LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117378 - 117378
Published: Jan. 1, 2025
Language: Английский
Antibiotics, Journal Year: 2022, Volume and Issue: 11(10), P. 1417 - 1417
Published: Oct. 16, 2022
The growing emergence of antimicrobial resistance represents a global problem that not only influences healthcare systems but also has grave implications for political and economic processes. As the discovery novel agents is lagging, one solutions innovative therapeutic options would expand our armamentarium against this hazard. Compounds interest in many such studies are peptides (AMPs), which actually represent host’s first line defense pathogens involved innate immunity. They have broad range activity Gram-negative Gram-positive bacteria, fungi, viruses, with specific mechanisms action utilized by different AMPs. Coupled lower propensity development, it becoming clear AMPs can be seen as emerging very promising candidates more pervasive usage treatment infectious diseases. However, their use quotidian clinical practice without challenges. In review, we aimed to summarize state-of-the-art evidence on structure AMPs, well provide detailed information activity. We present contemporary trials application highlight beyond diseases potential challenges may arise increasing availability.
Language: Английский
Citations
142
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2655 - 2655
Published: Feb. 24, 2024
One of the key mechanisms enabling bacterial cells to create biofilms and regulate crucial life functions in a global highly synchronized way is communication system called quorum sensing (QS). QS cell-to-cell process that depends on population density mediated by small signalling molecules autoinducers (AIs). In bacteria, controls biofilm formation through regulation gene expression involved extracellular polymeric matrix (EPS) synthesis, virulence factor production, stress tolerance metabolic adaptation. Forming one antimicrobial resistance (AMR). A common feature human pathogens ability form biofilm, which poses serious medical issue due their high susceptibility traditional antibiotics. Because associated with formation, there belief inhibition activity quenching (QQ) may provide alternative therapeutic methods for treating microbial infections. This review summarises recent progress research, focusing biofilms, especially those formed pathogenic become resistant antibiotic treatment. Subsequently, potential approach highlighting innovative non-antibiotic strategies control AMR bacteria has been discussed.
Language: Английский
Citations
27
Antibiotics, Journal Year: 2024, Volume and Issue: 13(3), P. 202 - 202
Published: Feb. 21, 2024
Antimicrobial peptides (AMPs) are usually made up of fewer than 100 amino acid residues. They found in many living organisms and an important factor those organisms’ innate immune systems. AMPs can be extracted from various sources, including bacteria, plants, animals, even humans. cationic with amphiphilic structure, which allows them to easily bind interact the cellular membranes viruses, fungi, other pathogens. act against both Gram-negative Gram-positive pathogens have modes action them. Some attack pathogens’ membranes, while others target their intracellular organelles, as well nucleic acids, proteins, metabolic pathways. A crucial area AMP use is related ability help emerging antibiotic resistance: some active resistant strains susceptible peptide engineering. This review considers three key sources—plants, humans—as sequences.
Language: Английский
Citations
21
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Antimicrobial peptides (AMPs) show potential as antibiotic alternatives for bacterial infections; nevertheless, the susceptibility to proteases limits their broader utilization. This study developed engineered lipopeptides using antienzymolysis modifications and cysteine (Cys)-dimerization strategy. As key parameters functioning of AMPs, hydrophobicity positive charges were concentrated within peptide sequence by adjusting intermolecular disulfide bond placement distribution effects. Their centralization in induces a differential propensity toward membranes. Positive charge-concentrated dimeric lipopeptide (C-C
Language: Английский
Citations
7
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 7, 2025
Antibiotic resistance is currently one of the most significant threats to global public health and safety. And studies have found that over next 25 years, 39 million people will die directly 169 indirectly due antibiotic-resistant diseases. Consequently, development new types antimicrobial drugs urgently needed. Antimicrobial peptides (AMPs) constitute an essential component innate immune response in all organisms. They exhibit a distinctive mechanism action endows them with broad spectrum biological activities, including antimicrobial, antibiofilm, antiviral, anti-inflammatory effects. However, AMPs also present certain limitations, such as cytotoxicity, susceptibility protein hydrolysis, poor pharmacokinetic properties, which impeded their clinical application. The delivery systems can address these challenges by modifying AMP enabling precise, controlled release at site infection or disease. This review offers comprehensive analysis mechanisms advantages AMPs. systematically evaluate how emerging drug systems, nanoparticles hydrogels, enhance stability bioavailability AMPs, discussing both strengths limitations. Moreover, unlike previous reviews, this highlight recent clinically approved AMP-based those development, emphasizing key translating into practice. With perspectives, it hoped provide some insights overcoming translational barriers advancing
Language: Английский
Citations
5
Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100827 - 100827
Published: Oct. 2, 2023
Biofilms are aggregates of organized microbial growth that function as barriers and create a stable internal environment for cell survival. The bacteria in the biofilms exhibit characteristics quite different from planktonic bacteria, such strong resistance to antibiotics other bactericides, getting out host immunity, developing harsh environments, which all contribute persistent intractable treatment. Hence, there is an urgent need develop novel materials strategies combat biofilms. However, most reviews on anti-biofilms published recent years based specific fields or materials. Microorganisms ubiquitous, except context medical health issues; however, exert detrimental effects advancement progress various fields. Therefore, this review aims provide comprehensive summary effective methodologies applicable across industries. Firstly, process formation was introduced enhance our comprehension "enemy". Secondly, intervene important links were discussed, taking timely action during early weak stages Thirdly, treatment mature summarized deal with break through defense line. Finally, several substances antibacterial properties presented. concludes standpoint author about potential developments strategies. This may help researchers quickly understand research challenges field design more efficient methods
Language: Английский
Citations
25
Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 794 - 794
Published: Aug. 23, 2024
The emergence of drug resistance genes and the detrimental health effects caused by overuse antibiotics are increasingly prominent problems. There is an urgent need for effective strategies to or antimicrobial in fields biomedicine therapeutics. pathogen-killing ability peptides (AMPs) linked their structure physicochemical properties, including conformation, electrical charges, hydrophilicity, hydrophobicity. AMPs a form innate immune protection found all life forms. A key aspect application involves potential combat emerging antibiotic resistance; certain against resistant microbial strains can be modified through peptide engineering. This review summarizes various used tackle resistance, with particular focus on role as agents that enhance host’s immunological functions. Most recent studies properties impregnation methods AMPs, along biomedical applications, discussed. provides researchers insights into latest advancements AMP research, highlighting compelling evidence effectiveness agents.
Language: Английский
Citations
13
Journal of Industrial Microbiology & Biotechnology, Journal Year: 2024, Volume and Issue: 51
Published: Jan. 1, 2024
The growing prevalence of fungal infections alongside rising resistance to antifungal drugs poses a significant challenge public health safety. At the close 2000s, major pharmaceutical firms began scale back on antimicrobial research due repeated setbacks and diminished economic gains, leaving only smaller companies labs pursue new solutions. Among various natural sources explored for novel compounds, peptides (AFPs) emerge as particularly promising. Despite their potential, AFPs receive less focus than antibacterial counterparts. These have been sourced extensively from nature, including plants, animals, insects, especially bacteria fungi. Furthermore, with advancements in recombinant biotechnology computational biology, can also be synthesized lab settings, facilitating peptide production. are noted wide-ranging efficacy, vitro vivo safety, ability combat biofilms. They distinguished by high specificity, minimal toxicity cells, reduced likelihood development. This review aims comprehensively cover AFPs, sources-both synthetic-their biofilm-fighting capabilities laboratory real-world action mechanisms, current status AFP research.
Language: Английский
Citations
9
BME Frontiers, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Nanotechnology offers innovative solutions for addressing the challenges posed by biofilm-forming bacteria, which are highly resistant to conventional antimicrobial therapies. This review explores integration of pharmaceutical nanotechnology with peptides (AMPs) enhance treatment biofilm-related infections. The use various nanoparticle systems-including inorganic/metallic, polymeric, lipid-based, and dendrimer nanostructures-provides promising avenues improving drug delivery, targeting, biofilm disruption. These nanocarriers facilitate penetration biofilms, down-regulate biofilm-associated genes, such as ALS1, ALS3, EFG1, HWP1, inhibit bacterial defense mechanisms through membrane disruption, reactive oxygen species generation, intracellular targeting. Furthermore, formulations NZ2114-NPs demonstrate enhanced efficacy reducing counts several orders magnitude. highlights potential combining AMPs create novel, targeted therapeutic approaches combatting infections overcoming limitations traditional treatments.
Language: Английский
Citations
1
Desalination and Water Treatment, Journal Year: 2025, Volume and Issue: unknown, P. 101044 - 101044
Published: Feb. 1, 2025
Language: Английский
Citations
1