Circadian disruption, clock genes, and metabolic health DOI Creative Commons

Lauren A. Schrader,

Sean M. Ronnekleiv‐Kelly, John B. Hogenesch

et al.

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(14)

Published: July 14, 2024

A growing body of research has identified circadian-rhythm disruption as a risk factor for metabolic health. However, the underlying biological basis remains complex, and complete molecular mechanisms are unknown. There is emerging evidence from animal human to suggest that expression core circadian genes, such locomotor output cycles kaput gene (CLOCK), brain muscle ARNT-Like 1 (BMAL1), period (PER), cyptochrome (CRY), consequent hundreds genes integral regulation cellular metabolism. These represent potential pathophysiological pathways linking adverse health outcomes, including obesity, syndrome, type 2 diabetes. Here, we aim summarize select in vivo models compare these results with epidemiologic findings advance understanding existing foundational mechanistic links between altered clock contributions health-related pathologies. Findings have important implications treatment, prevention, control pathologies leading causes death disability, diabetes, cardiovascular disease, cancer.

Language: Английский

Sleep health of Australian adults in 2016: results of the 2016 Sleep Health Foundation national survey DOI
Robert Adams, Sarah Appleton, Anne Taylor

et al.

Sleep Health, Journal Year: 2017, Volume and Issue: 3(1), P. 35 - 42

Published: Jan. 24, 2017

Language: Английский

Citations

255

Disruption of adolescents’ circadian clock: The vicious circle of media use, exposure to light at night, sleep loss and risk behaviors DOI
Yvan Touitou, D Touitou,

Alain Reinberg

et al.

Journal of Physiology-Paris, Journal Year: 2016, Volume and Issue: 110(4), P. 467 - 479

Published: Nov. 1, 2016

Language: Английский

Citations

247

Circadian disruption: What do we actually mean? DOI
Céline Vetter

European Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 51(1), P. 531 - 550

Published: Nov. 7, 2018

The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced when traveling across time zones, will eventually result in re-synchronization local environmental cues, but this is oftentimes accompanied by adverse short-term consequences. When are chronically, adaptation may not be achieved, for example case of rotating night shift workers. transient chronic disturbance most frequently referred "circadian disruption", many other terms have been proposed used refer similar situations. It now beyond doubt that contributes health disease, emphasizing need clear terminology describing their goal review provide an overview describe disruption discuss quantifications experimental observational settings with a focus on human research, highlight limitations currently available tools. For research advance translational science, clear, operationalizable, scalable key, they enable improved assessment reproducibility results, ideally ranging from mechanistic settings, including animal large-scale randomized clinical trials.

Language: Английский

Citations

246

Impact of Circadian Disruption on Cardiovascular Function and Disease DOI
Sarah L. Chellappa,

Nina Vujović,

Jonathan S. Williams

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2019, Volume and Issue: 30(10), P. 767 - 779

Published: Aug. 16, 2019

Language: Английский

Citations

241

Sleep timing, sleep consistency, and health in adults: a systematic review DOI Creative Commons
Jean‐Philippe Chaput, Caroline Dutil, Ryan B. Featherstone

et al.

Applied Physiology Nutrition and Metabolism, Journal Year: 2020, Volume and Issue: 45(10 (Suppl. 2)), P. S232 - S247

Published: Oct. 1, 2020

The objective of this systematic review was to examine the associations between sleep timing (e.g., bedtime/wake-up time, midpoint sleep), consistency/regularity intra-individual variability in duration, social jetlag, catch-up and health outcomes adults aged 18 years older. Four electronic databases were searched December 2018 for articles published previous 10 years. Fourteen examined. A total 41 articles, including 92 340 unique participants from 14 countries, met inclusion criteria. Sleep assessed objectively 37% studies subjectively 63% studies. Findings suggest that later greater generally associated with adverse outcomes. However, because most reported linear associations, it not possible identify thresholds “late timing” or “large variability”. In addition, jetlag outcomes, while weekend better quality evidence ranged “very low” “moderate” across study designs using GRADE. conclusion, available supports earlier regularity patterns consistent bedtimes wake-up times are favourably health. (PROSPERO registration no.: CRD42019119534.) Novelty This is first influence consistency on Later both adults. Regularity should be encouraged.

Language: Английский

Citations

230

Chronotype, gender and general health DOI
Fabio Fabbian,

Beatrice Zucchi,

Alfredo De Giorgi

et al.

Chronobiology International, Journal Year: 2016, Volume and Issue: 33(7), P. 863 - 882

Published: May 5, 2016

Background: Light–dark alternation has always been the strongest external circadian “zeitgeber” for humans. Due to its growing technological preference, our society is quickly transforming toward a progressive “eveningness” (E), with consequences on personal preference (chronotype), depending gender as well. The aim of this study was review available evidence possible relationships between chronotype and gender, relevance disturbances that could negatively impact general health, including daily life aspects. Methods: Electronic searches published literature were performed in databases MEDLINE Web Science, by using Medical Subject Heading (MeSH), when available, or other specific keywords. Results: Results grouped into four areas, i.e. (a) “General Cardiovascular Issues”, (b) “Psychological Psychopathological (c) “Sleep Sleep-Related Issues” (d) “School School-Related Issues”. E associated unhealthy dietary habits, smoking alcohol drinking (in younger subjects) and, adults, diabetes metabolic syndrome; impulsivity anger, depression, anxiety disorders nightmares (especially women), risk taking behavior, use alcohol, coffee stimulants, psychopathology personality traits; associated, especially young subjects, later bedtime wake-up time, irregular sleep–wake schedule, subjective poor sleep, school performance motivation, health-related quality life; lowest mood lower overall grade point average women). Conclusions: Eveningness may either physical mental, results achievements, age women. role family support crucial, parents should be deeply informed abuse devices during night hours lead immature adjustment function children’s endogenous pacemakers.

Language: Английский

Citations

229

The Association between Social Jetlag, the Metabolic Syndrome, and Type 2 Diabetes Mellitus in the General Population: The New Hoorn Study DOI Creative Commons
Anitra D.M. Koopman, Simone P. Rauh,

Esther van ’t Riet

et al.

Journal of Biological Rhythms, Journal Year: 2017, Volume and Issue: 32(4), P. 359 - 368

Published: June 20, 2017

Only a few studies have investigated the metabolic consequences of social jetlag. Therefore, we examined association jetlag with syndrome and type 2 diabetes mellitus in population-based cohort. We used cross-sectional data from New Hoorn Study cohort ( n = 1585, 47% men, age 60.8 ± 6 years). Social was calculated as difference midpoint sleep (in hours) between weekdays weekend days. Poisson linear regression models were to study associations, regarded possible effect modifier. adjusted for sex, employment status, education, smoking, physical activity, duration, body mass index. In total population, only observed an syndrome, prevalence ratios educational levels 1.64 (95% CI 1.1-2.4), participants >2 h jetlag, compared <1 However, interaction median (<61 older (≥61 years), no significant associations or prediabetes. younger group 1.29 0.9-1.9) 2.13 1.3-3.4) 1.39 1.1-1.9) 1.75 1.2-2.5) diabetes/prediabetes, 1-2 conclusion, our cohort, associated 2-fold increased risk especially years) participants.

Language: Английский

Citations

219

Human circadian phase–response curves for exercise DOI Creative Commons

Shawn D. Youngstedt,

Jeffrey A. Elliott, Daniel F. Kripke

et al.

The Journal of Physiology, Journal Year: 2019, Volume and Issue: 597(8), P. 2253 - 2268

Published: Feb. 20, 2019

Exercise elicits circadian phase-shifting effects, but additional information is needed. The phase-response curve describing the magnitude and direction of rhythm phase shifts, depending on time zeigeber (time cue) stimulus, most fundamental chronobiological tool for alleviating misalignment related morbidity. Fifty-one older 48 young adults followed a rhythms measurement protocol up to 5.5 days, performed 1 h moderate treadmill exercise 3 consecutive days at one eight times day/night. Temporal changes in 6-sulphatoxymelatonin (aMT6s) were measured from evening onset, cosine acrophase, morning offset duration excretion. Significant curves established aMT6 onset acrophase with large delays 7:00 pm 10:00 advances both am 1:00 4:00 pm. Delays or would be desired, example, adjustment westward eastward air travel, respectively. Along known synergism bright light, above PRCs second advance region (afternoon) could support practical clinical applications.Although light regarded as primary zeitgeber, its limitations exploring alternative zeitgebers. significant regarding these effects aim present study was establish (PRCs) documenting size shifts relation exercise. Aerobically fit (n = 51; 59-75 years) 48; 18-30 90 min laboratory ultrashort sleep-wake cycle (60 wake/30 sleep) 5½ days. At same clock three each participant 60 (65-75% heart rate reserve) To describe PRCs, cosine-fitted urinary (aMT6s), well rise, decline change aMT6s found duration, peak corresponding pm, minimal around 2:00 am. There no age sex differences. amplitudes are comparable expectations equal duration. afternoon exercise-induced PRC novel findings. results further research additive health benefits.

Language: Английский

Citations

204

Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health DOI Creative Commons
Suzana Almoosawi, Snieguole Vingeliene, Frédéric Gachon

et al.

Advances in Nutrition, Journal Year: 2018, Volume and Issue: 10(1), P. 30 - 42

Published: Aug. 20, 2018

Chrono-nutrition is an emerging research field in nutritional epidemiology that encompasses 3 dimensions of eating behavior: timing, frequency, and regularity. To date, few studies have investigated how individual's circadian typology, i.e., one's chronotype, affects the association between chrono-nutrition cardiometabolic health. This review sets directions for future by providing a narrative overview recent epidemiologic on its determinants, with dietary intake Limited was found chronotype infants, children, older adults. Moreover, most evidence adolescents adults restricted to cross-sectional surveys longitudinal cohorts simultaneously collecting data intake. There gap concerning chrono-nutrition. Whether modifies diet health outcomes remains be elucidated. In conclusion, further required understand interplay chrono-nutrition, outcomes.

Language: Английский

Citations

178

Circadian rhythms and disorders of the timing of sleep DOI
Nicholas Meyer, Allison G. Harvey, Steven W. Lockley

et al.

The Lancet, Journal Year: 2022, Volume and Issue: 400(10357), P. 1061 - 1078

Published: Sept. 1, 2022

Language: Английский

Citations

178