Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
134(14)
Published: July 14, 2024
A
growing
body
of
research
has
identified
circadian-rhythm
disruption
as
a
risk
factor
for
metabolic
health.
However,
the
underlying
biological
basis
remains
complex,
and
complete
molecular
mechanisms
are
unknown.
There
is
emerging
evidence
from
animal
human
to
suggest
that
expression
core
circadian
genes,
such
locomotor
output
cycles
kaput
gene
(CLOCK),
brain
muscle
ARNT-Like
1
(BMAL1),
period
(PER),
cyptochrome
(CRY),
consequent
hundreds
genes
integral
regulation
cellular
metabolism.
These
represent
potential
pathophysiological
pathways
linking
adverse
health
outcomes,
including
obesity,
syndrome,
type
2
diabetes.
Here,
we
aim
summarize
select
in
vivo
models
compare
these
results
with
epidemiologic
findings
advance
understanding
existing
foundational
mechanistic
links
between
altered
clock
contributions
health-related
pathologies.
Findings
have
important
implications
treatment,
prevention,
control
pathologies
leading
causes
death
disability,
diabetes,
cardiovascular
disease,
cancer.
Endocrine Reviews,
Journal Year:
2016,
Volume and Issue:
37(6), P. 584 - 608
Published: Oct. 20, 2016
Abstract
Circadian
(∼24-hour)
timing
systems
pervade
all
kingdoms
of
life
and
temporally
optimize
behavior
physiology
in
humans.
Relatively
recent
changes
to
our
environments,
such
as
the
introduction
artificial
lighting,
can
disorganize
circadian
system,
from
level
molecular
clocks
that
regulate
cellular
activities
synchronization
between
daily
cycles
solar
day.
Sleep/wake
are
intertwined
with
global
trends
indicate
these,
too,
increasingly
subject
disruption.
A
large
proportion
world's
population
is
at
increased
risk
environmentally
driven
rhythm
sleep
disruption,
a
minority
individuals
also
genetically
predisposed
misalignment
disorders.
The
consequences
disruption
system
profound
include
myriad
metabolic
ramifications,
some
which
may
be
compounded
by
adverse
effects
on
dietary
choices.
If
not
addressed,
deleterious
will
continue
cause
widespread
health
problems;
therefore,
implementation
numerous
behavioral
pharmaceutical
interventions
help
restore
alignment
enhance
important.
RAND Corporation eBooks,
Journal Year:
2016,
Volume and Issue:
unknown
Published: Jan. 1, 2016
The
Centers
for
Disease
Control
and
Prevention
(CDC)
in
the
United
States
has
declared
insufficient
sleep
a
"public
health
problem."
Indeed,
according
to
recent
CDC
study,
more
than
third
of
American
adults
are
not
getting
enough
on
regular
basis.
However,
is
exclusively
US
problem,
equally
concerns
other
industrialised
countries
such
as
Kingdom,
Japan,
Germany,
or
Canada.
According
some
evidence,
proportion
people
sleeping
less
recommended
hours
rising
associated
with
lifestyle
factors
related
modern
24/7
society,
psychosocial
stress,
alcohol
consumption,
smoking,
lack
physical
activity
excessive
electronic
media
use,
among
others.
This
alarming
been
found
be
range
negative
social
outcomes,
including
success
at
school
labour
market.
Over
last
few
decades,
example,
there
growing
evidence
suggesting
strong
association
between
short
duration
elevated
mortality
risks.
Given
potential
adverse
effects
health,
well-being
productivity,
consequences
sleep-deprivation
have
far-reaching
economic
consequences.
Hence,
order
raise
awareness
scale
public-health
issue,
comparative
quantitative
figures
need
provided
policy-
decision-makers,
well
recommendations
solutions
that
can
help
tackling
problem.
Biology,
Journal Year:
2019,
Volume and Issue:
8(3), P. 54 - 54
Published: July 12, 2019
The
Munich
ChronoType
Questionnaire
(MCTQ)
has
now
been
available
for
more
than
15
years
and
its
original
publication
cited
1240
times
(Google
Scholar,
May
2019).
Additionally,
online
version,
which
was
until
July
2017,
produced
almost
300,000
entries
from
all
over
the
world
(MCTQ
database).
MCTQ
gone
through
several
versions,
translated
into
13
languages,
validated
against
other
objective
measures
of
daily
timing
in
independent
studies.
Besides
being
used
as
a
method
to
correlate
circadian
features
human
biology
with
factors—ranging
health
issues
geographical
factors—the
gave
rise
quantification
old
wisdoms,
like
“teenagers
are
late”,
new
concepts,
social
jetlag.
Some
MCTQ’s
simplicity
some
view
it
critically.
Therefore,
is
time
present
self-critical
on
MCTQ,
address
misunderstandings,
give
definitions
MCTQ-derived
chronotype
concept
European Heart Journal,
Journal Year:
2019,
Volume and Issue:
41(11), P. 1182 - 1189
Published: Nov. 26, 2019
To
quantify
the
association
of
combined
sleep
behaviours
and
genetic
susceptibility
with
incidence
cardiovascular
disease
(CVD).This
study
included
385
292
participants
initially
free
CVD
from
UK
Biobank.
We
newly
created
a
healthy
score
according
to
five
factors
defined
low-risk
groups
as
follows:
early
chronotype,
7-8
h
per
day,
never/rarely
insomnia,
no
snoring,
frequent
excessive
daytime
sleepiness.
Weighted
risk
scores
coronary
heart
(CHD)
or
stroke
were
calculated.
During
median
8.5
years
follow-up,
we
documented
7280
incident
cases
including
4667
CHD
2650
cases.
Compared
those
0-1,
5
had
35%
(19-48%),
34%
(22-44%),
(25-42%)
reduced
CVD,
CHD,
stroke,
respectively.
Nearly
10%
events
in
this
cohort
could
be
attributed
poor
pattern.
Participants
pattern
high
showed
highest
stroke.In
large
prospective
study,
was
associated
risks
among
low,
intermediate,
risk.
