.
They
play
crucial
role
in
occurrence
development
PH
by
regulating
function
phenotype
endothelial
cells
(PAECs),
smooth
muscle
(PASMCs),
fibroblasts,
alveolar
macrophages,
inflammatory
cells.
alterations
PUFAs
oxylipins
pivotal
causing
vasoconstriction,
remodeling,
ultimately
leading
to
right
heart
failure
PH.
Despite
limited
understanding
pathophysiology,
there
potential
for
novel
interventions
dietary
pharmacological
approaches
targeting
aim
this
review
summarize
significant
advances
clinical
basic
research
on
vascular
disease,
particularly
PH,
propose
targeted
therapeutic
modality
against
PUFAs.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 11, 2023
Pulmonary
arterial
hypertension
(PAH)
is
a
severe
progressive
disease
that
may
cause
early
right
ventricular
failure
and
eventual
cardiac
failure.
The
pathogenesis
of
PAH
involves
endothelial
dysfunction,
aberrant
proliferation
pulmonary
artery
smooth
muscle
cells
(PASMCs),
vascular
fibrosis.
Hypoxia
has
been
shown
to
induce
elevated
secretion
growth
factor
(VEGF),
leading
the
development
hypoxic
PAH.
However,
molecular
mechanisms
underlying
remain
incompletely
understood.
Programmed
cell
death
(PCD)
natural
regulated
by
certain
genes.
Emerging
evidence
suggests
apoptotic
resistance
contributes
Moreover,
several
novel
types
PCD,
such
as
autophagy,
pyroptosis,
ferroptosis,
have
reported
be
involved
in
Additionally,
multiple
diverse
epigenetic
including
RNA
methylation,
DNA
histone
modification,
non-coding
molecule-mediated
processes
strongly
linked
These
modifications
affect
expression
genes,
which
produce
important
changes
cellular
biological
processes,
PCD.
Consequently,
better
understanding
PCD
modification
will
provide
novel,
specific
therapeutic
strategies
for
diagnosis
treatment.
In
this
review,
we
aim
discuss
recent
advances
elucidate
role
regulating
hypoxia-induced
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(4)
Published: April 6, 2024
Abstract
Mesenchymal
stem
cells
(MSCs)
are
widely
distributed
pluripotent
with
powerful
immunomodulatory
capacity.
MSCs
transplantation
therapy
(MSCT)
is
used
in
the
fields
of
tissue
regeneration
and
repair,
treatment
inflammatory
diseases.
Apoptosis
an
important
way
for
tissues
to
maintain
cell
renewal,
but
it
also
plays
role
various
And
many
studies
have
shown
that
improves
diseases
by
regulating
apoptosis.
The
regulation
on
apoptosis
double-sided.
On
one
hand,
significantly
inhibit
diseased
cells.
other
promote
tumor
excessive
immune
Furthermore,
regulate
through
multiple
molecules
pathways,
including
three
classical
apoptotic
signaling
pathways
pathways.
In
this
review,
we
summarize
current
evidence
MSCs.
International Journal of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
54(3)
Published: July 4, 2024
PANoptosis,
a
complex
form
of
proinflammatory
programmed
cell
death,
including
apoptosis,
pyroptosis
and
necroptosis,
has
been
an
emerging
concept
in
recent
years
that
widely
reported
cancer,
infectious
diseases
neurological
disorders.
Cardiovascular
(CVDs)
are
important
global
health
problem,
posing
serious
threat
to
individuals'
lives.
An
increasing
body
research
shows
inflammation
pivotal
role
CVDs,
which
provides
theoretical
basis
for
PANoptosis
promote
the
progression
CVDs.
To
date,
only
sporadic
studies
on
CVDs
have
its
field
not
fully
explored.
Elucidating
various
modes
cardiomyocyte
specific
molecular
mechanisms
links
among
death
under
stressful
stimuli
is
notable
clinical
significance
deeper
understanding
pathophysiology
The
present
review
summarizes
pyroptosis,
necroptosis
their
prospects
Oxidative Medicine and Cellular Longevity,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 18
Published: Feb. 8, 2023
Neurogenic
erectile
dysfunction
(NED)
is
a
common
and
serious
complication
after
pelvic
surgery.
The
clinical
translation
of
adipose-derived
mesenchymal
stem
cell
(ADSC)
therapies
in
NED
remains
major
challenge
due
to
their
low
survival
rate
limited
therapeutic
effect.
Peroxiredoxin
2
(PRDX2)
member
the
peroxidase
family
that
exerts
its
effects
by
inhibiting
oxidative
stress
(OS)
ferroptosis,
PRDX2
expected
enhance
effect
ADSCs
treating
NED.
purpose
this
study
was
investigate
whether
could
improve
determine
overexpression
(PRDX2-ADSCs)
This
investigated
potential
role
PRDX2-ADSCs
through
model
induced
bilateral
cavernous
nerve
injury
(BCNI)
three
vitro
models
established
H2O2-stimulated
ADSCs,
corpus
cavernosum
smooth
muscle
cells
(CCSMCs),
RSL3-stimulated
CCSMCs.
We
found
significantly
viability
suppressing
apoptosis
OS
ADSCs.
also
BCNI
triggered
ferroptosis
cavernosum,
which
manifested
increased
reactive
oxygen
species
(ROS),
total
iron
content,
MDA
as
well
decreased
SOD
GSH.
Our
results
further
demonstrated
changes
expression
key
proteins
(GPX4
ACSL4)
pathway,
whereas
ameliorated
BCNI-induced
rats.
Consistently,
attenuated
CCSMCs
inhibited
CCSMCs,
evidenced
decrease
ROS,
increase
GSH
together
with
ferroptosis-related
protein
expression.
In
conclusion,
enhanced
rat
neurogenic
via
regulation
GPX4/ACSL4
axis.
Stem Cells and Development,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Hypertension,
commonly
known
as
high
blood
pressure,
is
a
significant
health
issue
that
increases
the
risk
of
cardiovascular
diseases,
stroke,
and
renal
failure.
This
condition
broadly
encompasses
both
primary
secondary
forms.
Despite
extensive
research,
underlying
mechanisms
systemic
arterial
hypertension-particularly
hypertension,
which
has
no
identifiable
cause
affected
by
genetic
lifestyle
agents-remain
complex
not
fully
understood.
Recent
studies
indicate
an
imbalance
in
gut
microbiota,
referred
to
dysbiosis,
may
promote
affecting
pressure
regulation
through
metabolites
such
short-chain
fatty
acids
trimethylamine
N-oxide.
Current
antihypertensive
medications
face
limitations,
including
resistance
adherence
issues,
highlighting
need
for
novel
therapeutic
approaches.
Stem
cell
therapy,
emerging
field
regenerative
medicine,
shows
promise
addressing
these
challenges.
cells,
with
mesenchymal
stem
cells
being
prime
example,
have
regenerative,
anti-inflammatory,
immunomodulatory
properties.
Emerging
research
indicates
can
modulate
reduce
inflammation,
improve
vascular
health,
potentially
aiding
management.
Research
shown
positive
impact
on
microbiota
various
disorders,
suggesting
their
potential
role
treating
hypertension.
review
synthesizes
recent
interactions
between
By
offering
thorough
analysis
current
literature,
it
highlights
key
insights,
uncovers
critical
gaps,
identifies
trends
will
inform
guide
future
investigations
this
rapidly
advancing
field.
