A comprehensive review of hydrogel strategies for repairing peripheral nerve injuries DOI Creative Commons
Shicheng Jia, Hongfa Zhou, Jiayou Chen

et al.

Brain‐X, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 8, 2025

Abstract As an etiological factor underlying physical and mental disability in humans, peripheral nerve injuries (PNIs) can induce pain, sensory impairment, disability. Despite their regenerative ability, nerves cannot self‐repair after severe defects. While grafting is the gold standard for treatment of PNIs, it limited by graft versus host reactions, surgical complications, donor nerves. field material science continues to develop, hydrogels have been proposed use PNI repair biomodification, targeted modification, or loading with biological factors cells. This article reviewed research advances used repair, including simple composite functionalized loaded Based on findings from these reviews, we determined that further clarification mechanisms action modulating cellular functions necessary. In addition, there a need explore synergistic effect novel other biological, physical, biochemical factors. clinical trials are still limited, scientific efforts expected promote application repair.

Language: Английский

A 3D printed biomimetic scaffold for cartilage regeneration with lubrication, load-bearing, and adhesive fixation properties DOI
Pengyu Wei,

Yuanya Ma,

Kaiqi Qin

et al.

Tribology International, Journal Year: 2024, Volume and Issue: 192, P. 109328 - 109328

Published: Jan. 24, 2024

Language: Английский

Citations

6
Multifunctional chitosan-based lanthanide luminescent hydrogel with stretchability, adhesion, self-healing, color tunability and antibacterial ability DOI
Jin‐Tao Wang,

Yingying Pei,

Bing-Jie Han

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130768 - 130768

Published: March 11, 2024

Language: Английский

Citations

6
Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives DOI Creative Commons

Zhuxing Zhou,

Jiajie Wang, Chaoqian Jiang

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(2), P. 114 - 114

Published: Feb. 1, 2024

Meniscus tissue engineering (MTE) has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, they possess tunable properties that allow them to mimic native extracellular matrices provide suitable microenvironment. Additionally, can be minimally invasively injected adjusted match the shape of implant site. They conveniently effectively deliver bioactive additives demonstrate good compatibility with other functional materials. These inherent qualities made hydrogel candidate therapeutic approaches This article provides comprehensive review advancements research on application engineering. Firstly, biomaterials crosslinking strategies used formation are summarized analyzed. Subsequently, role additives, including cells, growth factors, active products, facilitating regeneration is thoroughly discussed. Furthermore, we summarize key issues designing MTE. Finally, conclude current challenges encountered by applications suggest potential solutions addressing these field We hope resource researchers practitioners interested thereby exploration new design possibilities.

Language: Английский

Citations

5
Remodelers of the vascular microenvironment: The effect of biopolymeric hydrogels on vascular diseases DOI
Minhao Li,

Meiqi Jin,

Huazhe Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130764 - 130764

Published: March 9, 2024

Language: Английский

Citations

5
Comprehensive analysis of anoikis-related genes in diagnosis osteoarthritis: based on machine learning and single-cell RNA sequencing data DOI Creative Commons
Jun-Song Zhang, Runsang Pan, Guolu Li

et al.

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 156 - 174

Published: Feb. 29, 2024

Osteoarthritis (OA) is a degenerative disease closely associated with Anoikis. The objective of this work was to discover novel transcriptome-based anoikis-related biomarkers and pathways for OA progression.The microarray datasets GSE114007 GSE89408 were downloaded using the Gene Expression Omnibus (GEO) database. A collection genes linked anoikis has been collected from GeneCards intersection differential (DEARGs) identified Venn diagram. Infiltration analyses used identify study differentially expressed (DEGs). Anoikis clustering DEGs. By gene clustering, two subgroups formed GSE152805 analyse cartilage on single cell level. 10 DEARGs by lasso analysis, subtypes constructed. MEgreen module found in WGCNA MEturquoise most significant clusters WGCNA. XGB, SVM, RF, GLM models five hub (CDH2, SHCBP1, SCG2, C10orf10, P FKFB3), diagnostic model built these performed well training validation cohorts. analysing single-cell RNA sequencing data GSE152805, including 25,852 cells 6 cartilage.

Language: Английский

Citations

5
Cartilage Decellularized Extracellular Matrix-Based Hydrogel with Enhanced Tissue Adhesion and Promoted Chondrogenesis for Cartilage Tissue Engineering DOI
Jun Li, Bo Jiang, Pu Zhang

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(8), P. 4394 - 4408

Published: April 8, 2024

Articular cartilage defects caused by trauma or osteoarthritis remain a significant challenge in clinical practice due to their poor self-healing capacity. Current approaches are generally limited complex procedures certain postoperation complications. Therefore, it is crucial develop an effective strategy for one-step repair with long-term functional regeneration. This study reports the creation of injectable hydrogel composed decellularized extracellular matrix (CdECM) and hyaluronic acid methacrylate (HAMA). In presence photoinitiator ruthenium (Ru)/sodium persulfate (SPS), visible light (450 nm) not only triggered polymerization CdECM HAMA form stable 1 min but also facilitated tyrosine cross-links between biotissue without any further moiety grafting, which cannot be achieved routinely used photoinitiators provides hybrid bioadhesive properties. dual-network demonstrated robust adhesion strength significantly enhanced mechanical performance comparison that alone. Further vitro culture promotive effect on encapsulated porcine bone marrow mesenchymal stem cells toward chondrogenic differentiation after 21 days incubation compared HAMA. Through vivo subcutaneous implantation mouse model two 4 weeks, we illustrated has improved biocompatibility Thus, presented promising biomaterial regeneration through minimally invasive arthroscopic injection practice.

Language: Английский

Citations

5
The application of exosomes in the early diagnosis and treatment of osteoarthritis DOI Creative Commons
Anjing Chen, Yangmengfan Chen, Rong Xiao

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: April 28, 2023

With the increase in human lifespan and aggravation of global aging, incidence osteoarthritis (OA) is increasing annually. To better manage control progression OA, prompt diagnosis treatment for early-stage OA are important. However, a sensitive diagnostic modality therapy early have not been well developed. The exosome class extracellular vesicles containing bioactive substances, that can be delivered directly from original cells to neighboring modulate cellular activities through intercellular communication. In recent years, exosomes considered important OA. Synovial fluid its encapsulated e.g., microRNA, lncRNA, proteins, only distinguish stages but also prevent by targeting cartilage or indirectly modulating immune microenvironment joints. this mini-review, we include studies on therapeutic modalities hope provide new direction disease future.

Language: Английский

Citations

12
Bioadhesive and Injectable Hydrogels and Their Correlation with Mesenchymal Stem Cells Differentiation for Cartilage Repair: A Mini-Review DOI Open Access
Ján Kováč, Petra Priščáková, Helena Gbelcová

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(21), P. 4228 - 4228

Published: Oct. 26, 2023

Injectable bioadhesive hydrogels, known for their capacity to carry substances and adaptability in processing, offer great potential across various biomedical applications. They are especially promising minimally invasive stem cell-based therapies treating cartilage damage. This approach harnesses readily available mesenchymal cells (MSCs) differentiate into chondrocytes regeneration. In this review, we investigate the relationship between bioadhesion MSC differentiation. We summarize fundamental principles of discuss recent trends hydrogels. Furthermore, highlight specific applications conjunction with cells, particularly context repair. The review also encompasses a discussion on testing methods hydrogels direct techniques differentiating MSCs hyaline chondrocytes. These approaches explored within both clinical laboratory settings, including use genetic tools. While offers valuable insights interconnected aspects these topics, it underscores need further research fully grasp complexities relationship.

Language: Английский

Citations

11
An injectable cartilage-coating composite with long-term protection, effective lubrication and chondrocyte nourishment for osteoarthritis treatment DOI

Hongfu Cao,

Siyan Deng,

Xi Chen

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 179, P. 95 - 105

Published: March 19, 2024

Language: Английский

Citations

4
Natural based hydrogels promote chondrogenic differentiation of human mesenchymal stem cells DOI Creative Commons

Tina Zahedi Tehrani,

Shiva Irani, Abdolreza Ardeshirylajimi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: March 19, 2024

Background: The cartilage tissue lacks blood vessels, which is composed of chondrocytes and ECM. Due to this vessel-less structure, it difficult repair damages. One the new methods damage use engineering. In present study, was attempted simulate a three-dimensional environment similar natural ECM by using hydrogels made materials, including Chitosan different ratios Alginate. Material methods: Chitosan, alginate Chitosan/Alginate were fabricated. Fourier Transform Infrared, XRD, swelling ratio, porosity measurement degradation tests applied scaffolds characterization. After that, human adipose derived-mesenchymal stem cells (hADMSCs) cultured on then their viability chondrogenic differentiation capacity studied. Safranin O Alcian blue staining, immunofluorescence staining real time RT-PCR used as analytical for potential evaluation hADMSCs when hydrogels. Results: highest rate detected in (1:0.5) group scaffold biocompatibility results revealed that groups not significantly with control group. PCR grown hydrogel higher than those cell other groups. Conclusion: Taken together, these suggest could be promising candidate engineering applications.

Language: Английский

Citations

4