Comprehensive comparison on the anti-inflammation and GC-MS-based metabolomics discrimination between Bupleuri chinense DC. and B. scorzonerifolium Willd DOI Creative Commons
Mingming Zhao,

Linxuan Xiao,

Ke‐Gang Linghu

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 14, 2022

Bupleuri Radix (BR) is a traditional Chinese medicine and widely used for cold fever, influenza, inflammation, hepatitis menstrual diseases. Two authentic medicinal plants of chinense DC. (Beichaihu, BCH) B. scorzonerifolium Willd. (Nanchiahu, NCH) are recommended by the current Pharmacopoeia BR. In present study, comparative investigations on anti-inflammatory effects gas chromatography-mass spectrometry (GC-MS)-based metabolomics species discrimination BCH NCH were conducted reported. The in vitro evaluations indicated that supercritical fluid extracts (SFEs) (IC50 6.39 ± 0.52 1.32 0.05 mg (herb)/mL determined to be more potent than those hydro-distillation (HDEs) 203.90 8.08 32.32 2.27 against LPS-induced inflammation RAW264.7 macrophages. higher associated its different chemical compositions as characterized GC-MS analysis. Furthermore, based deep chemometric approaches, minimum combination containing 15 markers was optimized from identified components successfully applied NCH. This study not only helps understand both phytochemistry pharmacology, but also provides potential improvement methods quality control

Language: Английский

The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications DOI Creative Commons
Chen Shen, Ke Wang,

Hongzhan Wang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107090 - 107090

Published: Feb. 2, 2024

Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as promising candidate, offering variety of therapeutic benefits may be effective in combating depression. This review delves into the multifaceted potential saikosaponins alleviating depressive symptoms. We summarized effects on structural functional neuroplasticity, elaborated regulatory mechanism modulating key factors affect such inflammation, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, brain-gut axis. Moreover, paper highlights existing gaps current researches outlines directions for future studies. A detailed plan provided clinical application saikosaponins, advocating more targeted to speed up its transition from preclinical trials practice.

Language: Английский

Citations

11
Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy DOI Creative Commons

Keyan Miao,

Weici Liu, Jingtong Xu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 15, 2023

At present, cancer is the largest culprit that endangers human health. The current treatment options for mainly include surgical resection, adjuvant radiotherapy and chemotherapy, but their therapeutic effects long-term prognosis are unsatisfactory. Immunotherapy an emerging therapy has completely transformed landscape of advanced cancers, tried to occupy a place in neoadjuvant resectable tumors. However, not all patients respond immunotherapy due immunological molecular features Traditional Chinese Medicine (TCM) provides new perspective considered have potential as promising anti-tumor drugs considering its immunoregulatory properties. This review concludes commonly used TCM monomers compounds from immune regulatory pathways, aiming clearly introduce basic mechanisms boosting several common TCM. In addition, we also summarized closed ongoing trials presented prospects future development. Due significant role non-small cell lung (NSCLC), combined with should be emphasized NSCLC.

Language: Английский

Citations

22
Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: a comprehensive review DOI Creative Commons

Yuhan Ma,

Yongxia Zhao,

Mingxia Luo

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 7, 2024

Recent research on traditional Chinese medicine (TCM) saponin pharmacokinetics has revealed transformative breakthroughs and challenges. The multicomponent nature of TCM makes it difficult to select representative indicators for pharmacokinetic studies. clinical application saponins is limited by their low bioavailability short half-life, resulting in fluctuating plasma concentrations. Future directions should focus novel compounds utilizing colon-specific delivery osmotic pump systems enhance oral bioavailability. Optimizing drug combinations, such as ginsenosides with aspirin, shows therapeutic potential. Rigorous validation essential practical applications. This review emphasizes a era research, highlighting the need validation. pharmacokinetics, guided principles, are development, multidisciplinary approaches comprehensive understanding. provides theoretical basis new drugs supports rational medication.

Language: Английский

Citations

8
Saponins as cytotoxic agents: an update (2010–2021). Part II—Triterpene saponins DOI Creative Commons
Irma Podolak, Karolina Grabowska, Danuta Sobolewska

et al.

Phytochemistry Reviews, Journal Year: 2022, Volume and Issue: 22(1), P. 113 - 167

Published: July 28, 2022

Abstract Saponins make up an important group of natural glycosidic compounds which are distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial flora, especially higher plants, they can also be found some marine organisms. Cytotoxic activity is one the most frequently reported from a wide array pharmacological activities known for these metabolites. The current review update our previous paper— as cytotoxic agents (Podolak et al. Phytochem Rev 9:425–474, 2010), and covers studies that were since published (2010–2021). This part refers to saponins complements first, was devoted solely (Sobolewska 19:139–189, 2020). vitro vivo presented with main focus on structure-activity relationships molecular mechanisms action.

Language: Английский

Citations

27
The therapeutic potential of traditional Chinese medicine in depression: Targeting adult hippocampal neurogenesis DOI
Lijin Feng, Hang Xing, Kuo Zhang

et al.

Phytomedicine, Journal Year: 2022, Volume and Issue: 98, P. 153980 - 153980

Published: Feb. 4, 2022

Language: Английский

Citations

25
Efficacy and safety of the traditional herbal medication Chai-Ling-Tang (in China), Siryung-tang (in Republic of Korea) or Sairei-To (in Japan) DOI Creative Commons
Christian Bailly

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117127 - 117127

Published: Sept. 7, 2023

Language: Английский

Citations

13
Saikosaponin D alleviates inflammatory response of osteoarthritis and mediates autophagy via elevating microRNA-199-3p to target transcription Factor-4 DOI Creative Commons
Ming Yan, Dawei Zhang, Min Yang

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 22, 2024

Abstract Objective This study was to investigate the underlying mechanism by which Saikosaponin D (SSD) mitigates inflammatory response associated with osteoarthritis (OA) and regulates autophagy through upregulation of microRNA (miR)-199-3p downregulation transcription Factor-4 (TCF4). Methods A mouse OA model established. Mice were intragastrically administered SSD (0, 5, 10 μmol/L) or injected miR-199-3p antagomir into knee. Then, pathological changes in cartilage tissues observed. Normal chondrocytes isolated identified. Chondrocytes treated and/or transfected oligonucleotides plasmid vectors targeting TCF4. Cell viability, apoptosis, inflammation, assessed. TCF4 expressions measured, their relationship analyzed. Results In vivo experiments, ameliorated histopathological damage, decreased factor content promoted mice. expression downregulated upregulated after treatment. Downregulation attenuated effect on vitro inhibited chondrocytes. addition, alone responses targeted Upregulation effects Conclusions alleviates mediates via elevating target

Language: Английский

Citations

5
Therapeutic Candidates for Alzheimer’s Disease: Saponins DOI Open Access
Ruifeng Zhang, Miao Zeng, Xiaolu Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10505 - 10505

Published: June 22, 2023

Drug development for Alzheimer's disease, the leading cause of dementia, has been a long-standing challenge. Saponins, which are steroid or triterpenoid glycosides with various pharmacological activities, have displayed therapeutic potential in treating disease. In comprehensive review literature from May 2007 to 2023, we identified 63 references involving 40 different types saponins that studied their effects on These studies suggest ameliorate disease by reducing amyloid beta peptide deposition, inhibiting tau phosphorylation, modulating oxidative stress, inflammation, and antiapoptosis. Most intriguingly, ginsenoside Rg1 pseudoginsenoside-F11 possess these important properties show best promise treatment This provides summary classification common showcasing underlying mechanisms. highlights promising

Language: Английский

Citations

11
Biosynthesis and functions of triterpenoids in cereals DOI Creative Commons
Jiaojiao Lu, Shan Yan, Zheyong Xue

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Triterpenoids are versatile secondary metabolites with a diverse array of physiological activities, possessing valuable pharmacological effects and influencing the growth development plants. As more triterpenoids in cereals unearthed characterized, their biological roles plant gaining recognition. This review provides an overview structures, biosynthetic pathways, functions identified cereals. Our goal is to establish basis for further exploration novel structures functional activities cereals, facilitate potential application grain breeding, thus accelerating superior varieties. consolidates information on various triterpenoid skeletons derivatives found summarizes pivotal enzyme genes involved, including oxidosqualene cyclase (OSC) other modifying enzymes like cytochrome P450, glycosyltransferase, acyltransferase. Triterpenoid-modifying exhibit specificity towards catalytic sites within skeletons, generating derivatives. Furthermore, have been shown significantly impact nutritional value, yield, disease resistance, stress response

Language: Английский

Citations

4
Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy DOI Creative Commons
Yuna Zhang, Xianglong Wu, Wenhui Yao

et al.

Pharmaceutical Biology, Journal Year: 2024, Volume and Issue: 62(1), P. 544 - 561

Published: June 30, 2024

Context Diabetic peripheral neuropathy (DPN) results in an enormous burden and reduces the quality of life for patients. Considering there is no specific drug management DPN, traditional Chinese medicine (TCM) has increasingly drawn attention clinicians researchers around world due to its characteristics multiple targets, active components, exemplary safety.

Language: Английский

Citations

4