Functions of Differentially Regulated miRNAs in Breast Cancer Progression: Potential Markers for Early Detection and Candidates for Therapy DOI Creative Commons

Kumar Subramanian,

Raghu Sinha

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 691 - 691

Published: March 20, 2024

Breast cancer remains a major global health concern, emphasizing the need for reliable biomarkers to enhance early detection and therapeutic interventions. MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNA (~22 nt in length) molecules, which aberrantly expressed seem influence tumor behavior progression. Specific miRNA dysregulation has been associated with breast initiation, proliferation, invasion, metastasis. Understanding functional roles of these miRNAs provides valuable insights into intricate molecular mechanisms underlying The diagnostic potential as non-invasive is burgeoning area research. This review aims elucidate functions differentially regulated progression assess their markers detection, stage-specific biomarkers, targets. Furthermore, ability specific serve prognostic indicators predictors treatment response highlights clinical utility guiding personalized

Language: Английский

Principles of CRISPR-Cas9 technology: Advancements in genome editing and emerging trends in drug delivery DOI Creative Commons
Alaa A. A. Aljabali, Mohamed El‐Tanani, Murtaza M. Tambuwala

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 92, P. 105338 - 105338

Published: Jan. 6, 2024

The rapid advancement of CRISPR-Cas9 technology has instigated a profound transformation in genome editing with significant implications for fields like health, agriculture, and biotechnology. This abstract provides an overview the historical significance fundamental components CRISPR-Cas9, notably Cas9 protein guide RNA, underscoring its pivotal role genetic manipulation. It emphasizes CRISPR-Cas9's preeminence domain precise editing, driving breakthroughs personalized medicine, gene therapy, agriculture. Of paramount importance is integration nanomaterials, encompassing lipid-based polymeric nanoparticles, alongside viral vectors, serving as potent vehicles augmenting delivery efficiency precision. We explore strategies aimed at enhancing through while also addressing ethical regulatory considerations. In expert opinion section, we offer nuanced perspective on present state field, highlighting potential transformative progress research therapy. stands brink unlocking new possibilities providing innovative solutions to address pressing global challenges.

Language: Английский

Citations

34
Epigenetics-targeted drugs: current paradigms and future challenges DOI Creative Commons

Wanlin Dai,

Xinbo Qiao, Yuanyuan Fang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Nov. 26, 2024

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone RNA remodeling, and non-coding regulation. These mechanisms their associated enzymes convey genetic information independently of base sequences, playing essential roles in organismal development homeostasis. Conversely, disruptions epigenetic landscapes critically influence the pathogenesis various human diseases. This understanding has laid robust theoretical groundwork for developing drugs that target epigenetics-modifying pathological conditions. Over past two decades, growing array small molecule targeting such as methyltransferase, deacetylase, isocitrate dehydrogenase, enhancer zeste homolog 2, have been thoroughly investigated implemented therapeutic options, particularly oncology. Additionally, numerous epigenetics-targeted are undergoing clinical trials, offering promising prospects benefits. review delineates epigenetics physiological contexts underscores pioneering studies on discovery implementation drugs. include inhibitors, agonists, degraders, multitarget agents, aiming to identify practical challenges avenues future research. Ultimately, this aims deepen epigenetics-oriented strategies further application settings.

Language: Английский

Citations

24
Insights into IL-6/JAK/STAT3 Signaling in the Tumor Microenvironment: Implications for Cancer Therapy DOI

Win Lwin Thuya,

Yang Cao,

Paul Chi-Lui Ho

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

3
Nanotechnology-based non-viral vectors for gene delivery in cardiovascular diseases DOI Creative Commons

Liping Jiao,

Zhuokai Sun,

Zhihong Sun

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 18, 2024

Gene therapy is a technique that rectifies defective or abnormal genes by introducing exogenous into target cells to cure the disease. Although gene has gained some accomplishment for diagnosis and of inherited acquired cardiovascular diseases, how efficiently specifically deliver targeted lesion sites without being cleared blood system remains challenging. Based on nanotechnology development, non-viral vectors provide promising strategy overcoming difficulties in therapy. At present, according physicochemical properties, nanotechnology-based include polymers, liposomes, lipid nanoparticles, inorganic nanoparticles. Non-viral have an advantage safety, efficiency, easy production, possessing potential clinical application value when compared with viral vectors. Therefore, we summarized recent research progress diseases based commonly used vectors, hopefully providing guidance orientation future relevant research.

Language: Английский

Citations

8
Epigenetic Mechanisms in CRSwNP: The Role of MicroRNAs as Potential Biomarkers and Therapeutic Targets DOI Creative Commons
Alkmini Gatsounia, Georgios Schinas,

Gerasimos Danielides

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 114 - 114

Published: Feb. 10, 2025

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent inflammatory disease of the upper airway, contributing significantly to global burden. CRSwNP characterized by sustained and exaggerated inflammation, accompanied marked changes in gene protein expression regulated through intricate molecular mechanisms. MicroRNAs (miRNAs), small single-stranded RNA molecules that regulate at transcriptional post-transcriptional levels, have emerged as pivotal players pathophysiology. Dysregulated miRNA implicated numerous human diseases, including cancer, asthma, disorders, highlighting their broad clinical relevance. In CRSwNP, miRNAs influence important pathways, T2 immune responses epithelial-mesenchymal transition (EMT), which leads chronic inflammation tissue remodeling. Profiling studies identified specific potential biomarkers for severity, prognosis, therapeutic response, offering pathway personalized medicine. Furthermore, advances extracellular vesicles (sEVs) exosomes, naturally transport miRNAs, provide innovative avenues targeted delivery, minimizing systemic side effects. This review explores current knowledge on function emphasizing role pathogenesis targets.

Language: Английский

Citations

1
Non-Coding RNAs in Cancer: Structure, Function, and Clinical Application DOI Open Access
Éva Márton, Alexandra Varga,

Dóra Domoszlai

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 579 - 579

Published: Feb. 8, 2025

We are on the brink of a paradigm shift in both theoretical and clinical oncology. Genomic transcriptomic profiling, alongside personalized approaches that account for individual patient variability, increasingly shaping discourse. Discussions future cancer medicine mainly dominated by potential non-coding RNAs (ncRNAs), which play prominent role progression metastasis formation regulating expression oncogenic or tumor suppressor proteins at transcriptional post-transcriptional levels; furthermore, their cell-free counterparts might be involved intercellular communication. Non-coding considered to promising biomarker candidates early diagnosis as well therapeutic agents. This review aims provide clarity amidst vast body literature focusing diverse species ncRNAs, exploring structure, origin, function, applications miRNAs, siRNAs, lncRNAs, circRNAs, snRNAs, snoRNAs, eRNAs, paRNAs, YRNAs, vtRNAs, piRNAs. discuss molecular methods used detection functional studies vitro vivo. also address challenges must overcome enter new era therapy will reshape

Language: Английский

Citations

1
Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence DOI

K Sandhanam,

Tamilanban Thamaraikani,

K. Manasa

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 553, P. 1 - 18

Published: June 27, 2024

Language: Английский

Citations

5
CRISPR/Cas9 gene editing: a novel strategy for fighting drug resistance in respiratory disorders DOI Creative Commons
Bashdar Mahmud Hussen,

Zana B. Najmadden,

Snur Rasool Abdullah

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 14, 2024

Abstract Respiratory disorders are among the conditions that affect respiratory system. The healthcare sector faces challenges due to emergence of drug resistance prescribed medications for these illnesses. However, there is a technology called CRISPR/Cas9, which uses RNA guide DNA targeting. This has revolutionized our ability manipulate and visualize genome, leading advancements in research treatment development. It can effectively reverse epigenetic alterations contribute resistance. Some studies focused on health have shown targeting genes using CRISPR/Cas9 be challenging when it comes reducing patients with disorders. Nevertheless, important acknowledge limitations this technology, such as off-target effects, immune system reactions Cas9, associated delivery methods. Despite limitations, review aims provide knowledge about genome editing tools explore how they help overcome Additionally, study discusses concerns related applications CRISPR provides an overview successful clinical trial studies.

Language: Английский

Citations

4
Machine learning predicts cuproptosis-related lncRNAs and survival in glioma patients DOI Creative Commons

Shaocai Hao,

Maoxiang Gao,

Qin Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 27, 2024

Language: Английский

Citations

4
MicroRNA155 in non-small cell lung cancer: a potential therapeutic target DOI Creative Commons
Xiangju Wei, Xiaolin Xiong, Zhiyuan Chen

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 3, 2025

Lung cancer (LC) is the second most commonly diagnosed among both men and women, it stands as leading cause of cancer-related mortality, characterized by high rates morbidity mortality. Among its subtypes, non-small cell lung (NSCLC) prevalent one challenging malignant tumors to treat. To date, various therapeutic approaches, including surgery, radiotherapy, chemotherapy, have been employed in management cancer; however, due aggressive nature, survival remain low. Consequently, exploring novel treatment strategies paramount importance. MicroRNAs (miRNAs), a large family non-coding RNAs, play crucial roles regulating several key biological processes, proliferation, differentiation, inflammation, apoptosis. these, microRNA155(miR-155) conserved versatile miRNAs, predominantly overexpressed diseases, tumors. This review elucidates functions miR-155 NSCLC discusses potential significance target for future research directions clinical applications.

Language: Английский

Citations

0