Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
Neuropathic
pain
(NP)
is
a
debilitating
condition
stemming
from
damage
to
the
somatosensory
system
frequently
caused
by
nerve
injuries
or
lesions.
While
existing
treatments
are
widely
employed,
they
often
lead
side
effects
and
lack
specificity.
This
study
aimed
alleviate
NP
developing
an
innovative
sustained-release
thermosensitive
hydrogel
system.
The
incorporates
hyaluronic
acid
(HA)/Pluronic
F127
injectable
bupivacaine
(Bup,
B)
in
combination
with
poly(lactic-co-glycolic
acid;
PLGA)/modified
magnesium
hydroxide
(MH)/luteolin
(Lut;
PML)
microspheres
(PML@B/Gel).
PML@B/Gel
was
designed
for
localized
prolonged
co-delivery
of
Bup
Lut
as
anesthetic
anti-inflammatory
agent,
respectively.
Our
studies
demonstrated
that
had
exceptional
biocompatibility,
anti-inflammatory,
antioxidant
properties.
In
addition,
it
exhibited
efficient
relief
vitro
cellular
assays.
Moreover,
this
functional
showed
substantial
sustained
drug
release
while
diminishing
microglial
activation.
Consequently,
effectively
mitigated
mechanical
allodynia
thermal
hyperalgesia
vivo
rat
models
chronic
constriction
injury
(CCI).
Based
on
our
research
findings,
emerges
promising
therapeutic
approach
protracted
treatment
NP.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(33), P. 7977 - 8006
Published: Jan. 1, 2024
The
objective
of
this
review
is
to
provide
an
up-to-date
and
all-encompassing
account
the
recent
advancements
in
domain
interactive
wound
dressings.
Considering
gap
between
achieved
desired
clinical
outcomes
with
currently
available
or
under-study
healing
therapies,
newer
more
specific
options
based
on
type
phase
are
reviewed.
Starting
from
comprehensive
description
process,
a
detailed
classification
dressings
presented.
Subsequently,
we
present
elaborate
significant
discussion
describing
(unconventional)
Latter
includes
biopolymer-based,
bioactive-containing
biosensor-based
smart
dressings,
which
discussed
separate
sections
together
their
applications
limitations.
Moreover,
(2-5
years)
trials,
patents
unconventional
marketed
products,
other
information
advanced
care
designs
techniques
discussed.
future
research
direction
highlighted,
peptides,
proteins,
human
amniotic
membranes
as
potential
Finally,
conclude
that
field
needs
further
development
offers
scope
for
integrating
process
technologies.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: March 1, 2023
The
tissue
reconstruction
of
diabetic
wounds
mainly
depends
on
the
proliferation
and
remodelling
cutaneous
cells
around
transplantation
random
skin
flaps,
however,
or
survival
flaps
are
difficult
due
to
severe
inflammation
other
problems
caused
by
diabetes.
stem
cell-derived
exosomes
loaded
with
miRNA
can
be
an
effective
therapeutic
strategy
for
promoting
wound
healing.
Therefore,
in
this
study,
engineered
derived
from
miR-132-overexpressing
adipose
(miR-132-exo)
was
obtained
healing
flaps.
In
vitro,
miR-132-exo
promoted
migration
human
umbilical
vein
endothelial
(HUVECs).
vivo,
streptozotocin
(STZ)
induced
mice
were
used
create
full-thickness
further
investigate
effect
miR-132-exo.
results
showed
evidently
enhanced
promote
healing,
through
reducing
local
inflammation,
angiogenesis
stimulating
M2-macrophages
polarization
mediated
NF-κB
signaling
pathway.
These
novel
findings
demonstrated
that
a
potent
treating
inflammatory-related
disease.
npj Materials Degradation,
Journal Year:
2024,
Volume and Issue:
8(1)
Published: July 6, 2024
Abstract
The
biological
response
to
biomaterials
plays
a
crucial
role
in
selecting
suitable
materials
for
the
formulation
and
development
of
tissue
engineering
platforms.
Biodegradation
is
one
properties
that
considered
appropriate
biomedical
applications.
process
breaking
down
large
molecules
into
smaller
with/without
aid
catalytic
enzymes.
biodegradation
chemical
absorption,
distribution,
metabolism,
excretion,
toxicity
(ADMET)
small
body.
Degradation
can
be
followed
by
assessing
physical,
mechanical,
attributes
biomaterials.
There
are
several
techniques/parameters
targeted
when
studying
degradation
biomaterials,
with
gravimetric
analysis,
surface
erosion,
morphological
changes
being
largely
employed
techniques.
However,
techniques
present
few
limitations,
such
as
technical
errors
material
solubility
mistaken
degradation,
these
infer
but
not
confirm
they
do
provide
composition
fragmenting/fragmented
molecules.
American
Society
Testing
Materials
(ASTM)
guidelines
parameters
biodegradation.
ASTM
assessment
approaches
need
updated
sufficient
evidence
draw
conclusive
decisions
regarding
In
this
review,
critically
reviewed
about
their
advantages
disadvantages,
suggestions
on
how
still
play
This
review
could
assist
researchers
employ
cost-effective,
efficient,
multiple
evaluate
information
Suggested
future
should
include
measuring
(such
chemical,
or
physical
biomaterials)
real-time,
employing
non-invasive,
continuous,
automated
processes.
Small,
Journal Year:
2024,
Volume and Issue:
20(23)
Published: Feb. 22, 2024
Abstract
Skin
injury
repair
is
a
dynamic
process
involving
series
of
interactions
over
time
and
space.
Linking
human
physiological
processes
with
materials’
changes
poses
significant
challenge.
To
match
the
wound
healing
process,
spatiotemporal
controllable
biomimetic
skin
developed,
which
comprises
three‐dimensional
(3D)
printed
membrane
as
epidermis,
cell‐containing
hydrogel
dermis,
cytokine‐laden
hypodermis.
In
initial
stage
wound,
frame
aids
closure
through
pre‐tension,
while
cells
proliferate
within
hydrogel.
Next,
disintegrates
time,
released
from
migrate
along
residual
membrane.
Throughout
continuous
cytokines
release
hypodermis
ensures
comprehensive
nourishment.
The
findings
reveal
that
in
rat
full‐thickness
defect
model,
demonstrated
rate
eight
times
higher
than
blank
group,
double
collagen
content,
particularly
early
process.
Consequently,
it
reasonable
to
infer
this
holds
promising
potential
accelerate
repair.
This
mechanobiological
effects
regulation
emerges
option
for
tissue
regeneration
engineering.
Engineered Regeneration,
Journal Year:
2024,
Volume and Issue:
5(1), P. 111 - 123
Published: Jan. 14, 2024
The
use
of
antibacterial
dressings
is
crucial
in
the
prevention
and
treatment
wound
infection
emergency
situations.
However,
efficacy
compromised
by
long-term
storage
or
exposure
to
harsh
conditions.
Here,
an
ultrastable
in-situ
silver
nanoparticle
dressing
(AgSNP@CD)
was
prepared
for
effective
emergency.
fabrication
process
AgSNP@CD
simple,
suitable
large-scale
production.
Due
strong
interaction
between
synthesized
AgNPs
cotton
fabric,
owned
remarkable
stability,
thus
retaining
its
antimicrobial
even
after
(up
2
years)
under
extreme
conditions
(damp
heat,
low
temperatures,
low-oxygen,
water
immersion,
acid-alkali
erosion).
Both
vitro
vivo
results
demonstrated
extraordinary
stability
AgSNP@CD,
facilitating
healing
In
particular,
exhibited
a
superior
effect
on
severe
bacteria-infected
trauma
can
prevent
occurrence
sepsis
effectively.
exceptional
complex
make
it
well-suited
strategy
Journal of Biological Engineering,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Feb. 5, 2025
The
rise
of
antibiotic
resistance
has
made
bacterial
infections
a
persistent
global
health
issue.
In
particular,
extracellular
polymeric
substances
(EPS)
secreted
by
bacteria
limit
the
effectiveness
conventional
antibiotics,
making
biofilm
removal
challenging.
To
address
this,
we
created
ND@PDA
nanoparticles
coating
surface
nanodiamonds
(ND)
with
polydopamine
(PDA).
These
were
then
integrated
into
polyvinyl
alcohol
to
fabricate
PVA/ND@PDA
nanofiber
scaffolds,
resulting
in
an
innovative
platform
enhanced
photothermal,
antibacterial
and
antibiofilm
properties.
Upon
exposure
near-infrared
(NIR)
light,
scaffolds
exhibited
significant
photothermal
activity,
oxidative
stress
effectively
damaging
key
components,
such
as
biofilm,
membranes,
proteins.
Additionally,
catechol
groups
PDA
provided
strong
cell
adhesion
high
biocompatibility
on
surface.
Our
research
proposes
that
not
only
addresses
antibiotic-resistant
but
also
contributes
advancements
wound
healing
therapies
enabling
controlled
action
minimal
toxicity.
