Relationships between the Intakes of Human Milk Components and Body Composition of Breastfed Infants: A Systematic Review DOI Open Access
Isabella Norrish, Azhar S. Sindi, Vanessa S. Sakalidis

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2370 - 2370

Published: May 18, 2023

Human milk provides all of the elements necessary for infant growth and development. Previous studies have reported associations between breastfeeding a reduced risk developing obesity late-onset metabolic disorders; however, underlying mechanisms are poorly understood. Recently, intakes human components been associated with body composition, which is likely partially implicated in childhood among breastfed infants. In this systematic review, we searched electronic bibliographic databases that explored relationships 24 h macronutrients bioactive composition and/or parameters. Of 13 eligible studies, 10 assessed outcomes macronutrients, while 8 components. Significant time-dependent anthropometrics were found no concentrations several components, such as lactose, total protein, oligosaccharides, suggesting measuring without quantifying intake by may provide limited understanding. Future investigating effect on should consider actual employ standardised methods intake.

Language: Английский

Breastfeeding: crucially important, but increasingly challenged in a market-driven world DOI Creative Commons
Rafael Pérez‐Escamilla, Cecília Tomori, Sonia Hernández‐Cordero

et al.

The Lancet, Journal Year: 2023, Volume and Issue: 401(10375), P. 472 - 485

Published: Feb. 1, 2023

Language: Английский

Citations

338

Effects of Malnutrition on the Immune System and Infection and the Role of Nutritional Strategies Regarding Improvements in Children’s Health Status: A Literature Review DOI Open Access
Fátima Morales, Sergio Montserrat‐de la Paz, María José León

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 1 - 1

Published: Dec. 19, 2023

Malnutrition refers to a person's status as under- or overnourished, and it is usually associated with an inflammation status, which can subsequently imply different health the risk of infection increased, along deterioration immune system. Children's systems are generally more susceptible problems than adults. In situation malnutrition, because malnourished children's compromised, they likely die. However, little known about underlying mechanism altered functioning how relates starvation. Nutritional interventions have been reported cost-effective strategies prevent treat development malnourishment, considering link between food intake health, especially in children, also susceptibility this population diseases their during childhood might affect long-term physiological growth. The ingestion specific nutrients (e.g., vitamins oligoelements) has contribute proper systems. review, we aim describe basis malnutrition linked system, role modulation system that occur these situations well identify nutritional improve health.

Language: Английский

Citations

78

Early-childhood linear growth faltering in low- and middle-income countries DOI Creative Commons
Jade Benjamin‐Chung, Andrew Mertens, John M. Colford

et al.

Nature, Journal Year: 2023, Volume and Issue: 621(7979), P. 550 - 557

Published: Sept. 13, 2023

Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards)

Language: Английский

Citations

62

Comparing early life nutritional sources and human milk feeding practices: personalized and dynamic nutrition supports infant gut microbiome development and immune system maturation DOI Creative Commons

Spencer R. Ames,

Larisa Lotoski, Meghan B. Azad

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 13, 2023

Exclusive breastfeeding is recommended for the first six months of life, but many infants receive pumped milk, formula, donor human or other nutritional sources during this critical period. Substantive evidence shows early nutrition influences development microbiome and immune system, affecting lifelong health. However, underlying mechanisms are unclear nuances milk feeding rarely considered. This review synthesizes from studies model systems to discuss impact different on co-development gut microbiome, antigen tolerance, immunity. We highlight two key mechanisms: epigenetics so-called "weaning reaction". Collectively, highlights i) fundamental role parents' own fed directly at breast, as a dynamic personalized source that drives developmental programming, ii) deficiencies alternative priority research areas improving these alternatives when direct not possible.

Language: Английский

Citations

56

Overcoming barriers to breastfeeding DOI
Cecília Tomori

Best Practice & Research Clinical Obstetrics & Gynaecology, Journal Year: 2022, Volume and Issue: 83, P. 60 - 71

Published: Feb. 3, 2022

Breastfeeding is the evolved human infant feeding norm, practiced historically and across cultures. Over past 200 years, breastfeeding practices have eroded, reaching a nadir in middle of 20th century. Mobilization from grassroots social movements, with support public health medicine, has yielded substantial rise overall prevalence. However, timely initiation, exclusive breastfeeding, duration still lag behind global targets. Inadequate leads to morbidity approximately 600,000 child deaths an additional 100,000 maternal annually. Most women pregnant people are physiologically able desire breastfeed, however, they face barriers. Effective interventions address systems, workplace policies, engage communities families. work remains implement fully supportive policies multiple sectors. Urgent action needed limit pervasive influence commercial milk formula (CMF) marketing policy, healthcare, on families achieve more equitable outcomes.

Language: Английский

Citations

51

Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior DOI
Carolina de Weerth, Anna‐Katariina Aatsinki, Meghan B. Azad

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(26), P. 7945 - 7982

Published: March 30, 2022

Human milk is a highly complex liquid food tailor-made to match an infant's needs. Beyond documented positive effects of breastfeeding on infant and maternal health, there increasing evidence that constituents also impact child neurodevelopment. Non-nutrient bioactives would contribute the (long-term) development cognition behavior, process termed 'Lactocrine Programming'. In this review we discuss current state field human composition its links with cognitive behavioral development. To promote state-of-the-art methodologies designs facilitate data pooling meta-analytic endeavors, present detailed recommendations best practices for future studies. Finally, determine important scientific gaps need be filled advance field, innovative directions research. Unveiling mechanisms underlying between behavior will deepen our understanding broad functions food, as well provide necessary information designing interventions.

Language: Английский

Citations

42

Applications of the INFOGEST In Vitro Digestion Model to Foods: A Review DOI Creative Commons
Hualu Zhou, Yunbing Tan, David Julian McClements

et al.

Annual Review of Food Science and Technology, Journal Year: 2022, Volume and Issue: 14(1), P. 135 - 156

Published: Nov. 29, 2022

The in vitro digestion model developed by the INFOGEST international consortium is widely used to simulate physicochemical processes occurring inside human gastrointestinal tract (mouth, stomach, and small intestine) during of foods. In this review, we provide a brief overview method procedures measure macronutrients (lipids, proteins, starch), bioaccessibility bioactive agents (vitamins, minerals, nutraceuticals), changes structure physical properties foods under conditions (particle size, charge, location). We then review application for monitoring fate different kinds beverages, including dairy, egg, meat, seafood, fruit, vegetable, cereal, emulsified products. also discuss studying digestibility next-generation plant-based foods, such as egg analogs. Finally, benefits limitations standardized are assessed.

Language: Английский

Citations

42

Phospholipid composition and fat globule structure II: Comparison of mammalian milk from five different species DOI
Wei Wei, Dan Li, Chenyu Jiang

et al.

Food Chemistry, Journal Year: 2022, Volume and Issue: 388, P. 132939 - 132939

Published: April 9, 2022

Language: Английский

Citations

41

Human Milk Bioactive Components and Child Growth and Body Composition in the First 2 Years: A Systematic Review DOI Creative Commons
Meredith Brockway, Allison I Daniel, Sarah M. Reyes

et al.

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 15(1), P. 100127 - 100127

Published: Oct. 5, 2023

Human milk (HM) contains macronutrients, micronutrients, and a multitude of other bioactive factors, which can have long-term impact on infant growth development. We systematically searched MEDLINE, EMBASE, Cochrane Library, Scopus, Web Science to synthesize evidence published between 1980 2022 HM components anthropometry through 2 y age among term-born infants. From 9992 abstracts screened, 141 articles were included categorized based their reporting or components. Bioactives including hormones, oligosaccharides (HMOs), immunomodulatory are reported here, 75 from 69 unique studies observations 9980 dyads. Research designs, collection strategies, sampling times, geographic socioeconomic settings, practices, outcomes varied considerably. Meta-analyses not possible because data times inconsistent the included. Few measured intake, adjusted for confounders, precisely captured breastfeeding exclusivity, adequately described protocols. Only 5 (6%) had high overall quality scores. Hormones most extensively examined with 46 (n = 6773 dyads), compared 13 2640 dyads) HMOs 12 1422 Two conducted untargeted metabolomics. Leptin adiponectin demonstrated inverse associations growth, although several found no associations. No consistent individual outcomes. Among in HM, IL-6 relationships growth. Current research bioactives is largely inconclusive insufficient address complex composition HM. Future should ideally capture use biologically relevant anthropometrics, integrate across categories, embracing systems biology approach better understand how work independently synergistically influence

Language: Английский

Citations

25

Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome DOI Creative Commons
Kelsey E. Johnson,

Timothy Heisel,

Mattea Allert

et al.

Cell Genomics, Journal Year: 2024, Volume and Issue: unknown, P. 100638 - 100638

Published: Sept. 1, 2024

Language: Английский

Citations

9