A comprehensive review of hydrogel strategies for repairing peripheral nerve injuries DOI Creative Commons
Shicheng Jia, Hongfa Zhou, Jiayou Chen

et al.

Brain‐X, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 8, 2025

Abstract As an etiological factor underlying physical and mental disability in humans, peripheral nerve injuries (PNIs) can induce pain, sensory impairment, disability. Despite their regenerative ability, nerves cannot self‐repair after severe defects. While grafting is the gold standard for treatment of PNIs, it limited by graft versus host reactions, surgical complications, donor nerves. field material science continues to develop, hydrogels have been proposed use PNI repair biomodification, targeted modification, or loading with biological factors cells. This article reviewed research advances used repair, including simple composite functionalized loaded Based on findings from these reviews, we determined that further clarification mechanisms action modulating cellular functions necessary. In addition, there a need explore synergistic effect novel other biological, physical, biochemical factors. clinical trials are still limited, scientific efforts expected promote application repair.

Language: Английский

The marriage of immunomodulatory, angiogenic, and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scaffold for military medicine DOI Creative Commons
Ping Wu,

Lin Shen,

Huifan Liu

et al.

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: July 31, 2023

Most bone-related injuries to grassroots troops are caused by training or accidental injuries. To establish preventive measures reduce all kinds of trauma and improve the combat effectiveness troops, it is imperative develop new strategies scaffolds promote bone regeneration.

Language: Английский

Citations

58
A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression DOI Creative Commons
Qiuyang Wang, Kai Feng,

Guangsheng Wan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 16, 2025

RNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), most prevalent degenerative joint disease. However, synergistic effects these approaches on attenuating OA progression remain largely unexplored. In this study, matrix metalloproteinase-13 siRNA (siMMP-13) was incorporated onto polyethylenimine (PEI)-polyethylene glycol (PEG) modified Fe3O4 nanoparticles, forming a nucleic acid nanocarrier termed si-Fe NPs. Subsequently, poly(vinyl alcohol) (PVA) crosslinked phenylboronic (PBA)-modified hyaluronic (HA) hydrogel (HPP) used to encapsulate NPs, resulting bifunctional (si-Fe-HPP) with reactive oxygen species (ROS)-responsive RNAi properties. Studies vitro demonstrated that si-Fe-HPP exhibited excellent biocompatibility, anti-inflammatory prolonged stable retention time knee joint. Intra-articular injection significantly attenuated cartilage degradation mice destabilization medial meniscus (DMM)-induced OA. The not only notably alleviated synovitis, osteophyte formation subchondral bone sclerosis, but also markedly improved physical activity reduced pain DMM-induced mice. This study reveals si-Fe-HPP, its ROS-responsive abilities, can protect chondrocytes attenuate progression, providing novel insights directions for development materials treatment.

Language: Английский

Citations

4
Engineering self-healing adhesive hydrogels with antioxidant properties for intrauterine adhesion prevention DOI Creative Commons

Luyao Feng,

Liqun Wang, Yao Ma

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 82 - 97

Published: March 29, 2023

Intrauterine adhesion (IUA) is the fibrosis within uterine cavity. It second most common cause of female infertility, significantly affecting women's physical and mental health. Current treatment strategies fail to provide a satisfactory therapeutic outcome for IUA patients, leaving an enormous challenge reproductive science. A self-healing adhesive hydrogel with antioxidant properties will be highly helpful in prevention. In this work, we prepare series hydrogels (P10G15, P10G20, P10G25) properties. Those exhibit good can adapt themselves different structures. They possess injectability fit shape human uterus. Moreover, tissue adhesiveness, which desirable stable retention efficacy. The vitro experiments using P10G20 show that effectively scavenges ABTS+, DPPH, hydroxyl radicals, rescuing cells from oxidative stress. addition, offers hemocompatibility vivo biocompatibility. Furthermore, lowers down stress prevents less fibrotic better endometrial regeneration animal model. downregulate fibrosis-related transforming growth factor beta 1 (TGF-β1) vascular endothelial (VEGF). Altogether, these adhesives may alternative clinical intrauterine adhesion.

Language: Английский

Citations

32
Applications of Hydrogels in Osteoarthritis Treatment DOI Creative Commons
Xin Gan, Xiaohui Wang, Yiwan Huang

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 923 - 923

Published: April 22, 2024

This review critically evaluates advancements in multifunctional hydrogels, particularly focusing on their applications osteoarthritis (OA) therapy. As research evolves from traditional natural materials, there is a significant shift towards synthetic and composite known for superior mechanical properties enhanced biodegradability. spotlights novel such as injectable microneedle technology, responsive which have revolutionized OA treatment through targeted efficient therapeutic delivery. Moreover, it discusses innovative hydrogel including protein-based superlubricating potential to reduce joint friction inflammation. The integration of bioactive compounds within hydrogels augment efficacy also examined. Furthermore, the anticipates continued technological deeper understanding hydrogel-based therapies. It emphasizes provide tailored, minimally invasive treatments, thus highlighting critical role advancing dynamic field biomaterial science management.

Language: Английский

Citations

15
Engineering injectable hyaluronic acid-based adhesive hydrogels with anchored PRP to pattern the micro-environment to accelerate diabetic wound healing DOI

Wanglin Duan,

Xianzhen Jin,

Yiyang Zhao

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 337, P. 122146 - 122146

Published: April 16, 2024

Language: Английский

Citations

12
Cocktail Cell‐Reprogrammed Hydrogel Microspheres Achieving Scarless Hair Follicle Regeneration DOI Creative Commons

Shuaifei Ji,

Yingying Li, Lei Xiang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Jan. 15, 2024

Abstract The scar repair inevitably causes damage of skin function and loss appendages such as hair follicles (HF). It is great challenge in wound that how to intervene formation while simultaneously remodeling HF niche inducing situ regeneration. Here, chemical reprogramming techniques are used identify a clinically cocktail (Tideglusib Tamibarotene) can drive fibroblasts toward dermal papilla cell (DPC) fate. Considering the advantage biomaterials tissue their regulation behavior may contributes cellular reprogramming, artificial seeding (AHFS) hydrogel microspheres, inspired by natural processes “seeding harvest”, constructed via using combination liposome nanoparticle drug delivery system, photoresponsive shell, positively charged polyamide modification, microfluidic photocrosslinking techniques. identified core nucleus AHFS. In vitro vivo studies show AHFS regulate fibroblast fate, induce fibroblast‐to‐DPC activating PI3K/AKT pathway, finally promoting healing regeneration inhibiting two‐pronged translational approach. conclusion, provides new effective strategy for functional wounds.

Language: Английский

Citations

11
An Osteoimmunomodulatory Biopatch Potentiates Stem Cell Therapies for Bone Regeneration by Simultaneously Regulating IL‐17/Ferroptosis Signaling Pathways DOI Creative Commons
Shan Liu, Wenle Wang, Zhiyu Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Currently, there are still great challenges in promoting bone defect healing, a common health problem affecting millions of people. Herein an osteoimmunity-regulating biopatch capable stem cell-based therapies for regeneration is developed. A totally biodegradable conjugate first synthesized, which can self-assemble into bioactive nano micelles (PPT NMs). This nanotherapy effectively improves the osteogenesis periodontal ligament cells (PDLSCs) under pathological conditions, by simultaneously regulating IL-17 signaling and ferroptosis pathways. Incorporation PPT NMs electrospun nanofibers affords patch, notably formation two rat models. Janus bio patch then engineered integrating with cell sheet PDLSCs. The obtained shows additionally potentiated capacity, synergistically osteoimmune microenvironment facilitating differentiation. Further surface functionalization tannic acid considerably increases its adhesion to defect, prolongs local retention, sustains bioactivities, thereby offering much better repair effects rats mandibular or cranial defects. Moreover, patches display good safety. Besides defects, this strategy be applied promote spinal cord injury, wound skin burns.

Language: Английский

Citations

10
Hydrogel adhesives for tissue recovery DOI

Haohao Cui,

Jinguo Li

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103496 - 103496

Published: March 1, 2025

Language: Английский

Citations

1
Attenuation of osteoarthritis progression via locoregional delivery of Klotho-expressing plasmid DNA and Tanshinon IIA through a stem cell-homing hydrogel DOI Creative Commons
Peng Wang, Zhibo Zhao,

Ziyang Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 10, 2024

Abstract Background Osteoarthritis (OA) is an aging-related degenerative joint disorder marked by discomfort and rigidity. Senescent chondrocytes release pro-inflammatory cytokines extracellular matrix-degrading proteins, creating inflammatory microenvironment that hinders chondrogenesis accelerates matrix degradation. Targeting of senescent may be a promising approach for the treatment OA. Herein, we describe engineering injectable peptide-hydrogel conjugating stem cell–homing peptide PFSSTKT carrying plasmid DNA-laden nanoparticles Tanshinon IIA (pPNP + TIIA@PFS) was designed to attenuate OA progression improving fostering cartilage regeneration. Results Specifically, pPNP TIIA@PFS elevates concentration anti-aging protein Klotho blocks transmission senescence signals adjacent healthy chondrocytes, significantly mitigating chondrocyte enhancing integrity. Additionally, recruit bone mesenchymal cells directs their subsequent differentiation into achieving satisfactory chondrogenesis. In surgically induced model rats, application results in reduced osteophyte formation attenuation articular degeneration. Conclusions Overall, this study introduces novel alleviation progression, offering foundation potential clinical translation therapy.

Language: Английский

Citations

7
Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review DOI Creative Commons

Diego De León-Oliva,

Diego Liviu Boaru,

Roque Emilio Perez-Exposito

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(11), P. 885 - 885

Published: Nov. 8, 2023

Bone and cartilage tissue play multiple roles in the organism, including kinematic support, protection of organs, hematopoiesis. and, above all, cartilaginous tissues present an inherently limited capacity for self-regeneration. The increasing prevalence disorders affecting these crucial tissues, such as bone fractures, metastases, osteoporosis, or osteoarthritis, underscores urgent imperative to investigate therapeutic strategies capable effectively addressing challenges associated with their degeneration damage. In this context, emerging field engineering regenerative medicine (TERM) has made important contributions through development advanced hydrogels. These crosslinked three-dimensional networks can retain substantial amounts water, thus mimicking natural extracellular matrix (ECM). Hydrogels exhibit exceptional biocompatibility, customizable mechanical properties, ability encapsulate bioactive molecules cells. addition, they be meticulously tailored specific needs each patient, providing a promising alternative conventional surgical procedures reducing risk subsequent adverse reactions. However, some issues need addressed, lack strength, inconsistent low-cell viability. This review describes structure regeneration tissue. Then, we overview hydrogels, classification, synthesis, biomedical applications. Following this, most relevant recent hydrogels TERM regeneration.

Language: Английский

Citations

14