Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin

Antioxidants, Journal Year: 2019, Volume and Issue: 8(2), P. 35 - 35

Published: Feb. 5, 2019

Inflammation has been reported to be intimately linked the development or worsening of several non-infectious diseases. A number chronic conditions such as cancer, diabetes, cardiovascular disorders, autoimmune diseases, and neurodegenerative disorders emerge a result tissue injury genomic changes induced by constant low-grade inflammation in around affected organ. The existing therapies for most these sometimes leave more debilitating effects than disease itself, warranting advent safer, less toxic, cost-effective therapeutic alternatives patients. For centuries, flavonoids their preparations have used treat various human illnesses, continual use persevered throughout ages. This review focuses on anti-inflammatory actions against illnesses neuroinflammation with special focus apigenin, relatively toxic non-mutagenic flavonoid remarkable pharmacodynamics. Additionally, central nervous system (CNS) due diseases multiple sclerosis (MS) gives ready access circulating lymphocytes, monocytes/macrophages, dendritic cells (DCs), causing edema, further inflammation, demyelination. As dearth safe is dire case CNS-related we reviewed neuroprotective apigenin other flavonoids. Existing epidemiological pre-clinical studies present considerable evidence favor developing natural alternative therapy inflammatory conditions.

Language: Английский

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Anticancer activities of TCM and their active components against tumor metastasis

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 133, P. 111044 - 111044

Published: Dec. 13, 2020

Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, slight side effects and good therapeutic effects. Good anti-tumor are shown by prescription, patent medicine, single medicine monomer compound. Clinically, TCM prolonged survival time patients improved life quality patients, due to less Cancer metastasis is a complex process involving numerous steps, genes their products. During tumor metastasis, firstly, cancer cell increases its proliferative capacity reducing autophagy apoptosis, then stimulated increasing ability tumors absorb nutrients from outside through angiogenesis. Both two steps can increase migration invasion. Finally, purpose achieved. By inhibiting apoptosis cells, angiogenesis EMT inhibit invasion cancer, consequently achieve metastasis. This review explores research achievements on breast lung hepatic carcinoma, colorectal gastric other in past five years, summarizes development direction years makes prospect for future.

Language: Английский

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Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

Molecules, Journal Year: 2020, Volume and Issue: 25(3), P. 762 - 762

Published: Feb. 10, 2020

Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a consequence of the pathological functioning nervous system rather than only symptom. In fact, significant social, health, and economic burden worldwide. Flavonoids are plant derivative compounds easily found in several fruits vegetables consumed daily food intake. vary terms classes, while structurally unique, they share basic structure formed by three rings, known as flavan nucleus. Structural differences pattern substitution one these rings. The hydroxyl group (–OH) position rings determines mechanisms action flavonoids reveals complex multifunctional activity. have been widely used for their antioxidant, analgesic, anti-inflammatory effects along with safe preclinical clinical profiles. this review, we discuss evidence on analgesic proprieties flavonoids. We also focus how development formulations containing flavonoids, understanding structure-activity relationship, harnessed to identify novel flavonoid-based therapies treat inflammation.

Language: Английский

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Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 113054 - 113054

Published: April 30, 2022

Cancer is one of the leading causes death and significantly burdens healthcare system. Due to its prevalence, there undoubtedly an unmet need discover novel anticancer drugs. The use natural products as agents acceptable therapeutic approach due accessibility, applicability, reduced cytotoxicity. Natural have been incomparable source drugs in modern era drug discovery. Along with their derivatives analogs, play a major role cancer treatment by modulating microenvironment different signaling pathways. These compounds are effective against several pathways, mainly cell pathways (apoptosis autophagy) embryonic developmental (Notch pathway, Wnt Hedgehog pathway). historical record strong, but investigate current discovery development determine possibility being important future agents. Many target-specific failed provide successful results, which accounts for multi-target characteristics achieve better outcomes. potential be promising makes them area research. This review explores significance inhibiting various that serve drivers carcinogenesis thus pave way developing discovering

Language: Английский

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Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer

Cancer Letters, Journal Year: 2021, Volume and Issue: 515, P. 36 - 48

Published: May 28, 2021

Language: Английский

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Potential Applications of NRF2 Inhibitors in Cancer Therapy

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 34

Published: April 11, 2019

The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms against exogenous or endogenous stressors. Indeed, by increasing expression several cytoprotective genes, transcription factor NRF2 can shelter cells and tissues from multiple sources damage including xenobiotic, electrophilic, metabolic, oxidative stress. Importantly, aberrant activation accumulation NRF2, a common event in many tumors, confers selective advantage to cancer is associated malignant progression, therapy resistance, poor prognosis. Hence, last years, has emerged as promising target treatment efforts have been made identify therapeutic strategies aimed at disrupting its prooncogenic role. By summarizing results past recent studies, this review, we provide an overview concerning pathway, biological impact solid hematologic malignancies, molecular causing hyperactivation cells. Finally, also describe some approaches that successfully employed counteract activity with particular emphasis on development natural compounds adoption drug repurposing strategies.

Language: Английский

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Anticancer Activity of Natural and Synthetic Chalcones

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11306 - 11306

Published: Oct. 20, 2021

Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells. Resistance treatment theleading cause inefficiency current standard therapies. Targeted therapies are most effective due low number side effects resistance. Among small molecule natural compounds, flavonoids particular interest for theidentification new anticancer agents. Chalcones precursors all have biological activities. The activity chalcones ability these compounds act on targets. Natural chalcones, such as licochalcones, xanthohumol (XN), panduretin (PA), loncocarpine, been extensively studied modulated. Modification basic structure in order obtain with superior cytotoxic properties has performed modulating aromatic residues, replacing residues heterocycles, obtaining hybrid molecules. A huge chalcone derivatives diaryl ether, sulfonamide, amine obtained, their presence being favorable activity. amino group aminochalconesis always antitumor This why molecules different nitrogen hetercycles obtained. From these, azoles (imidazole, oxazoles, tetrazoles, thiazoles, 1,2,3-triazoles, 1,2,4-triazoles) importance identification

Language: Английский

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Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 43(4), P. 1141 - 1200

Published: March 17, 2023

Abstract Epithelial‐mesenchymal transition (EMT) is a complex process with primordial role in cellular transformation whereby an epithelial cell transforms and acquires mesenchymal phenotype. This plays pivotal tumor progression self‐renewal, exacerbates resistance to apoptosis chemotherapy. EMT can be initiated promoted by deregulated oncogenic signaling pathways, hypoxia, cells the microenvironment, resulting loss‐of‐epithelial polarity, cell–cell adhesion, enhanced invasive/migratory properties. Numerous transcriptional regulators, such as Snail, Slug, Twist, ZEB1/ZEB2 induce through downregulation of markers gain‐of‐expression markers. Additionally, cascades Wnt/β‐catenin, Notch, Sonic hedgehog, nuclear factor kappa B, receptor tyrosine kinases, PI3K/AKT/mTOR, Hippo, transforming growth factor‐β pathways regulate whereas they are often cancers leading aberrant EMT. Furthermore, noncoding RNAs, tumor‐derived exosomes, epigenetic alterations also involved modulation Therefore, regulation vital strategy control aggressive metastatic characteristics cells. Despite vast amount preclinical data on cancer progression, there lack clinical translation at therapeutic level. In this review, we have discussed thoroughly aforementioned transcription factors, RNAs (microRNAs, long RNA, circular RNA), modifications, exosomes cancers. We emphasized contribution drug possible interventions using plant‐derived natural products, their semi‐synthetic derivatives, nano‐formulations that described promising blockers.

Language: Английский

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Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

Phytomedicine, Journal Year: 2021, Volume and Issue: 90, P. 153554 - 153554

Published: Aug. 6, 2021

Language: Английский

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A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

Heliyon, Journal Year: 2021, Volume and Issue: 7(11), P. e08404 - e08404

Published: Nov. 1, 2021

In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal bacterial infections. The present study reviewed phytochemicals, essential oils, pharmacological activities O. gratissimum. bioactive compounds extracted from include phytochemicals (oleanolic acid, caffeic ellagic epicatechin, sinapic rosmarinic chlorogenic luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic catechin, quercetin, rutin, kaempfero) oils (camphene, β-caryophyllene, α- β-pinene, α-humulene, sabinene, β-myrcene, limonene, 1,8-cineole, trans-β-ocimene, linalool, δ-terpineol, eugenol, α-copaene, β-elemene, p-cymene, thymol, carvacrol). Various vivo vitro studies have shown that its constituents possess properties antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrhoeal, antimicrobial properties. This review demonstrated has a strong preventive therapeutic effect against several diseases. effectiveness to ameliorate may be attributed antioxidant well capacity improve systems. However, despite widespread gratissimum, further experiments human clinical trial are needed establish effective safe doses for

Language: Английский

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