International Journal of Peptide Research and Therapeutics, Journal Year: 2023, Volume and Issue: 29(3)
Published: May 3, 2023
Language: Английский
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: July 31, 2024
Antibiotic resistance is a growing global problem that requires innovative therapeutic approaches and strategies for administering antibiotics. One promising approach combination therapy, in which two or more drugs are combined to combat an infection. Along this line, the of antimicrobial peptides (AMPs) with conventional antibiotics has gained attention mainly due complementary mechanisms action AMPs In article, we review both
Language: Английский
Citations
25
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 145, P. 107151 - 107151
Published: Jan. 27, 2024
Language: Английский
Citations
21
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7473 - 7473
Published: April 18, 2023
Antibiotic resistance is one of the greatest threats to global health and food security today. It becomes increasingly difficult treat infectious disorders because antibiotics, even newest ones, are becoming less effective. One ways taken in Global Plan Action announced at World Health Assembly May 2015 ensure prevention treatment diseases. In order do so, attempts made develop new antimicrobial therapeutics, including biomaterials with antibacterial activity, such as polycationic polymers, polypeptides, polymeric systems, provide non-antibiotic therapeutic agents, selected biologically active nanoparticles chemical compounds. Another key issue preventing from contamination by developing packaging materials, particularly based on degradable polymers biocomposites. This review, a cross-sectional way, describes most significant research activities conducted recent years field development materials polymer composites properties. We focus natural i.e., polysaccharides which present mechanism for combating many highly pathogenic microorganisms. also attempt use this knowledge obtain synthetic similar activity.
Language: Английский
Citations
36
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: May 17, 2023
Mycobacterium tuberculosis (Mtb) is one of the most important infectious agents worldwide and causes more than 1.5 million deaths annually. To make matters worse, drug resistance among Mtb strains has risen substantially in last few decades. Nowadays, it not uncommon to find patients infected with that are virtually resistant all antibiotics, which led urgent search for new molecules therapies. Over previous decades, several studies have demonstrated efficiency antimicrobial peptides eliminate even multidrug-resistant bacteria, making them outstanding candidates counterattack this growing health problem. Nevertheless, complexity cell wall makes us wonder whether can effectively kill persistent Mycobacterium. In present review, we explore analyze effectiveness bacilli.
Language: Английский
Citations
34
Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 794 - 794
Published: Aug. 23, 2024
The emergence of drug resistance genes and the detrimental health effects caused by overuse antibiotics are increasingly prominent problems. There is an urgent need for effective strategies to or antimicrobial in fields biomedicine therapeutics. pathogen-killing ability peptides (AMPs) linked their structure physicochemical properties, including conformation, electrical charges, hydrophilicity, hydrophobicity. AMPs a form innate immune protection found all life forms. A key aspect application involves potential combat emerging antibiotic resistance; certain against resistant microbial strains can be modified through peptide engineering. This review summarizes various used tackle resistance, with particular focus on role as agents that enhance host’s immunological functions. Most recent studies properties impregnation methods AMPs, along biomedical applications, discussed. provides researchers insights into latest advancements AMP research, highlighting compelling evidence effectiveness agents.
Language: Английский
Citations
13
Journal of Natural Products, Journal Year: 2024, Volume and Issue: 87(3), P. 600 - 616
Published: Feb. 27, 2024
Since the 1980s, studies of antimicrobial peptides (AMPs) derived from anuran skin secretions have unveiled remarkable structural diversity and a wide range activities. This study explores potential these for drug development by examining granted patents, amino acid modifications related to patented peptides, recent amphibians' taxonomic updates influencing AMP names. A total 188 patents different were found, with Asia North America being predominant regions, contributing 65.4% 15.4%, respectively. Conversely, although Neotropical region is world's most diversified amphibians, it holds only 3.7% identified patents. The activities are claimed in 118 Additionally, 160 66 registered natural sequence, 69 both derivative sequences, 20 exclusively sequence derivatives. Notably, common include alterations side chains acids peptides' N- C-termini. review underscores biomedical anuran-derived AMPs, emphasizing need bridge gap between description practical while highlighting urgency biodiversity conservation facilitate discoveries.
Language: Английский
Citations
8
Bioelectrochemistry, Journal Year: 2024, Volume and Issue: 160, P. 108784 - 108784
Published: July 27, 2024
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10788 - 10788
Published: Oct. 8, 2024
Antimicrobial peptides (AMPs) are short, usually cationic with an amphiphilic structure, which allows them to easily bind and interact the cellular membranes of viruses, bacteria, fungi, other pathogens. Bacterial AMPs, or bacteriocins, can be produced from Gram-negative Gram-positive bacteria via ribosomal synthesis eliminate competing organisms. AMPs vital in addressing increasing antibiotic resistance various pathogens, potentially serving as alternative ineffective antibiotics. Bacteriocins have a narrow spectrum action, making highly specific antibacterial compounds that target particular bacterial This review covers two main groups bacteriocins by their modes classification, sources positive effects they play on human body, limitations future perspectives
Language: Английский
Citations
8
Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)
Published: Oct. 20, 2024
Abstract Antibacterial bone cements (ABCs), such as antibiotic-loaded (ALBCs), have been widely utilized in clinical treatments. Currently, loaded with vancomycin, gentamicin, tobramycin, or clindamycin are approved by the US Food and Drug Administration. However, traditional ALBCs exhibit drawbacks like burst release bacterial resistance. Therefore, there is a demand for development of antibacterial containing novel agents to address these defects. In this review, we provide an overview prospect new that can be used potential applied cement, including metallic agents, pH-switchable cationic polymers, N -halamines, non-leaching acrylic monomers, antimicrobial peptides enzymes. Additionally, conducted preliminary assessment feasibility cement -halamine, which has demonstrated good activities. The conclusion review research utilization contribute addressing limitations ALBCs. it necessary continue expanding use incorporating agents. This offers perspectives designing ABCs treating infections. Graphical abstract
Language: Английский
Citations
8
Fermentation, Journal Year: 2025, Volume and Issue: 11(1), P. 36 - 36
Published: Jan. 17, 2025
The article reviews the literature on antimicrobial peptides (AMPs) that exhibit unique mechanisms, such as broad-spectrum activity, low development of resistance, and ability to modulate immune response host organism. Information is provided significant potential AMPs in fight against pathogens threatening human health food safety. Enrichment diet with biologically active obtained using proteolytic activity lactic acid bacteria (LAB) proposed a simple, accessible, viable alternative antibiotics does not have harmful side effect. review briefly covers methods for obtaining features LAB system responsible producing bioactive environment. It has been shown various strains makes it possible produce high-quality whey-based beverages different directions antagonistic opportunistic helps optimize gastrointestinal microbiota. assumed drinks can reduce dose antimicrobials combined therapy infectious diseases be preventive measure contagion spread resistance.
Language: Английский
Citations
1