Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
134(14)
Published: July 14, 2024
A
growing
body
of
research
has
identified
circadian-rhythm
disruption
as
a
risk
factor
for
metabolic
health.
However,
the
underlying
biological
basis
remains
complex,
and
complete
molecular
mechanisms
are
unknown.
There
is
emerging
evidence
from
animal
human
to
suggest
that
expression
core
circadian
genes,
such
locomotor
output
cycles
kaput
gene
(CLOCK),
brain
muscle
ARNT-Like
1
(BMAL1),
period
(PER),
cyptochrome
(CRY),
consequent
hundreds
genes
integral
regulation
cellular
metabolism.
These
represent
potential
pathophysiological
pathways
linking
adverse
health
outcomes,
including
obesity,
syndrome,
type
2
diabetes.
Here,
we
aim
summarize
select
in
vivo
models
compare
these
results
with
epidemiologic
findings
advance
understanding
existing
foundational
mechanistic
links
between
altered
clock
contributions
health-related
pathologies.
Findings
have
important
implications
treatment,
prevention,
control
pathologies
leading
causes
death
disability,
diabetes,
cardiovascular
disease,
cancer.
European Journal of Neuroscience,
Journal Year:
2018,
Volume and Issue:
51(1), P. 531 - 550
Published: Nov. 7, 2018
The
circadian
system
regulates
physiology
and
behavior.
Acute
challenges
to
the
system,
such
as
those
experienced
when
traveling
across
time
zones,
will
eventually
result
in
re-synchronization
local
environmental
cues,
but
this
is
oftentimes
accompanied
by
adverse
short-term
consequences.
When
are
chronically,
adaptation
may
not
be
achieved,
for
example
case
of
rotating
night
shift
workers.
transient
chronic
disturbance
most
frequently
referred
"circadian
disruption",
many
other
terms
have
been
proposed
used
refer
similar
situations.
It
now
beyond
doubt
that
contributes
health
disease,
emphasizing
need
clear
terminology
describing
their
goal
review
provide
an
overview
describe
disruption
discuss
quantifications
experimental
observational
settings
with
a
focus
on
human
research,
highlight
limitations
currently
available
tools.
For
research
advance
translational
science,
clear,
operationalizable,
scalable
key,
they
enable
improved
assessment
reproducibility
results,
ideally
ranging
from
mechanistic
settings,
including
animal
large-scale
randomized
clinical
trials.
Applied Physiology Nutrition and Metabolism,
Journal Year:
2020,
Volume and Issue:
45(10 (Suppl. 2)), P. S232 - S247
Published: Oct. 1, 2020
The
objective
of
this
systematic
review
was
to
examine
the
associations
between
sleep
timing
(e.g.,
bedtime/wake-up
time,
midpoint
sleep),
consistency/regularity
intra-individual
variability
in
duration,
social
jetlag,
catch-up
and
health
outcomes
adults
aged
18
years
older.
Four
electronic
databases
were
searched
December
2018
for
articles
published
previous
10
years.
Fourteen
examined.
A
total
41
articles,
including
92
340
unique
participants
from
14
countries,
met
inclusion
criteria.
Sleep
assessed
objectively
37%
studies
subjectively
63%
studies.
Findings
suggest
that
later
greater
generally
associated
with
adverse
outcomes.
However,
because
most
reported
linear
associations,
it
not
possible
identify
thresholds
“late
timing”
or
“large
variability”.
In
addition,
jetlag
outcomes,
while
weekend
better
quality
evidence
ranged
“very
low”
“moderate”
across
study
designs
using
GRADE.
conclusion,
available
supports
earlier
regularity
patterns
consistent
bedtimes
wake-up
times
are
favourably
health.
(PROSPERO
registration
no.:
CRD42019119534.)
Novelty
This
is
first
influence
consistency
on
Later
both
adults.
Regularity
should
be
encouraged.
Chronobiology International,
Journal Year:
2016,
Volume and Issue:
33(7), P. 863 - 882
Published: May 5, 2016
Background:
Light–dark
alternation
has
always
been
the
strongest
external
circadian
“zeitgeber”
for
humans.
Due
to
its
growing
technological
preference,
our
society
is
quickly
transforming
toward
a
progressive
“eveningness”
(E),
with
consequences
on
personal
preference
(chronotype),
depending
gender
as
well.
The
aim
of
this
study
was
review
available
evidence
possible
relationships
between
chronotype
and
gender,
relevance
disturbances
that
could
negatively
impact
general
health,
including
daily
life
aspects.
Methods:
Electronic
searches
published
literature
were
performed
in
databases
MEDLINE
Web
Science,
by
using
Medical
Subject
Heading
(MeSH),
when
available,
or
other
specific
keywords.
Results:
Results
grouped
into
four
areas,
i.e.
(a)
“General
Cardiovascular
Issues”,
(b)
“Psychological
Psychopathological
(c)
“Sleep
Sleep-Related
Issues”
(d)
“School
School-Related
Issues”.
E
associated
unhealthy
dietary
habits,
smoking
alcohol
drinking
(in
younger
subjects)
and,
adults,
diabetes
metabolic
syndrome;
impulsivity
anger,
depression,
anxiety
disorders
nightmares
(especially
women),
risk
taking
behavior,
use
alcohol,
coffee
stimulants,
psychopathology
personality
traits;
associated,
especially
young
subjects,
later
bedtime
wake-up
time,
irregular
sleep–wake
schedule,
subjective
poor
sleep,
school
performance
motivation,
health-related
quality
life;
lowest
mood
lower
overall
grade
point
average
women).
Conclusions:
Eveningness
may
either
physical
mental,
results
achievements,
age
women.
role
family
support
crucial,
parents
should
be
deeply
informed
abuse
devices
during
night
hours
lead
immature
adjustment
function
children’s
endogenous
pacemakers.
Journal of Biological Rhythms,
Journal Year:
2017,
Volume and Issue:
32(4), P. 359 - 368
Published: June 20, 2017
Only
a
few
studies
have
investigated
the
metabolic
consequences
of
social
jetlag.
Therefore,
we
examined
association
jetlag
with
syndrome
and
type
2
diabetes
mellitus
in
population-based
cohort.
We
used
cross-sectional
data
from
New
Hoorn
Study
cohort
(
n
=
1585,
47%
men,
age
60.8
±
6
years).
Social
was
calculated
as
difference
midpoint
sleep
(in
hours)
between
weekdays
weekend
days.
Poisson
linear
regression
models
were
to
study
associations,
regarded
possible
effect
modifier.
adjusted
for
sex,
employment
status,
education,
smoking,
physical
activity,
duration,
body
mass
index.
In
total
population,
only
observed
an
syndrome,
prevalence
ratios
educational
levels
1.64
(95%
CI
1.1-2.4),
participants
>2
h
jetlag,
compared
<1
However,
interaction
median
(<61
older
(≥61
years),
no
significant
associations
or
prediabetes.
younger
group
1.29
0.9-1.9)
2.13
1.3-3.4)
1.39
1.1-1.9)
1.75
1.2-2.5)
diabetes/prediabetes,
1-2
conclusion,
our
cohort,
associated
2-fold
increased
risk
especially
years)
participants.
The Journal of Physiology,
Journal Year:
2019,
Volume and Issue:
597(8), P. 2253 - 2268
Published: Feb. 20, 2019
Exercise
elicits
circadian
phase-shifting
effects,
but
additional
information
is
needed.
The
phase-response
curve
describing
the
magnitude
and
direction
of
rhythm
phase
shifts,
depending
on
time
zeigeber
(time
cue)
stimulus,
most
fundamental
chronobiological
tool
for
alleviating
misalignment
related
morbidity.
Fifty-one
older
48
young
adults
followed
a
rhythms
measurement
protocol
up
to
5.5
days,
performed
1
h
moderate
treadmill
exercise
3
consecutive
days
at
one
eight
times
day/night.
Temporal
changes
in
6-sulphatoxymelatonin
(aMT6s)
were
measured
from
evening
onset,
cosine
acrophase,
morning
offset
duration
excretion.
Significant
curves
established
aMT6
onset
acrophase
with
large
delays
7:00
pm
10:00
advances
both
am
1:00
4:00
pm.
Delays
or
would
be
desired,
example,
adjustment
westward
eastward
air
travel,
respectively.
Along
known
synergism
bright
light,
above
PRCs
second
advance
region
(afternoon)
could
support
practical
clinical
applications.Although
light
regarded
as
primary
zeitgeber,
its
limitations
exploring
alternative
zeitgebers.
significant
regarding
these
effects
aim
present
study
was
establish
(PRCs)
documenting
size
shifts
relation
exercise.
Aerobically
fit
(n
=
51;
59-75
years)
48;
18-30
90
min
laboratory
ultrashort
sleep-wake
cycle
(60
wake/30
sleep)
5½
days.
At
same
clock
three
each
participant
60
(65-75%
heart
rate
reserve)
To
describe
PRCs,
cosine-fitted
urinary
(aMT6s),
well
rise,
decline
change
aMT6s
found
duration,
peak
corresponding
pm,
minimal
around
2:00
am.
There
no
age
sex
differences.
amplitudes
are
comparable
expectations
equal
duration.
afternoon
exercise-induced
PRC
novel
findings.
results
further
research
additive
health
benefits.
Advances in Nutrition,
Journal Year:
2018,
Volume and Issue:
10(1), P. 30 - 42
Published: Aug. 20, 2018
Chrono-nutrition
is
an
emerging
research
field
in
nutritional
epidemiology
that
encompasses
3
dimensions
of
eating
behavior:
timing,
frequency,
and
regularity.
To
date,
few
studies
have
investigated
how
individual's
circadian
typology,
i.e.,
one's
chronotype,
affects
the
association
between
chrono-nutrition
cardiometabolic
health.
This
review
sets
directions
for
future
by
providing
a
narrative
overview
recent
epidemiologic
on
its
determinants,
with
dietary
intake
Limited
was
found
chronotype
infants,
children,
older
adults.
Moreover,
most
evidence
adolescents
adults
restricted
to
cross-sectional
surveys
longitudinal
cohorts
simultaneously
collecting
data
intake.
There
gap
concerning
chrono-nutrition.
Whether
modifies
diet
health
outcomes
remains
be
elucidated.
In
conclusion,
further
required
understand
interplay
chrono-nutrition,
outcomes.