Antibiotics and Bacterial Resistance—A Short Story of an Endless Arms Race

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5777 - 5777

Published: March 17, 2023

Despite the undisputed development of medicine, antibiotics still serve as first-choice drugs for patients with infectious disorders. The widespread use results from a wide spectrum their actions encompassing mechanisms responsible for: inhibition bacterial cell wall biosynthesis, disruption membrane integrity, suppression nucleic acids and/or proteins synthesis, well disturbances metabolic processes. However, availability antibiotics, accompanied by overprescription, acts double-edged sword, since overuse misuse leads to growing number multidrug-resistant microbes. This, in turn, has recently emerged global public health challenge facing both clinicians and patients. In addition intrinsic resistance, bacteria can acquire resistance particular antimicrobial agents through transfer genetic material conferring resistance. Amongst most common strategies are: drug target site changes, increased permeability antibiotic inactivation, efflux pumps. A better understanding interplay between defense against is crucial developing new or combinations. Herein, we provide brief overview current nanomedicine-based that aim improve efficacy antibiotics.

Language: Английский

---

Comprehensive evaluation of antibiotic pollution in a typical tributary of the Yellow River, China: Source-specific partitioning and fate analysis

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137294 - 137294

Published: Jan. 20, 2025

Language: Английский

---

Presence of Tetracycline and Sulfonamide Resistance Genes in Salmonella spp.: Literature Review

Antibiotics, Journal Year: 2021, Volume and Issue: 10(11), P. 1314 - 1314

Published: Oct. 28, 2021

Tetracyclines and sulfonamides are broad-spectrum antibacterial agents which have been used to treat bacterial infections for over half a century. The widespread use of tetracyclines led the emergence resistance in diverse group bacteria. This can be studied by searching genes present bacteria responsible different mechanisms. Salmonella is one leading causing foodborne diseases worldwide, its has widely reported. literature review searched Virtual Health Library articles with specific data samples: found, primers PCR, thermocycler conditions. results revealed that presented high rates tetracycline sulfonamide, most frequent samples isolate were poultry pork. frequently detected from spp. tetA followed tetB. gene sul1 sul2 sulfonamide Salmonella. These associated plasmids, transposons, or both, often conjugative, highlighting transference potential these other bacteria, environments, animals, humans.

Language: Английский

---

Monitoring and detection of antibiotic residues in animal derived foods: Solutions using aptamers

Trends in Food Science & Technology, Journal Year: 2022, Volume and Issue: 125, P. 200 - 235

Published: May 17, 2022

Language: Английский

---

Synthesis, characterization, molecular docking and network pharmacology of bioactive metallic sulfonamide-isatin ligands against promising drug targets

Journal of Molecular Structure, Journal Year: 2022, Volume and Issue: 1277, P. 134780 - 134780

Published: Dec. 13, 2022

Language: Английский

---

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(5), P. 1483 - 1519

Published: May 1, 2024

The development of effective antibacterial solutions has become paramount in maintaining global health this era increasing bacterial threats and rampant antibiotic resistance. Traditional antibiotics have played a significant role combating infections throughout history. However, the emergence novel resistant strains necessitates constant innovation research. We analyzed data on antibacterials from CAS Content Collection, largest human-curated collection published scientific knowledge, which proven valuable for quantitative analysis knowledge. Our focuses mining Collection recent publications (since 2012). This article aims to explore intricate landscape research while reviewing advancement traditional emerging strategies. By delving into resistance mechanisms, paper highlights need find alternate strategies address growing concern.

Language: Английский

---

Antibiotic Resistance and Genetic Profiles of Vibrio parahaemolyticus Isolated from Farmed Pacific White Shrimp (Litopenaeus vannamei) in Ningde Regions

Microorganisms, Journal Year: 2024, Volume and Issue: 12(1), P. 152 - 152

Published: Jan. 12, 2024

To better understand the antibiotic resistance, virulence genes, and some related drug-resistance genes of

Language: Английский

---

Interactions between microplastics and organic contaminants: the microbial mechanisms for priming effects of organic compounds on microplastic biodegradation

Water Research, Journal Year: 2024, Volume and Issue: 267, P. 122523 - 122523

Published: Sept. 26, 2024

Language: Английский

---

Antibiotic Resistance in Vibrio parahaemolyticus: Mechanisms, Dissemination, and Global Public Health Challenges—A Comprehensive Review

Reviews in Aquaculture, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 1, 2025

ABSTRACT Vibrio parahaemolyticus , a ubiquitous pathogen in marine and estuarine environments, is foodborne microorganism whose infections have become global public health challenge. In recent years, the overuse misuse of antibiotics led to emergence increasing numbers antibiotic‐resistant strains V. worldwide. These harbor resistance genes that mediate various mechanisms, presenting significant challenge antibiotic therapy. Furthermore, horizontal gene transfer (HGT) accelerating impacts climate change facilitated formation spread resistance, contributing proliferation resistant exacerbating threat. This review aims provide comprehensive overview mechanisms effects on its strategies curb transmission strains. Additionally, we conducted statistical analysis data from 6727 isolates obtained 27 countries across Asia, Africa, Americas, Europe, through literature review, better understand distribution trends this pathogen. We hope study will serve as an important reference for controlling addressing critical issue.

Language: Английский

---

Synthesis, molecular modelling, and antibacterial evaluation of new sulfonamide-dyes based pyrrole compounds

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 14, 2024

In this study, we synthesized new series of 5-oxo-2-phenyl-4-(arylsulfamoyl)sulphenyl) hydrazono)-4,5-dihydro-1H-pyrrole-3-carboxylate hybrids 4a-f with the goal overcoming sulfonamide resistance and identifying novel therapeutic candidates by chemical changes. The structures were established over spectroscopic tools. frontier molecular orbitals configuration energetic possessions compounds discovered utilizing DFT/B3LYP/6-311++ G** procedure. 3D plots both HOMO LUMO showed comparable led to close values their energies. Amongst prepared analogues, 4a-f, hybrid 4a presented potent inhibitory towards S. typhimurium (IZD = 15 mm, MIC 19.24 µg/mL) significant inhibition 19 11.31 against E.coli in contrast (Sulfamethoxazole) reference Whereas, 4d demonstrated 16 enhanced E. Coli, Additionally, generated analogues'' docking was estimated (PDB: 3TZF 6CLV) proteins. Analogue 4e had highest documented binding score as soon linked other analogues. consequences fitting addressed antibacterial valuation.

Language: Английский

---