50th Anniversary Perspective: There Is a Great Future in Sustainable Polymers

Macromolecules, Journal Year: 2017, Volume and Issue: 50(10), P. 3733 - 3749

Published: May 1, 2017

It is likely that a half-century ago even enthusiastic and optimistic proponents of the synthetic polymer industry (Mr. McGuire included) could not have predicted massive scale on which polymers would be manufactured used today. Ultimately, future success this will rely development sustainable polymers—materials derived from renewable feedstocks are safe in both production use can recycled or disposed ways environmentally innocuous. Meeting these criteria an economical manner cannot achieved without transformative basic research hallmark journal. In Perspective we highlight five topics—the synthesis monomers degradable polymers, chemical recycling strategies, new classes reprocessable thermosets, design advanced catalysts—that believe play vital role polymers. We also offer our outlook several outstanding challenges facing community broad area

Language: Английский

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Occurrence of bisphenol S in the environment and implications for human exposure: A short review

The Science of The Total Environment, Journal Year: 2017, Volume and Issue: 615, P. 87 - 98

Published: Oct. 17, 2017

Language: Английский

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Abundance and characteristics of microplastics in beach sediments: Insights into microplastic accumulation in northern Gulf of Mexico estuaries

Marine Pollution Bulletin, Journal Year: 2016, Volume and Issue: 109(1), P. 178 - 183

Published: June 8, 2016

Language: Английский

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Evidence for bisphenol A-induced female infertility: a review (2007–2016)

Fertility and Sterility, Journal Year: 2016, Volume and Issue: 106(4), P. 827 - 856

Published: July 15, 2016

We summarized the scientific literature published from 2007 to 2016 on potential effects of bisphenol A (BPA) female fertility. focused overall fertility outcomes (e.g., ability become pregnant, number offspring), organs that are important for reproduction (i.e., oviduct, uterus, ovary, hypothalamus, and pituitary), reproductive-related processes estrous cyclicity, implantation, hormonal secretion). The reviewed indicates BPA may be associated with infertility in women. Potential explanations this association can generated experimental studies. Specifically, alter reproductive capacity by affecting morphology function hypothalamus-pituitary-ovarian axis animal models. In addition, disrupt cyclicity implantation. Nevertheless, further studies needed better understand exact mechanisms action detect toxicity at earlier stages. Discuss: You discuss article its authors other ASRM members https://www.fertstertdialog.com/users/16110-fertility-and-sterility/posts/10958-evidence-for-bisphenol-a-induced-female-infertility-review-2007-2016 Female is generally defined as inability get pregnant naturally deliver a live healthy newborn. According Centers Disease Control Prevention (CDC; http://www.cdc.gov/nchs/nsfg/key_statistics/i.htm#infertility), between 2011 2013, 6.1% married women were considered infertile United States alone. percentage reach 30% worldwide (1Inhorn M.C. Patrizio P. Infertility around globe: new thinking gender, technologies global movements 21st century.Hum Reprod Update. 2015; 21: 411-426Crossref PubMed Scopus (18) Google Scholar). result various factors, including physical problems, endocrine lifestyle habits, environmental factors. Environmental such exposure chemicals disrupting properties, mimic or block activity endogenous hormones thus adversely affect reproduction. One most extensively studied (BPA). Bisphenol incorporated many daily used products; it manufacturers polycarbonate plastics epoxy resins. Despite relatively short half-life (6–24 hours) (2Volkel W. Colnot T. Csanady G.A. Filser J.G. Dekant Metabolism kinetics humans low doses following oral administration.Chem Res Toxicol. 2002; 15: 1281-1287Crossref (389) Scholar), was measured tissues (3Vandenberg L.N. Hauser R. Marcus M. Olea N. Welshons W.V. Human (BPA).Reprod 2007; 24: 139-177Crossref (830) ovarian follicular fluid, placenta, breast milk, colostrum. Findings previous publications suggest toxicant (4Peretz J. Vrooman L. Ricke W.A. Hunt P.A. Ehrlich S. et al.Bisphenol health: update human evidence, 2007–2013.Environ Health Perspect. 2014; 122: 775-786PubMed Scholar, 5Vandenberg Belcher S.M. Ben-Jonathan Dolinoy D.C. Hugo E.R. al.Low dose A.Endocrine Disruptors. 2013; 1: e26490Crossref 6Maffini M.V. Rubin B.S. Sonnenschein C. Soto A.M. Endocrine disruptors case bisphenol-A.Mol Cell Endocrinol. 2006; 254-255: 179-186Crossref (273) current review focuses evidence BPA-induced problems females. main findings epidemiological examined 2016. included morphological mechanistic reported articles. overall: [1] fertility, [2] cycle, [3] tissues. (http://www.ncbi.nlm.nih.gov/pubmed) searches years 2007–2016 conducted using key words: BPA, A, female, reproduction, pregnancy, ovulation, fertilization, pituitary. articles expand reports same topic 7Fowler Bellingham Sinclair K.D. Evans N.P. Pocar Fischer B. al.Impact endocrine-disrupting compounds (EDCs) health.Mol 2012; 355: 231-239Crossref (70) 8Caserta D. Di Segni Mallozzi Giovanale V. Mantovani A. Marci tract: an overview recent laboratory studies.Reprod Biol 12: 37Crossref (16) 9Aghajanova Giudice L.C. Effect endometrial stromal fibroblasts vitro.Reprod Biomed Online. 2011; 22: 249-256Abstract Full Text PDF (13) 10Machtinger Orvieto oocyte maturation, IVF outcome: data.Reprod 29: 404-410Abstract (0) 11Gore A.C. Chappell V.A. Fenton S.E. Flaws J.A. Nadal Prins G.S. al.EDC-2: Society's second statement chemicals.Endocrinol Rev. 36: E1-E150Crossref references relevant information. dealt fertility/infertility related uterine function, hypothalamus-pituitary, hormone levels (luteinizing [LH], stimulating [FSH], prolactin [PRL]), ovary. excluded about topics out scope ones will investigators special issue sexual maturation/behavior, quality steroidogenesis, miscarriage, endometriosis, polycystic syndrome [PCOS], fibroids/leiomyoma). have study designs wide range doses. Based definitions studies, we "low dose" follows: below lowest observable adverse effect level 50 mg/kg/d models 12Richter C.A. Birnbaum L.S. Farabollini F. Newbold R.R. Talsness C.E. al.In vivo rodent 199-224Crossref (502) 13Vom Saal F.S. Akingbemi B.T. Crain D.A. Eriksen al.Chapel Hill expert panel consensus statement: integration mechanisms, animals impact health exposure.Reprod 131-138Crossref (363) 17.2 mg/L aquatic (5Vandenberg 14Crain Iguchi Jobling Laufer H. LeBlanc al.An ecological assessment bisphenol-A: comparative biology.Reprod 225-239Crossref (120) 1 × 10−7 M cell culture experiments 15Wetherill Y.B. Kanno McLachlan vitro molecular action.Reprod 178-198Crossref (339) typical (not occupational) exposures 16Vandenberg Colborn Hayes T.B. Heindel J.J. Jacobs Jr., D.R. Lee D.H. al.Hormones chemicals: low-dose nonmonotonic responses.Endocrinol 33: 378-455Crossref Most described within category dose. Throughout text review, indicated if high based these categories. Tables, specific each detail. Last, similar Peretz al. time during pregnancy utero; after birth ended before weaning neonatal; any postnatal adult exposure. years, several research groups Epidemiological whether higher than fertile (Table 1). (19Caserta Bordi G. Ciardo La Rocca Tait al.The influence selected population women.Gynecol 444-447Crossref (24) 26La Guerranti Busani Bergamasco al.Exposure disrupters nuclear receptor gene expression different Italian areas.Int J Environ Public Health. 11: 10146-10164Crossref (4) Scholar) indicate serum compared Furthermore, (17Bloom M.S. Kim Vom Taylor Cheng Lamb J.D. reduces estradiol response gonadotropin stimulation fertilization.Fertil Steril. 96: 672-677.e2Abstract (38) 21Ehrlich Williams P.L. Missmer S.A. Ye X. Calafat al.Urinary concentrations early among undergoing IVF.Hum Reprod. 27: 3583-3592Crossref (52) 22Fujimoto V.Y. vom Bloom Serum unconjugated 95: 1816-1819Abstract (37) 28Mok-Lin E. Petrozza Wright D.L. IVF.Int Androl. 2010; 385-393Crossref (80) 29Bloom Fujimoto men embryo indicators fertilization.Environ Toxicol Pharmacol. 32: 319-323Crossref (21) treatments show (total BPA) inversely peak E2 levels, oocytes retrieved, fertilization rates, quality. Thus, increased decrease success rate treatments. did not take into account modifying factors co-exposure location sample collection pointed Teeguarden (30Teeguarden Waechter J.M. Clewell 3rd, H.J. Covington T.R. Barton H.A. Evaluation intravenous route pharmacokinetics, plasma protein binding, tissue metrics A: physiologically pharmacokinetic approach.Toxicol Sci. 2005; 85: 823-838Crossref (73) 31Teeguarden Hanson-Drury systematic context exposure: establishing standards reporting "low-dose" chemicals.Food Chem 62: 935-948Crossref additional fully associations women.Table 1BPA (epidemiological studies).Study designStudy populationSample sizeTime measurementBPA concentrationOutcomeReference no.Cross-sectionalWomen IVF44Day retrievalMedian 2.53 ng/mL (range, 0.3–67.36 ng/mL)BPA estradiol; no retrieved17Bloom ScholarMatched cohortWomen discontinuing contraception210On day expectedmenstruationUrine BPA), mean (95% confidence interval): pregnant: 0.63 (0.54–0.73); nonpregnant: 0.68 (0.53–0.87)No impaired fecundity pregnancy18Buck Louis G.M. Sundaram Sweeney Schisterman E.F. Maisog Kannan K. Urinary phthalates, couple fecundity: Longitudinal Investigation Fertility Environment (LIFE) Study.Fertil 101: 1359-1366Abstract (26) ScholarCross-sectionalFertile women12 fertile35 infertileEnrollmentNot indicated; limit detection 0.5 (serum samples)Higher detectable levels19Caserta ScholarProspectiveWomen IVF239 (63 soy food intake); 347 cyclesBetween days 3 9 phase retrievalUrine BPA); Range, <0.4–16.6 μg/L; median, 1.3 μg/L (interquartile range, 0.9–1.9 μg/L)Soy consumption modifies correlation treatment outcomes20Chavarro J.E. Minguez-Alarcon Chiu Y.H. Gaskins A.J. Souter I. al.Soy intake relation urinary assisted reproduction.J Clin Endocrinol Metab. 2016; 1082-1090Crossref (2) IVF174 (237 cycles)Day retrievalUrinary geometric 1.50 (SD 2.22) μg/LHigher lower estradiol, yield, MII count, normally fertilizing oocytes21Ehrlich ICSI IVF58Day 0.0–67.4 ng/mL)Inverse maturation (Asian women) normal (all women)22Fujimoto ScholarPregnancy-based retrospectiveWomen 1st trimester1,742Spot urine trimester visitUrinary 0.78 (0.73–0.82) ng/mLNo diminished fecundity23Velez M.P. Arbuckle T.E. Fraser W.D. phenols phthalates pregnancy: Maternal-Infant Research Chemicals (MIREC) study.Fertil 103: 1011-1020.e2Abstract IVF35 58Day 2.4 0.0–67.4)Up-regulation TSP50 due loss methylation24Hanna C.W. Robinson W.P. Parsons P.J. al.DNA methylation changes whole blood contaminants, mercury, lead, cadmium 1401-1410Crossref (43) ScholarProspectiveFertile discontinued contraception221Pooled throughout menstrual cyclesUrinary median 2.7 1.8, 4.3), adjustedBPA shorter luteal phase; null follicular-phase length, loss25Jukic McConnaughey Longnecker Hoppin Weinberg C.R. phthalate metabolites luteal-phase fecundability, loss.Environ 124: 321-328PubMed ScholarCross-sectionalWomen who volunteered110 infertile, 43 fertileWhole prior treatmentMean serum) (ng/mL): 4.8 10.6BPA (odds ratio 8.3) metropolitan area26La IVF256 (375 cycles)Between 1.87 μg/LNo thickness, quality, clinical rates27Minguez-Alarcon Chavarro clinic.Hum 30: 2120-2128Crossref (5) IVF84 (112 <0.4–25.5 2.52 3.2)BPA retrieved levels28Mok-Lin IVF36Day 3.3 ng/mL)No quality29Bloom ScholarNote: = A; intracytoplasmic sperm injection. Open table tab Note: Limited information available targets Hanna (24Hanna decreased promoter samples However, researchers provide oncogene (32Shan Yuan Xiao Q. Chiorazzi Budman Teichberg al.TSP50, possible protease testes, activated cancer epithelial cells.Cancer Res. 290-294PubMed 33Yuan Shan de Risi Broome Lovecchio Gal al.Isolation novel gene, TSP50, hypomethylated DNA fragment cancer.Cancer 1999; 59: 3215-3221PubMed Interesting (20Chavarro inverse correlations total outcomes. Overall, suggestive infertility. determine cause relationship mechanism BPA-mediated Not all found Null (18Buck 23Velez 25Jukic another (27Minguez-Alarcon rates differences results explained characteristics without issues vs. treatments) size. Studies insights 2). mice, Berger (34Berger R.G. Hancock deCatanzaro Influence subcutaneous bisphenol-A intrauterine implantation fertilized ova inseminated mice.Reprod 23: 138-144Crossref (31) dams preimplantation period significantly reduced litters litter size controls. utero affected females subsequent generations (45Wang Hafner K.S. disrupts germ nest breakdown age mouse.Toxicol Appl 276: 157-164Crossref (15) 49Ziv-Gal Wang Zhou mice.Toxicol 284: 354-362Crossref Cabaton (35Cabaton N.J. Wadia P.R. Zalko Schaeberle C.M. Askenase M.H. al.Perinatal environmentally decreases CD-1 mice.Environ 119: 547-552Crossref performed forced breeding BPA-exposed had fewer pregnancies cumulative pups Moore-Ambriz (40Moore-Ambriz Acuna-Hernandez D.G. Ramos-Robles Sanchez-Gutierrez Santacruz-Marquez Sierra-Santoyo young mice does ovulation but oocytes.Toxicol 289: 507-514Crossref later life. exposed also three F1 gestationally maintain term gestational index) controls (49Ziv-Gal F2 index

Language: Английский

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Thyroid Disruption by Bisphenol S Analogues via Thyroid Hormone Receptor β: in Vitro, in Vivo, and Molecular Dynamics Simulation Study

Environmental Science & Technology, Journal Year: 2018, Volume and Issue: 52(11), P. 6617 - 6625

Published: May 15, 2018

Bisphenol S (4-hydroxyphenyl sulfone, BPS) is increasingly used as a bisphenol A (BPA) alternative. The global usage of BPS and its analogues (BPSs) resulted in the frequent detection their residues multiple environmental media. We investigated potential endocrine-disrupting effects toward thyroid hormone receptor (TR) β. molecular interaction BPSs TRβ ligand binding domain (LBD) was probed by fluorescence spectroscopy dynamics (MD) simulations. caused static quenching LBD. 100 ns MD simulations revealed that significant changes distance between residue His435 at helix 11(H11) Phe459 H12 comparison to no ligand-bound LBD, indicating relative repositioning H12. recombinant two-hybrid yeast assay showed tetrabromobisphenol (TBBPS) (TBBPA) have potent antagonistic activity TRβ, with an IC10 10.1 21.1 nM, respectively. BPA 312 884 significantly altered expression level mRNA gene zebrafish embryos. TBBPS environmentally relevant concentrations implying are not safe alternatives many BPA-free products. Future health risk assessments for TR disruption other adverse should focus more on structure–activity relationship design benign alternatives.

Language: Английский

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The occurrence, potential toxicity, and toxicity mechanism of bisphenol S, a substitute of bisphenol A: A critical review of recent progress

Ecotoxicology and Environmental Safety, Journal Year: 2019, Volume and Issue: 173, P. 192 - 202

Published: Feb. 14, 2019

Language: Английский

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Low‐Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer

Advanced Science, Journal Year: 2016, Volume and Issue: 4(2)

Published: Nov. 21, 2016

Breast cancer is the fifth most common cause of death in world and second fatal women. Epidemiological studies clinical data have indicated that hormones, including estrogen, progesterone, prolactin, play important roles initiation progression breast cancer. Bisphenol A (BPA) one commonly used thoroughly studied endocrine disruptors. It can be released from consumer products deposited environment, thus creating potential for human exposure through oral, inhaled, dermal routes. Some recent reviews summarized known mechanisms disruptions by BPA diseases, obesity, reproductive disorders, birth defects. However, large knowledge gaps still exist on may development. Evidence animal vitro has suggested an association between increased incidence at doses below safe reference are environmentally relevant. Most current paid little attention to cancer‐promoting properties low doses. In this review, findings carcinogenic effects low‐dose discussed possible biologic summarized.

Language: Английский

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Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review

Nutrients, Journal Year: 2020, Volume and Issue: 12(2), P. 532 - 532

Published: Feb. 19, 2020

In recent years, bisphenol analogues such as S (BPS) have come to replace A in food packaging and containers, since (BPA) has been shown leach into water, causing numerous negative health effects. Unfortunately, little or no research was done determine the safety of these BPA-free products before they were marketed public a healthier alternative. The latest studies that some may be even more harmful than original BPA situations. This article used literature survey investigate analogue BPS compare it other with regards increased obesity, metabolic disorders, cancer, reproductive defects; among others. It found works via different pathways does while equivalent obesogenic effects, activating preadipocytes, correlated gestational diabetes, not with. also toxic system hormonally promote certain breast cancers at same rate BPA. Therefore, strong argument made regulate exactly manner

Language: Английский

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Indoor Air Sources of Outdoor Air Pollution: Health Consequences, Policy, and Recommendations: An Official American Thoracic Society Workshop Report

Annals of the American Thoracic Society, Journal Year: 2024, Volume and Issue: 21(3), P. 365 - 376

Published: March 1, 2024

Section:ChooseTop of pageAbstract <

Language: Английский

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Bisphenols: Application, occurrence, safety, and biodegradation mediated by bacterial communities in wastewater treatment plants and rivers

Chemosphere, Journal Year: 2018, Volume and Issue: 201, P. 214 - 223

Published: Feb. 28, 2018

Language: Английский

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