Microorganisms, Journal Year: 2021, Volume and Issue: 9(11), P. 2212 - 2212

Published: Oct. 25, 2021

Integrons were first identified because of their central role in assembling and disseminating antibiotic resistance genes commensal pathogenic bacteria. However, these clinically relevant integrons represent only a small proportion integron diversity. are now known to be ancient genetic elements that hotspots for genomic diversity, helping generate adaptive phenotypes. This perspective examines the functions, activities within both natural clinical environments. We show how fundamental properties exquisitely pre-adapted them respond selection pressures imposed by human use antimicrobial compounds. then follow extraordinary increase abundance one class (class 1) has resulted from its acquisition multiple mobile elements, subsequent colonisation diverse bacterial species, wide range animal hosts. Consequently, this become significant pollutant own right, extent it can detected most ecosystems. As continue drive environmental instability, will likely play key roles adaptation settings. Understanding ecological evolutionary dynamics help us predict shape outcomes have direct relevance ecosystem health.

Language: Английский