Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

The Lancet, Journal Year: 2023, Volume and Issue: 402(10397), P. 203 - 234

Published: June 23, 2023

Diabetes is one of the leading causes death and disability worldwide, affects people regardless country, age group, or sex. Using most recent evidentiary analytical framework from Global Burden Diseases, Injuries, Risk Factors Study (GBD), we produced location-specific, age-specific, sex-specific estimates diabetes prevalence burden 1990 to 2021, proportion type 1 2 in attributable selected risk factors, projections through 2050.

Language: Английский

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Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Sept. 8, 2020

Abstract Diabetes mellitus is a leading cause of mortality and reduced life expectancy. We aim to estimate the burden diabetes by type, year, regions, socioeconomic status in 195 countries territories over past 28 years, which provide information achieve goal World Health Organization Global Action Plan for Prevention Control Noncommunicable Diseases 2025. Data were obtained from Burden Disease Study 2017. Overall, global had increased significantly since 1990. Both trend magnitude related diseases varied substantially across regions countries. In 2017, incidence, prevalence, death, disability-adjusted life-years (DALYs) associated with 22.9 million, 476.0 1.37 67.9 projection 26.6 570.9 1.59 79.3 million 2025, respectively. The type 2 was similar that total (including 1 diabetes), while age-standardized rate DALYs declined. Globally, metabolic risks (high BMI) behavioral factors (inappropriate diet, smoking, low physical activity) contributed most attributable death diabetes. These estimations could be useful policy-making, priority setting, resource allocation prevention treatment.

Language: Английский

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Sex and gender: modifiers of health, disease, and medicine

The Lancet, Journal Year: 2020, Volume and Issue: 396(10250), P. 565 - 582

Published: Aug. 1, 2020

Clinicians can encounter sex and gender disparities in diagnostic therapeutic responses. These are noted epidemiology, pathophysiology, clinical manifestations, disease progression, response to treatment. This Review discusses the fundamental influences of as modifiers major causes death morbidity. We articulate how genetic, epigenetic, hormonal biological influence physiology disease, social constructs affect behaviour community, clinicians, patients health-care system interact with pathobiology. aim guide clinicians researchers consider their approach diagnosis, prevention, treatment diseases a necessary step towards precision medicine, which will benefit men's women's health.

Language: Английский

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The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(24), P. 9739 - 9739

Published: Dec. 20, 2020

Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component ECM. The degradation ECM is great importance, since it related embryonic development and angiogenesis. It also involved in cell repair tissues. When expression MMPs altered, can generate abnormal This initial cause chronic degenerative diseases vascular complications generated by diabetes. In addition, this process has an association with neurodegeneration cancer progression. Within ECM, tissue inhibitors (TIMPs) inhibit proteolytic activity MMPs. TIMPs important regulators turnover, remodeling, cellular behavior. Therefore, (similar MMPs) modulate angiogenesis, proliferation, apoptosis. An interruption balance between been implicated pathophysiology progression several diseases. review focuses on participation both (e.g., MMP-2 MMP-9) TIMP-1 TIMP-3) physiological processes how their regulation associated human inclusion current strategies mechanisms MMP inhibition new therapies targeting was considered.

Language: Английский

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Cardiovascular Risks Associated with Gender and Aging

Journal of Cardiovascular Development and Disease, Journal Year: 2019, Volume and Issue: 6(2), P. 19 - 19

Published: April 27, 2019

The aging and elderly population are particularly susceptible to cardiovascular disease. Age is an independent risk factor for disease (CVD) in adults, but these risks compounded by additional factors, including frailty, obesity, diabetes. These factors known complicate enhance cardiac that associated with the onset of advanced age. Sex another potential given older females reported be at a greater CVD than age-matched men. However, both men women, increase age, correspond overall decline sex hormones, primarily estrogen testosterone. Despite this, hormone replacement therapies largely shown not improve outcomes patients may also events adults. This review discusses current findings regarding impacts age gender on heart

Language: Английский

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Animal models of obesity and diabetes mellitus

Nature Reviews Endocrinology, Journal Year: 2018, Volume and Issue: 14(3), P. 140 - 162

Published: Jan. 19, 2018

Language: Английский

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Sex differences in metabolic regulation and diabetes susceptibility

Diabetologia, Journal Year: 2019, Volume and Issue: 63(3), P. 453 - 461

Published: Nov. 21, 2019

Abstract Gender and biological sex impact the pathogenesis of numerous diseases, including metabolic disorders such as diabetes. In most parts world, diabetes is more prevalent in men than women, especially middle-aged populations. line with this, considering almost all animal models, males are likely to develop obesity, insulin resistance hyperglycaemia females response nutritional challenges. As summarised this review, it now obvious that many aspects energy balance glucose metabolism regulated differently influence their predisposition type 2 During reproductive life, women exhibit specificities partitioning compared men, carbohydrate lipid utilisation fuel sources favour storage subcutaneous adipose tissues preserve them from visceral ectopic fat accumulation. Insulin sensitivity higher who also characterised by capacities for secretion incretin responses men; although, these advantages disappear when tolerance deteriorates towards Clinical experimental observations evidence protective actions endogenous oestrogens, mainly through oestrogen receptor α activation various tissues, brain, liver, skeletal muscle, tissue pancreatic beta cells. However, beside steroids, underlying mechanisms need be further investigated, role chromosomes, fetal/neonatal programming epigenetic modifications. On path precision medicine, deciphering sex-specific traits homeostasis indeed a priority topic optimise individual approaches prevention treatment.

Language: Английский

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Understanding the impact of sex and gender in Alzheimer's disease: A call to action

Alzheimer s & Dementia, Journal Year: 2018, Volume and Issue: 14(9), P. 1171 - 1183

Published: June 12, 2018

Abstract Introduction Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, management Alzheimer's disease (AD) dementia. However, sex gender not yet been adequately integrated into many these approaches. Methods The Society for Women's Health Research Interdisciplinary Network on AD, comprised an expert panel scientists clinicians, reviewed ongoing published research related to differences in AD. Results current review is a result this Network's efforts aims to: (1) highlight state‐of‐the‐science AD field differences; (2) address knowledge gaps assessing (3) discuss 12 priority areas that merit further research. Discussion exclusion has impeded faster advancement detection, treatment, care across spectrum. Greater attention will improve outcomes both sexes.

Language: Английский

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<p>Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship</p>

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2019, Volume and Issue: Volume 12, P. 1057 - 1072

Published: July 1, 2019

Abstract: The incidence and prevalence of metabolic musculoskeletal diseases are increasing. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, inflammation, advanced glycation end-product accumulation increased oxidative stress. These characteristics can negatively affect various aspects muscle health, including mass, strength, quality function through impairments in protein metabolism, vascular mitochondrial dysfunction, cell death. Sarcopenia a term used to describe the age-related loss skeletal mass has been implicated as both cause consequence T2DM. may contribute development progression T2DM altered glucose disposal due low also localized which arise inter- intramuscular adipose tissue accumulation. Lifestyle modifications important for improving maintaining mobility health individuals with sarcopenia. However, evidence most effective feasible exercise dietary interventions this population lacking. In review, we discuss current literature highlighting bidirectional relationship between sarcopenia, highlight research gaps treatments, provide recommendations future research. Keywords: type mellitus, obesity

Language: Английский

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From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research

Medicina, Journal Year: 2019, Volume and Issue: 55(9), P. 546 - 546

Published: Aug. 29, 2019

Diabetes, a silent killer, is one of the most widely prevalent conditions present time. According to 2017 International Diabetes Federation (IDF) statistics, global prevalence diabetes among age group 20-79 years 8.8%. In addition, 1 in every 2 persons unaware condition. This unawareness and ignorance lead further complications. Pre-diabetes preceding condition diabetes, cases, this ultimately leads development diabetes. can be classified into three types, namely type mellitus (T2DM) gestational The diagnosis both pre-diabetes based on glucose criteria; common modalities used are fasting plasma (FPG) test oral tolerance (OGTT). A glucometer commonly by diabetic patients measure blood levels with fast rather accurate measurements. few more advanced minimally invasive include glucose-sensing patch, SwEatch, eyeglass biosensor, breath analysis, etc. Despite considerable amount data being collected analyzed regarding actual molecular mechanism developing still unknown. Both genetic epigenetic factors associated T2DM. complications predominantly two categories: microvascular macrovascular. Retinopathy, nephropathy, neuropathy grouped under complications, whereas stroke, cardiovascular disease, peripheral artery disease (PAD) belong macrovascular Unfortunately, until now, no complete cure for has been found. However, treatment shown significant success preventing progression To prevent from T2DM, lifestyle intervention found very promising. Various aspects including aforementioned topics, have reviewed paper.

Language: Английский

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