A deep‐learning retinal aging biomarker for cognitive decline and incident dementia DOI Creative Commons
Ming Ann Sim,

Yih‐Chung Tham,

Simon Nusinovici

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

The utility of retinal photography-derived aging biomarkers for predicting cognitive decline remains under-explored. A memory-clinic cohort in Singapore was followed-up 5 years. RetiPhenoAge, a biomarker, derived from photographs using deep-learning. Using competing risk analysis, we determined the associations RetiPhenoAge with and dementia, UK Biobank utilized as replication cohort. MRI markers(cerebral small vessel disease [CSVD] neurodegeneration) its underlying plasma proteomic profile were evaluated. Of 510 subjects(N = 155 decline), associated incident (subdistribution hazard ratio [SHR] 1.34, 95% confidence interval [CI] 1.10-1.64, p 0.004), dementia (SHR 1.43, CI 1.02-2.01, 0.036). In (N 33 495), similarly predicted 1.25, 1.09-1.41, 0.008). significantly CSVD, brain atrophy, signatures related to aging. may provide non-invasive prognostic screening tool dementia. marker, studied an Asian memory clinic Older future It also linked neuropathological markers, profiles found that 12-year Future studies should validate biomarker

Language: Английский

Biomarkers of aging for the identification and evaluation of longevity interventions DOI Creative Commons
Mahdi Moqri, Chiara Herzog, Jesse R. Poganik

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(18), P. 3758 - 3775

Published: Aug. 1, 2023

Language: Английский

Citations

262
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial DOI Creative Commons
Reem Waziry, Calen P. Ryan, David L. Corcoran

et al.

Nature Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 9, 2023

The geroscience hypothesis proposes that therapy to slow or reverse molecular changes occur with aging can delay prevent multiple chronic diseases and extend healthy lifespan

Language: Английский

Citations

112
Epigenetic aging as a biomarker of dementia and related outcomes: a systematic review DOI Creative Commons
Aoshuang Zhou, Zimu Wu, Aung Zaw Zaw Phyo

et al.

Epigenomics, Journal Year: 2022, Volume and Issue: 14(18), P. 1125 - 1138

Published: Sept. 1, 2022

Background: Biological aging may be a robust biomarker of dementia or cognitive performance. This systematic review synthesized the evidence for an association between epigenetic and dementia, mild impairment function. Methods: A search was conducted according to Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines. Results: 30 eligible articles were included. There no strong that accelerated associated with dementia/mild (n = 7). some poorer cognition 20), particularly GrimAge acceleration, but this inconsistent varied across domains. meta-analysis not performed due high study heterogeneity. Conclusion: is insufficient indicate current clocks can clinically useful biomarkers aging.

Language: Английский

Citations

43
The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022 DOI Creative Commons
Dallas P. Veitch, Michael W. Weiner,

Melanie J. Miller

et al.

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 20(1), P. 652 - 694

Published: Sept. 12, 2023

The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging, and cognitive data, biofluid samples. We used conventional search methods identify 1459 publications from 2021 2022 using data/samples reviewed 291 impactful studies. This review details how studies improved progression understanding trial efficiency. Advances in subject selection, detection of treatment effects, harmonization, modeling trials plasma biomarkers like phosphorylated tau showed promise for use. Biomarkers amyloid beta, tau, neurodegeneration, inflammation, others were prognostic with individualized prediction algorithms available online. Studies supported the cascade, emphasized importance neuroinflammation, detailed widespread heterogeneity disease, linked genetic vascular risk, co-pathologies, sex, resilience. Biological subtypes consistently observed. Generalizability results is limited by lack cohort diversity, an issue ADNI-4 address enrolling a diverse cohort.

Language: Английский

Citations

35
Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective DOI Creative Commons
Stefano Salvioli, Maria Sofia Basile, Leonardo Bencivenga

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102044 - 102044

Published: Aug. 28, 2023

According to the Geroscience concept that organismal aging and age-associated diseases share same basic molecular mechanisms, identification of biomarkers age can efficiently classify people as biologically older (or younger) than their chronological (i.e. calendar) is becoming paramount importance. These will be in fact at higher lower) risk for many different diseases, including cardiovascular neurodegeneration, cancer, etc. In turn, patients suffering from these are healthy age-matched individuals. Many correlate with have been described so far. The aim present review discuss usefulness some (especially soluble, circulating ones) order identify frail patients, possibly before appearance clinical symptoms, well diseases. An overview selected discussed this regard, particular we focus on related metabolic stress response, inflammation, cell death (in neurodegeneration), all phenomena connected inflammaging (chronic, low-grade, inflammation). second part review, next-generation markers such extracellular vesicles cargos, epigenetic gut microbiota composition, discussed. Since recent progresses omics techniques allowed an exponential increase production laboratory data also field age, making it difficult extract biological meaning huge mass available data, Artificial Intelligence (AI) approaches increasingly important strategy extracting knowledge raw providing practitioners actionable information treat patients.

Language: Английский

Citations

27
Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status DOI Creative Commons
Kyeezu Kim, Brian T. Joyce, Drew Nannini

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(26)

Published: June 28, 2023

Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated association between 20-year greenness [Normalized Difference Vegetation Index (NDVI)] and a large, biracial (Black/white), U.S. urban cohort. Using generalized estimating equations adjusted for individual neighborhood socioeconomic characteristics, greater was slower aging. Black participants had less surrounding an attenuated [β

Language: Английский

Citations

26
Epigenetic clocks in neurodegenerative diseases: a systematic review DOI

Tianmi Yang,

Yi Xiao, Yangfan Cheng

et al.

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2023, Volume and Issue: 94(12), P. 1064 - 1070

Published: March 24, 2023

Background Biological ageing is one of the principal risk factors for neurodegenerative diseases. It becoming increasingly clear that acceleration DNA methylation age, as measured by epigenetic clock, closely associated with many age-related Methods We searched PubMed and Web Science databases to identify eligible studies reporting clocks in several diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS) Huntington’s (HD). Results Twenty-three (12 AD, 4 PD, 5 ALS, 2 HD) were included. systematically summarised clinical utility 11 (based on blood brain tissues) assessing factors, age onset, diagnosis, progression, prognosis pathology ALS HD. also critically described our current understandings these evidences, further discussed key challenges, potential mechanisms future perspectives Conclusions Epigenetic hold great Further research encouraged evaluate promote application. PROSPERO registration number CRD42022365233.

Language: Английский

Citations

22
Metal mixtures and DNA methylation measures of biological aging in American Indian populations DOI Creative Commons
K. M. Boyer, Arce Domingo‐Relloso,

Enoch Jiang

et al.

Environment International, Journal Year: 2023, Volume and Issue: 178, P. 108064 - 108064

Published: June 24, 2023

Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases diabetes. DNA methylation is a sensitive biomarker of aging-related processes novel epigenetic-based "clocks" can be used to estimate accelerated biological aging that may underlie risk. Metals alter methylation, yet little known about their individual combined impact on epigenetic age acceleration. Our objective was investigate the associations metals several methylation-based measures in Strong Heart Study (SHS) cohort.

Language: Английский

Citations

20
Biological age is superior to chronological age in predicting hospital mortality of the critically ill DOI Creative Commons
Kwok M. Ho, David Morgan,

Mason Johnstone

et al.

Internal and Emergency Medicine, Journal Year: 2023, Volume and Issue: 18(7), P. 2019 - 2028

Published: Aug. 28, 2023

Abstract Biological age is increasingly recognized as being more accurate than chronological in determining chronic health outcomes. This study assessed whether biological age, on intensive care unit (ICU) admission, can predict hospital mortality. retrospective cohort study, conducted a tertiary multidisciplinary ICU Western Australia, used the Levine PhenoAge model to estimate each patient’s (also called PhenoAge). Each was calibrated generate regression residual which equivalent unexplained by local context. PhenoAgeAccel dichotomized measure of residuals, and its presence suggested that one biologically older corresponding age. Of 2950 critically ill adult patients analyzed, 291 died (9.9%) before discharge. Both residuals (after regressing age) had significantly better ability differentiate between survivors non-survivors (area under receiver-operating-characteristic curve 0.648 0.654 vs. 0.547 respectively). Being phenotypically one’s associated with an increased risk mortality (PhenoAgeAccel hazard ratio [HR] 1.997, 95% confidence interval [CI] 1.568–2.542; p = 0.001) dose-related fashion did not reach plateau until at least 20-year gap. adverse association remained significant (adjusted HR 1.386, CI 1.077–1.784; 0.011) after adjusted for severity acute illness comorbidities. prevalent among those pre-existing cardiovascular disease, end-stage renal failure, cirrhosis, immune diabetes mellitus, or treated immunosuppressive therapy. common comorbidities, this fully explained comorbidities illness.

Language: Английский

Citations

20
Targeting epigenetics: A novel promise for Alzheimer’s disease treatment DOI
Danko Jeremic, Lydia Jiménez‐Díaz, Juan D. Navarro‐López

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 90, P. 102003 - 102003

Published: July 7, 2023

Language: Английский

Citations

18