Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(3), P. e3001571 - e3001571

Published: March 17, 2022

Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms sleep, as well neuroendocrine cognitive functions. Prevailing patterns do not optimally engage these actions for many individuals, but advances in our understanding the underpinning mechanisms emerging lighting technologies now present opportunities to adjust promote optimal physical mental performance. A newly developed, international standard provides a SI-compliant way quantifying influence intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate effects. The report recommendations lighting, based an expert scientific consensus expressed easily measured quantity (melanopic equivalent daylight illuminance (melaponic EDI)) defined within this standard. are supported by detailed analysis sensitivity circadian, neuroendocrine, alerting responses ocular provide straightforward framework inform design practice.

Language: Английский

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Melatonin: Roles in influenza, Covid‐19, and other viral infections

Reviews in Medical Virology, Journal Year: 2020, Volume and Issue: 30(3)

Published: April 21, 2020

Summary There is a growing appreciation that the regulation of melatonergic pathways, both pineal and systemic, may be an important aspect in how viruses drive cellular changes underpin their control function. We review pathway role viral infections, emphasizing influenza covid‐19 infections. Viral, or preexistent, suppression melatonin disinhibits neutrophil attraction, thereby contributing to initial “cytokine storm”, as well other immune cells. Melatonin induces circadian gene, Bmal1, which pyruvate dehydrogenase complex (PDC), countering inhibition Bmal1/PDC. PDC drives mitochondrial conversion acetyl‐coenzyme A (acetyl‐CoA), increasing tricarboxylic acid cycle, oxidative phosphorylation, ATP production. Pineal attenuates this, preventing “resetting” metabolism. This especially relevant cells, where shifting metabolism from glycolytic switches cells reactive quiescent phenotypes. Acetyl‐CoA necessary cosubstrate for arylalkylamine N‐acetyltransferase, providing acetyl group serotonin, initiating pathway. Consequently, regulates cell phenotype. Virus‐ cytokine‐storm‐driven therefore responses. Virus‐and cytokine storm‐driven also increase gut permeability dysbiosis, suppressing levels short‐chain fatty acid, butyrate, circulating lipopolysaccharide (LPS). The alterations butyrate LPS can promote replication host symptom severity via impacts on Focussing regulators has treatment implications

Language: Английский

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Genetics of circadian rhythms and sleep in human health and disease

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 24(1), P. 4 - 20

Published: Aug. 26, 2022

Language: Английский

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The importance of sleep regularity: a consensus statement of the National Sleep Foundation sleep timing and variability panel

Sleep Health, Journal Year: 2023, Volume and Issue: 9(6), P. 801 - 820

Published: Sept. 7, 2023

To develop and present consensus findings of the National Sleep Foundation sleep timing variability panel regarding impact on health performance.

Language: Английский

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Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study

SLEEP, Journal Year: 2023, Volume and Issue: 47(1)

Published: Sept. 21, 2023

Abstract Abnormally short and long sleep are associated with premature mortality, achieving optimal duration has been the focus of health guidelines. Emerging research demonstrates that regularity, day-to-day consistency sleep–wake timing, can be a stronger predictor for some outcomes than duration. The role regularity in however, not investigated large cohort objective data. We therefore aimed to compare how predicted risk all-cause cause-specific mortality. calculated Sleep Regularity Index (SRI) scores from > 10 million hours accelerometer data 60 977 UK Biobank participants (62.8 ± 7.8 years, 55.0% female, median[IQR] SRI: 81.0[73.8–86.3]). Mortality was reported up years after recording 1859 (4.84 deaths per 1000 person-years, mean (±SD) follow-up 6.30 0.83 years). Higher 20%–48% lower mortality (p < .001 p = 0.004), 16%–39% cancer 0.001 0.017), 22%–57% cardiometabolic 0.048), across top four SRI quintiles compared least regular quintile. Results were adjusted age, sex, ethnicity, sociodemographic, lifestyle, factors. duration, by comparing equivalent models, nested SRI-mortality models without 0.14–0.20). These findings indicate is an important may simple, effective target improving general survival.

Language: Английский

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Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3392 - 3392

Published: Feb. 8, 2023

Availability of artificial light and light-emitting devices have altered human temporal life, allowing 24-hour healthcare, commerce production, expanding social life around the clock. However, physiology behavior that evolved in context 24 h solar days are frequently perturbed by exposure to at night. This is particularly salient circadian rhythms, result endogenous biological clocks with a rhythm ~24 h. Circadian rhythms govern features behavior, set precisely primarily during day, though other factors, such as timing meals, can also affect rhythms. significantly affected night shift work because nocturnal light, electronic devices, shifts meals. Night workers increased risk for metabolic disorder, well several types cancer. Others who exposed or late mealtimes show disrupted cardiac disorders. It imperative understand how alter function develop strategies mitigate their negative effects. In this review, we provide an introduction physiological regulation homeostasis suprachiasmatic nucleus (SCN), SCN-mediated hormones display including melatonin glucocorticoids. Next, discuss circadian-gated processes sleep food intake, followed modern lighting disrupts molecular clock Lastly, identify disruptions metabolism increase susceptibility syndrome cardiovascular diseases, various harmful consequences associated on health.

Language: Английский

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The sleep–circadian interface: A window into mental disorders

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 23, 2024

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances alleviate psychopathology. Conversely, poor disrupt clock-controlled processes. Despite progress elucidating underlying mechanisms, a cohesive approach integrates dynamic interactions between disorder with both processes is lacking. This review synthesizes recent evidence for dysfunction as transdiagnostic contributor range disorders, an emphasis on biological mechanisms. We highlight observations from adolescent young adults, who at greatest risk developing whom early detection intervention promise benefit. In particular, we aim a) integrate factors implicated pathophysiology treatment mood, anxiety, psychosis spectrum perspective; b) need reframe existing knowledge adopt integrated which recognizes interaction factors; c) identify important gaps opportunities further research.

Language: Английский

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Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 14, 2024

Abstract Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even people without prior history of disease. To address this issue and improve function, it crucial investigate the molecular mechanisms underlying senescence. This review summarizes main key proteins involved further discusses modulators cellular senescence aging hearts. Furthermore, discussion will encompass comprehensive descriptions drugs, modes action potential targets for intervention By offering fresh perspective insights into seeks provide important theoretical foundations development drugs targeting condition.

Language: Английский

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Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 675 - 694

Published: March 14, 2024

The impact of circadian rhythms on cardiovascular function and disease development is well established, with numerous studies in genetically modified animals emphasizing the molecular clock's significance pathogenesis pathophysiology myocardial ischemia heart failure progression. However, translational preclinical targeting heart's biology are just now emerging leading to a novel field medicine termed medicine. In this review, we explore mechanisms therapies, including (1) intense light, (2) small molecules modulating mechanism, (3) chronotherapies such as drugs meal timings. These promise significant clinical translation for disease. (4) Additionally, address differential functioning mechanism males versus females, consideration biological sex, gender, aging therapies

Language: Английский

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Late eating is associated with cardiometabolic risk traits, obesogenic behaviors, and impaired weight loss

American Journal of Clinical Nutrition, Journal Year: 2020, Volume and Issue: 113(1), P. 154 - 161

Published: Aug. 26, 2020

Language: Английский

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