Redox Biology,
Journal Year:
2022,
Volume and Issue:
57, P. 102489 - 102489
Published: Sept. 29, 2022
Cannabidiol
(CBD),
the
major
non-psychoactive
phytocannabinoid
of
Cannabis
sativa
L.,
is
one
most
studied
compounds
in
pharmacotherapeutic
approaches
to
treat
oxidative
stress-related
diseases
such
as
cardiovascular,
metabolic,
neurodegenerative,
and
neoplastic
diseases.
The
literature
data
date
indicate
possibility
both
antioxidant
pro-oxidative
effects
CBD.
Thus,
mechanism
action
this
natural
compound
regulation
nuclear
factor
2
associated
with
erythroid
(Nrf2),
which
plays
role
main
cytoprotective
regulator
redox
balance
inflammation
under
stress
conditions,
seems
be
particularly
important.
Moreover,
Nrf2
strongly
correlated
cellular
profile
malignancy,
turn
critical
determining
response
induced
by
CBD
pathophysiological
conditions.
This
paper
summarizes
CBD-mediated
pathways
system
altering
expression
modification
proteins
directly
involved
transcriptional
activity
relationship
between
kappa
B
(NF-κB)
another
redox-sensitive
transcription
factor.
Antioxidants,
Journal Year:
2019,
Volume and Issue:
8(7), P. 235 - 235
Published: July 22, 2019
Poultry
in
commercial
settings
are
exposed
to
a
range
of
stressors.
A
growing
body
information
clearly
indicates
that
excess
ROS/RNS
production
and
oxidative
stress
major
detrimental
consequences
the
most
common
stressors
poultry
production.
During
evolution,
antioxidant
defence
systems
were
developed
survive
an
oxygenated
atmosphere.
They
include
complex
network
internally
synthesised
(e.g.,
enzymes,
(glutathione)
GSH,
(coenzyme
Q)
CoQ)
externally
supplied
(vitamin
E,
carotenoids,
etc.)
antioxidants.
In
fact,
all
antioxidants
work
cooperatively
as
team
maintain
optimal
redox
balance
cell/body.
This
is
key
element
providing
necessary
conditions
for
cell
signalling,
vital
process
regulation
expression
various
genes,
adaptation
homeostasis
maintenance
body.
Since
considered
be
important
signalling
molecules,
their
concentration
strictly
regulated
by
conjunction
with
transcription
factors
vitagenes.
activation
vitagenes
via
such
Nrf2
leads
additional
synthesis
array
protective
molecules
which
can
deal
increased
Therefore,
it
challenging
task
develop
system
supplementation
help
growing/productive
birds
effective
defences
On
one
hand,
antioxidants,
vitamin
or
minerals
Se,
Mn,
Cu
Zn)
compulsory
part
pre-mixes
poultry,
and,
cases,
adequate
meet
physiological
requirements
these
elements.
other
due
aforementioned
commercially
relevant
stressors,
there
need
support
poultry.
new
direction
improving
related
opportunity
activate
(via
Nrf2-related
mechanisms:
superoxide
dismutase,
SOD;
heme
oxygenase-1,
HO-1;
GSH
thioredoxin,
Heat
shock
protein
(HSP)/heat
factor
(HSP),
sirtuins,
maximise
internal
AO
protection
maintenance.
development
vitagene-regulating
nutritional
supplements
on
agenda
many
companies
worldwide.
Cell chemical biology,
Journal Year:
2020,
Volume and Issue:
27(4), P. 436 - 447
Published: April 1, 2020
Ferroptosis
is
a
non-apoptotic
mode
of
regulated
cell
death
that
iron
and
lipid
peroxidation
dependent.
As
new
mechanistic
insight
into
ferroptotic
effectors
how
they
are
in
different
disease
contexts
uncovered,
our
understanding
the
physiological
pathological
relevance
this
continues
to
grow.
Along
these
lines,
host
pharmacological
modulators
pathway
have
been
identified,
targeting
proteins
involved
homeostasis;
generation
reduction
peroxides;
or
cystine
import
glutathione
metabolism.
Also,
note,
many
components
ferroptosis
cascade
target
genes
transcription
factor
nuclear
erythroid
2-related
2
(NRF2),
indicating
its
critical
role
mediating
response.
In
review,
we
discuss
vitro,
vivo,
clinical
evidence
disease,
including
brief
discussion
upstream
mediators
cascade,
NRF2,
treat
ferroptosis-driven
diseases.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(7), P. 3765 - 3765
Published: April 5, 2021
Anti-angiogenic
therapy
is
an
old
method
to
fight
cancer
that
aims
abolish
the
nutrient
and
oxygen
supply
tumor
cells
through
decrease
of
vascular
network
avoidance
new
blood
vessels
formation.
Most
anti-angiogenic
agents
approved
for
treatment
rely
on
targeting
endothelial
growth
factor
(VEGF)
actions,
as
VEGF
signaling
considered
main
angiogenesis
promotor.
In
addition
control
angiogenesis,
these
drugs
can
potentiate
immune
also
exhibits
immunosuppressive
functions.
Despite
mechanistic
rational
strongly
supports
benefit
stop
progression,
they
revealed
be
insufficient
in
most
cases.
We
hypothesize
rehabilitation
interfere
with
mechanisms
related
microenvironment
might
represent
a
promising
strategy.
this
review,
we
deepened
research
molecular
underlying
strategies
their
failure
went
further
into
alternative
impact
angiogenesis.
concluded
combinatory
effectors
angiogenic
pathways
putative
solution
therapies.
Abstract
Chemotherapeutic
drugs
are
used
to
treat
advanced
stages
of
cancer
or
following
surgery.
However,
cancers
often
develop
resistance
against
drugs,
leading
failure
treatment
and
recurrence
the
disease.
Polyphenols
a
family
organic
compounds
with
more
than
10,000
members
which
have
three-membered
flavan
ring
system
in
common.
These
natural
known
for
their
beneficial
properties,
such
as
free
radical
scavenging,
decreasing
oxidative
stress,
modulating
inflammation.
Herein,
we
discuss
role
polyphenols
(mainly
curcumin,
resveratrol,
epigallocatechin
gallate
[EGCG])
different
aspects
drug
resistance.
Increasing
uptake
by
tumor
cells,
metabolism
enzymes
(e.g.
cytochromes
glutathione-S-transferases),
reducing
efflux
some
mechanisms
increase
sensitivity
cells
chemotherapeutic
agents.
also
affect
other
targets
overcoming
chemoresistance
including
cell
death
(i.e.
autophagy
apoptosis),
EMT,
ROS,
DNA
repair
processes,
stem
epigenetics
miRNAs).
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(7), P. 2452 - 2452
Published: July 18, 2021
Here
we
present
an
extensive
narrative
review
of
the
broadly
understood
modifications
to
lifestyles
women
with
polycystic
ovary
syndrome
(PCOS).
The
PubMed
database
was
analyzed,
combining
PCOS
entries
causes,
diseases,
diet
supplementation,
lifestyle,
physical
activity,
and
use
herbs.
metabolic
pathways
leading
disturbances
in
lipid,
carbohydrate,
hormonal
metabolism
targeted
patients
are
described.
article
refers
sleep
disorders,
changes
mental
health
parameters,
causes
oxidative
stress
inflammation.
These
conditions
consistently
lead
occurrence
severe
diseases
suffering
from
diabetes,
fatty
degeneration
internal
organs,
infertility,
atherosclerosis,
cardiovascular
dysbiosis,
cancer.
modification
lifestyles,
patterns
proper
selection
nutrients,
pharmacological
natural
supplementation
form
herbs,
activity
have
been
proposed.
progress
consequences
largely
modifiable
depend
on
patient’s
approach,
although
take
into
account
also
genetic
determinants.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(5), P. 1417 - 1417
Published: March 5, 2021
Cancer
is
one
of
the
most
fatal
diseases
with
an
increasing
incidence
and
mortality
all
over
world.
Thus,
there
urgent
need
for
novel
therapies
targeting
major
cancer-related
pathways.
Nuclear
factor-erythroid
2-related
factor
2
(NRF2)
its
negative
modulator
Kelch-like
ECH-associated
protein
1
(KEAP1)
are
main
players
cellular
defense
mechanisms
against
internal
external
cell
stressors.
However,
NRF2/KEAP1
signaling
pathway
dysregulated
in
various
cancers,
thus
promoting
tumor
survival
metastasis.
In
present
review,
we
discuss
normal
deregulated
NRF2
focusing
on
functions.
We
further
explore
activators
inhibitors
this
as
cancer
drug
candidates
order
to
provide
extensive
background
subject.
