Colonization and development of the gut microbiome in calves DOI Creative Commons
Yufeng Du, Ya Gao, Mingyang Hu

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 9, 2023

Abstract Colonization and development of the gut microbiome are crucial for growth health calves. In this review, we summarized colonization, beneficial nutrition, immune function microbiota, barrier, evolution core microbiota in calves different ages. Homeostasis is nutritional system Disruption leads to digestive diseases calves, such as diarrhea intestinal inflammation. Microbiota already exists calf fetuses, colonization continues change dynamically under influence various factors, which include probiotics, diet, age, genotype. depends on interaction between The abundance diversity these commensal stabilize play a critical role

Language: Английский

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines DOI Creative Commons
Irene Maeve Rea, David S. Gibson, Victoria McGilligan

et al.

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: April 9, 2018

Cytokine dysregulation is believed to play a key role in the remodeling of immune system at older age, with evidence pointing an inability fine-control systemic inflammation, which seems be marker unsuccessful aging. This reshaping cytokine expression pattern, progressive tendency toward pro-inflammatory phenotype has been called 'inflamm-aging'. Despite research there no clear understanding about causes 'inflamm-aging' that underpin most major age-related diseases including atherosclerosis, diabetes, Alzheimer's disease, rheumatoid arthritis, cancer and aging itself. While inflammation part normal repair response for healing, essential keeping us safe from bacterial viral infections noxious environmental agents, not all good. When becomes prolonged persists, it can become damaging destructive. Several common molecular pathways have identified are associated both low-grade inflammation. The change redox balance, increase senescent cells SASP decline effective autophagy trigger inflammasome, suggest may possible delay itself by suppressing mechanisms or improving timely resolution Conversely learning genetic long-lived cohorts who exemplify good quality Here we will discuss some current ideas highlight appear contribute imbalance dysregulation, 'inflammageing' parainflammation. Evidence these findings drawn cardiovascular disease two

Language: Английский

Citations

1053
Gut microbiome and aging: Physiological and mechanistic insights DOI Creative Commons
Ravinder Nagpal,

Rabina Mainali,

Shokouh Ahmadi

et al.

Nutrition and Healthy Aging, Journal Year: 2017, Volume and Issue: 4(4), P. 267 - 285

Published: Nov. 7, 2017

The development of human gut microbiota begins as soon the neonate leaves protective environment uterus (or maybe in-utero) and is exposed to innumerable microorganisms from mother well surrounding environment. Concurrently, host responses these microbes during early life manifest an otherwise hitherto immature immune system. microbiome, which comprises extremely diverse complex community inhabiting intestinal tract, keeps on fluctuating different stages life. While deviations are largely natural, inevitable benign, recent studies show that unsolicited perturbations in configuration could have strong impact several features health disease. Our undergoes most prominent infancy old age and, interestingly, our also its weakest unstable state two critical life, indicating develop hand-in-hand. However, mechanisms underlying interactions only now beginning be revealed. present review summarizes evidences related age-associated changes vice-versa, involved this bi-directional relationship, prospective for microbiota-based interventions such probiotics healthy aging.

Language: Английский

Citations

578
New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis DOI Creative Commons
Ting Yuan, Ting Yang, Huan Chen

et al.

Redox Biology, Journal Year: 2018, Volume and Issue: 20, P. 247 - 260

Published: Oct. 20, 2018

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis. Intracellular hyperglycemia promotes production mitochondrial reactive oxygen species (ROS), increased formation intracellular advanced glycation end-products, activation protein kinase C, polyol pathway flux. ROS directly increase expression inflammatory adhesion factors, oxidized-low density lipoprotein, insulin resistance. They activate ubiquitin pathway, inhibit AMP-protein adiponectin, decrease endothelial nitric oxide synthase activity, all which accelerate Changes composition gut microbiota changes microRNA that influence regulation target genes occur diabetes with to promote This review highlights consequences sustained acceleration atherosclerosis by diabetes. The potential contributions are discussed.

Language: Английский

Citations

568
Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis DOI Creative Commons
Zhe Zhao,

Jingwen Ning,

Xiu‐Qi Bao

et al.

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: Nov. 17, 2021

Parkinson's disease (PD) is a prevalent neurodegenerative disorder, displaying not only well-known motor deficits but also gastrointestinal dysfunctions. Consistently, it has been increasingly evident that gut microbiota affects the communication between and brain in PD pathogenesis, known as microbiota-gut-brain axis. As an approach to re-establishing normal community, fecal transplantation (FMT) exerted beneficial effects on recent studies. Here, this study, we established chronic rotenone-induced mouse model evaluate protective of FMT treatment explore underlying mechanisms, which proves involvement dysbiosis pathogenesis via axis.We demonstrated induced by rotenone administration caused function impairment poor behavioral performances mice. Moreover, 16S RNA sequencing identified increase bacterial genera Akkermansia Desulfovibrio samples By contrast, remarkably restored microbial thus ameliorating dysfunctions Further experiments revealed alleviated intestinal inflammation barrier destruction, reducing levels systemic inflammation. Subsequently, attenuated blood-brain (BBB) suppressed neuroinflammation substantia nigra (SN), further decreased damage dopaminergic neurons. Additional mechanistic investigation discovered reduced lipopolysaccharide (LPS) colon, serum, SN, thereafter suppressing TLR4/MyD88/NF-κB signaling pathway its downstream pro-inflammatory products both SN colon.Our current study demonstrates can correct ameliorate model, suppression mediated LPS-TLR4 possibly plays significant role. Further, prove involved genesis Video abstract.

Language: Английский

Citations

379
Microbiome–microglia connections via the gut–brain axis DOI Creative Commons
Reem Abdel-Haq, Johannes C. M. Schlachetzki, Christopher K. Glass

et al.

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(1), P. 41 - 59

Published: Nov. 1, 2018

Microglia, the resident immune cells in brain, are essential for modulating neurogenesis, influencing synaptic remodeling, and regulating neuroinflammation by surveying brain microenvironment. Microglial dysfunction has been implicated onset progression of several neurodevelopmental neurodegenerative diseases; however, multitude factors signals microglial activity have not fully elucidated. Microglia only respond to local within but also receive input from periphery, including gastrointestinal (GI) tract. Recent preclinical findings suggest that gut microbiome plays a pivotal role maturation function, altered microbial community composition reported neurological disorders with known involvement humans. Collectively, these bidirectional crosstalk between may influence disease pathogenesis. Herein, we discuss recent studies showing development function homeostatic conditions highlight possible future research develop novel treatments brain.

Language: Английский

Citations

373
Oscillospira - a candidate for the next-generation probiotics DOI Creative Commons
Jingpeng Yang, Yanan Li, Zhiqiang Wen

et al.

Gut Microbes, Journal Year: 2021, Volume and Issue: 13(1)

Published: Jan. 1, 2021

Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and widely present the animal human intestines. There strong association between variation abundance obesity, leanness, health. In addition, growing body studies shown also implicated other diseases, such as gallstones chronic constipation, some correlation with positive or negative changes its course. Sequencing combined metabolic profiling indicate likely to be genus capable producing short-chain fatty acids (SCFAs) butyrate, which an important reference indicator for screening "next-generation probiotics ". Considering effects specific obesity-related it already characterized one next-generation probiotic candidates therefore great potential development application future food, health care, biopharmaceutical products.

Language: Английский

Citations

314
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages DOI
Anthony J. Covarrubias, Abhijit Kale, Rosalba Perrone

et al.

Nature Metabolism, Journal Year: 2020, Volume and Issue: 2(11), P. 1265 - 1283

Published: Nov. 16, 2020

Language: Английский

Citations

299
The aging gut microbiome and its impact on host immunity DOI Open Access
Nabil Bosco, Mario Noti

Genes and Immunity, Journal Year: 2021, Volume and Issue: 22(5-6), P. 289 - 303

Published: April 19, 2021

Language: Английский

Citations

292
Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance DOI Creative Commons

Hannah E. Da Silva,

Anastasia Teterina, Elena M. Comelli

et al.

Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)

Published: Jan. 17, 2018

Abstract This study aimed to determine if there is an association between dysbiosis and nonalcoholic fatty liver disease (NAFLD) independent of obesity insulin resistance (IR). a prospective cross-sectional assessing the intestinal microbiome (IM) 39 adults with biopsy-proven NAFLD (15 simple steatosis [SS]; 24 steatohepatitis [NASH]) 28 healthy controls (HC). IM composition (llumina MiSeq Platform) in patients compared HC were identified by two statistical methods (Metastats, Wilcoxon). Selected taxa was validated using quantitative PCR (qPCR). Metabolites feces serum also analyzed. In NAFLD, 8 operational taxonomic units, 6 genera, families 2 phyla (Bacteroidetes, Firmicutes) less abundant and; 1 genus ( Lactobacillus ) family (Lactobacillaceae) more HC. Lower abundance both NASH SS confirmed qPCR for Ruminococcus, Faecalibacterium prausnitzii Coprococcus . No difference found SS. lower (NASH+SS) BMI IR. had higher concentrations fecal propionate isobutyric acid 2-hydroxybutyrate L-lactic acid. These findings suggest potential role specific community functional profile pathogenesis NAFLD.

Language: Английский

Citations

239
Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain DOI Creative Commons
Aimée Parker, Stefano Romano, Rebecca Ansorge

et al.

Microbiome, Journal Year: 2022, Volume and Issue: 10(1)

Published: April 29, 2022

Altered intestinal microbiota composition in later life is associated with inflammaging, declining tissue function, and increased susceptibility to age-associated chronic diseases, including neurodegenerative dementias. Here, we tested the hypothesis that manipulating influences development of major comorbidities aging and, particular, inflammation affecting brain retina.

Language: Английский

Citations

229