Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era DOI Creative Commons
Yoscelina Estrella Martínez-López, Diego Esquivel-Hernández,

Jean Paul Sánchez-Castañeda

et al.

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: Aug. 24, 2022

The association between the physio-pathological variables of type 2 diabetes (T2D) and gut microbiota composition suggests a new avenue to track disease improve outcomes pharmacological non-pharmacological treatments. This enterprise requires strategies elucidate metabolic disturbances occurring in microbiome as progresses. To this end, physiological knowledge systems biology pave way for characterizing identifying move toward healthy compositions. Here, we dissect recent associations T2D. In addition, discuss advances how drugs, diet, exercise modulate favor stages. Finally, present computational approaches disentangling activity underlying host-microbiota codependence. Altogether, envision that combination physiology modeling metabolism will drive us optimize diagnosis treatment T2D patients personalized way.

Language: Английский

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity DOI
Robert H. Mills, Parambir S. Dulai, Yoshiki Vázquez‐Baeza

et al.

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(2), P. 262 - 276

Published: Jan. 27, 2022

Language: Английский

Citations

224
The need to study human milk as a biological system DOI Creative Commons
Parul Christian, Emily R. Smith, Sun Eun Lee

et al.

American Journal of Clinical Nutrition, Journal Year: 2021, Volume and Issue: 113(5), P. 1063 - 1072

Published: Feb. 25, 2021

Critical advancement is needed in the study of human milk as a biological system that intersects and interacts with myriad internal (maternal biology) external (diet, environment, infections) factors its plethora influences on developing infant. Human-milk composition resulting function more than sum parts. Our failure to fully understand this biology large part contributes why duration exclusive breastfeeding remains an unsettled science (if not policy). current understanding human-milk individual components their functions fails recognize importance chronobiology systems context synthesis, optimal timing feeding, period lactation. The overly simplistic, but common, approach analyzing single, mostly nutritive insufficient contribution either or matrix within which they exist both maternal child health. There need for shift conceptual studying improve strategies interventions support better lactation, breastfeeding, full range infant feeding practices, particularly women infants living undernourished infectious environments. Recent technological advances have led rising movement towards advancing biology. Herein, we describe rationale critical unveiling multifunctionality various nutritional, nonnutritional, immune, signaling pathways drive development maturation, growth, very early postnatal life. We provide vision framework research strategy agenda change field implications global policy, innovation, interventions.

Language: Английский

Citations

159
Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies DOI Open Access
Umair Shabbir, Muhammad Sajid Arshad, Aysha Sameen

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 690 - 690

Published: Feb. 21, 2021

The gut microbiota (GM) represents a diverse and dynamic population of microorganisms about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest GM can influence health host, several factors modify composition, such as diet, drug intake, lifestyle, geographical locations. Gut dysbiosis affect brain immune homeostasis through microbiota-gut-brain axis play key role pathogenesis neurodegenerative diseases, including dementia Alzheimer's disease (AD). relationship between AD is still elusive, but emerging evidence suggests it enhance secretion lipopolysaccharides amyloids may disturb intestinal permeability blood-brain barrier. In addition, promote hallmarks AD, oxidative stress, neuroinflammation, amyloid-beta formation, insulin resistance, ultimately causation neural death. Poor dietary habits aging, along with inflammatory responses due to dysbiosis, contribute AD. Thus, modulation probiotics, or fecal transplantation could represent potential therapeutics this review, we discuss therapeutic strategies modulate

Language: Английский

Citations

144
Potential Role of the Gut Microbiome In Colorectal Cancer Progression DOI Creative Commons
Jae-Ho Kim, Heung Kyu Lee

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 7, 2022

An increasing number of studies have revealed that the progression colorectal cancer (CRC) is related to gut microbiome composition. Under normal conditions, acts as a barrier other pathogens or infections in intestine and modulates inflammation by affecting host immune system. These microbiota are not only intestinal associated with tumorigenesis but also modulation anti-cancer response. Thus, they tumor treatment efficacy. Studies shown can be used biomarkers predict effect immunotherapy improve efficacy treating CRC through modulation. In this review, we discuss role recent growth along its synergistic modalities.

Language: Английский

Citations

137
The gut microbiome and hypertension DOI
Joanne A. O’Donnell, Tenghao Zheng, Guillaume Méric

et al.

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 19(3), P. 153 - 167

Published: Jan. 11, 2023

Language: Английский

Citations

134
Host microbiota can facilitate pathogen infection DOI Creative Commons
Emily J. Stevens, Kieran A. Bates, Kayla C. King

et al.

PLoS Pathogens, Journal Year: 2021, Volume and Issue: 17(5), P. e1009514 - e1009514

Published: May 13, 2021

Animals live in symbiosis with numerous microbe species. While some can protect hosts from infection and benefit host health, components of the microbiota or changes to microbial landscape have potential facilitate infections worsen disease severity. Pathogens pathobionts exploit metabolites, take advantage a depletion defences changing conditions within host, cause opportunistic infection. The might also favour more virulent evolutionary trajectory for invading pathogens. In this review, we consider ways which contributes infectious throughout host’s life potentially across time. We further discuss implications these negative outcomes manipulation engineering management.

Language: Английский

Citations

121
Wekemo Bioincloud: A user‐friendly platform for meta‐omics data analyses DOI Creative Commons
Yunyun Gao, Guo‐Xing Zhang,

Shunyao Jiang

et al.

iMeta, Journal Year: 2024, Volume and Issue: 3(1)

Published: Feb. 1, 2024

The increasing application of meta-omics approaches to investigate the structure, function, and intercellular interactions microbial communities has led a surge in available data. However, this abundance human environmental microbiome data exposed new scalability challenges for existing bioinformatics tools. In response, we introduce Wekemo Bioincloud-a specialized platform -omics studies. This offers comprehensive analysis solution, specifically designed alleviate tool selection users face expanding sets. As now, Bioincloud been regularly equipped with 22 workflows 65 visualization tools, establishing itself as user-friendly widely embraced studying diverse Additionally, enables online modification vector outputs, registration-independent personalized dashboard system ensures privacy traceability. is freely at https://www.bioincloud.tech/.

Language: Английский

Citations

90
Fecal microbiota transplantation: Emerging applications in autoimmune diseases DOI Creative Commons

Ruixue Yang,

Zhenzhen Chen,

Jun Cai

et al.

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 141, P. 103038 - 103038

Published: April 26, 2023

Both genetic susceptibility and environmental factors are important contributors to autoimmune disease pathogenesis. As an factor, the gut microbiome plays a crucial role in development progression of diseases. Thus, strategies targeting alterations can potentially be used treat disease. Microbiota-based interventions, such as prebiotics, probiotics, dietary fecal microbiota transplantation (FMT), have attracted growing interest novel treatment approaches. FMT is effective method for treating recurrent Clostridioides difficile infections; moreover, it emerging promising patients with inflammatory bowel other Although mechanisms underpinning interaction between host not fully understood disease, has been shown restore altered composition, rebuild intestinal microecosystem, mediate innate adaptive immune responses achieve therapeutic effect. In this review, we provide overview discuss how approach Furthermore, recent challenges offer future research directions.

Language: Английский

Citations

47
Anaerostipes hadrus , a butyrate-producing bacterium capable of metabolizing 5-fluorouracil DOI Creative Commons
Danping Liu,

Lisheng Xie,

Shitao Lian

et al.

mSphere, Journal Year: 2024, Volume and Issue: 9(4)

Published: March 12, 2024

(

Citations

16
MicrobiomeStatPlots: Microbiome statistics plotting gallery for meta‐omics and bioinformatics DOI Creative Commons

Defeng Bai,

Chuang Ma,

Jiani Xun

et al.

iMeta, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract The rapid growth of microbiome research has generated an unprecedented amount multi‐omics data, presenting challenges in data analysis and visualization. To address these issues, we present MicrobiomeStatPlots, a comprehensive platform offering streamlined, reproducible tools for This integrates essential bioinformatics workflows with pipelines provides 82 distinct visualization cases interpreting datasets. By incorporating basic tutorials advanced R‐based strategies, MicrobiomeStatPlots enhances accessibility usability researchers. Users can customize plots, contribute to the platform's expansion, access wealth knowledge freely on GitHub ( https://github.com/YongxinLiu/MicrobiomeStatPlot ). Future plans include extending support metabolomics, viromics, metatranscriptomics, along seamless integration into omics workflows. bridges gaps visualization, paving way more efficient, impactful research.

Language: Английский

Citations

3