Exploring the emerging trends in the synthesis and theranostic paradigms of cerium oxide nanoparticles (CeONPs): A comprehensive review

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 35, P. 101894 - 101894

Published: Jan. 1, 2024

Language: Английский

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Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2023, Volume and Issue: Volume 16, P. 1387 - 1406

Published: May 1, 2023

Abstract: Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women. Traditionally, topical minoxidil oral finasteride have been standard care yielding mixed results. New treatments such as Low-Level Laser Therapy (LLLT), microneedling, platelet-rich plasma (PRP), others extensively studied literature, purpose this review to provide a comprehensive discussion latest treatment methods their efficacy treating AGA. Novel therapies minoxidil, finasteride, spironolactone, botulinum toxin, stem cell therapy offer interesting alternatives for patients. In review, we present data from recent studies on clinical these treatments. Furthermore, new emerged, clinicians tested combination assess whether there may be synergistic relationship between multiple modalities. While has great increase available AGA, quality evidence varies greatly still need randomized double blinded trials adequately some PRP LLLT demonstrated encouraging results, standardized protocols are needed inform how use therapies. Given abundance therapeutic options, patients must weigh benefits risks each option Keywords: androgenetic alopecia, platelet rich plasma, microneedling

Language: Английский

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An overview of topical lipid-based and polymer-based nanocarriers for treatment of psoriasis

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 638, P. 122938 - 122938

Published: April 8, 2023

Language: Английский

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Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Scientia Pharmaceutica, Journal Year: 2023, Volume and Issue: 91(2), P. 27 - 27

Published: May 31, 2023

Microneedles are gaining popularity as a new paradigm in the area of transdermal drug delivery for biomedical and healthcare applications. Efficient with minimal invasion is prime advantage microneedles. The concept microneedle array provides an extensive surface efficient delivery. Various types inorganics (silicon, ceramic, metal, etc.) polymeric materials used fabrication microneedles have various advantages over other fabricated using inorganic material, such biocompatibility, biodegradation, non-toxicity. wide variety polymers can provide broad scope Multiple metallic be functionalized by polymer coatings shifting from conventional to advanced 3D 4D printing technology. multifaceted applications include delivery, vaccine biosensing, diagnostic Here, we overview current information on fabrication, selection criteria polymers, applications, regulatory perspective polymer-based polymer-coated microneedles, along patent scenario.

Language: Английский

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The cubosome-based nanoplatforms in cancer therapy: Seeking new paradigms for cancer theranostics

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116894 - 116894

Published: Aug. 14, 2023

Language: Английский

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3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 237 - 237

Published: Feb. 6, 2024

Microneedle (MN) technology is an optimal choice for the delivery of drugs via transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine and disease diagnostics. The biomedical device that offers many advantages including but not limited to painless experience, being time-effective, real-time sensing. This research implements additive manufacturing (AM) fabricate arrays advanced therapeutic applications. Stereolithography (SLA) was used six designs three aspect ratios. array included conical-shaped 100 needles (10 × 10 needle) in each array. microneedles were characterized using optical scanning electron microscopy evaluate dimensional accuracy. Further, mechanical insertion tests performed analyze strength skin penetration capabilities polymeric MN. MNs higher ratios had deformation characteristics suitable deeper levels beyond stratum corneum. both 0.3 mm 0.4 base diameters displayed consistent force–displacement behavior during skin-equivalent test. establishes guidelines fabricating high-accuracy low-cost 3D printing.

Language: Английский

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Efficient Loading and Sustained Delivery of Methotrexate Using a Tip-Swellable Microneedle Array Patch for Psoriasis Treatment

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(2), P. 921 - 931

Published: Jan. 30, 2024

Methotrexate (MTX), a primary treatment for moderate to severe psoriasis, is limited in clinical use due suboptimal results and side effects from subcutaneous (SC) injection oral administration. Microneedles offer promising alternative direct MTX delivery targeted skin lesions, but issues such as drug wastage, dosage inaccuracy, residence time the lesions remain. This study introduces tip-swellable microneedle array patch (TSMAP) using photo-cross-linked methacrylated hyaluronic acid (MeHA) biocompatible resin effective loading sustained delivery. A two-cast micromolding with vacuum drying employed concentrate cross-linked MeHA about 30% of needle's height at tip, thereby ensuring that only TSMAP tip swells. Efficient into tips achieved through 30 s solution immersion 10 min drying, potentially minimizing waste incomplete insertion elasticity. The MTX-loaded effectively penetrates both porcine psoriasis-like mouse its detaching substrate embedding deeply tissue, functioning release reservoir. significantly prolongs retention compared SC dissolvable microneedles. vivo demonstrates TSMAP-mediated substantially enhances therapeutic outcomes alleviating psoriasis symptoms downregulating psoriasis-associated cytokines, outperforming administration, injection, Thus, could an efficient user-friendly administration various diseases.

Language: Английский

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Calcipotriol Nanosuspension-Loaded Trilayer Dissolving Microneedle Patches for the Treatment of Psoriasis: In Vitro Delivery and In Vivo Antipsoriatic Activity Studies

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(6), P. 2813 - 2827

Published: May 16, 2024

Psoriasis, affecting 2–3% of the global population, is a chronic inflammatory skin condition without definitive cure. Current treatments focus on managing symptoms. Recognizing need for innovative drug delivery methods to enhance patient adherence, this study explores new approach using calcipotriol monohydrate (CPM), primary topical treatment psoriasis. Despite its effectiveness, CPM's therapeutic potential often limited by factors like greasiness applications, poor permeability, low retention, and lack controlled delivery. To overcome these challenges, introduces CPM in form nanosuspensions (NSs), characterized an average particle size 211 ± 2 nm. These NSs are then incorporated into trilayer dissolving microneedle patch (MAP) made from poly(vinylpyrrolidone) w poly(vinyl alcohol) as needle arrays prefrom 3D printed polylactic acid backing layer. This MAP features rapidly tips exhibits good mechanical properties insertion capability with efficiency compared conventional Daivonex ointment. The effectiveness novel was tested Sprague–Dawley rats imiquimod-induced psoriasis, demonstrating efficacy comparable marketed represents promising local system calcipotriol, potentially revolutionizing psoriasis enhancing compliance.

Language: Английский

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Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Oct. 31, 2023

Abstract Nanosponges are unique sponge‐like carrier systems with numerous cavities and a mesh‐like network throughout their surface. They categorized into three types based on the material of construction, i.e., polymer‐, inorganic‐, bio‐derived material‐based nanosponges. Unlike conventional nanoparticles, nanosponges bear countless interconnected voids that enables maximum drug, imaging probe, or photosensitizer loading via absorption, encapsulation, conjugation, complexion. The can be further sealed using suitable lipids polymers to avoid leakage drugs at non‐target site, protect therapeutics from biological conditions, control release for prolonged period. Recently, have grasped attention researchers in area cancer by overcoming drawbacks associated delivery immunotherapeutic, targeted therapeutic, chemotherapeutic agents. Interestingly, several reports also witnessed potential theranostics. Owing this supremacy, could an apt platform therapy diagnosis. current review discusses general aspects, types, preparation methods In addition, ambit treating different is meticulously discussed, along detailed descriptions corresponding patents. Furthermore, role phototherapy theranostics selectively canvassed.

Language: Английский

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Microneedle‐Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 19, 2024

Disorders in the regulatory arm of adaptive immune system result autoimmune-mediated diseases. While systemic immunosuppression is prevailing approach to manage them, it fails achieve long-lasting remission due concomitant suppression and carries risk heightened susceptibility infections malignancies. Alopecia areata a condition characterized by localized hair loss autoimmunity. The accessibility skin allows local rather than intervention avoid broad immunosuppression. It hypothesized that expansion endogenous T cells (T

Language: Английский

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