Safety and risks of CBD oils purchased online: unveiling uncertain quality and vague health claims DOI Creative Commons
Róbert György Vida,

Lilien Victoria Strauss,

Ákos Bajtel

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 14, 2023

Introduction: The unmet need for highly effective, naturally derived products with minimal side effects results in the over-popularity of ever-newer medicinal plants. In middle 2010, containing cannabidiol (CBD), one special metabolites Cannabis sativa , started to gain popularity. For consumers and healthcare providers alike, legal context surrounding marketing CBD is not entirely clear, safety using some doubt. Companies online product market profit from confusion around oils. Methods: our study, we employed a complex method known as risk-based mapping pharmaceutical market, which included health claim content analysis stores, test purchases, labeling quantitative content. Results: There were discovered 16 retailers selling an average 2–7 goods oils concentration 3%–5% (30–50 mg/mL) CBD. majority (n/N = 10/16, 62.5%) displayed potential health-related benefits indirectly on their website, case web shop 1/16, 6.3%), detected COVID-19-related use. Altogether, 30 types purported “indications” collected. A total 12 oil test-purchased December 2020. Upon evaluating packaging information, noticed that three 3/12, 25%) lacked instructions use, hence increasing risk inappropriate application dosing. was quantified UHPLC. measured concentrations ranged 19.58 mg/mL 54.09 (mean 35.51 mg/mL, median 30.63 SD ± 12.57 mg/mL). One (8.33%) underlabeled, five (41.67%) over-labeled, only every second (50%) appropriately labeled based assessment concentration. Discussion: Further research quality control are necessary establish regulatory usage classification other cannabinoids nonmedicinal (e.g., food supplements), authorities policymakers worldwide struggle uncertainties products.

Language: Английский

Product labeling accuracy and contamination analysis of commercially available cannabidiol product samples DOI Creative Commons

Barry E. Gidal,

Ryan G. Vandrey,

Chela Wallin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 18, 2024

Background and objective: Commercially available cannabidiol (CBD) products are increasingly being used for medicinal purposes, including the treatment of various neurological conditions, but there growing concerns around adherence to quality control measures that protect consumers. This study was conducted assess purity label accuracy commercially CBD products. Methods: were chosen from open stream commerce in United States based on formulations as a tincture, gummy, vape, or topical product. Cannabinoid concentrations analyzed verify “full spectrum,” “broad “CBD isolate” claims product label. Analysis presence contaminants included evaluation heavy metals, pesticides, residual solvents. Labeled actual total amounts levels impurities such solvents, pesticides measured. Results: A 202 (100 tinctures, 48 gummies, 34 vape products, 20 topicals) represent broad sample States. Of tested (full spectrum, n = 84; 28; isolate, 37), 26% did not meet definition type claimed packaging. The majority (74%) deviated their claim potency by at least 10%. Heavy metals detected 52 times across 44 tested, with lead most prevalent metal. Residual solvents 446 181 highest reported hexane, m/p-xylene, methanol, o-xylene. 232 26 found 55 30 3% 1% violated >1 regulatory threshold. Discussion: demonstrated within current inaccurately labeled. several some which thresholds. Thus, uniform compliance is lacking raises consumer protection concerns. Improved oversight this industry recommended.

Language: Английский

Citations

11
Validated LC-MS/MS methodology for the quantification of CBD, trace level THCA and UK controlled cannabinoids (Δ9THC, Δ8THC, CBN and THCV) in food samples DOI Creative Commons
Tabatha Hambidge,

Ralph G. Nash,

Steve Corless

et al.

Analytical Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Quantitative analysis of CBD containing food samples to assess compliance with label claims and controlled substances regulations.

Language: Английский

Citations

1
Evaluation of cannabidiol-based products in Brazil: how can current regulations influence their labeling quality? DOI Creative Commons
Andréa Donatti Gallassi, André Wagner Carvalho de Oliveira, Nathália Silva Mendes

et al.

Journal of Cannabis Research, Journal Year: 2025, Volume and Issue: 7(1)

Published: Feb. 22, 2025

Abstract There is concern about the quality of cannabis-based products used in Brazil, mainly cannabidiol (CBD). This study aimed to evaluate labeling on CBD marketed Brazil authorized by two regulations – N660/2022 imported and N327/2019 with temporary trade permits whether there were differences between them concerning four domains: prescription, good manufacturing practices (GMP), laboratory tests, safety use. Determined was based a score 45 criteria divided per domain weights from 1 3 (according relevance for users' prescribers' safety) built public information provided product manufacturers/representatives websites e-mail consultations. The classified as very satisfactory, or not represented median interquartile range. Between N327 N660 products, scores compared using Mann–Whitney U-test. All tests considered two-tailed hypotheses significance level 5%. After applying inclusion criteria, 148 selected, 105 evaluated. Most evaluated satisfactory (47), followed (39) (19). presented that more accessible than products. Similarly, significant difference groups domains prescription use; showed better results those N660. contributes urgent debate risks widely Brazil.

Language: Английский

Citations

1
Cannabis sativa Cannabinoids as Functional Ingredients in Snack Foods—Historical and Developmental Aspects DOI Creative Commons

Marlize Krüger,

Tertia van Eeden, Daniso Beswa

et al.

Plants, Journal Year: 2022, Volume and Issue: 11(23), P. 3330 - 3330

Published: Dec. 1, 2022

The published health benefits of Cannabis sativa has caught the attention health-conscious consumers and food industry. Historically, seeds have long been utilized as a source currently there is an increasing number edibles on market that contain cannabis. Cannabinoids include psychoactive constituent, delta-9-tetrahydrocannabinol (THC), non-psychoactive cannabidiol (CBD) are both compounds interest in sativa. This paper looks at distribution nutrients phytocannabinoids low-THC sativa, historical uses hemp, cannabis edibles, possible side-effects concerns related to edibles. Several authors pointed out even though use considered safe, it important mention their any its consumption negatively influence consumer acceptance Such risks unintentional overdose by adults accidental ingestion children adolescents resulting serious adverse effects. Therefore, should be specifically packaged labelled differentiate them from known similar non-cannabis so that, together with tamperproof packaging, these measures reduce appeal products children.

Language: Английский

Citations

34
Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment DOI Open Access
Herman J. Woerdenbag, Peter Olinga, Ellen A. Kok

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(7), P. 2119 - 2119

Published: April 1, 2023

The application of cannabis products in oncology receives interest, especially from patients. Despite the plethora research data available, added value curative or palliative cancer care and possible risks involved are insufficiently proven therefore a matter debate. We aim to give recommendation on position clinical by assessing recent literature. Various types products, characteristics, quality pharmacology discussed. Standardisation is essential for reliable reproducible quality. oromucosal/sublingual route administration preferred over inhalation drinking tea. Cannabinoids may inhibit efflux transporters drug-metabolising enzymes, possibly inducing pharmacokinetic interactions with anticancer drugs being substrates these proteins. This enhance cytostatic effect and/or drug-related adverse effects. Reversely, it enable dose reduction. Similar likely used symptom management treating pain, nausea, vomiting anorexia. Cannabis usually well tolerated improve life patients (although not unambiguously proven). combination immunotherapy seems undesirable because immunosuppressive action cannabinoids. Further warranted scientifically support (refraining from) using cancer.

Language: Английский

Citations

17
Opportunities, Challenges, and Scientific Progress in Hemp Crops DOI Creative Commons
Kacper Piotr Kaminski, Julia Hoeng,

Fernando Goffman

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2397 - 2397

Published: May 20, 2024

The resurgence of cannabis (Cannabis sativa L.) has been propelled by changes in the legal framework governing its cultivation and use, increased demand for hemp-derived products, studies recognizing industrial health benefits hemp. This led to creation novel high-cannabidiol, low-Δ9-tetrahydrocannabinol varieties, enabling hemp crop expansion worldwide. review elucidates recent implications Europe, with a focus on legislative impacts practices, prospective breeding efforts, dynamic scientific landscape surrounding this crop. We also current cultivars’ cannabinoid composition European market major differences that United States.

Language: Английский

Citations

7
Cannabidiol and cannabis-inspired terpene blends have acute prosocial effects in the BTBR mouse model of autism spectrum disorder DOI Creative Commons

Jenika Staben,

Megan Koch,

Keelee Reid

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: June 16, 2023

Cannabidiol (CBD) is a non-intoxicating phytocannabinoid with increasing popularity due to its purported therapeutic efficacy for numerous off-label conditions including anxiety and autism spectrum disorder (ASD). Those ASD are commonly deficient in endogenous cannabinoid signaling GABAergic tone. CBD has complex pharmacodynamic profile that includes enhancing GABA endocannabinoid signaling. Thus, there mechanistic justification investigating CBD's potential improve social interaction related symptoms ASD. Recent clinical trials children support beneficial effects comorbid symptoms, but impact on behavior understudied.Here, we tested the prosocial general anxiolytic of commercially available CBD-rich broad hemp oil delivered by repeated puff vaporization consumed via passive inhalation female cohort BTBR strain, common inbred mouse line preclinical assessment ASD-like behaviors.We observed enhanced behaviors using 3-Chamber Test different vapor dose-response relationship between anxiety-related elevated plus maze. We also identified vaporized terpene blend from popular OG Kush cannabis strain increased independently acted together promote robust effect. similar two additional blends Do-Si-Dos Blue Dream strains, further reveal these benefits rely combination multiple terpenes comprise blends.Our results illustrate added benefit CBD-based treatment

Language: Английский

Citations

14
Oral delivery of cannabidiol: Revealing the formulation and absorption challenges DOI
Andrejs Šitovs, Konstantīns Logviss, Līga Lauberte

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 92, P. 105316 - 105316

Published: Dec. 27, 2023

Language: Английский

Citations

12
Commercial Delta-8 THC Products: an Analysis of Content and Labeling DOI
Eric E. Kaczor,

Kevin Greene,

Kavita M. Babu

et al.

Journal of Medical Toxicology, Journal Year: 2023, Volume and Issue: 20(1), P. 31 - 38

Published: Nov. 2, 2023

Language: Английский

Citations

11
Cannabis use to manage opioid cravings among people who use unregulated opioids during a drug toxicity crisis DOI Creative Commons
Hudson Reddon, Stephanie Lake, M. Eugenia Socías

et al.

International Journal of Drug Policy, Journal Year: 2023, Volume and Issue: 119, P. 104113 - 104113

Published: July 21, 2023

Language: Английский

Citations

10