Biology,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1063 - 1063
Published: July 28, 2023
Mesenchymal
stromal/stem
cells
(MSCs)
have
emerged
as
a
therapeutic
tool
in
regenerative
medicine.
Recent
studies
shown
that
exosome
(EXO)-derived
microRNAs
(miRNAs)
play
crucial
role
mediating
MSC
functions.
Additionally,
intracellular
miRNAs
been
found
to
regulate
capacities.
However,
the
molecular
mechanisms
underlying
miRNA-mediated
effects
are
not
fully
understood.
We
used
3D
culture
and
IFN-γ
prime/enhance
terms
of
functional
miRNAs.
After
priming,
our
analysis
revealed
stable
variations
miRNA
among
biological
replicates.
Conversely,
significant
variability
was
observed
EXOs
released
from
replicates
priming
treatment.
For
each
we
distinct
expression
profiles
between
MSCs
their
EXOs.
Moreover,
both
types
gene
ontology
(GO)
deregulated
highlighted
involvement
tissue
repair/regeneration
pathways.
In
particular,
enhanced
angiogenic
properties
EXOs,
while
treatment
enriched
associated
with
immunomodulatory
These
findings
suggest
promising
strategies
for
enhancing
potential
by
modulating
expression.
identified
may
contribute
understanding
MSCs.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(30)
Published: Sept. 15, 2023
Wound
healing
is
an
urgent
clinical
challenge,
particularly
in
the
case
of
chronic
wounds.
Traditional
approaches
to
wound
have
limited
therapeutic
efficacy
due
lengthy
times,
risk
immune
rejection,
and
susceptibility
infection.
Recently,
adipose-derived
mesenchymal
stem
cell-derived
exosomes
(ADSC-exos)
emerged
as
a
promising
modality
for
tissue
regeneration
repair.
In
this
study,
development
novel
extracellular
matrix
hydrogel@exosomes
(ECM@exo)
reported,
which
entails
incorporation
ADSC-exos
into
hydrogel
(ECM
hydrogel).
This
solution
forms
at
physiological
temperature
(≈37
°C)
upon
local
injection
site.
ECM@exo
enables
sustained
release
from
ECM
hydrogel,
maintains
high
concentrations
The
displays
good
biocompatibility
biodegradability.
vivo
vitro
results
demonstrate
that
treatment
effectively
reduces
inflammation
promotes
angiogenesis,
collagen
deposition,
cell
proliferation,
migration,
thereby
accelerating
process.
Overall,
innovative
approach
offers
new
avenue
via
biological
with
controlled
exosome
release.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 5, 2024
Abstract
Diabetic
wounds
are
characterized
by
incomplete
healing
and
delayed
healing,
resulting
in
a
considerable
global
health
care
burden.
Exosomes
lipid
bilayer
structures
secreted
nearly
all
cells
express
characteristic
conserved
proteins
parent
cell-associated
proteins.
harbor
diverse
range
of
biologically
active
macromolecules
small
molecules
that
can
act
as
messengers
between
different
cells,
triggering
functional
changes
recipient
thus
endowing
the
ability
to
cure
various
diseases,
including
diabetic
wounds.
accelerate
wound
regulating
cellular
function,
inhibiting
oxidative
stress
damage,
suppressing
inflammatory
response,
promoting
vascular
regeneration,
accelerating
epithelial
facilitating
collagen
remodeling,
reducing
scarring.
from
tissues
or
potentially
possess
functions
varying
levels
promote
healing.
For
example,
mesenchymal
stem
cell-derived
exosomes
(MSC-exos)
have
favorable
potential
field
due
their
superior
stability,
permeability,
biocompatibility,
immunomodulatory
properties.
Exosomes,
which
derived
skin
components,
modulate
inflammation
regeneration
key
turn
promotes
Therefore,
this
review
mainly
emphasizes
roles
mechanisms
sources,
represented
MSCs
improving
A
deeper
understanding
therapeutic
will
yield
promising
candidates
perspectives
for
management.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(5), P. 1778 - 1795
Published: Jan. 1, 2024
Skin
tissue,
composed
of
epidermis,
dermis,
and
subcutaneous
is
the
largest
organ
human
body.It
serves
as
a
protective
barrier
against
pathogens
physical
trauma
plays
crucial
role
in
maintaining
homeostasis.Skin
diseases,
such
psoriasis,
dermatitis,
vitiligo,
are
prevalent
can
seriously
impact
quality
patient
life.Exosomes
lipid
bilayer
vesicles
derived
from
multiple
cells
with
conserved
biomarkers
important
mediators
intercellular
communication.Exosomes
skin
cells,
blood,
stem
main
types
exosomes
that
involved
modulating
microenvironment.The
dysregulation
exosome
occurrence
transmission,
well
alterations
their
cargoes,
complex
pathogenesis
inflammatory
autoimmune
diseases.Therefore,
promising
diagnostic
therapeutic
targets
for
diseases.Importantly,
exogenous
exosomes,
or
play
improving
environment
repairing
damaged
tissues
by
carrying
various
specific
active
substances
involving
variety
pathways.In
domain
clinical
practice,
have
garnered
attention
prospective
agents
including
psoriasis
vitiligo.Furthermore,
investigations
substantiated
regenerative
efficacy
cell-derived
repair.In
this
review,
we
mainly
summarize
latest
studies
about
mechanisms
applications
dermatology,
atopic
systemic
lupus
erythematosus,
sclerosis,
diabetic
wound
healing,
hypertrophic
scar
keloid,
aging.This
will
provide
novel
perspective
diagnosis
treatment
dermatosis.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 6, 2024
Abstract
Adipose-derived
stem
cells
(ADSCs)
are
a
subset
of
mesenchymal
(MSCs)
isolated
from
adipose
tissue.
They
possess
remarkable
properties,
including
multipotency,
self-renewal,
and
easy
clinical
availability.
ADSCs
also
capable
promoting
tissue
regeneration
through
the
secretion
various
cytokines,
factors,
extracellular
vesicles
(EVs).
ADSC-derived
EVs
(ADSC-EVs)
act
as
intercellular
signaling
mediators
that
encapsulate
range
biomolecules.
These
have
been
found
to
mediate
therapeutic
activities
donor
by
proliferation
migration
effector
cells,
facilitating
angiogenesis,
modulating
immunity,
performing
other
specific
functions
in
different
tissues.
Compared
themselves,
ADSC-EVs
offer
advantages
such
fewer
safety
concerns
more
convenient
transportation
storage
for
application.
As
result,
these
received
significant
attention
cell-free
agents
with
potential
future
application
regenerative
medicine.
In
this
review,
we
focus
on
recent
research
progress
regarding
medical
use
across
conditions,
wound
healing,
chronic
limb
ischemia,
myocardial
infarction,
diabetic
nephropathy,
fat
graft
survival,
bone
regeneration,
cartilage
tendinopathy
tendon
peripheral
nerve
acute
lung
injury,
among
others.
We
discuss
underlying
mechanisms
responsible
inducing
effects.
believe
deciphering
biological
effects,
associated
will
provide
foundation
developing
novel
approach
Graphical
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3943 - 3956
Published: May 1, 2024
Autoimmune
diseases
refer
to
a
group
of
conditions
where
the
immune
system
produces
an
response
against
self-antigens,
resulting
in
tissue
damage.
These
have
profound
impacts
on
health
patients.
In
recent
years,
with
rapid
development
field
biomedicine,
engineered
exosomes
emerged
as
noteworthy
class
biogenic
nanoparticles.
By
precisely
manipulating
cargo
and
surface
markers
exosomes,
gained
enhanced
anti-inflammatory,
immunomodulatory,
reparative
abilities,
providing
new
prospects
for
treatment
autoimmune
diseases.
Engineered
not
only
facilitate
efficient
delivery
bioactive
molecules
including
nucleic
acids,
proteins,
cytokines,
but
also
possess
capability
modulate
cell
functions,
suppress
inflammation,
restore
homeostasis.
This
review
mainly
focuses
applications
several
typical
Additionally,
this
article
comprehensively
summarizes
current
approaches
modification
engineering
outlines
their
clinical
applications.
conclusion,
innovative
therapeutic
approach,
hold
promise
management
However,
while
significant
progress
has
been
made,
further
rigorous
research
is
still
needed
address
challenges
that
may
encounter
intervention
process,
order
successful
translation
into
practice
ultimately
benefit
broader
population
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2278 - 2278
Published: March 4, 2025
The
depletion
of
the
ozone
layer
has
intensified
ultraviolet
(UV)
radiation
exposure,
leading
to
oxidative
stress,
DNA
damage,
inflammation,
photoaging,
and
skin
cancer.
Medicinal
plants,
widely
used
in
Traditional
Herbal
Medicine
(THM),
particularly
Chinese
(TCM),
have
demonstrated
significant
therapeutic
potential
due
their
well-characterized
active
compounds
established
photoprotective
effects.
This
review
systematically
evaluates
18
medicinal
plants
selected
based
on
traditional
use
skin-related
conditions
emerging
evidence
supporting
efficacy
against
UV-induced
damage.
Their
bioactive
components
exert
antioxidant,
anti-inflammatory,
repair,
depigmentation
effects
by
modulating
key
signaling
pathways,
including
Nrf2/ARE-,
MAPK/AP-1-,
PI3K/Akt-,
MITF/TYR-related
melanogenesis
pathways.
Moreover,
novel
drug
delivery
systems,
such
as
exosomes,
hydrogels,
nanoemulsions,
significantly
enhanced
stability,
bioavailability,
penetration
these
compounds.
However,
challenges
remain
standardizing
plant-derived
formulations,
elucidating
complex
synergistic
mechanisms,
translating
preclinical
findings
into
clinical
applications.
Future
interdisciplinary
research
technological
advancements
will
be
essential
harness
full
for
damage
prevention
treatment.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 725 - 725
Published: March 16, 2025
The
bulk
of
RNA
produced
from
the
genome
complex
organisms
consists
a
very
large
number
transcripts
lacking
protein
translational
potential
and
collectively
known
as
noncoding
RNAs
(ncRNAs).
Initially
thought
to
be
mere
products
spurious
transcriptional
noise,
ncRNAs
are
now
universally
recognized
pivotal
players
in
cell
regulatory
networks
across
broad
spectrum
biological
processes.
Owing
their
critical
roles,
ncRNA
dysfunction
is
closely
associated
with
etiopathogenesis
various
human
malignancies,
including
cancer.
As
such,
represent
valuable
diagnostic
biomarkers
well
targets
for
innovative
therapeutic
intervention.
In
this
review,
we
focus
on
microRNAs
(miRNAs)
long
(lncRNAs),
two
most
extensively
studied
classes
field
biology.
After
outlining
key
concepts
miRNA
lncRNA
biogenesis
pathways,
examine
multiple
roles
mediating
epigenetic
regulation
gene
expression
chromatin
organization.
Finally,
by
providing
numerous
examples
specific
miRNAs
lncRNAs,
discuss
how
dysregulation
these
mechanisms
contributes
onset
and/or
progression
diseases.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 14, 2023
Wound
healing
is
a
sophisticated
process
consisting
of
serial
phases
with
overlaps,
including
hemostasis,
inflammation,
proliferation,
and
remodeling.
The
inflammation
response
an
early
that
plays
crucial
role
in
eliminating
microbes
clearing
damaged
cell
debris.
However,
some
pathological
circumstances,
such
as
diabetes
mellitus,
ischemia,
trauma,
deep
burn,
etc.,
abnormal
can
cause
impaired
wound
healing.
Adipose-derived
stem
cells
(ADSCs)
belong
to
the
mesenchymal
(MSC)
family
exhibit
prospective
applications
tissue
regeneration
dermatological
repairs.
ADSC-secreted
extracellular
vesicles
(ADSC-EVs)
mimic
functions
ADSCs
without
concerns
survival,
immune
response,
or
ethical
issues.
Studies
have
revealed
ADSC-EVs
inhibit
responses
accelerate
through
various
mechanisms.
Moreover,
studies
explored
modifications
cargo
components
enhance
their
therapeutic
efficacy.
Given
increasing
focusing
on
potential
healing,
how
they
interfere
different
this
has
been
investigated
pieces.
In
review,
we
summarized
all
up-to-date
evidence
map
clearer
picture
underlying
mechanisms
response.
aiming
at
were
also
reviewed
provide
strategies
for
future
investigators.
