Cyclodextrin microneedles for the delivery of a nanoparticle-based peptide antigen vaccine DOI Creative Commons

Silvana Geisshüsler,

Frida Nilsson,

Nicole Ziak

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 198, P. 114249 - 114249

Published: March 11, 2024

In recent years, microneedles (MNs) have gained considerable interest in drug formulation due to their non-invasive and patient-friendly nature. Dissolving MNs emerged as a promising approach enhance delivery across the skin painless manner without generating sharp waste providing possibility for self-administration. Cyclodextrins, group of cyclic oligosaccharides, are well-established pharmaceutical products safety unique ability form inclusion complexes with various molecules. this manuscript, we report development characterization dissolving composed cyclodextrins intradermal cyclodextrin-based nanoparticulate vaccine. Different were tested most candidates fabricated into by micromolding. The MNs' piercing effectiveness permeation ex vivo. Furthermore, vivo studies carried out assess skin's tolerance MNs, evaluate immune response using model peptide antigen mouse model. data revealed that well-tolerated effective, even leading dose-sparing effects. This study highlights potential versatile platform vaccine delivery, compatible matrix formulations responses.

Language: Английский

Microneedles as a momentous platform for psoriasis therapy and diagnosis: A state-of-the-art review DOI
B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Umme Hani

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 632, P. 122591 - 122591

Published: Jan. 7, 2023

Language: Английский

Citations

39
Rising role of 3D-printing in delivery of therapeutics for infectious disease DOI Creative Commons
Anthony J. Kyser, Bassam Fotouh, Mohamed Y. Mahmoud

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 349 - 365

Published: Jan. 8, 2024

Language: Английский

Citations

15
Beyond the Needle: Innovative Microneedle-Based Transdermal Vaccination DOI Creative Commons
Hiep X. Nguyen

Medicines, Journal Year: 2025, Volume and Issue: 12(1), P. 4 - 4

Published: Feb. 7, 2025

Vaccination represents a critical preventive strategy in the current global healthcare system, serving as an indispensable intervention against diverse pathogenic threats. Although conventional immunization relies predominantly on hypodermic needle-based administration, this method carries substantial limitations, including needle-associated fear, bloodborne pathogen transmission risks, occupational injuries among workers, waste management issues, and dependence trained medical personnel. Microneedle technology has emerged innovative vaccine delivery offering convenient, effective, minimally invasive administration. These microscale needle devices facilitate targeted antigen to epidermal dermal tissues, where abundant populations of antigen-presenting cells, specifically Langerhans dendritic provide robust immunological responses. Multiple research groups have extensively investigated microneedle-based vaccination strategies. This transdermal technique offers several advantages, notably circumventing cold-chain requirements enabling self-administration. Numerous preclinical investigations clinical trials demonstrated safety profile, immunogenicity, patient acceptance microneedle-mediated across applications. comprehensive review examines fundamental aspects immunization, principles, transcutaneous strategies, delivery-including classifications, barriers. Furthermore, addresses technical considerations, such treatment efficacy, application methodologies, wear duration, dimensional optimization, manufacturing processes, regulatory frameworks, sustainability followed by analysis future perspective technology.

Language: Английский

Citations

1
Enhancing vaccine stability in transdermal microneedle platforms DOI
Suman Pahal,

Feifei Huang,

Parbeen Singh

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

1
Clinical perspective on topical vaccination strategies DOI Creative Commons
Petya Popova, Sunny P. Chen,

Suiyang Liao

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 208, P. 115292 - 115292

Published: March 24, 2024

Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious and saves millions lives every year. Vaccine design development remains critical involves many aspects, including choice platform, antigen, adjuvant, route administration. Topical vaccination, defined herein as introduction a vaccine any three layers human skin, has attracted interest recent years an alternative vaccination approach conventional intramuscular administration because its potential be needle-free induce superior immune response against pathogens. In this review, we describe progress developing topical vaccines, highlight delivery technologies for discuss factors that might impact efficacy, provide overview current clinical landscape vaccines.

Language: Английский

Citations

8
Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold DOI Creative Commons
Rio Yamagishi,

Sayaka Miura,

Kana Yabu

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(1), P. 65 - 65

Published: Jan. 15, 2024

Microneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO

Language: Английский

Citations

7
Microneedle-mediated drug delivery for neurological diseases DOI

Shuna Tan,

Yitian Wang, Wei Xuan

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 661, P. 124400 - 124400

Published: June 29, 2024

Language: Английский

Citations

7
Microneedle‐Mediated Transcutaneous Immunization: Potential in Nucleic Acid Vaccination DOI
Haochen Wang, Junhua Xu, Lin Xiang

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: April 28, 2023

Abstract Efforts aimed at exploring economical and efficient vaccination have taken center stage to combat frequent epidemics worldwide. Various vaccines been developed for infectious diseases, among which nucleic acid attracted much attention from researchers due their design flexibility wide application. However, the lack of an delivery system considerably limits clinical translation vaccines. As mass vaccinations via syringes are limited by low patient compliance high costs, microneedles (MNs), can achieve painless, cost‐effective, drug delivery, provide ideal strategy. The MNs break through stratum corneum barrier in skin deliver immune cell‐rich epidermis dermis. In addition, feasibility MN‐mediated is demonstrated both preclinical studies has tremendous potential this work, current status research on MN reviewed. Moreover, improvements summarized challenges its future discussed.

Language: Английский

Citations

16
Responsive Microneedles as a New Platform for Precision Immunotherapy DOI Creative Commons
Xinyang Liu,

Haohao Song,

Sun Tai-ran

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1407 - 1407

Published: May 4, 2023

Microneedles are a well-known transdermal or drug delivery system. Different from intramuscular injection, intravenous etc., the microneedle system provides unique characteristics for immunotherapy administration. can deliver immunotherapeutic agents to epidermis and dermis, where immune cells abundant, unlike conventional vaccine systems. Furthermore, devices be designed respond certain endogenous exogenous stimuli including pH, reactive oxygen species (ROS), enzyme, light, temperature, mechanical force, thereby allowing controlled release of active compounds in dermis. In this way, multifunctional stimuli-responsive microneedles could enhance efficacy responses prevent mitigate disease progression lessen systemic adverse effects on healthy tissues organs. Since promising accurate release, review focuses progress using immunotherapy, especially tumors. Limitations current summarized, controllable administration targeting systems examined.

Language: Английский

Citations

12
Establishing immunogenicity and safety of needle-free intradermal delivery by nanoporous ceramic skin patch of mRNA SARS-CoV-2 vaccine as a revaccination strategy in healthy volunteers DOI Creative Commons
Margaretha Prins, Corine Prins, Jutte J.C. de Vries

et al.

Virus Research, Journal Year: 2023, Volume and Issue: 334, P. 199175 - 199175

Published: July 21, 2023

Nanoporous microneedle arrays (npMNA) are being developed as skin patches for vaccine delivery. As alternative needle-based immunisation, they may potentially result in higher acceptance, which is important future mass vaccination campaigns to control outbreaks, such COVID-19, and public general. In this study we investigated the safety immunogenicity of needle-free intradermal delivery a fractional third or fourth dose mRNA-1273 by npMNA.This was an open-label, randomised-controlled, proof-of-concept study. Healthy adults were eligible if had received primary immunisation series against SARS-CoV-2 with two doses (Moderna) BNT162b2 (Pfizer-BioNTech) mRNA vaccine. A history COVID-19 infection booster allowed it occurred at least three months before inclusion. Participants randomised 1:1 ratio receive 20 µg vaccine, either through npMNA patch applied on (ID-patch group), intramuscular (IM) injection (IM-control group). Primary outcomes reactogenicity up weeks after vaccination, fold-increase spike S1-specific IgG antibodies 14 days post-vaccination.In April 2022, participants enroled. The geometric mean concentration (GMC) did not increase ID-patch group contrast IM-control (GMC 1,006 BAU/mL (95% CI 599-1,689), 3,855 (2,800-5,306), 3,513 (2,554-4,833) day 1, 15 29, respectively). addition, SARS-CoV-2-specific T cell responses lower ID npMNA.Needle-free failed induce antibody responses. very useful method, determine adjustments needed make successful. CLINICAL TRIAL REGISTRY (ON CLINICALTRIAL.GOV): NCT05315362.

Language: Английский

Citations

12