Therapeutic peptides: current applications and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Feb. 14, 2022

Abstract Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced modified using both chemical biological methods, together with novel design delivery strategies, which helped overcome inherent drawbacks of peptides allowed continued advancement this field. A wide variety natural obtained studied, covering multiple therapeutic areas. This review summarizes efforts achievements peptide discovery, their current applications. We also discuss value challenges associated future developments peptides.

Language: Английский

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Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(11), P. 1615 - 1615

Published: Nov. 15, 2023

Antibiotics have revolutionized medicine, saving countless lives since their discovery in the early 20th century. However, origin of antibiotics is now overshadowed by alarming rise antibiotic resistance. This global crisis stems from relentless adaptability microorganisms, driven misuse and overuse antibiotics. article explores subsequent emergence It delves into mechanisms employed bacteria to develop resistance, highlighting dire consequences drug including compromised patient care, increased mortality rates, escalating healthcare costs. The elucidates latest strategies against drug-resistant encompassing innovative approaches such as phage therapy, CRISPR-Cas9 technology, exploration natural compounds. Moreover, it examines profound impact resistance on development, rendering pursuit new economically challenging. limitations challenges developing novel are discussed, along with hurdles regulatory process that hinder progress this critical field. Proposals for modifying facilitate development presented. withdrawal major pharmaceutical firms research examined, potential re-engage interest. also outlines initiatives overcome economic incentivize emphasizing international collaborations partnerships. Finally, sheds light government-led a specific focus Middle East. discusses proactive measures taken governments region, Saudi Arabia United Arab Emirates, combat threat. In face multifaceted approach imperative. provides valuable insights complex landscape challenges, collaborative efforts required ensure future where remain effective tools safeguarding public health.

Language: Английский

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: March 28, 2023

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical biophysical cues that mimic the in vivo extracellular matrix (ECM). Additionally, such mechanical adaptability, microstructure interconnectivity, inherent bioactivity, making them ideal design living implants specific applications TE This paper provides an overview recent progress (BNBMs), including advances their preparation, functionality, potential future challenges. We highlight fabrication BNBMs outline general strategies functionalizing tailoring with various biological physicochemical characteristics native ECM. Moreover, we key functionalization versatile applications. Finally, conclude by offering our perspective open challenges developments this rapidly-evolving field.

Language: Английский

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Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

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Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications

Antibiotics, Journal Year: 2022, Volume and Issue: 11(10), P. 1417 - 1417

Published: Oct. 16, 2022

The growing emergence of antimicrobial resistance represents a global problem that not only influences healthcare systems but also has grave implications for political and economic processes. As the discovery novel agents is lagging, one solutions innovative therapeutic options would expand our armamentarium against this hazard. Compounds interest in many such studies are peptides (AMPs), which actually represent host’s first line defense pathogens involved innate immunity. They have broad range activity Gram-negative Gram-positive bacteria, fungi, viruses, with specific mechanisms action utilized by different AMPs. Coupled lower propensity development, it becoming clear AMPs can be seen as emerging very promising candidates more pervasive usage treatment infectious diseases. However, their use quotidian clinical practice without challenges. In review, we aimed to summarize state-of-the-art evidence on structure AMPs, well provide detailed information activity. We present contemporary trials application highlight beyond diseases potential challenges may arise increasing availability.

Language: Английский

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Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides

Molecules, Journal Year: 2022, Volume and Issue: 27(9), P. 2675 - 2675

Published: April 21, 2022

Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and components the innate immunity almost all living things. They play an important role resisting foreign invading microorganisms. have wide range antibacterial activities against bacteria, fungi, viruses other active traditional antibiotic-resistant strains do not easily induce development drug resistance. Therefore, they become hot spot medical research expected to new substitute for fighting microbial infection represent method treating drug-resistant bacteria. This review briefly introduces source structural characteristics antimicrobial describes those been used common clinical microorganisms (bacteria, viruses, especially coronaviruses), focusing on their mechanism action application prospects.

Language: Английский

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Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability

Biotechnology Advances, Journal Year: 2022, Volume and Issue: 59, P. 107962 - 107962

Published: April 19, 2022

Language: Английский

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Pathogenesis-Related Proteins (PRs) with Enzyme Activity Activating Plant Defense Responses

Plants, Journal Year: 2023, Volume and Issue: 12(11), P. 2226 - 2226

Published: June 5, 2023

Throughout evolution, plants have developed a highly complex defense system against different threats, including phytopathogens. Plant depends on constitutive and induced factors combined as mechanisms. These mechanisms involve signaling network linking structural biochemical defense. Antimicrobial pathogenesis-related (PR) proteins are examples of this mechanism, which can accumulate extra- intracellular space after infection. However, despite their name, some PR present at low levels even in healthy plant tissues. When they face pathogen, these PRs increase abundance, acting the first line Thus, play key role early events, reduce damage mortality caused by pathogens. In context, review will discuss response proteins, been identified PRs, with enzymatic action, enzymes, β-1,3 glucanase, chitinase, peroxidase ribonucleases. From technological perspective, we advances last decade applied to study important events higher

Language: Английский

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Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 274 - 274

Published: Jan. 30, 2023

Antimicrobial resistance (AMR) is one of the most important global public health problems. The imprudent use antibiotics in humans and animals has resulted emergence antibiotic-resistant bacteria. dissemination these strains their resistant determinants could endanger antibiotic efficacy. Therefore, there an urgent need to identify develop novel strategies combat resistance. This review provides insights into evolution mechanisms AMR. Additionally, it discusses alternative approaches that might be used control AMR, including probiotics, prebiotics, antimicrobial peptides, small molecules, organic acids, essential oils, bacteriophage, fecal transplants, nanoparticles.

Language: Английский

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Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(9), P. 8004 - 8025

Published: April 20, 2023

Self-assembly has emerged as an extensively used method for constructing biomaterials with sizes ranging from nanometers to micrometers. Peptides have been investigated self-assembly. They are widely applied owing their desirable biocompatibility, biodegradability, and tunable architecture. The development of peptide-based nanoparticles often requires complex synthetic processes involving chemical modification supramolecular Stimuli-responsive peptide nanoparticles, also termed "smart" capable conformational changes in response stimuli, a class promising materials. These smart find diverse range biomedical applications, including drug delivery, diagnostics, biosensors. systems include external stimuli (such light, temperature, ultrasound, magnetic fields) internal pH, redox environment, salt concentration, biomarkers), facilitating the generation library self-assembled imaging therapy. Thus, this review, we mainly focus on built by self-assembly strategy systematically discuss mechanisms various stimuli. Furthermore, summarize applications nanomaterials, diagnosis therapy, demonstrate potential medical translation.

Language: Английский

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