Pharmaceutical Biology,
Journal Year:
2021,
Volume and Issue:
59(1), P. 1478 - 1487
Published: Jan. 1, 2021
Context
Bupleuri
Radix,
the
dried
root
of
Bupleurum
chinense
DC
and
scorzonerifolium
Willd
(Apiaceae),
is
an
important
medicinal
herb
widely
used
to
treat
cancers
for
hundreds
years
in
Asian
countries.
As
most
antitumour
component
but
also
main
toxic
saikosaponin
D
(SSD)
has
attracted
extensive
attention.
However,
no
summary
studies
have
been
reported
on
effects,
toxicity
pharmacokinetics
this
potential
natural
anticancer
substance.Objective
To
analyse
summarise
existing
findings
regarding
SSD.Materials
methods
We
collected
relevant
information
published
before
April
2021
by
conducting
a
search
literature
available
various
online
databases
including
PubMed,
Science
Direct,
CNKI,
Wanfang
database
Chinese
Biological
Medicine
Database.
Bupleurum,
saikosaponin,
D,
tumour,
toxicity,
were
as
keywords.Results
The
effects
SSD
multi-targeted
can
be
realised
through
mechanisms,
inhibition
proliferation,
invasion,
metastasis
angiogenesis,
well
induction
cell
apoptosis,
autophagy,
differentiation.
toxicological
mainly
included
hepatotoxicity,
neurotoxicity,
haemolysis
cardiotoxicity.
Pharmacokinetic
demonstrated
that
had
alter
some
drugs
its
influence
CYPs
P-gp,
oral
bioavailability
actual
pharmacodynamic
substances
vivo
are
still
controversial.Conclusions
potentially
effective
relatively
safe
substance,
more
research
needed,
especially
compound.
Acta Physiologica,
Journal Year:
2024,
Volume and Issue:
240(3)
Published: Jan. 22, 2024
Abstract
Introduction
Abnormal
lipid
metabolism,
one
of
the
hallmarks
in
cancer,
has
gradually
emerged
as
a
novel
target
for
cancer
treatment.
As
organelles
that
store
and
release
excess
lipids,
droplets
(LDs)
resemble
“gears”
facilitate
development
body.
Aim
This
review
discusses
life
cycle
LDs,
relationship
between
abnormal
LDs
hallmarks,
application
theragnostic
clinical
contexts
to
provide
contemporary
understanding
role
cancer.
Methods
A
systematic
literature
search
was
conducted
PubMed
SPORTDiscus.
Retrieve
summarize
trials
drugs
proteins
associated
with
LD
formation
using
Clinical
Trials
website.
Create
schematic
diagram
tumor
microenvironment
Adobe
Illustrator.
Conclusion
top
ten
metabolism
caused
by
excessive
generation
interrelates
other
hallmarks.
The
crosstalk
intracellular
free
fatty
acids
(FFAs)
promotes
an
inflammatory
environment
supports
growth.
Moreover,
contribute
metastasis
cell
death
resistance
vivo.
Statins,
HMGCR
inhibitors,
are
promising
be
pioneering
commercially
available
anti‐cancer
formation.
Journal of Cellular Biochemistry,
Journal Year:
2024,
Volume and Issue:
125(3)
Published: Feb. 12, 2024
Abstract
Mechanical
forces
may
be
generated
within
a
cell
due
to
tissue
stiffness,
cytoskeletal
reorganization,
and
the
changes
(even
subtle)
in
cell's
physical
surroundings.
These
of
impose
mechanical
tension
intracellular
protein
network
(both
cytosolic
nuclear).
could
released
by
series
protein–protein
interactions
often
facilitated
membrane
lipids,
lectins
sugar
molecules
thus
generate
type
signal
drive
cellular
processes,
including
differentiation,
polarity,
growth,
adhesion,
movement,
survival.
Recent
experimental
data
have
accentuated
molecular
mechanism
this
transduction
pathway,
dubbed
mechanotransduction.
Mechanosensitive
proteins
plasma
discern
channel
information
interior.
Cells
respond
message
altering
their
arrangement
directly
transmitting
nucleus
through
connection
cytoskeleton
nucleoskeleton
before
despatched
biochemical
signaling
pathways.
Nuclear
transmission
force
leads
activation
chromatin
modifiers
modulation
epigenetic
landscape,
inducing
reorganization
gene
expression
regulation;
time
chemical
messengers
(transcription
factors)
arrive
into
nucleus.
While
significant
research
has
been
done
on
role
mechanotransduction
tumor
development
cancer
progression/metastasis,
mechanistic
basis
force‐activated
carcinogenesis
is
still
enigmatic.
Here,
review,
we
discussed
various
cues
connections
better
comprehend
also
explored
detailed
some
multiple
players
(proteins
macromolecular
complexes)
involved
Thus,
described
an
avenue:
how
stress
directs
modulate
epigenome
cells
aberrant
phenotype.
Circulation Research,
Journal Year:
2024,
Volume and Issue:
134(7)
Published: Feb. 20, 2024
BACKGROUND:
Many
cardiovascular
pathologies
are
induced
by
signaling
through
G-protein-coupled
receptors
via
Gsα
(G
protein
stimulatory
α
subunit)
proteins.
However,
the
specific
cellular
mechanisms
that
driven
and
contribute
to
development
of
atherosclerosis
remain
unclear.
METHODS:
High-throughput
screening
involving
data
from
single-cell
bulk
sequencing
were
used
explore
expression
in
atherosclerosis.
The
differentially
activity
analyzed
immunofluorescence
cAMP
measurements.
Macrophage-specific
knockout
(Mac-Gsα
KO
)
mice
generated
study
effect
on
role
was
determined
transplanting
bone
marrow
performing
assays
for
foam
cell
formation,
Dil-ox-LDL
(oxidized
low-density
lipoprotein)
uptake,
chromatin
immunoprecipitation,
luciferase
reporter
assays.
RESULTS:
ScRNA-seq
showed
elevated
Gnas
atherosclerotic
mouse
aorta’s
cholesterol
metabolism
macrophage
cluster,
while
confirmed
increased
GNAS
human
plaque
content.
A
significant
upregulation
active
occurred
macrophages
plaques.
Ox-LDL
could
translocate
lipid
rafts
short-term
promote
transcription
ERK1/2
activation
C/EBPβ
phosphorylation
oxidative
stress
long-term.
Atherosclerotic
lesions
Mac-Gsα
displayed
decreased
deposition
compared
with
those
control
mice.
Additionally,
deficiency
alleviated
uptake
formation.
Mechanistically,
levels
transcriptional
response
element
binding
protein,
which
resulted
CD36
SR-A1.
In
translational
experiments,
inhibiting
suramin
or
cpGN13
reduced
progression
plaques
vivo.
CONCLUSIONS:
is
enhanced
during
increases
genetic
chemical
inactivation
inhibit
mice,
suggesting
drugs
targeting
may
be
useful
treatment
Pharmaceutical Biology,
Journal Year:
2021,
Volume and Issue:
59(1), P. 1478 - 1487
Published: Jan. 1, 2021
Context
Bupleuri
Radix,
the
dried
root
of
Bupleurum
chinense
DC
and
scorzonerifolium
Willd
(Apiaceae),
is
an
important
medicinal
herb
widely
used
to
treat
cancers
for
hundreds
years
in
Asian
countries.
As
most
antitumour
component
but
also
main
toxic
saikosaponin
D
(SSD)
has
attracted
extensive
attention.
However,
no
summary
studies
have
been
reported
on
effects,
toxicity
pharmacokinetics
this
potential
natural
anticancer
substance.Objective
To
analyse
summarise
existing
findings
regarding
SSD.Materials
methods
We
collected
relevant
information
published
before
April
2021
by
conducting
a
search
literature
available
various
online
databases
including
PubMed,
Science
Direct,
CNKI,
Wanfang
database
Chinese
Biological
Medicine
Database.
Bupleurum,
saikosaponin,
D,
tumour,
toxicity,
were
as
keywords.Results
The
effects
SSD
multi-targeted
can
be
realised
through
mechanisms,
inhibition
proliferation,
invasion,
metastasis
angiogenesis,
well
induction
cell
apoptosis,
autophagy,
differentiation.
toxicological
mainly
included
hepatotoxicity,
neurotoxicity,
haemolysis
cardiotoxicity.
Pharmacokinetic
demonstrated
that
had
alter
some
drugs
its
influence
CYPs
P-gp,
oral
bioavailability
actual
pharmacodynamic
substances
vivo
are
still
controversial.Conclusions
potentially
effective
relatively
safe
substance,
more
research
needed,
especially
compound.
