Metabolites,
Journal Year:
2024,
Volume and Issue:
14(6), P. 309 - 309
Published: May 28, 2024
Lipids,
as
multifunctional
molecules,
play
a
crucial
role
in
variety
of
cellular
processes.
These
include
regulating
membrane
glycoprotein
functions,
controlling
trafficking,
influencing
apoptotic
pathways,
and
affecting
drug
transport.
In
addition,
lipid
metabolites
can
alter
the
surrounding
microenvironment
ways
that
might
encourage
tumor
progression.
The
reprogramming
metabolism
is
pivotal
promoting
tumorigenesis
cancer
progression,
with
tumors
often
displaying
significant
changes
profiles.
This
review
concentrates
on
essential
factors
drive
metabolic
reprogramming,
which
contributes
to
advancement
resistance
melanoma.
Moreover,
we
discuss
recent
advances
current
therapeutic
strategies
employ
small-molecule
inhibitors
target
skin
cancers,
particularly
those
associated
inflammation
Military Medical Research,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Feb. 11, 2025
Abstract
Cancer
recurrence,
driven
by
the
phenomenon
of
tumor
dormancy,
presents
a
formidable
challenge
in
oncology.
Dormant
cancer
cells
have
ability
to
evade
detection
and
treatment,
leading
relapse.
This
review
emphasizes
urgent
need
comprehend
dormancy
its
implications
for
recurrence.
Despite
notable
advancements,
significant
gaps
remain
our
understanding
mechanisms
underlying
lack
reliable
biomarkers
predicting
provides
comprehensive
analysis
cellular,
angiogenic,
immunological
aspects
dormancy.
It
highlights
current
therapeutic
strategies
targeting
dormant
cells,
particularly
combination
therapies
immunotherapies,
which
hold
promise
preventing
By
elucidating
these
proposing
innovative
research
methodologies,
this
aims
deepen
ultimately
facilitating
development
more
effective
recurrence
improving
patient
outcomes.
Transcription,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 44
Published: March 3, 2025
The
transcription
factor
p53
is
the
most
frequently
impaired
tumor
suppressor
in
human
cancers.
In
response
to
various
stress
stimuli,
activates
of
genes
that
mediate
its
tumor-suppressive
functions.
Distinctive
characteristics
outlined
here
enable
a
well-defined
program
involved
cell
cycle
arrest,
apoptosis,
senescence,
differentiation,
metabolism,
autophagy,
DNA
repair,
anti-viral
response,
and
anti-metastatic
functions,
as
well
facilitating
autoregulation
within
network.
This
versatile,
anti-cancer
network
governed
chiefly
by
single
protein
represents
an
immense
opportunity
for
targeted
cancer
treatment,
since
about
half
tumors
retain
unmutated
p53.
During
last
two
decades,
numerous
compounds
have
been
developed
block
interaction
with
main
negative
regulator
MDM2.
However,
small
molecule
inhibitors
MDM2
only
induce
therapeutically
desirable
apoptotic
limited
number
types.
Moreover,
clinical
trials
monotherapies
not
met
expectations
revealed
hematological
toxicity
characteristic
adverse
effect
across
this
drug
class.
Currently,
combination
treatments
are
leading
strategy
enhancing
efficacy
reducing
effects
inhibitors.
review
summarizes
efforts
identify
test
therapeutics
work
synergistically
Two
types
drugs
emerged
among
used
following
treatments:
first,
modulators
p53-regulated
transcriptome
(including
chromatin
modifiers),
translatome,
proteome,
second,
targeting
downstream
pathways
such
metabolic
immune
ferroptosis,
growth
signaling.
Here,
we
current
literature
field,
while
also
highlighting
overarching
principles
could
guide
target
selection
future
treatments.
Cell Proliferation,
Journal Year:
2024,
Volume and Issue:
58(1)
Published: Aug. 28, 2024
Abstract
Interleukin‐12
(IL‐12)
holds
significant
potential
in
cancer
therapy;
however,
its
clinical
applicability
is
hindered
by
dose‐limiting
toxicity.
Delivery
of
the
IL‐12
gene
directly
to
tumours
for
constitutive
expression
a
possible
strategy
enhance
effectiveness
while
minimizing
systemic
In
this
study,
we
investigate
red
blood
cell‐derived
extracellular
vesicles
(RBCEVs)
as
carrier
Il‐12
plasmid
delivery.
We
demonstrate
that
RBCEVs
can
be
loaded
with
minicircle
encoding
and
delivered
MB49
bladder
cells
expression.
The
transgenes
from
minicircles
was
significantly
higher
than
parental
plasmids.
RBCEV‐mediated
stimulated
immune
responses
mouse
splenocytes.
Intratumoral
delivery
plasmid‐loaded
suppressed
tumour
growth,
promoted
cell
infiltration.
conclusion,
our
study
demonstrates
promising
an
effective,
safe
redosable
nucleic
acid
drug
platform
IL‐12.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(1), P. 134 - 134
Published: Jan. 8, 2025
Oral
squamous
cell
carcinoma
(OSCC)
is
one
of
the
most
common
malignancies
head
and
neck
(HNSCC).
HNSCC
recognized
as
eighth
commonly
occurring
cancer
globally
in
men.
It
essential
to
distinguish
between
cancers
arising
regions
due
significant
differences
their
etiologies,
treatment
approaches,
prognoses.
As
Cancer
Genome
Atlas
(TCGA)
dataset
available
HNSCC,
survival
analysis
prognosis
OSCC
patients
based
on
TCGA
for
discovering
gene
expression-based
prognostic
biomarkers
limited.
To
address
this
paucity,
we
aimed
provide
comprehensive
evidence
by
recruiting
studies
that
have
reported
new
biomarkers/signatures
establish
a
model
predict
patients.
Using
PubMed
search,
identified
34
been
using
least
absolute
shrinkage
selection
operator
(LASSO)-based
Cox
regression
analyses
signature
related
different
pathways
from
past
4
years.
Our
review
was
focused
summarizing
these
signatures
implications
targeted
therapy
FDA-approved
drugs.
Furthermore,
conducted
an
LASSO
signatures.
findings
revealed
13
correlated
greater
number
regulatory
T
cells
(Tregs)
protective
with
increased
recurrence-free
overall
rates.
Conversely,
two
displayed
opposing
trend
cases
OSCC.
We
will
also
explore
how
dysregulation
impacts
immune
status,
promoting
tumor
evasion
or,
conversely,
enhancing
surveillance.
Overall,
insight
future
anti-cancer
therapies
potential
associated
poor
